Umlobi: Robert Simon
Usuku Lokudalwa: 24 Ujuni 2021
Ukuvuselela Usuku: 10 Ufebhuwari 2025
Anonim
Cinqair (reslizumab)- Asthma- by Saro Arakelians, PharmD- Episode # 123
Ividiyo: Cinqair (reslizumab)- Asthma- by Saro Arakelians, PharmD- Episode # 123

-Delile

Yini iCinqair?

ICinqair umuthi kadokotela wegama lomuthi. Isetshenziselwa ukwelapha i-asthma enamandla eosinophilic kubantu abadala. Ngalolu hlobo lwesifuba somoya esinamandla, unamazinga aphezulu ama-eosinophil (uhlobo lweseli elimhlophe). Uzothatha iCinqair ngaphezu kweminye imithi yakho yesifuba somoya. ICinqair ayisetshenziselwa ukwelapha ukuqhuma kwesifuba somoya.

ICinqair iqukethe i-reslizumab, okuwuhlobo lomuthi obizwa nge-biologic. I-biologics idalwe kusuka kumaseli hhayi kumakhemikhali.

ICinqair iyingxenye yesigaba semithi ebizwa ngama-interleukin-5 antagonist monoclonal antibodies (IgG4 kappa). Isigaba sezidakamizwa siyiqoqo lemithi esebenza ngendlela efanayo.

Umhlinzeki wezokunakekelwa kwezempilo uzokunika uCinqair njengomjovo we-intravenous (IV) ehhovisi likadokotela wakho noma emtholampilo. Lo ngumjovo emthanjeni wakho oconsa kancane ngokuhamba kwesikhathi. I-Cinqair infusions ivame ukuthatha imizuzu engama-20 kuye kwengama-50.

Ukusebenza ngempumelelo

ICinqair kutholakale ukuthi iyasebenza ekwelapheni i-asthma eosinophilic.


Ezifundweni ezimbili zomtholampilo, ama-62% kanye nama-75% abantu abathola iCinqair yesifo se-asthma esinamandla abanayo i-asthma flare-up. Kodwa kuphela u-46% no-55% wabantu abathathe i-placebo (akukho ukwelashwa) abangenayo i-asthma flare-up. Bonke abantu belashwe ngeCinqair noma nge-placebo amasonto angama-52. Futhi, iningi labantu belithatha ama-corticosteroids ahogelwayo nama-beta-agonists ngesikhathi kufundwa.

ICinqair ejwayelekile noma i-biosimilar

ICinqair itholakala kuphela njengomuthi wegama lomkhiqizo. Iqukethe i-reslizumab esebenzayo yezidakamizwa.

ICinqair okwamanje ayitholakali ngendlela ye-biosimilar.

I-biosimilar umuthi ofana nomuthi wegama lomkhiqizo. Imithi ejwayelekile, ngakolunye uhlangothi, ikhophi eliqondile lomuthi onegama lomkhiqizo. Ama-biosimilars asuselwa kwimithi ye-biologic, edalwe kusuka ezingxenyeni zezinto eziphilayo. Ama-Generics asekelwe emithini ejwayelekile eyenziwe ngamakhemikhali.

Ama-biosimilars kanye ne-generic zombili ziphephe futhi zisebenza kahle njengomuthi wegama lomkhiqizo ezenziwe ukukopisha. Futhi, bathambekele ekubizeni ngaphansi kwemithi yamagama.


Izindleko zeCinqair

Njengayo yonke imithi, izindleko zeCinqair zingahluka. Umhlinzeki wezokunakekelwa kwezempilo uzokunika lesi sidakamizwa njenge-infravenous (IV) ukumnika ehhovisi likadokotela wakho noma emtholampilo. Izindleko ozikhokhela ukumnika kwakho zizoya ngohlelo lwakho lomshuwalense nalapho uthola khona ukwelashwa kwakho. ICinqair ayitholakali ongayithenga ekhemisi lendawo.

Usizo lwezezimali nolomshuwalense

Uma udinga uxhaso lwezezimali ukukhokhela iCinqair, noma uma udinga usizo lokuqonda umshuwalense wakho, usizo luyatholakala.

I-Teva Respiratory, LLC, umkhiqizi weCinqair, unikeza iTeva Support Solutions. Ukuthola eminye imininingwane nokuthola ukuthi ukulungele yini ukwesekwa, shayela ku-844-838-2211 noma uvakashele iwebhusayithi yohlelo.

Imiphumela emibi yeCinqair

ICinqair ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engaba khona ngenkathi ithola iCinqair. Lezi zinhlu azibandakanyi yonke imiphumela emibi engaba khona.

Ukuthola eminye imininingwane ngemiphumela engemihle yeCinqair, khuluma nodokotela wakho noma usokhemisi. Bangakunika amathiphu okuthi ungabhekana kanjani nanoma yimiphi imiphumela emibi engase ikukhathaze.


Imiphumela emibi ejwayelekile

Umphumela ojwayelekile kakhulu weCinqair ubuhlungu be-oropharyngeal. Lobu ubuhlungu engxenyeni yomphimbo wakho esemva komlomo wakho. Ezifundweni zokwelashwa, u-2.6% wabantu abathathe iCinqair babenezinhlungu ze-oropharyngeal. Lokhu kwaqhathaniswa nabantu abangu-2.2% abathathe i-placebo (alukho umuthi).

Ubuhlungu be-Oropharyngeal bungaphela zingakapheli izinsuku ezimbalwa noma amasonto ambalwa. Uma ubuhlungu bukhulu noma bungapheli, khuluma nodokotela wakho noma usokhemisi. Bangaphakamisa ukwelashwa ukukusiza uzizwe ungcono.

Imiphumela emibi kakhulu

Imiphumela emibi ebucayi evela kuCinqair ayijwayelekile, kepha ingenzeka. Shayela udokotela wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Imiphumela emibi kanye nezimpawu zayo zingafaka okulandelayo:

  • I-Anaphylaxis * (uhlobo lokuphendula okweqile). Izimpawu zingafaka:
    • ukuphefumula kanzima, kufaka phakathi ukukhwehlela nokuphefumula
    • inkinga yokugwinya
    • ukuvuvukala ebusweni bakho, emlonyeni, noma emphinjeni
    • ishayela kancane
    • ukushaqeka kwe-anaphylactic (ukwehla okungazelelwe kwengcindezi yegazi nenkinga yokuphefumula)
    • ukuqubuka
    • isikhumba esilumayo
    • inkulumo engahambi kahle
    • ubuhlungu besisu (esiswini)
    • isicanucanu
    • ukudideka
    • ukukhathazeka
  • Umdlavuza. Izimpawu zingafaka:
    • izinguquko emzimbeni wakho (umbala ohlukile, ukuthungwa, ukuvuvukala, noma izigaxa esifubeni sakho, esinyeni, emathunjini, noma esikhunjeni)
    • ikhanda
    • isithuthwane
    • umbono noma inkinga yokuzwa
    • thela ohlangothini olulodwa lobuso bakho
    • ukopha noma ukulimaza
    • ukukhwehlela
    • izinguquko ekudleni
    • ukukhathala (ukungabi namandla)
    • imfiva
    • ukuvuvukala noma izigaxa
    • ukukhuluphala noma ukuncipha

Imininingwane yomphumela oseceleni

Ungase uzibuze ukuthi kaningi kangakanani imiphumela emibi ethile eba khona ngalo muthi. Nayi imininingwane ngemiphumela emibi embalwa engabangelwa yilesi sidakamizwa.

Ukusabela okweqile

Njengezidakamizwa eziningi, abanye abantu bangaba ne-allergen reaction ngemuva kokuthola i-Cinqair. Izimpawu zokuphendula okuncane komzimba zingabandakanya:

  • ukuqubuka kwesikhumba
  • ukulunywa
  • ukuqhuma (ukufudumala nokubomvu esikhunjeni sakho)

Akwaziwa ukuthi bangaki abantu abahlakulela ukusabela okweqile ngemuva kokuthola i-Cinqair.

Ukusabela okweqile okwedlulele akuvamile kodwa kungenzeka. Ibizwa ngokuthi i-anaphylaxis (bheka ngezansi).

I-Anaphylaxis

Ngenkathi bethola iCinqair, abanye abantu bangahle bahlakulele ukungezwani komzimba okungajwayelekile okubizwa nge-anaphylaxis. Lokhu kusabela kunzima futhi kungasongela impilo. Ezifundweni zokwelashwa, u-0.3% wabantu abathola iCinqair bahlakulela i-anaphylaxis.

Amasosha omzimba wakho asiza ukuvikela umzimba wakho ezintweni ezingadala izifo. Kodwa kwesinye isikhathi umzimba wakho uyadideka futhi ulwe nezinto ezingabangeli izifo. Kwabanye abantu, amasosha abo omzimba ahlasela izithako eCinqair. Lokhu kungaholela ku-anaphylaxis.

Izimpawu ze-anaphylaxis zingafaka:

  • ukuvuvukala ngaphansi kwesikhumba sakho, imvamisa ezinkalweni zakho, izindebe, izandla, noma izinyawo
  • ukuvuvukala kolimi lwakho, umlomo, noma umphimbo
  • inkinga yokuphefumula

I-Anaphylaxis ingenzeka ngemuva nje komthamo wakho wesibili weCinqair, ngakho-ke kubalulekile ukuthi impendulo ilawulwe ngasikhathi sinye.

Kungakho umhlinzeki wakho wezokunakekelwa kwezempilo ezokuqapha amahora ambalwa ngemuva kokuthola iCinqair. Uma uthuthukisa izimpawu ze-anaphylaxis, umhlinzeki wakho wokunakekelwa kwezempilo uzokuphatha khona manjalo. Bazokwazisa nodokotela wakho.

Uma udokotela wakho efuna ukuthi uyeke ukusebenzisa iCinqair, bangancoma umuthi ohlukile.

Ukusabela kwe-Anaphylactic kwesinye isikhathi kungadala i-biphasic anaphylaxis. Lokhu ukuhlaselwa kwesibili kwe-anaphylaxis. I-biphasic anaphylaxis ingenzeka amahora kuye ezinsukwini ezimbalwa ngemuva kokuhlaselwa kokuqala. Uma une-anaphylactic reaction, umhlinzeki wakho wezokunakekelwa kwempilo angafuna ukukuqapha ngokuqhubekayo. Bazofuna ukuqinisekisa ukuthi awuthuthukisi i-biphasic anaphylaxis.

Izimpawu ze-biphasic anaphylaxis zingabandakanya:

  • isikhumba esilumayo, esibomvu, noma esinezinyosi (i-itchy welts)
  • ukuvuvukala ubuso nolimi
  • inkinga yokuphefumula
  • ubuhlungu besisu (esiswini)
  • ukuhlanza
  • isifo sohudo
  • umfutho wegazi ophansi
  • ukulahlekelwa ukwazi (ukuquleka)
  • ukushaqeka kwe-anaphylactic (ukwehla okungazelelwe kwengcindezi yegazi nenkinga yokuphefumula)

Uma ungekho esikhungweni sokunakekelwa kwezempilo futhi ucabanga ukuthi une-anaphylactic noma i-biphasic reaction kuCinqair, shayela ku-911 khona manjalo. Ngemuva kokuthi ukwelashwa kuphethwe, yazisa udokotela wakho. Bangancoma umuthi wesifuba ohlukile.

Umdlavuza

Imithi ethile ingadala ukuthi amaseli akho aqhubeke nokukhula ngosayizi noma kwinombolo futhi abe nomdlavuza. Kwesinye isikhathi lawa maseli anomdlavuza ahambela ezicutshini ezingxenyeni ezihlukene zomzimba wakho. Lezi zicubu zezicubu zibizwa ngokuthi izicubu.

Ezifundweni zomtholampilo, u-0.6% wabantu abathola iCinqair baba nezicubu ezakheka ezingxenyeni ezihlukene zomzimba. Iningi labantu litholwe linezicubu kungakapheli izinyanga eziyisithupha zomthamo wokuqala weCinqair. Lokhu kwaqhathaniswa nabantu abangu-0.3% abathathe i-placebo (alukho umuthi).

Uma ubona noma yiziphi izimpawu zamathumba ezingapheli, tshela udokotela wakho. (Bheka isigaba esithi "Imiphumela emibi kakhulu" ngenhla ukuthola uhlu lwezimpawu.) Ungadinga ukuhlolwa ukusiza udokotela wakho ukuthola okwengeziwe ngamathumba. Udokotela wakho futhi angancoma imithi ehlukile yesifuba somoya.

Isilinganiso seCinqair

Umthamo weCinqair odonswa ngudokotela wakho uzoncika kusisindo sakho.

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, umhlinzeki wakho wezokunakekelwa kwempilo angakunika okuhlukile uma eyalelwa ngudokotela wakho ukuthi enze njalo. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukuhlangabezana nezidingo zakho.

Amafomu wezidakamizwa namandla

ICinqair iza ngebhodlela le-10-mL. Isitsha ngasinye siqukethe i-100 mg ye-reslizumab. Umhlinzeki wakho wezokunakekelwa kwezempilo uzokunika lesi sixazululo njengokufakwa ngaphakathi emthanjeni (IV). Lo ngumjovo emthanjeni wakho oconsa kancane ngokuhamba kwesikhathi. I-Cinqair infusions ivame ukuthatha imizuzu engama-20 kuye kwengama-50.

Isikali se-asthma

ICinqair ijwayele ukunikezwa imithamo ye-3 mg / kg, kanye njalo emavikini amane.

Inani leCinqair olitholayo lizoya ngokuthi ulinganisa kangakanani. Isibonelo, i-150-lb. indoda inesisindo esingaba ngama-68 kg. Uma udokotela wakhe emnika u-3 mg / kg weCinqair kanye njalo emavikini amane, umthamo weCinqair uzoba ngu-204 mg ukumnika (68 x 3 = 204).

Kuthiwani uma ngiphuthelwa umthamo?

Uma uphuthelwa isikhathi sokuthola i-Cinqair, shayela umhlinzeki wakho wezokunakekelwa kwezempilo ngokushesha okukhulu. Bangakwazi ukuhlela i-aphoyintimenti entsha futhi balungise isikhathi sokunye ukuvakashelwa uma kudingeka.

Kungumqondo ohlakaniphile ukubhala uhlelo lwakho lokwelashwa ekhalendeni. Ungasetha futhi isikhumbuzi efonini yakho ukuze ungaphuthelwa i-aphoyintimenti.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

ICinqair yenzelwe ukuthi isetshenziswe njengokwelashwa kwesikhathi eside kwesifo se-asthma esinamandla. Uma wena nodokotela wakho nibona ukuthi iCinqair iphephile futhi iyasebenza kuwe, cishe uzoyisebenzisa isikhathi eside.

ICinqair yesifuba somoya

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvumela imishanguzo kadokotela efana neCinqair ukwelapha izimo ezithile. ICinqair ivunyelwe ukwelapha i-asthma enamandla eosinophilic kubantu abadala. Isidakamizwa asivunyelwe ukwelapha ezinye izinhlobo ze-asthma. Futhi, iCinqair ayivunyelwe ukwelapha ukuqhuma kwesifuba somoya.

Uzothatha uCinqair ngaphezu komuthi wakho wamanje wesifuba somoya.

Esifundweni somtholampilo, uCinqair wanikezwa abantu abangama-245 abane-asthma enamandla eosinophilic amasonto angama-52. Kuleli qembu, abantu abangu-62% babengenayo i-asthma flare-up ngaleso sikhathi. Lokhu kwaqhathaniswa nabantu abangama-46% abathole i-placebo (alukho umuthi). Kulabo ababene-asthma flare-up:

  • Abantu abathole iCinqair babenezinga eliphansi lama-50 lama-flare-ups ngonyaka owodwa kunabantu abathola i-placebo.
  • Abantu abathole iCinqair babenezinga eliphansi lama-flare-ups elalingama-55% elidinga ukusetshenziswa kwama-corticosteroids kunabantu abathola i-placebo.
  • Abantu abathole iCinqair babenezinga eliphansi lama-34% lama-flare-ups aholela ekuhlaleni esibhedlela kunabantu abathola i-placebo.

Kwesinye isifundo somtholampilo, iCinqair yanikezwa abantu abangama-232 abane-asthma enamandla eosinophilic amasonto angama-52. Kuleli qembu, abantu abangu-75% babengenayo i-asthma flare-up ngaleso sikhathi. Lokhu kwaqhathaniswa nabantu abangama-55% abathole i-placebo (alukho ukwelashwa). Kulabo ababene-asthma flare-up:

  • Abantu abathole iCinqair babenezinga eliphansi lama-flare-59% kunabantu abathola i-placebo.
  • Abantu abathola iCinqair babenezinga eliphansi lama-flare-61% elidinga ama-corticosteroids kunabantu abathola i-placebo.
  • Abantu abathole iCinqair babenezinga eliphansi lama-flare-up elingu-31% eliholele ekuhlaleni esibhedlela kunabantu abathola i-placebo.

Ukusetshenziswa kweCinqair nezinye izidakamizwa

Uhloselwe ukusebenzisa iCinqair kanye nemithi yakho yamanje ye-asthma. Izibonelo zemithi engasetshenziswa neCinqair ukwelapha i-asthma enamandla eosinophilic ifaka:

  • I-corticosteroids emuncwe nangomlomo. I-asthma esetshenziswa kakhulu ifaka phakathi:
    • i-beclomethasone dipropionate (Qvar Redihaler)
    • i-budesonide (Pulmicort Flexhaler)
    • i-ciclesonide (Alvesco)
    • i-fluticasone propionate (i-ArmonAir RespiClick, i-Arnuity Ellipta, i-Flovent Diskus, i-Flovent HFA)
    • i-mometasone furoate (Asmanex HFA, Asmanex Twisthaler)
    • i-prednisone (iRayos)
  • Ama-bronchodilators we-Beta-adrenergic. I-asthma esetshenziswa kakhulu ifaka phakathi:
    • i-salmeterol (iSerevent)
    • i-formoterol (Foradil)
    • i-albuterol (i-ProAir HFA, i-ProAir RespiChofoza, i-Proventil HFA, i-Ventolin HFA)
    • levalbuterol (Xopenex, Xopenex HFA)
  • Izinguquko zendlela yeLeukotriene. I-asthma esetshenziswa kakhulu ifaka phakathi:
    • i-montelukast (Singulair)
    • zafirlukast (I-Accolate)
    • zileuton (Zyflo)
  • Ama-Muscarinic blockers, uhlobo lwe-anticholinergic. I-asthma esetshenziswa kakhulu ifaka phakathi:
    • i-tiotropium bromide (i-Spiriva Respimat)
    • ipratropium
  • Theophylline

Eminingi yale mithi futhi iza njengemikhiqizo ehlanganisiwe. Isibonelo, i-Symbicort (budesonide ne-formoterol) ne-Advair Diskus (i-fluticasone ne-salmeterol).

Olunye uhlobo lomuthi ozodinga ukuqhubeka ulusebenzisa neCinqair yi-inhaler yokutakula. Yize uCinqair esebenza ukusiza ukuvimbela ukuqubuka kwesifuba somoya, ungahle ube nokuhlaselwa yisifuba somoya. Uma lokhu kwenzeka, kuzodingeka usebenzise i-inhaler yokutakula ukulawula i-asthma yakho ngokushesha. Ngakho-ke qiniseka ukuthi uphatha i-inhaler yakho yokutakula ngaso sonke isikhathi.

Uma usebenzisa iCinqair, ungayeki ukuthatha eminye imishanguzo yesifuba somoya ngaphandle kokuthi udokotela wakho akutshele. Futhi uma unemibuzo mayelana nenani lemithi oyiphuzayo, buza udokotela wakho.

Ezinye izindlela zeCinqair

Ezinye izidakamizwa ziyatholakala ezingelapha i-asthma eosinophilic. Ezinye zingakulungela kangcono kunabanye. Uma unentshisekelo yokuthola enye indlela yeCinqair, khuluma nodokotela wakho. Bangakutshela ngeminye imithi engakusebenzela kahle.

Izibonelo zezinye izidakamizwa ezingasetshenziswa ukwelapha i-asthma enamandla eosinophilic zifaka:

  • mepolizumab (Nucala)
  • i-benralizumab (Fasenra)
  • i-omalizumab (Xolair)
  • dupilumab (Dupixent)

ICinqair vs. Nucala

Ungase uzibuze ukuthi iCinqair iqhathanisa kanjani neminye imithi enqunyelwe ukusetshenziswa okufanayo. Lapha sibheka ukuthi uCinqair noNucala bafana futhi bahlukene kanjani.

Isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvume uCinqair noNucala ukwelapha i-asthma enamandla eosinophilic kubantu abadala. UNucala uphinde avunyelwe ukwelapha i-asthma enamandla eosinophilic ezinganeni ezineminyaka engu-12 kuya kwengu-18 ubudala. Yomibili le mithi isetshenziswa kanye nezinye izidakamizwa ze-asthma ozisebenzisayo.

Ngaphezu kwalokho, uNucala uvunyelwe ukwelapha isifo esingajwayelekile esibizwa nge-eosinophilic granulomatosis nge-polyangiitis (EGPA). Lesi sifo saziwa nangokuthi yi-Churg-Strauss syndrome, futhi sidala ukuvuvukala kwemithambo yegazi.

Bobabili uCinqair noNucala basekilasini lezidakamizwa ezibizwa ngama-interleukin-5 antagonist monoclonal antibodies. Isigaba sezidakamizwa siyiqoqo lemithi esebenza ngendlela efanayo.

Amafomu wezidakamizwa nokuphathwa

ICinqair iqukethe i-reslizumab yezidakamizwa esebenzayo. INucala iqukethe isidakamizwa esisebenzayo i-mepolizumab.

ICinqair iza ngezimbiza. Umhlinzeki wakho wezokunakekelwa kwempilo uzokunika isisombululo njengomjovo emthanjeni wakho (ukumnika ngaphakathi). I-Cinqair infusions ivame ukuthatha imizuzu engama-20 kuye kwengama-50.

UNucala uza ngezindlela ezintathu ezihlukene:

  • Isitsha esisodwa se-powder. Umhlinzeki wakho wezokunakekelwa kwempilo uzoxuba impuphu namanzi oyinyumba. Bese bezokunikeza isisombululo njengomjovo ngaphansi kwesikhumba sakho (umjovo ongaphansi).
  • Ipeni elilodwa eligcwaliswe ngepeni le-autoinjector. Umhlinzeki wakho wezokunakekelwa kwempilo uzokufundisa kuqala ukuthi usetshenziswa kanjani usiba. Ngemuva kwalokho ungazinikeza imijovo ngaphansi kwesikhumba sakho.
  • Umjovo owodwa owenziwe ngomthamo owodwa. Umhlinzeki wakho wezokunakekelwa kwempilo uzokufundisa kuqala ukuthi ungasisebenzisa kanjani isirinji. Ngemuva kwalokho ungazinikeza imijovo ngaphansi kwesikhumba sakho.

ICinqair ijwayele ukunikezwa imithamo ye-3 mg / kg, kanye njalo emavikini amane. Inani lomuthi olitholayo lizoya ngokuthi ulinganisa kangakanani.

Umthamo onconywayo weNucala we-asthma yi-100 mg, kanye njalo emavikini amane.

Imiphumela emibi kanye nezingozi

UCinqair noNucala bobabili basekilasini elilodwa lezidakamizwa, ngakho-ke zisebenza ngendlela efanayo. Le mithi emibili ingadala imiphumela ehlukile kakhulu noma efanayo kakhulu. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka ngeCinqair noma ngeNucala.

  • Kungenzeka ngeCinqair:
    • ubuhlungu be-oropharyngeal (ubuhlungu engxenyeni yomphimbo wakho osemva komlomo wakho)
  • Kungenzeka ngeNucala:
    • ikhanda
    • ukuhlungu obusemhlane
    • ukukhathala (ukungabi namandla)
    • ukusabela kwesikhumba endaweni yomjovo, kufaka phakathi ubuhlungu, ubomvu, ukuvuvukala, ukulunywa, umuzwa ovuthayo

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona neCinqair, neNucala, noma ngazo zombili izidakamizwa (uma zinikezwa ngazodwana).

  • Kungenzeka ngeCinqair:
    • izimila
  • Kungenzeka ngeNucala:
    • ukutheleleka kwe-herpes zoster (shingles)
  • Kungenzeka ngeCinqair neNucala:
    • ukusabela okunzima, kufaka phakathi i-anaphylaxis *

Ukusebenza ngempumelelo

ICinqair neNucala zombili zisetshenziselwa ukwelapha i-asthma enamandla eosinophilic.

Le mithi ayikaze iqhathaniswe ngqo ezifundweni zomtholampilo, kodwa ukubuyekezwa kwezifundo kuthole ukuthi uCinqair noNucala bayasebenza ekunciphiseni inani lama-asthma flare-ups.

Izindleko

ICinqair neNucala zombili izidakamizwa ezinamagama. Okwamanje azikho izinhlobo ze-biosimilar zomuthi othile.

I-biosimilar umuthi ofana nomuthi wegama lomkhiqizo. Imithi ejwayelekile, ngakolunye uhlangothi, ikhophi eliqondile lomuthi onegama lomkhiqizo. Ama-biosimilars asuselwa kwimithi ye-biologic, edalwe kusuka ezingxenyeni zezinto eziphilayo. Ama-Generics asekelwe emithini ejwayelekile eyenziwe ngamakhemikhali. Ama-biosimilars nama-generics zombili ziphephe futhi zisebenza kahle njengomuthi wegama lomkhiqizo abazama ukuwukopisha. Futhi, bathambekele ekubizeni ngaphansi kwemithi yamagama.

Ngokusho kwe-WellRx.com, iCinqair ngokuvamile ibiza ngaphansi kukaNucala. Inani langempela ozolikhokhela noma yimuphi umuthi lincike ohlelweni lwakho lomshuwalense nasendaweni okuyo.

ICinqair vs. Fasenra

Ngaphezu kukaNucala (ngenhla), iFasenra ngomunye umuthi osetshenziswa ngendlela efanayo neCinqair. Lapha sibheka ukuthi uCinqair noFasenra bafana futhi bahlukile kanjani.

Isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvume uCinqair noFasenra ukuthi belaphe i-asthma enamandla eosinophilic kubantu abadala. I-Fasenra nayo ivunyelwe ukwelapha i-asthma enamandla eosinophilic ezinganeni ezineminyaka eyi-12 kuya kwengu-18. Zombili lezi zidakamizwa zisetshenziswa kanye nezinye izidakamizwa ze-asthma ozisebenzisayo.

Bobabili uCinqair noFasenra basekilasini lezidakamizwa ezibizwa ngama-interleukin-5 antagonist monoclonal antibodies. Isigaba sezidakamizwa siyiqoqo lemithi esebenza ngendlela efanayo.

Amafomu wezidakamizwa nokuphathwa

ICinqair iqukethe i-reslizumab yezidakamizwa esebenzayo. I-Fasenra iqukethe i-benralizumab esebenzayo yesidakamizwa.

ICinqair iza ngesivalo. Umhlinzeki wakho wezokunakekelwa kwezempilo uzokunika isisombululo njengomjovo emthanjeni wakho (ukumnika ngaphakathi). I-Cinqair infusions ivame ukuthatha imizuzu engama-20 kuye kwengama-50.

UFasenra uza ngesirinji ekhethiwe. Umhlinzeki wezokunakekelwa kwezempilo uzokunika umuthi njengomjovo ngaphansi kwesikhumba sakho (umjovo ongaphansi).

ICinqair ijwayele ukunikezwa imithamo ye-3 mg / kg, kanye njalo emavikini amane. Inani lomuthi olitholayo lizoya ngokuthi ulinganisa kangakanani.

Emithamo yakho yokuqala emithathu yeFasenra, uzothola ama-30 mg kanye njalo emavikini amane. Ngemuva kwalokho, uzothola ama-30 mg weFasenra kanye njalo emavikini ayisishiyagalombili.

Imiphumela emibi kanye nezingozi

UCinqair noFasenra bobabili basekilasini elilodwa lezidakamizwa, ngakho-ke zisebenza ngendlela efanayo. Le mithi emibili ingadala imiphumela ehlukile kakhulu noma efanayo kakhulu. Ngezansi kunezibonelo zale miphumela emibi.

Imiphumela emibi ejwayelekile

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi ejwayelekile engenzeka ngeCinqair noma ngeFasenra.

  • Kungenzeka ngeCinqair:
    • ubuhlungu be-oropharyngeal (ubuhlungu engxenyeni yomphimbo wakho osemva komlomo wakho)
  • Kungenzeka ngeFasenra:
    • ikhanda
    • Umphimbo obuhlungu

Imiphumela emibi kakhulu

Lezi zinhlu ziqukethe izibonelo zemiphumela emibi engaba khona neCinqair, neFasenra, noma ngazo zombili izidakamizwa (uma zinikezwa ngazodwana).

  • Kungenzeka ngeCinqair:
    • izimila
  • Kungenzeka ngeFasenra:
    • nemiphumela engemihle embalwa ejwayelekile
  • Kungenzeka ngeCinqair neFasenra:
    • ukusabela okunzima, kufaka phakathi i-anaphylaxis *

Ukusebenza ngempumelelo

ICinqair neFasenra zombili zisetshenziselwa ukwelapha i-asthma enamandla eosinophilic.

Le mithi ayikaze iqhathaniswe ngqo ezifundweni zokwelashwa. Kepha ukubuyekezwa kwezifundo kuthole ukuthi iCinqair iphumelela kakhulu ekuvimbeleni ukuqhuma kwesifuba somoya kuneFasenra.

Izindleko

ICinqair neFasenra zombili izidakamizwa ezidla igama. Okwamanje azikho izinhlobo ze-biosimilar zomuthi othile.

I-biosimilar umuthi ofana nomuthi wegama lomkhiqizo. Imithi ejwayelekile, ngakolunye uhlangothi, ikhophi eliqondile lomuthi onegama lomkhiqizo. Ama-biosimilars asuselwa kwimithi ye-biologic, edalwe kusuka ezingxenyeni zezinto eziphilayo. Ama-Generics asekelwe emithini ejwayelekile eyenziwe ngamakhemikhali. Ama-biosimilars nama-generics zombili ziphephe futhi zisebenza kahle njengomuthi wegama lomkhiqizo ezizama ukuzikopisha. Futhi, bathambekele ekubizeni ngaphansi kwemithi yamagama.

Ngokuya ngokulinganiselwa ku-WellRx.com, iCinqair ngokuvamile ibiza ngaphansi kukaFasenra. Inani langempela ozolikhokhela noma yisiphi isidakamizwa lizoya ngohlelo lwakho lomshuwalense nendawo okuyo.

ICinqair notshwala

Akukho ukuxhumana okwaziwayo phakathi kweCinqair notshwala ngalesi sikhathi. Kodwa abanye abantu abane-asthma bangathuthuka lapho bephuza utshwala noma ngemuva kokuphuza utshwala. Iwayini, i-cider, nobhiya kunamathuba amaningi okuthi kubangele lokhu kuqhuma kunezinye iziphuzo ezidakayo.

Uma une-asthma flare-up ngenkathi uphuza utshwala, yeka ukuphuza utshwala ngaso leso sikhathi. Yazisa udokotela wakho ngokuqhuma ngesikhathi sokuvakasha kwakho okulandelayo.

Futhi, khuluma nodokotela wakho mayelana nokuthi uphuza kangakanani nokuthi hlobo luni lotshwala. Bangakutshela ukuthi kuphephe kangakanani ukuphuza ngesikhathi sokwelashwa kwakho.

Ukusebenzisana kweCinqair

Akukho ukuxhumana okwaziwayo phakathi kweCinqair neminye imithi, amakhambi, izithasiselo, noma ukudla. Kepha okunye kwalokhu kungakhuphula amathuba akho okuba ne-asthma flare-up. Isibonelo, okunye ukungezwani kokudla noma kwezidakamizwa kungadala ukuqhuma kwesifuba somoya.

Uma unenkinga yokungezwani nokudla noma izidakamizwa, tshela udokotela wakho. Yisho futhi noma iziphi izidakamizwa, amakhambi, noma izithasiselo ozithathayo. Udokotela wakho angancoma ukulungiswa kokudla kwakho, imithi, noma indlela yokuphila uma kudingeka.

ICinqair inikezwa kanjani

Umhlinzeki wezokunakekelwa kwezempilo uzokunika uCinqair njengomjovo we-intravenous (IV) ehhovisi likadokotela wakho noma emtholampilo. Lo ngumjovo emthanjeni wakho oconsa kancane ngokuhamba kwesikhathi.

Okokuqala, umhlinzeki wakho wezokunakekelwa kwempilo uzobeka inaliti komunye wemithambo yakho. Bese bezoxhuma isikhwama esineCinqair enaliti. Umuthi uzogeleza usuke esikhwameni uye emzimbeni wakho. Lokhu kuzothatha cishe imizuzu engama-20 kuye kwengama-50.

Ngemuva kokuthola umthamo wakho, umhlinzeki wakho wezokunakekelwa kwempilo angakuqapha ukuze abone ukuthi ngabe uba ne-anaphylaxis yini. (Ukuze uthole izimpawu ezingaba khona, bheka isigaba se- “Cinqair side effects” ngenhla). I-Anaphylaxis kungenzeka ngemuva kwanoma imuphi umthamo weCinqair. Ngakho-ke umhlinzeki wakho wezokunakekelwa kwempilo angakuqapha noma ngabe uke wamthola uCinqair ngaphambilini.

Uyithola nini iCinqair

ICinqair ivame ukunikezwa kanye njalo emavikini amane. Wena nodokotela wakho ningaxoxa ngesikhathi esingcono kakhulu sosuku sokuthola ukumnika kwakho.

Kungumqondo ohlakaniphile ukubhala uhlelo lwakho lokwelashwa ekhalendeni. Ungasetha futhi isikhumbuzi efonini yakho ukuze ungaphuthelwa i-aphoyintimenti.

Isebenza kanjani iCinqair

Isifuba somoya yisimo lapho imigwaqo yomoya eholela emaphashini akho ivuvuka (ivuvuke). Imisipha ezungeze imigwaqo yomoya iyakhanywa, okuvimba umoya ukuthi ungadluli kuyo. Ngenxa yalokho, i-oxygen ayikwazi ukufinyelela egazini lakho.

Nge-asthma enamandla, izimpawu zingase zibe zimbi kakhulu kune-asthma ejwayelekile. Futhi kwesinye isikhathi izidakamizwa ezisiza ukwelapha i-asthma azisebenzi ku-asthma enamandla. Ngakho-ke uma une-asthma enamandla, ungadinga imishanguzo eyengeziwe.

Uhlobo olulodwa lwesifuba somoya esibucayi yi-asthma enamandla eosinophilic. Ngalolu hlobo lwe-asthma, unamazinga aphezulu ama-eosinophil egazini lakho. Ama-eosinophil awuhlobo oluthile lweseli emhlophe yegazi. (Amaseli egazi amhlophe amangqamuzana avela kumasosha akho omzimba, okusiza ukukuvikela ezifweni.) Inani elandayo lama-eosinophil liletha ukuvuvukala ezindleleni zakho zomoya nasemaphashini. Lokhu kubangela izimpawu zakho ze-asthma.

Wenzani uCinqair?

Inani lama-eosinophils egazini lakho lincike ezintweni eziningi. Okubaluleke kakhulu kuhlobene neprotheyini ebizwa nge-interleukin-5 (IL-5). I-IL-5 ivumela ama-eosinophil ukuthi akhule futhi ahambe aye egazini lakho.

ICinqair inamathela ku-IL-5. Ngokunamathisela kuyo, iCinqair imisa i-IL-5 ekusebenzeni. ICinqair isiza ukuvimbela i-IL-5 ekuvumeleni ama-eosinophil akhule futhi aye egazini lakho. Uma ama-eosinophil engakwazi ukufinyelela egazini lakho, awakwazi ukufinyelela emaphashini akho. Ngakho-ke ama-eosinophil awakwazi ukudala ukuvuvukala ezindleleni zakho zomoya nasemaphashini.

Kuthatha isikhathi esingakanani ukusebenza?

Ngemuva komthamo wakho wokuqala weCinqair, kungathatha amasonto amane ukuthi izimpawu zakho ze-asthma ziphele.

ICinqair empeleni ifinyelela egazini lakho okwamanje unikezwa wena. Umuthi uhamba ngegazi lakho uye kumaseli akho khona manjalo. Lapho iCinqair ifinyelela kumaseli akho, inamathela ku-IL-5 futhi iyimise ekusebenzeni ngokushesha.

Kepha uma i-IL-5 iyeka ukusebenza, kusazoba namazinga aphezulu ama-eosinophil egazini lakho. ICinqair izosiza ukuvimbela le mali ukuthi ingakhuphuki. Isidakamizwa sizosiza futhi ukwehlisa inani lama-eosinophil, kepha lokhu ngeke kwenzeke ngokushesha.

Kungathatha cishe amasonto amane ukwehlisa inani lama-eosinophil egazini lakho. Ngakho-ke izimpawu zakho ze-asthma zingathatha amasonto amane ukuthi zinyamalale ngemuva komthamo wakho wokuqala weCinqair. Uma nje izimpawu zakho seziphelile, cishe ngeke zibuye uma nje uqhubeka nokuthola iCinqair.

ICinqair nokukhulelwa

Azikho izifundo ezanele zokwelashwa ezenziwe kubantu ukufakazela ukuthi iCinqair iphephile yini ukuthi ingasetshenziswa ngesikhathi sokukhulelwa. Kodwa kuyaziwa ukuthi uCinqair uhamba nge-placenta futhi ufinyelela enganeni. I-placenta isitho esikhula esiswini sakho ngenkathi ukhulelwe.

Ucwaningo ezilwaneni lukhombisa ukuthi akukho miphumela emibi ezokwenzeka enganeni. Kepha izifundo zezilwane azikhombisi njalo ukuthi kwenzekani kubantu.

Uma uthatha uCinqair futhi ukhulelwa noma ufuna ukukhulelwa, khuluma nodokotela wakho. Bangakusiza unqume ukuthi ngabe iCinqair noma omunye umuthi wesifuba ungcono yini kuwe.

ICinqair nokuncelisa ibele

Azikho izifundo zomtholampilo kubantu ezifakazela ukuthi kuphephile yini ukuncelisa ibele ngenkathi uthatha iCinqair. Kepha izifundo zabantu ziphakamisa ukuthi amaprotheni afana nalawa aseCinqair akhona obisini lwebele lomuntu. Futhi, ezifundweni zezilwane, uCinqair watholakala obisini lwebele lomama. Ngakho-ke kulindeleke ukuthi iCinqair itholakale nasobisini lwebele lomuntu, nayo. Akwaziwa ukuthi lokhu kuzoyithinta kanjani ingane.

Uma ufuna ukuncelisa ngenkathi uthola iCinqair, tshela udokotela wakho. Bangakwazi ukuxoxa ngobuhle nobubi bakho nawe.

Imibuzo ejwayelekile mayelana neCinqair

Nazi izimpendulo zemibuzo ebuzwa njalo mayelana neCinqair.

Ingabe uCinqair umuthi we-biologic?

Yebo. ICinqair uhlobo lomuthi obizwa nge-biologic, owenziwe ngezinto eziphilayo. Imithi ejwayelekile, ngakolunye uhlangothi, yenziwe ngamakhemikhali.

ICinqair nayo iyi-antibody eyodwa. Lolu uhlobo lwe-biologic oluthinta amasosha akho omzimba. (Amasosha omzimba wakho yiwo asiza ukuvikela umzimba wakho ezifweni.) Amasosha omzimba angama-monoclonal afana neCinqair anamathisela amaprotheni kumasosha akho omzimba. Lapho iCinqair inamathela kula maprotheni, iyawavimba ekubangeleni ukuvuvukala (ukuvuvukala) nezinye izimpawu zesifo somoya.

Kungani iCinqair ingezi njengomuthi wokuhogela noma njengephilisi?

Umzimba wakho awukwazi ukucubungula iCinqair nge-inhaler noma ifomu lephilisi, ngakho-ke umuthi ubungeke ukwazi ukusiza ukwelapha i-asthma.

ICinqair wuhlobo lwesidakamizwa se-biologic esaziwa njenge-antibody monoclonal. (Ukuthola okuningi nge-biologics, bheka “Ingabe iCinqair umuthi ophilayo?” Ngenhla.) Amasosha omzimba angama-monoclonal angamaprotheni amakhulu. Uma uthatha le mithi njengamaphilisi, izongena ngqo esiswini nasemathunjini akho. Lapho, ama-acid namanye amaprotheni amancane angadiliza ama-antibody monoclonal. Ngoba ama-antibody monoclonal ahlukaniswe aba yizicucu ezincane, awasasebenzi ekwelapheni i-asthma. Ngakho-ke efomini lephilisi, lolu hlobo lomuthi ngeke lusebenze kahle.

Awukwazi ukuhogela ama-antibody amaningi we-monoclonal noma. Uma wenza kanjalo, amaprotheni emaphashini akho azokwephula umuthi ohogelwayo ngokushesha. Mncane kakhulu umuthi ongawenza egazini lakho nakumaseli. Lokhu kuzonciphisa ukuthi umuthi usebenza kahle kangakanani emzimbeni wakho.

Indlela engcono kakhulu yokuthi uthathe ama-antibody monoclonal, kufaka phakathi iCinqair, kungukufakwa nge-intravenous (IV). (Lo ngumjovo emthanjeni wakho oconsa kancane ngokuhamba kwesikhathi.) Kuleli fomu, umuthi ungena ngqo egazini lakho. Awekho ama-asidi noma amaprotheni azokwephula umuthi okungenani amasonto ambalwa. Ngakho-ke umuthi ungahamba ngegazi lakho futhi usebenze ezingxenyeni zomzimba wakho eziwudingayo.

Kungani ngingayitholi iCinqair ekhemisi?

Ukuphela kwendlela yokuthola iCinqair ngudokotela wakho. Umhlinzeki wezokunakekelwa kwezempilo uzokunika uCinqair njengomjovo we-intravenous (IV) ehhovisi likadokotela wakho noma emtholampilo. Lo ngumjovo emthanjeni wakho oconsa kancane ngokuhamba kwesikhathi. Ngakho-ke awukwazi ukuthenga iCinqair ekhemisi bese uzithatha ngokwakho.

Ngabe izingane zingayisebenzisa iCinqair?

Cha. Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvume kuphela iCinqair yokwelapha abantu abadala. Izifundo zomtholampilo zihlole ukusetshenziswa kweCinqair ezinganeni ezineminyaka eyi-12 kuya kwengu-18. Kodwa imiphumela ayibonisanga ukuthi umuthi ubusebenza kahle yini futhi uphephe ngokwanele ukuthi ungasetshenziswa ezinganeni.

Uma ingane yakho ine-asthma eosinophilic enamandla, khuluma nodokotela wayo. Bangancoma imithi ngaphandle kweCinqair engasiza ekwelapheni ingane yakho.

Ngabe ngisazodinga ukuthatha i-corticosteroid neCinqair?

Kungacishe kwenzeke. Awuhloselwe ukuthatha iCinqair iyodwa. Kufanele usebenzise lesi sidakamizwa kanye nemithi yakho yamanje ye-asthma, engafaka i-corticosteroid.

ICinqair isiza kuphela ukudambisa i-asthma enamandla ye-eosinophilic. Lolu uhlobo lwesifuba somoya olubangelwa amazinga aphezulu ama-eosinophil (uhlobo lweseli elimhlophe) egazini lakho.

NjengoCinqair, ama-corticosteroids asebenza ngokunciphisa ukuvuvukala (ukuvuvukala) emaphashini akho. Kodwa-ke, ama-corticosteroids anciphisa ukuvuvukala ngezindlela ezihluke kancane. Abantu abaningi abane-asthma enamandla badinga iCinqair kanye ne-corticosteroid ukusiza ukulawula isifuba somoya. Ngakho-ke, udokotela wakho angakunika yomibili le mithi. Ungayeki ukuthatha i-corticosteroid ngaphandle kokuthi udokotela wakho akutshele.

Ngabe ngisazodinga ukuthola i-inhaler yokutakula nami?

Yebo. Usazodinga ukuphatha i-inhaler yokutakula uma uthola i-Cinqair.

Noma iCinqair isiza ukwelapha i-asthma eosinophilic ezinzima isikhathi eside, ungahle ube nokuqubuka. Futhi iCinqair ayisebenzi ngokushesha okwanele ukwelapha izimpawu zesifuba somoya ngokuzumayo.

Uma ungazilawuli izimpawu ze-asthma flare-up ngokushesha, zingaba zimbi kakhulu. Ngakho-ke indlela engcono yokuthola isibambo kuzo ukusebenzisa i-inhaler yokutakula. Le divayisi izosiza ukunciphisa izimpawu zakho ze-asthma.

Khumbula ukuthi usazodinga ukuthatha eminye imithi yakho ye-asthma, kufaka phakathi iCinqair.

Ukuqapha kweCinqair

Lesi sidakamizwa siza nezixwayiso eziningana.

Isexwayiso se-FDA: Anaphylaxis

Lesi sidakamizwa sinesixwayiso esibhakeleni. Lesi yisexwayiso esibi kakhulu esivela ku-Food and Drug Administration (FDA). Isexwayiso sebhokisi sixwayisa odokotela nabantu ngemiphumela yezidakamizwa engaba yingozi.

Ukusabela okweqile okubizwa nge-anaphylaxis kungenzeka ngemuva kokuthola iCinqair. Isidakamizwa sinikezwa ngumhlinzeki wezokunakekelwa kwempilo, ngakho-ke bazobheka ukuthi umzimba wakho uphendula kanjani kuCinqair. Bangakwazi futhi ukwelapha i-anaphylaxis ngokushesha uma uyihlakulela.

Ezinye izexwayiso

Ngaphambi kokuthatha iCinqair, khuluma nodokotela wakho ngomlando wakho wezempilo. ICinqair kungenzeka ingakulungeli uma unezimo ezithile zezokwelapha. Lokhu kufaka phakathi:

Ukutheleleka kwe-helminth

ICinqair kungenzeka ingakulungeli uma unesifo se-helminth (ukutheleleka okubangelwa yizikelemu okubangelwa yizikelemu). Udokotela wakho uzodinga ukwelapha ukutheleleka ngaphambi kokuba uqale ukusebenzisa iCinqair.

Uma uthola ukutheleleka kwe-helminth ngenkathi usebenzisa iCinqair, udokotela wakho angamisa isikhashana ukwelashwa kwakho. Bangase banikeze nemithi yokuqeda ukutheleleka. Lapho ukutheleleka sesidlulile, udokotela wakho angakwenza ukuthi uqale ukwamukela iCinqair futhi.

Gcina engqondweni izimpawu zokutheleleka kwe-helminth ukuze wazi ukuthi yini okufanele uyibheke. Izimpawu zingafaka isifo sohudo, ubuhlungu esiswini sakho, ukungondleki nobuthakathaka.

Ukukhulelwa

Azikho izifundo ezanele zokwelashwa ezenziwe kubantu ukufakazela ukuthi iCinqair iphephile yini ukuthi ingasetshenziswa ngesikhathi sokukhulelwa. Ukuze ufunde kabanzi, bheka isigaba se- “Cinqair and pregnancy” ngenhla.

Qaphela: Ngeminye imininingwane ngemiphumela emibi engaba khona yeCinqair, bona isigaba se- “Cinqair side effects” ngenhla.

Imininingwane yobuchwepheshe yeCinqair

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Izinkomba

ICinqair ikhonjisiwe ekwelapheni i-asthma enamandla. Ukuvunyelwa komuthi kulungiselwe ukusetshenziswa kwaso njengesengezo sokwelashwa kwesondlo somoya. ICinqair akufanele ithathe indawo yendlela yokwelashwa yamanje echazwe ezigulini, kufaka phakathi ukusetshenziswa kwama-corticosteroids.

Ukuvunywa kweCinqair kungokwelashwa kwabantu abane-eosinophilic phenotype. Isidakamizwa akufanele sinikezwe abantu abane-phenotypes ehlukene. Akufanele futhi inikezwe ukwelashwa kwezinye izifo ezihlobene ne-eosinophilic.

Futhi, iCinqair ayikhonjisiwe ukwelapha ama-bronchospasms abukhali noma i-asthmaticus yesimo. Ukusetshenziswa kwesidakamizwa ukukhulula izimpawu akuzange kuhlaziywe phakathi nezifundo zomtholampilo.

Ukusetshenziswa kweCinqair kufanele kubekelwe abantu abadala kuneminyaka eyi-18. Ayinayo imvume ye-Food and Drug Administration (FDA) yabantu abancane kunaleyo minyaka.

Indlela yokusebenza

Indlela eqondile yokusebenza kweCinqair ayikacaciswanga ngokuphelele okwamanje. Kodwa kukholakala ukuthi isebenza ngendlela ye-interleukin-5 (IL-5).

ICinqair iyi-antibody ye-IgG4-kappa monoclonal eboshwe ku-IL-5. Ukubopha kunokuhlala njalo kwe-dissociation kwe-81 picomolar (pM). Ngokubophezela ku-IL-5, iCinqair iphikisana ne-IL-5 futhi ivimbela ukusebenza kwayo kwezinto eziphilayo. Lokhu kwenzeka ngoba iCinqair ivimbela i-IL-5 ekuzibophezeleni ku-IL-5 receptor ekhona ebusweni beselula yama-eosinophil.

I-IL-5 yi-cytokine ebaluleke kakhulu ekukhuleni, ukwahlukanisa, ukuqasha, ukwenza kusebenze, nokusinda kwama-eosinophil. Ukuntuleka kokuxhumana phakathi kwe-IL-5 nama-eosinophil kuvimbela i-IL-5 ekubeni nalezi zenzo zamaselula kuma-eosinophil. Ngakho-ke umjikelezo weselula we-eosinophil nemisebenzi yezinto eziphilayo iyancipha. Ama-eosinophil ayeke ukusebenza kahle futhi afe.

Kubantu abane-eosinophil prototype ye-asthma enamandla, ama-eosinophil ayimbangela ebalulekile yalesi sifo. Ama-eosinophil abangela ukuvuvukala okungapheli emaphashini, okuholela esifuba somoya esingamahlalakhona. Ngokunciphisa inani nokusebenza kwama-eosinophil, iCinqair inciphisa ukuvuvukala kwephaphu. Isifuba somoya esibi kakhulu silawulwa okwesikhashana.

Amaseli amancane, ama-macrophage, ama-neutrophils, nama-lymphocyte nawo angashisa amaphaphu. Ngaphezu kwalokho, ama-eicosanoids, i-histamine, ama-cytokines, nama-leukotrienes angadala lokhu kuvuvukala. Akwaziwa ukuthi uCinqair usebenza kulawa maseli nabalamuli ukulawula ukuvuvukala emaphashini.

I-Pharmacokinetics ne-metabolism

ICinqair ifinyelela ukugxila kwayo okuphezulu ekupheleni kwesikhathi sokufakwa. Ukuphathwa okuningi kweCinqair kuholela ekuqongeleleni kwayo ku-serum ka-1.5- kuye ku-1.9. Ukugxila kwe-serum kwehla ejikeni le-biphasic. Lokhu kugxila akuguquki ngokuba khona kwama-anti-Cinqair antibodies.

Uma sekuphethwe, iCinqair inenani lokusatshalaliswa kwamalitha ama-5. Lokhu kusho ukuthi amanani aphezulu eCinqair kungenzeka angafiki ezicutshini ze-extravascular.

Njengama-antibody amaningi we-monoclonal, iCinqair ihlupheka ngokonakala kwe-enzymatic. Ama-enzyme ama-Proteolytic ayiguqula ibe ama-peptide amancane nama-amino acid. Ukuqedwa kwe-proteolysis yeCinqair kuthatha isikhathi. Ingxenye yokuphila kwayo cishe izinsuku ezingama-24. Futhi, isilinganiso sayo sokususwa cishe siyi-7 milliliters ngehora (mL / hr). Ukuvunyelwa okuqondiswe ekuqondisweni kweCinqair akunakwenzeka ukuthi kwenzeke. Lokhu kungenxa yokuthi ibophezela i-interleukin-5 (IL-5), eyi-cytokine encibilikayo.

Izifundo ze-Pharmacokinetics zeCinqair ziyefana kakhulu phakathi kwabantu bobudala obuhlukile, ubulili, noma ubuhlanga. Ukuhlukahluka phakathi kwabantu kuphakathi kuka-20% kuya ku-30% wokuhlushwa okuphezulu nokuvezwa okuphelele.

Ucwaningo lwe-Pharmacokinetics alukhombisi mehluko obonakalayo phakathi kwabantu abanezivivinyo ezijwayelekile futhi ezikhuphuke kancane zokusebenza kwesibindi. Umsebenzi ojwayelekile ubandakanya amazinga we-bilirubin ne-aspirate aminotransferase engaphansi noma elingana nomkhawulo ophezulu ojwayelekile (i-ULN). Ukuhlolwa kokusebenza okukhuphuke kancane kufaka amazinga we-bilirubin ngaphezulu kwe-ULN futhi ngaphansi noma okulingana no-1.5-phinda i-ULN. Kungabandakanya futhi amazinga we-aspartate aminotransferase aphezulu kune-ULN.

Futhi, izifundo ze-pharmacokinetics azibonisi mehluko phakathi kwabantu abanomsebenzi wezinso ojwayelekile noma okhubazekile. Umsebenzi ojwayelekile we-renal usho isilinganiso esilinganisiwe se-glomerular filtration (eGFR) esikhudlwana noma esilingana no-90 mL ngomzuzu ngemitha eli-1.73. (ml / iminithi / 1.73 m2). Imisebenzi yezinso emnene futhi elinganiselayo isho ukulinganiselwa kwe-eGFR phakathi kuka-60 kuye ku-89 mL / min / 1.73 m2 futhi 30 kuya ku-59 ml / min / 1.73 m2, ngokulandelana.

Izimo

ICinqair iyaphikiswa kubantu abake bakhulisa ukuzwela ngokweqile kunoma isiphi isithako esisebenzayo noma esingasebenzi seCinqair.

Ukuzwela ngokweqile kungenzeka ngemuva nje kokuphathwa kweCinqair. Kodwa kwezinye izimo, kungenzeka ngaphakathi kwamahora ambalwa kulandela ukuphathwa komuthi. Ukuqashwa kweziguli ngemuva kokuphathwa kweCinqair kubalulekile ukubuka ukukhula kokuthintana nokuzwela.

I-Hypersensitivity yisifo esinamalungu amaningi esingadala i-anaphylaxis nokufa ngokushaqeka kwe-anaphylactic. Zonke iziguli ezine-hypersensitivity to Cinqair kufanele ziphazamise ukwelashwa ngokushesha. Kulokhu, izimpawu zokwelashwa ngokweqile kufanele ziphathwe. Lezi ziguli akufanele ziphinde zithole ukwelashwa kweCinqair.

Khuluma neziguli zakho ngezimpawu ze-hypersensitivity ne-anaphylaxis. Batshele ukuthi bashayele i-911 ngokushesha uma becabanga ukuthi banazo lezi zimo. Futhi, batshele ukuthi bazise abahlinzeki babo bezempilo uma bezwa ukuzwela ngokweqile noma i-anaphylaxis ukuchaza kabusha indlela yokwelashwa.

Isitoreji

ICinqair kufanele ifakwe esiqandisini phakathi kuka-36 ° F kuye ku-46 ° F (2 ° C kuye ku-8 ° C). Kubalulekile ukuthi umuthi ungafrizi noma unyakaziswe. Kubalulekile futhi ukugcina iCinqair kwiphakheji yayo yangempela kuze kube yilapho isetshenziswa. Lokhu kuzovikela lesi sidakamizwa ekonakaleni okuncane.

Ukuzikhulula: IMedical News Namuhla yenze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane iyiqiniso, iphelele futhi ihambisana nesikhathi. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.

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