I-Enbrel vs. Humira ye-Rheumatoid Arthritis: Ukuqhathanisa Kohlangothi Nhlangothi

-Delile

• Ukubuka konke
• Okuyisisekelo ku-Enbrel naseHumira
• Izici zezidakamizwa zihambisana
• Ukugcinwa kwezidakamizwa
• Izindleko, ukutholakala, nomshuwalense
• Okuqhamuka uma udla imishanguzo
• Ukusebenzisana kwezidakamizwa
• Sebenzisa nezinye izimo zezokwelapha
• Khuluma nodokotela wakho

Ukubuka konke

Uma une-arthritis ye-rheumatoid (RA), nonke nijwayelene kakhulu nohlobo lobuhlungu nokuqina kwamalunga okungenza ngisho ukuvuka embhedeni ekuseni kube ngumzabalazo.

U-Enbrel noHumira yizidakamizwa ezimbili ezingasiza. Bheka ukuthi lezi zidakamizwa zenzani nokuthi zihlangana kanjani.

Okuyisisekelo ku-Enbrel naseHumira

U-Enbrel noHumira yimithi kadokotela esetshenziselwa ukwelapha i-RA.

Yomibili le mithi iyi-alpha inhibitors ye-tumor necrosis factor (TNF). I-alfa ye-TNF yiprotheni elenziwa amasosha akho omzimba. Inomthelela ekuvukeleni nasekulimaleni ngokuhlanganyela.

U-Enbrel noHumira bavimba isenzo se-TNF alpha esiholela ekulimaleni kokuvuvukala okungavamile.

Imihlahlandlela yamanje ayincomi i-TNF inhibitors njengokwelashwa komugqa wokuqala kwe-RA. Esikhundleni salokho, bancoma ukwelashwa nge-DMARD (njenge-methotrexate).

Ngaphandle kweRA, bobabili u-Enbrel noHumira nabo bayaphatha:

• i-juvenile idiopathic arthritis (JIA)
• i-psoriatic arthritis (i-PsA)
• i-ankylosing spondylitis
• uqweqwe psoriasis

Ngaphezu kwalokho, uHumira uphinde aphathe:

• Isifo sikaCrohn
• i-ulcerative colitis (UC)
• i-hidradenitis suppurativa, isimo sesikhumba
• uveitis, ukuvuvukala esweni

Izici zezidakamizwa zihambisana

U-Enbrel noHumira basebenza ngendlela efanayo ukuphatha i-RA, futhi izici zabo eziningi ziyefana.

Imihlahlandlela ayivezi okuthandayo nge-inhibitor eyodwa ye-TNF phezu kwenye, ngenxa yokushoda kobufakazi obukholisayo bokuthi enye iyasebenza ukwedlula enye.

Abanye abantu bayazuza ngokushintshela ku-TNF inhibitor ehlukile uma eyokuqala ingasebenzi, kepha iningi lodokotela lingancoma ukushintshela kumuthi ohlukile we-RA esikhundleni salokho.

Ithebula elilandelayo liqokomisa izici zale mithi emibili:

Ungathola ukuthi amapeni agcwalisiwe we-Enbrel SureClick Autoinjector kanye neHumira kulula futhi kulula ukuwasebenzisa kunemijovo ekhethiwe. Zidinga izinyathelo ezimbalwa.

Abantu bazobona izinzuzo ezithile zomuthi ngemuva kwamanani ama-2 kuye kwayi-3, kepha isivivinyo esanele somuthi cishe siyizinyanga ezi-3 ukubona inzuzo yabo ephelele.

Indlela umuntu ngamunye aphendula ngayo kunoma yisiphi isidakamizwa izohluka.

Ukugcinwa kwezidakamizwa

I-Enbrel neHumira zigcinwa ngendlela efanayo.

Kokubili kufanele kugcinwe kwikhathoni yoqobo ukuvikela ekulimaleni kokukhanya noma komzimba. Amanye amathiphu wesitoreji abonakala ngezansi:

• Gcina umuthi esiqandisini ezingeni lokushisa eliphakathi kuka-36 ° F no-46 ° F (2 ° C no-8 ° C).
• Uma uhamba, gcina umuthi ekamelweni lokushisa (68-77 ° F noma 20-25 ° C) kuze kube yizinsuku eziyi-14.
  • Vikela lesi sidakamizwa ekukhanyeni nasemswakeni.
  • Ngemuva kwezinsuku eziyi-14 ekamelweni lokushisa, lahla umuthi kude. Ungayibeki esiqandisini.
  • Ungasiqandisi lesi sidakamizwa noma usisebenzise uma simisiwe bese sincibilika.

Izindleko, ukutholakala, nomshuwalense

I-Enbrel ne-Humira zitholakala kuphela njengezidakamizwa ezinegama lomkhiqizo, hhayi ama-generics, futhi zibiza ngokufana.

Iwebhusayithi iGoodRx ingakunika umbono oqondile mayelana nezindleko zabo zamanje, ngqo.

Abahlinzeki abaningi bomshuwalense badinga ukugunyazwa kwangaphambili kudokotela wakho ngaphambi kokuthi bakhokhe futhi bakhokhele noma imuphi wale mithi. Buza enkampanini yakho yomshuwalense noma ekhemisi ukubona ukuthi udinga yini ukugunyazwa kwangaphambili kuka-Enbrel noma uHumira.

Ikhemisi lakho lingakusiza ngamaphepha uma kudingeka imvume.

Iningi lamakhemisi lithwala i-Enbrel neHumira. Kodwa-ke, kuwumqondo omuhle ukubiza ikhemisi lakho kusengaphambili ukuze uqiniseke ukuthi umuthi wakho usesitokweni.

Ama-biosimilars ayatholakala kuzo zombili izidakamizwa. Uma sezitholakala, ama-biosimilars angabiza kakhulu kunomuthi woqobo wegama lomkhiqizo.

I-biosimilar ye-Enbrel yi-Erelzi.

Ama-biosimilars amabili we-Humira, i-Amjevita ne-Cyltezo, avunyelwe yi-U.S. Food and Drug Administration (FDA). Noma kunjalo, okwamanje ayitholakali ukuthengwa e-United States.

I-Amjevita yatholakala eYurophu ngo-2018, kodwa akulindelekile ukuthi ifike ezimakethe zase-U.S. Kuze kube unyaka we-2023.

Okuqhamuka uma udla imishanguzo

U-Enbrel noHumira basekilasini elifanayo lezidakamizwa. Ngenxa yalokho, banemiphumela emibi efanayo.

Eminye yemiphumela emibi ejwayelekile ifaka phakathi:

• ukusabela endaweni yomjovo
• ukutheleleka kwesono
• ikhanda
• ukuqubuka

Imiphumela emibi kakhulu ingafaka:

• ingozi eyengeziwe yomdlavuza
• izinkinga zesistimu yezinzwa
• izinkinga zegazi
• ukwehluleka kwenhliziyo okusha noma okuya ngokuya kuba kubi
• i-psoriasis entsha noma ekhulayo
• ukusabela okweqile
• ukusabela okuzenzakalelayo
• izifo ezinzima
• ukucindezela amasosha omzimba

Omunye wabantu abangu-177 uthole ukuthi i-adalimumab, noma i-Humira, abasebenzisi bayo bebengaphezu kokuphindwe kathathu amathuba okubika ngomjovo / ngomfutho indawo yokulimala ngemuva kokulashwa izinyanga eziyisithupha.

Ukusebenzisana kwezidakamizwa

Hlala wazisa udokotela wakho ngayo yonke imithi, amavithamini, noma amakhambi owathathayo. Lokhu kungasiza udokotela wakho ukuthi avimbele ukuhlangana kwezidakamizwa okungenzeka, okungashintsha indlela osebenza ngayo umuthi wakho.

Ukusebenzisana kungaba yingozi noma kuvimbele izidakamizwa ukuthi zisebenze kahle.

U-Enbrel noHumira bahlangana nezinye izidakamizwa ezifanayo. Ukusebenzisa i-Enbrel noma i-Humira ngemigomo kanye nezidakamizwa ezilandelayo kwandisa ingozi yokutheleleka:

• Imishanguzo ebukhoma, efana nale:
  • Imishanguzo ye-varicella ne-varicella zoster (yenkukhu)
  • imishanguzo ye-herpes zoster (shingles)
  • I-FluMist, isifutho se-intranasal somkhuhlane
  • umuthi wokugomela isimungumungwane, mumps, kanye ne-rubella (MMR)
  • izidakamizwa ezisetshenziselwa ukucindezela amasosha akho omzimba njenge-anakinra (Kineret) noma i-abatacept (i-Orencia)
• Izidakamizwa ezithile zomdlavuza, njenge-cyclophosphamide ne-methotrexate
• Eminye imithi ye-RA efana ne-sulfasalazine
• Izidakamizwa ezithile ezicutshungulwa yiprotheni ebizwa nge-cytochrome p450, kufaka phakathi:
  • i-warfarin (i-Coumadin)
  • i-cyclosporine (i-Neoral, iSandimmune)
  • thindokuhle

Sebenzisa nezinye izimo zezokwelapha

Uma unegciwane lesifo se-hepatitis B, ukuthatha i-Enbrel noma i-Humira kungaqalisa ukutheleleka kwakho. Lokho kusho ukuthi ungaqala ukuzwa izimpawu ze-hepatitis B, njenge:

• ukukhathala
• ukungabi nesifiso sokudla
• ukuphuzi kwesikhumba sakho noma okumhlophe kwamehlo akho
• ubuhlungu ohlangothini lwesokunene sesisu sakho

Ukutheleleka okusebenzayo nakho kungaholela ekuhlulekeni kwesibindi nasekufeni. Udokotela wakho uzohlola igazi lakho ukuze aqiniseke ukuthi awunayo i-hepatitis B ngaphambi kokuthola noma iyiphi yalezi zidakamizwa.

Khuluma nodokotela wakho

U-Enbrel noHumira bayizidakamizwa ezifanayo. Zisebenza ngokulinganayo ekudambiseni izimpawu ze-RA.

Kodwa-ke, kukhona umehluko omncane, okunye okungenza ukuthi kube lula kuwe ukuthi ukusebenzise.

Isibonelo, uHumira angathathwa njalo ngesonto noma ngesonto, kanti i-Enbrel ingathathwa kuphela masonto onke. Ungase futhi uthole ukuthi ukhetha abafaka izicelo abathile, njengamapeni noma ama-autoinjectors. Lokho kukhetha kunganquma ukuthi imuphi umuthi owukhethayo.

Ukwazi okwengeziwe ngalezi zidakamizwa ezimbili kungakusiza ukuthi ukhulume nodokotela wakho ukuthola ukuthi ngabe enye yazo iyindlela ongakhetha ngayo yini.