AmaGlucocorticoids

-Delile

• Yini ama-glucocorticoids?
• Uhlu lwezidakamizwa ze-glucocorticoid
• Yikuphi ukwelashwa kwe-glucocorticoids
• Ukuphazamiseka okuzenzakalelayo
• Ukungezwani komzimba nesifuba somoya
• Ukungasebenzi kahle kwe-adrenal
• Ukwehluleka kwenhliziyo
• Umdlavuza
• Izimo zesikhumba
• Ukuhlinzwa
• Okuqhamuka uma udla imishanguzo
• Khuluma nodokotela wakho

Ukubuka konke

Izinkinga eziningi zempilo zibandakanya ukuvuvukala. Ama-Glucocorticoids ayasebenza ekunqandeni ukuvuvukala okulimazayo okudalwa yizinkinga eziningi zesistimu yomzimba. Le mithi inezinye izinto eziningi ezisetshenziswayo. Kodwa-ke, nazo ziza nemiphumela emibi. Lokhu kungaba nzima, ikakhulukazi uma usebenzisa le mithi isikhathi eside kakhulu.

Yini ama-glucocorticoids?

Izidakamizwa ze-glucocorticoid yizinhlobo ezenziwe ngama-glucocorticoids, ama-steroids avela ngokwemvelo emzimbeni wakho. Banemisebenzi eminingi. Okokuqala ukuphazamisa ukuvuvukala ngokungena kumaseli nokucindezela amaprotheni aqhubeka nokukhuthaza ukuvuvukala. Zisiza nomzimba wakho ukuthi uphendule ekucindezelekeni futhi ulawule nokuthi umzimba wakho uwasebenzisa kanjani amafutha noshukela.

Ngenxa yokuthi i-glucocorticoids inemisebenzi eminingi kangaka, i-glucocorticoids eyenziwe ngabantu noma yokwenziwa isetshenziselwe ukusiza ukuphatha izimo eziningi ezahlukahlukene.

Uhlu lwezidakamizwa ze-glucocorticoid

Izibonelo zezidakamizwa ze-glucocorticoid zifaka:

• beclomethasone
• betamethasone
• ebudeside
• i-cortisone
• dexamethasone
• i-hydrocortisone
• imethylprednisolone
• webhilo
• umabhebhana
• umagazine

Yikuphi ukwelashwa kwe-glucocorticoids

I-synthetic glucocorticoids ingaba namandla kakhulu kune-steroids eyenzeka ngokwemvelo. Zisetshenziselwa ukwelapha izimo eziningi.

Ukuphazamiseka okuzenzakalelayo

Izifo ezizimele zingadala umonakalo omkhulu ekuvukeleni lapho umzimba uzihlasela ngephutha. Izifo ezizimele zihlanganisa:

• i-multiple sclerosis
• isifo samathambo
• ukuvuvukala kwamathumbu
• ukulunywa yizilonda emathunjini
• ukhwekhwe
• eczema

I-Glucocorticoids inganciphisa ukuthi amaseli omzimba asebenzayo kanjani. Lokhu kusiza ukunciphisa ukulimala kwangaphakathi kulezi zifo. Bacindezela ukuvuvukala kusuka ekuphenduleni okuzenzakalelayo. Lokhu kunganciphisa ubuhlungu, ukuvuvukala, ukuqunjelwa, nokunwaya.

Ukungezwani komzimba nesifuba somoya

Ukungezwani komzimba nesifuba somoya yizimo lapho amasosha akho omzimba ephendula ezintweni ezivamile ezingenabungozi. Kulezi zimo, izinto ezifana nempova noma amakinati zingadala ukusabela okunamandla kokuvuvukala. Izimpawu zingahluka futhi zifake:

• ukulunywa
• ukulunywa, amehlo anamanzi
• ubumhlophe
• ububomvu, isifuba, noma ukuqubuka
• ukuthimula nokucinana noma ikhala eligijimayo
• ukuvuvukala kobuso bakho, izindebe, noma umphimbo
• inkinga yokuphefumula

I-Glucocorticoids ingaphatha lokhu kusabela ngokweqile ngokumisa ukuvuvukala nokuzola ukusebenza kwamaseli omzimba.

Ukungasebenzi kahle kwe-adrenal

Uma une-adrenal insufficiency, umzimba wakho awukwazi ukukhiqiza i-cortisol eyanele. Lokhu kungaba umphumela wesimo esifana nesifo i-Addison noma ukususwa kokuhlinzwa kwezindlala zakho ze-adrenal. Ama-glucocorticoids angasetshenziselwa ukufaka esikhundleni se-cortisol umzimba wakho ongeke usakwazi ukuyenza.

Ukwehluleka kwenhliziyo

Ukusetshenziswa kwesikhashana (ngaphansi kwezinsuku eziyi-7) zama-glucocorticoids kungasiza ekwelapheni ukwehluleka kwenhliziyo ngokwandisa amandla omzimba wakho wokuphendula kuma-diuretics athile. Noma kunjalo, lokhu akuyona ukusetshenziswa okuvamile.

Umdlavuza

I-Glucocorticoids ingasetshenziswa ekwelashweni komdlavuza ukunciphisa eminye yemiphumela emibi yokwelashwa ngamakhemikhali. Zingasetshenziswa futhi ukubulala amanye amangqamuzana omdlavuza kwamanye amagciwane, kufaka phakathi:

• i-acute lymphoblastic leukemia
• i-leukemia engapheli ye-lymphoblastic
• IHodgkin lymphoma
• I-non-Hodgkin lymphoma
• i-myeloma eminingi

Izimo zesikhumba

Izimo zesikhumba kusuka ku-eczema kuya ku-poison ivy ziphathwa ngama-glucocorticoids. Lokhu kufaka phakathi okhilimu abangaphezu kwekhawunta kanye nodokotela owafaka esikhumbeni sakho nasemithini oyiphuzayo ngomlomo.

Ukuhlinzwa

Ama-glucocorticoids angasetshenziswa ngesikhathi sezinzwa ezibucayi ezibucayi. Zinciphisa ukuvuvukala kwezicubu ezintekenteke. Zibuye zenziwe ngemuva kokufakwa kwesitho ukusiza ukuvikela amasosha omzimba ekwenqabeni isitho sabanikeli.

Okuqhamuka uma udla imishanguzo

AmaGlucocorticoids angazwakala njengezidakamizwa eziyisimangaliso, kepha anemiphumela engemihle. Eminye yale miphumela engemihle ingalimaza kakhulu. Yingakho le mithi ingabekiwe ukusetshenziswa kwesikhathi eside.

Le mithi inga:

• ukwandisa izinga lakho likashukela egazini, elingadala isifo sikashukela sesikhashana futhi mhlawumbe sesikhathi eside
• cindezela amandla omzimba wakho wokumunca i-calcium, engaholela ekuthini kwamathambo
• ukwandisa amazinga akho e-cholesterol ne-triglyceride
• ukwandisa ingozi yezilonda kanye nesisu
• ukubambezela ukuphulukiswa kwesilonda, okudinga inani elithile lokuvuvukala
• cindezela amasosha akho omzimba futhi ukwenze uthambekele kakhulu ekuthelelekeni

Ukusetshenziswa kwesikhathi eside kwama-glucocorticoids kungadala ukulahleka kwezicubu zemisipha. Kungabanga futhi ne-Cushing's syndrome, engaholela ku:

• isikhumba esinamafutha phakathi kwamahlombe akho
• ubuso obuyindilinga
• ukuzuza kwesisindo
• ama-pink stretch marks
• amathambo abuthakathaka
• isifo sikashukela
• umfutho wegazi ophakeme
• isikhumba esincane
• ukuphulukiswa kancane
• induna
• imijikelezo yokuya esikhathini engajwayelekile
• kwehle i-libido
• ukukhathala
• ukudana

Uma usebenzise i-glucocorticoids isikhathi esingaphezu kwamasonto ambalwa, udokotela wakho cishe uzothatha umthamo wakho kancane kunokuba uyeke ukuwuthatha ngasikhathi sinye. Lokhu kusiza ukuvimbela imiphumela yokuhoxa. Umzimba wakho ngokwemvelo wenza ama-glucocorticoids, kepha uma uqala ukuwaphuza njengomuthi, umzimba wakho uphendula ngokwenza okuncane kuwo uwedwa. Uma uyeka ukuthatha ama-glucocorticoids, umzimba wakho udinga isikhathi sokuqala ukuzenzela okuningi emazingeni ajwayelekile futhi.

Khuluma nodokotela wakho

I-Glucocorticoids ingaba yimithi ewusizo ekwelashweni okuningi okuhlukahlukene. Kodwa-ke, kubalulekile ukulinganisela isidingo sokwelapha i-glucocorticoid ngemiphumela emibi. Uma udokotela wakho ekunika ukwelashwa kwe-glucocorticoid, batshele nganoma yimiphi imiphumela emibi onayo. Kubalulekile futhi ukuphuza imishanguzo njengoba kuqondisiwe, kufaka phakathi ukuthi uyiyeka nini. Udokotela wakho angakususa emithini yakho kancane ukuvimbela ukuhoxiswa.