Ngabe iGlucosamine iyasebenza? Izinzuzo, Isilinganiso kanye Nemiphumela emibi

-Delile

• Kuyini iGlucosamine?
• Kwangathi Kunganciphisa Ukuvuvukala
• Isekela Amalunga Aphilile
• Imvamisa Isetshenziselwa Ukwelapha Ukuphazamiseka Kwamathambo Nokubambisana
• Okunye Ukusetshenziswa kweGlucosamine
• I-Cystitis yangaphakathi
• Izifo Zamathumbu Okuvuvukala (IBD)
• I-Multiple Sclerosis (MS)
• I-Glaucoma
• I-Temporomandibular Joint (TMJ)
• Ingabe Kuyasebenza Ngempela?
• Amafomu Esilinganiso Nesengezo
• Izingozi Ezingaba khona Nemiphumela engemihle
• Okusemqoka

I-Glucosamine yi-molecule eyenzeka ngokwemvelo emzimbeni wakho, kodwa futhi iyisengezo esidumile sokudla.

Ngokuvamile okusetshenziselwa ukwelapha izimpawu zokuphazamiseka kwethambo nokuhlangana, kusetshenziswa ngokufanayo ukukhomba ezinye izifo eziningana zokuvuvukala.

Lo mbhalo uhlola izinzuzo ze-glucosamine, isilinganiso semiphumela kanye nemiphumela engemihle.

Kuyini iGlucosamine?

I-Glucosamine iyinhlanganisela eyenzeka ngokwemvelo ehlukaniswa ngamakhemikhali njengoshukela we-amino (1).

Isebenza njengesakhi sokwakheka kwama-molecule ahlukahlukene asebenzayo emzimbeni wakho kepha yaziwa ngokuyinhloko ngokuthuthukisa nokugcina uqwanga ngaphakathi kwamalunga akho (1).

I-Glucosamine iyatholakala nakwezinye izicubu zezilwane nezinye okungezona ezomuntu, kufaka phakathi amagobolondo e-shellfish, amathambo ezilwane nesikhunta. Izinhlobo zokwengeza ze-glucosamine zivame ukwenziwa ngale mithombo yemvelo (2).

I-Glucosamine isetshenziswa kaningi ekwelapheni nasekuvimbeleni ukuphazamiseka okuhlangene, okufana ne-osteoarthritis. Kungathathwa ngomlomo noma kusetshenziswe ngokwezihloko kokhilimu noma isalufu (2).

IGlucosamine iyinhlanganisela yamakhemikhali eyenzeka ngokwemvelo kuzicubu zomuntu nezilwane. Kubantu, kuyasiza ukwakha uqwanga futhi kuvame ukusetshenziswa njengesengezo sokudla ukwelapha ukuphazamiseka okuhlangene njenge-osteoarthritis.

Kwangathi Kunganciphisa Ukuvuvukala

I-Glucosamine ivame ukusetshenziselwa ukwengeza izimpawu zezimo ezahlukahlukene zokuvuvukala.

Yize izindlela ze-glucosamine zingaqondakali kahle, kubonakala sengathi kunciphisa kalula ukuvuvukala.

Ucwaningo olulodwa lwe-test-tube lubonise umthelela omkhulu wokulwa nokuvuvukala lapho i-glucosamine isetshenziswa kumaseli abandakanyeka ekwakhekeni kwethambo ().

Ucwaningo oluningi nge-glucosamine lubandakanya ukwengeza ngasikhathi sinye ne-chondroitin - ikhompiyutha efana ne-glucosamine, nayo ebandakanyekayo ekukhiqizweni komzimba nasekugcinweni kwe-cartilage enempilo (4).

Ucwaningo olwenziwe kubantu abangaphezu kuka-200 luxhumanise izithasiselo ze-glucosamine kwehliswa ngama-28% kanye nama-24% kuzimpawu ezimbili eziqondile zamakhemikhali zokuvuvukala: i-CRP ne-PGE. Kodwa-ke, le miphumela ibingabalulekanga ngokwezibalo ().

Kuyaphawuleka ukuthi ucwaningo olufanayo luthole ukwehla okungama-36% kwalaba bantu abamaka ukuvuvukala kwabantu abathatha i-chondroitin. Lo mphumela, empeleni, wawubalulekile ().

Ezinye izifundo zengeza lokho okutholakele. Khumbula ukuthi ababambiqhaza abaningi abathatha i-chondroitin nabo babika ngasikhathi sinye ukufaka i-glucosamine.

Ngakho-ke, kusalokhu kungacaci ukuthi imiphumela iqhutshwa yi-chondroitin iyodwa noma inhlanganisela yazo zombili izithasiselo ezithathwe ndawonye ().

Ekugcineni, kudingeka olunye ucwaningo ngendima ye-glucosamine ekwehliseni omaka bokuvuvukala emzimbeni wakho.

Indlela i-glucosamine esebenza ngayo ekwelashweni kwezifo ayiqondakali kahle, kepha olunye ucwaningo lukhombisa ukuthi kunganciphisa ukuvuvukala - ikakhulukazi uma kusetshenziswa eceleni kwezithako ze-chondroitin.

Isekela Amalunga Aphilile

I-Glucosamine ikhona ngokwemvelo emzimbeni wakho. Enye yezindima zayo eziphambili ukuxhasa ukukhula okunempilo kwezicubu eziphakathi kwamalunga akho (1).

I-articular cartilage wuhlobo lwezicubu ezimhlophe ezibushelelezi ezihlanganisa imikhawulo yamathambo akho lapho zihlangana khona zenze amalunga.

Lolu hlobo lwezicubu - kanye noketshezi oluthambisa olubizwa nge-synovial fluid - luvumela amathambo ukuthi ahambisane ngokukhululekile, anciphise ukungqubuzana futhi avumele ukunyakaza okungenabuhlungu emajoyini akho.

I-Glucosamine isiza ukwakha amakhemikhali amaningana abandakanyeka ekwakheni uqwanga lwe-articular kanye ne-synovial fluid.

Olunye ucwaningo lukhombisa ukuthi i-supplementary glucosamine ingavikela izicubu ezihlangene ngokuvimbela ukuwohloka koqwanga.

Ucwaningo olulodwa oluncane kubagibeli bamabhayisikili abangama-41 luthole ukuthi ukwengeza kufinyelela ku-3 gramu we-glucosamine nsuku zonke kunciphisa ukonakala kwe-collagen emadolweni ngo-27% uma kuqhathaniswa no-8% eqenjini le-placebo ().

Olunye ucwaningo oluncane luthole isilinganiso esincishiswe kakhulu sokuqhekeka kwe-collagen kuya kumaka we-collagen-synthesis kumajoyini we-articular wabadlali bebhola abaphathwa ngama-3 gramu we-glucosamine nsuku zonke esikhathini esiyizinyanga ezintathu ().

Le miphumela iphakamisa umphumela ohlanganyelwe wokuvikela i-glucosamine. Kodwa-ke, kudingeka olunye ucwaningo.

I-Glucosamine ibandakanyeka ekwakheni izicubu ezibalulekile ekusebenzeni ngokufanele. Ngenkathi kudingeka izifundo eziningi, olunye ucwaningo lukhombisa ukuthi i-supplementary glucosamine ingavikela amalunga akho ekulimaleni.

Imvamisa Isetshenziselwa Ukwelapha Ukuphazamiseka Kwamathambo Nokubambisana

Izithasiselo ze-Glucosamine zivame ukuthathwa ukwelapha izimo ezahlukahlukene zethambo nezokuhlangana.

Le molekyuli ifundelwe ngokukhethekile amandla ayo okwelapha izimpawu nokuqhubekela phambili kwezifo okuhambisana ne-osteoarthritis, isifo samathambo nesifo samathambo.

Ucwaningo oluningi lukhombisa ukuthi ukwengeza nsuku zonke nge-glucosamine sulfate kunganikeza ukwelashwa okusebenzayo, okuhlala isikhathi eside kwe-osteoarthritis ngokunikeza ukwehliswa okukhulu kobuhlungu, ukugcinwa kwendawo ehlanganyelwe kanye nokwehla okuphelele kokuqhubeka kwezifo (,, 10, 11).

Ezinye izifundo ziveze izimpawu ezinciphise kakhulu i-rheumatoid arthritis (RA) kumagundane aphathwa ngezindlela ezahlukahlukene ze-glucosamine (,).

Ngokuphambene nalokho, isifundo esisodwa somuntu asibonisanga noma yiziphi izinguquko ezinkulu ekuqhubekeni kweRA ngokusebenzisa i-glucosamine. Kodwa-ke, ababambiqhaza bokutadisha babike kakhulu ukuphathwa kwezimpawu ().

Olunye ucwaningo lwangaphambilini kumagundane ane-osteoporosis lukhombisa nokuthi kungenzeka kusetshenziswe ukwengeza kwe-glucosamine ukuthuthukisa amandla amathambo ().

Yize le miphumela ikhuthaza, kudingeka ucwaningo olwengeziwe lwabantu ukuqonda izindlela zokusebenza okuhle kakhulu kwe-glucosamine ezifweni ezihlangene nezethambo.

Yize i-glucosamine isetshenziswa kaningi ekwelapheni izimo ezahlukahlukene zamathambo nezokuhlangana, kudingeka olunye ucwaningo ngemiphumela yalo.

Okunye Ukusetshenziswa kweGlucosamine

Yize abantu besebenzisa i-glucosamine ukwelapha izifo ezinhlobonhlobo ezingapheli zokuvuvukala, idatha yesayensi yokusekela ukusetshenziswa okunjalo inqunyelwe.

I-Cystitis yangaphakathi

I-Glucosamine iphakanyiswa kabanzi njengokwelashwa kwe-interstitial cystitis (IC), isimo esihambisana nokushoda kwe-glycosaminoglycan.

Ngenxa yokuthi i-glucosamine iyisandulela salesi sakhi, kuthiwa umbono wokuthi izithako ze-glucosamine zingasiza ukuphatha i-IC ().

Ngeshwa, idatha ethembekile yesayensi yokusekela le mbono iyashoda.

Izifo Zamathumbu Okuvuvukala (IBD)

Njenge-cystitis yangaphakathi, isifo samathumbu esivuthayo (IBD) sihlotshaniswa nokushoda kwe-glycosaminoglycan ().

Ucwaningo oluncane kakhulu lusekela umbono wokuthi i-glucosamine ingaphatha i-IBD. Kodwa-ke, ucwaningo olwenziwe kumagundane ne-IBD lukhombisile ukuthi ukwengeza nge-glucosamine kunganciphisa ukuvuvukala ().

Ekugcineni, kudingeka olunye ucwaningo ukudweba noma iziphi iziphetho.

I-Multiple Sclerosis (MS)

Eminye imithombo ithi i-glucosamine ingaba yindlela yokwelapha ephumelelayo ye-multiple sclerosis (MS). Noma kunjalo, ukusekela ucwaningo kuyashoda.

Ucwaningo olulodwa luhlolisise umphumela wokusebenzisa i-glucosamine sulphate eceleni kokwelapha kwendabuko kwe-MS ebuyisa kabusha. Imiphumela ayibonisanga mthelela omkhulu ezingeni lokubuyela emuva noma ukuqhubeka kwesifo njengomphumela we-glucosamine ().

I-Glaucoma

I-glaucoma kukholelwa kakhulu ukuthi iyelapheka nge-glucosamine.

Olunye ucwaningo lwakuqala lukhombisa ukuthi i-glucosamine sulfate ingakhuthaza impilo yamehlo ngokuncipha kokuvuvukala nemiphumela ye-antioxidant ku-retina yakho).

Ngakolunye uhlangothi, isifundo esisodwa esincane sakhombisa ukuthi ukudla ngokweqile kwe-glucosamine kungalimaza abantu abane-glaucoma ().

Sekukonke, idatha yamanje ayihambelani.

I-Temporomandibular Joint (TMJ)

Eminye imithombo ithi i-glucosamine iyindlela yokwelapha esebenzayo ye-TMJ, noma i-temporomandibular joint. Kodwa-ke, ucwaningo lokusekela lesi simangalo alwanele.

Ucwaningo olulodwa oluncane lukhombise ukwehla okukhulu kwezinhlungu nezimpawu zokuvuvukala, kanye nokunyuka komhlathi okwandayo kwabahlanganyeli abathole isengezo esihlanganisiwe se-glucosamine sulfate ne-chondroitin ().

Olunye ucwaningo oluncane aluvezanga mthelela omkhulu wesikhashana wesithasiselo se-glucosamine hydrochloride kubantu abane-TMJ. Kodwa-ke, kubikwe intuthuko enkulu ekuphathweni kobuhlungu besikhathi eside ().

Le miphumela yokufunda iyathembisa kepha ayinikezi idatha eyanele ukusekela noma iziphi iziphetho ezicacile. Ucwaningo olwengeziwe luyadingeka.

Ngenkathi i-glucosamine ivame ukubhekwa njengokwelapha okusebenzayo kwezimo ezahlukahlukene, ayikho imininingwane eqondile ngomthelela wayo.

Ingabe Kuyasebenza Ngempela?

Yize kwenziwa izimangalo ezibanzi ngemiphumela emihle ye-glucosamine ezifweni eziningi, ucwaningo olutholakalayo lusekela kuphela ukusetshenziswa kwalo ebangeni elincanyana lezimo.

Njengamanje, ubufakazi obuqine kakhulu busekela ukusetshenziswa kwe-glucosamine sulfate ekwelashweni kwesikhathi eside kwezimpawu ze-osteoarthritis. Lokho kusho, kungahle kungasebenzi kuwo wonke umuntu ().

Ngokuya ngemininingwane etholakalayo, mancane amathuba okuthi kube ukwelashwa okusebenzayo kwezinye izifo noma izimo zokuvuvukala.

Uma ucabanga ukusebenzisa i-glucosamine, khumbula ikhwalithi yesengezo osikhethayo - ngoba lokhu kungenza umehluko ekutheni kukuthinta kanjani wena.

Kwamanye amazwe - kufaka phakathi i-US - kunemithetho emincane kakhulu yezithasiselo zokudla. Ngakho-ke, amalebula angakhohlisa (2).

Kuhle ngaso sonke isikhathi ukubheka isitifiketi senkampani yangaphandle ukuqinisekisa ukuthi uthola kahle lokho okukhokhelayo. Abakhiqizi abazimisele ukuthi imikhiqizo yabo ihlolelwe ubumsulwa ngumuntu wesithathu bavame ukuba namazinga aphezulu.

I-ConsumerLab, i-NSF International ne-US Pharmacopeia (USP) yizinkampani ezimbalwa ezizimele ezihlinzeka ngezinsizakalo zezitifiketi. Uma ubona olunye lwamalogo ku-supplement yakho, kungenzeka ukuthi ikhwalithi enhle.

Ucwaningo oluningi lusekela ukusetshenziswa kwe-glucosamine-sulfate kuphela ekuphatheni izimpawu ze-osteoarthritis. Akunamathuba amancane okusebenza kwezinye izinhlelo zokusebenza.

Amafomu Esilinganiso Nesengezo

Umthamo ojwayelekile we-glucosamine yi-1,500 mg ngosuku, ongayithatha ngasikhathi sinye noma ngemithamo emincane eminingi usuku lonke (2).

Izithasiselo ze-Glucosamine zenziwa ngemithombo yemvelo - njengamagobolondo e-shellfish noma isikhunta - noma zenziwe elebhu ngokufanele.

Izithako ze-Glucosamine zitholakala ngezindlela ezimbili (1):

• I-Glucosamine sulfate
• I-Glucosamine hydrochloride

Kwesinye isikhathi, i-glucosamine sulfate nayo ithengiswa ihlanganiswe ne-chondroitin sulfate.

Imininingwane eminingi yesayensi ikhombisa ukusebenza okuhle kakhulu kwe-glucosamine sulfate noma i-glucosamine sulfate kuhlanganiswe ne-chondroitin.

I-Glucosamine ijwayele ukukhishwa ku-1,500 mg ngosuku. Kumafomu atholakalayo, i-glucosamine sulfate - nge-chondroitin noma ngaphandle kwayo - kungenzeka ukuthi iyona ephumelela kakhulu.

Izingozi Ezingaba khona Nemiphumela engemihle

Izithasiselo ze-Glucosamine kungenzeka ziphephile kubantu abaningi. Noma kunjalo, kukhona ezinye izingozi ezikhona.

Imiphumela engaba khona emibi ihlanganisa (1):

• Isicanucanu nokuhlanza
• Uhudo
• Isilungulela
• Ubuhlungu besisu

Akufanele uthathe i-glucosamine uma ukhulelwe noma uncelisa ngenxa yokushoda kobufakazi obusekela ukuphepha kwayo.

I-Glucosamine ingase ibe yimbi kakhulu ukulawula ushukela egazini kubantu abanesifo sikashukela, yize le ngozi incane. Uma unesifo sikashukela noma uthatha imishanguzo yesifo sikashukela, khuluma nodokotela wakho ngaphambi kokuthatha i-glucosamine (2).

I-Glucosamine kungenzeka iphephile kubantu abaningi. Kubikwe ukuphatheka kabi okuncane kwamathumbu. Uma unesifo sikashukela, i-glucosamine ingahle yenze kube nzima ukulawula ushukela egazini.

Okusemqoka

I-Glucosamine ikhona ngokwemvelo emzimbeni wakho futhi idlala indima ebalulekile ekuthuthukiseni nasekulondolozeni amalunga enempilo.

Yize i-glucosamine isetshenziselwa ukwelapha izifo ezahlukahlukene ezihlangene, zamathambo nezokuvuvukala, njenge-IBD, i-interstitial cystitis ne-TMJ, ucwaningo oluningi lusekela ukusebenza kwalo ekuphatheni izimpawu zesifo se-osteoarthritis zesikhathi eside.

Kubonakala kuphephile kubantu abaningi kumthamo we-1,500 mg ngosuku kepha kungadala imiphumela emibi.

Uma ufuna ukukhululeka kwe-osteoarthritis, ukuthatha isengezo se-glucosamine kungakufanele ukucatshangelwa, kodwa qiniseka ukuthi ukhuluma nodokotela wakho kuqala.