Ukuhlolwa Kwehormone Yokukhula: Okudingeka Ukwazi

-Delile

• Iphrothokholi yokuhlola ye-GH nezinhlobo
• Ukuhlolwa kwe-serum ye-GH
• Isivivinyo esikhula nge-insulini-1 test
• Ukuhlolwa kokucindezelwa kwe-GH
• Ukuhlolwa kokukhuthaza kwe-GH
• Izindleko zokuhlolwa kwe-GH
• Ukuhumusha imiphumela yokuhlolwa kwe-GH
• Ububanzi obujwayelekile bemiphumela yokuhlolwa kwe-GH
• Ukuhlolwa kwe-GH ezinganeni
• Ukuhlolwa kwe-GH kubantu abadala
• Ukuthatha

Ukubuka konke

I-hormone yokukhula (GH) ingelinye lamahomoni amaningi akhiqizwa yindlala yobuchopho ebuchosheni bakho. Yaziwa nangokuthi i-hormone yokukhula komuntu (HGH) noma i-somatotropin.

I-GH ibamba iqhaza elibalulekile ekukhuleni nasekukhuleni komuntu okujwayelekile, ikakhulukazi ezinganeni nasebusheni. Amazinga e-GH aphezulu noma aphansi kunalokho okufanele abe yikho angaholela ezinkingeni zezempilo ezinganeni nakubantu abadala.

Uma udokotela wakho esola ukuthi umzimba wakho kungenzeka ukhiqiza i-GH eningi kakhulu noma encane kakhulu, bazo-oda ukuhlolwa ukuze kukalwe amazinga e-GH egazini lakho. Ukuhlonza noma yiziphi izingqinamba ezihlobene ne-GH kuzosiza udokotela wakho ukuthi enze ukuxilongwa futhi anqume indlela yokwelashwa engcono kakhulu kuwe.

Iphrothokholi yokuhlola ye-GH nezinhlobo

Kunezinhlobo ezahlukahlukene zokuhlolwa kwe-GH, futhi inqubo ethize yokuhlola iyahluka kuye ngokuthi iluphi uhlolo oluyalelwe ngudokotela wakho.

Njengakuzo zonke izivivinyo zezokwelapha, kubalulekile ukulandela yonke imiyalo yokulungiselela evela ethimbeni lakho lokunakekelwa kwezempilo. Ngokuvamile, ekuhlolweni kwe-GH udokotela wakho uzokucela ukuthi:

• shesha isikhathi esithile ngaphambi kokuhlolwa
• yeka ukuthatha i-vitamin biotin, noma i-B7, okungenani amahora ayi-12 ngaphambi kokuhlolwa
• yeka ukuthatha imishanguzo ethile kadokotela ezinsukwini ezimbalwa ngaphambi kokuhlolwa, uma ingaphazamisa imiphumela yokuhlolwa

Kokunye ukuhlolwa, udokotela wakho angakunikeza imiyalo eyengeziwe yokulungiselela.

Akuvamile ukuthi abantu babe namazinga e-GH angaphandle kwebanga elijwayelekile, ngakho-ke ukuhlolwa kwe-GH akwenziwa ngokujwayelekile. Uma udokotela wakho ecabanga ukuthi amazinga e-GH emzimbeni wakho angahle abe angajwayelekile, kungenzeka a-oda olunye noma eziningi zalezi zivivinyo ezilandelayo.

Ukuhlolwa kwe-serum ye-GH

Ukuhlolwa kwe-serum ye-GH kusetshenziselwa ukukala inani le-GH egazini lakho lapho kudonswa igazi. Ekuhlolweni, uchwepheshe wezokunakekelwa kwempilo uzosebenzisa inaliti ukuqoqa isampula yegazi lakho. Isivivinyo ngokwaso sijwayelekile futhi sithwala ukungaphatheki kahle okuncane noma ingozi.

Isampula yegazi izothunyelwa ebhodini ukuze liyohlaziywa. Imiphumela yokuhlolwa kwe-serum ye-GH ikhombisa udokotela wakho izinga le-GH egazini lakho ngesikhathi esisodwa ngesikhathi kuthathwa isampula yegazi lakho.

Kodwa-ke, lokhu kungenzeka kungabi imininingwane eyanele yokusiza udokotela wakho ukuthi axilonge ngoba amazinga e-GH emzimbeni wakho ayakhuphuka futhi awele usuku lonke.

Isivivinyo esikhula nge-insulini-1 test

Ukuhlolwa okufana nokukhula kwe-insulin-1 test (ukuhlolwa kwe-IGF-1) kuvame uku-odwa ngesikhathi esifanayo nokuhlolwa kwe-serum ye-GH. Uma une-GH eyeqile noma eswelekile, uzoba namazinga aphezulu noma aphansi kunokujwayelekile we-IGF-1.

Inzuzo esemqoka yokuhlola i-IGF ukuthi, ngokungafani ne-GH, amazinga ayo ahlala ezinzile. Kudingeka isampula yegazi eyodwa kuphela kuzo zombili izivivinyo.

Ukuhlolwa kwe-GH serum ne-IGF-1 ngokuvamile akunikezi udokotela wakho ulwazi olwanele lokwenza ukuxilongwa. Lezi zivivinyo zivame ukusetshenziselwa ukuhlolwa, ukuze udokotela wakho anqume ukuthi kudingeka olunye uvivinyo. Uma udokotela wakho esola ukuthi umzimba wakho ukhiqiza i-GH eningi kakhulu noma encane kakhulu, kungenzeka ukuthi ba-ode ukuhlolwa kokucindezelwa kwe-GH noma ukuhlolwa kokukhuthaza kwe-GH.

Ukuhlolwa kokucindezelwa kwe-GH

Ukuhlolwa kokucindezela i-GH kusiza udokotela wakho aqinisekise ukuthi umzimba wakho ukhiqiza i-GH eningi kakhulu.

Kulolu vivinyo, uchwepheshe wezokunakekelwa kwempilo uzosebenzisa inaliti noma i-IV ukuthatha isampula yegazi. Ngemuva kwalokho uzocelwa ukuthi uphuze ikhambi elijwayelekile eliqukethe i-glucose, uhlobo lukashukela. Lokhu kuzonambitha kamnandi futhi kungahle kufike ezinhlotsheni ezihlukile.

Uchwepheshe wezokunakekelwa kwezempilo uzodweba amasampula amaningi egazi lakho ngezikhathi ezithile phakathi namahora amabili ngemuva kokuphuza isisombululo. Lawa masampula azothunyelwa elebhu ukuyohlaziywa.

Kubantu abaningi, i-glucose yehlisa ukukhiqizwa kwe-GH. Ilebhu izobheka amazinga akho e-hormone ngokuya ngamazinga alindelekile esikhathini ngasinye sokuhlola.

Ukuhlolwa kokukhuthaza kwe-GH

Isivivinyo sokukhuthaza i-GH sisiza udokotela wakho ukuthi ahlolisise ngokweqile noma ukushoda ekukhiqizeni kwe-GH.

Kulolu vivinyo, uchwepheshe wezokunakekelwa kwempilo ngokuvamile uzosebenzisa i-IV ukuthatha isampula yegazi lokuqala. Ngemuva kwalokho bazokunikeza umuthi owenza umzimba wakho ukhulule i-GH. Isazi sezempilo sizokuqapha futhi sithathe amasampula amaningi egazi ngezikhathi ezibekiwe ngaphezu kwamahora amabili.

Amasampula azothunyelwa elebhu futhi aqhathaniswe namazinga we-GH alindelekile ngesikhathi ngasinye ngemuva kokuthatha okokuvuselela amandla.

Izindleko zokuhlolwa kwe-GH

Izindleko zezivivinyo ze-GH ziyehluka ngokuya ngembozo yakho yomshuwalense, indawo lapho izivivinyo zenziwe khona, nokuthi iyiphi ilebhu esetshenziselwa ukwenza ukuhlaziywa.

Ukuhlolwa okulula kunazo zonke ukuhlolwa kwe-GH serum ne-IGF-1, okudinga kuphela ukudonsa igazi. Izindleko ezijwayelekile ngalunye lwalezi zivivinyo cishe zingama- $ 70 uma zi-ode ngqo ebhodini. Izindleko zakho zangempela zingahluka ngokuya ngokuthi ithimba lakho lezokunakekelwa kwempilo likhokhisa malini ngezinsizakalo, njengokudweba igazi lakho nokulithumela ebhodini.

Ukuhumusha imiphumela yokuhlolwa kwe-GH

Udokotela wakho uzothola imiphumela yakho yelabhu bese eyihumusha. Uma imiphumela yakho yokuhlolwa ikhombisa ukuthi ungaba nesimo esihlobene ne-GH noma uma udinga ukuhlolwa okwengeziwe, ihhovisi likadokotela wakho lizojwayele ukuxhumana nawe ukuze uthole ukuqokwa kokulandelela.

Ngokuvamile, imiphumela yokuhlolwa kwe-serum ye-GH kanye nokuhlolwa kwe-IGF-1 ayinikezi imininingwane eyanele yokuthola isifo esihlobene ne-GH. Uma imiphumela ingajwayelekile, udokotela wakho kungenzeka a-oda ukucindezelwa kwe-GH noma ukuvuselelwa kovivinyo.

Uma izinga lakho le-GH ngesikhathi sokuhlolwa kokucindezela liphezulu, kusho ukuthi i-glucose ayizange yehlise umkhiqizo wakho we-GH njengoba bekulindelekile. Uma i-IGF-1 yakho nayo ibiphezulu, udokotela wakho angahlola ukuthi ukukhiqizwa ngokweqile kwe-GH. Ngoba izimo ezihlobene ne-hormone yokukhula azivamile futhi kungaba inselele ukuxilonga, udokotela wakho angase asikisele ukuhlolwa okwengeziwe.

Uma amazinga akho e-hormone ngesikhathi sokuhlolwa kwe-GH stimulation ephansi, umzimba wakho awukhipanga i-GH eningi njengokulindelekile. Uma izinga lakho le-IGF-1 nalo beliphansi, lingakhombisa ukuntuleka kwe-GH. Futhi, udokotela wakho kungenzeka ancoma ukuhlolwa okwengeziwe ukuze aqiniseke.

Ububanzi obujwayelekile bemiphumela yokuhlolwa kwe-GH

Ekuhlolweni kokucindezela, imiphumela engaphansi kwama-0.3 nanograms ngemililitha (ng / mL) ithathwa njengebanga elijwayelekile, ngokusho kweMayo Clinic. Noma yini ephakeme iphakamisa ukuthi umzimba wakho kungenzeka ukuthi ukhiqiza i-hormone yokukhula eningi kakhulu.

Ekuhlolweni kokuvuselela, inani eliphakeme elingaphezu kwe-5 ng / mL ezinganeni nangaphezulu kwe-4 ng / mL kubantu abadala ngokuvamile libhekwa ebangeni elijwayelekile.

Kodwa-ke, ibanga lemiphumela ejwayelekile lingahluka ngokuya ngelebhu nomhlinzeki wakho wezokunakekelwa kwempilo. Isibonelo, eminye imihlahlandlela ithanda ukugxila okuphezulu ngenhla ezinganeni ukukhipha ngokuphelele ukushoda kwe-GH kusetshenziswa izivivinyo zokukhuthaza.

Ukuhlolwa kwe-GH ezinganeni

Udokotela anga-oda ukuhlolwa kwe-GH kwezingane ezibonisa izimpawu zokuntula kwe-GH. Lokhu kufaka phakathi:

• ukukhula okuphuzile nokukhula kwamathambo
• ukubambezeleka kokuthomba
• ubude obungaphansi kwesilinganiso

I-GHD ayivamile futhi ngokuvamile ayiyona imbangela yokufushane kwengane noma ukukhula kancane. Ingane ingaba ngaphansi kobude obuphakathi ngezizathu eziningi, kufaka phakathi ufuzo olulula.

Izikhathi zokukhula kancane zivamile ezinganeni, ikakhulukazi ngaphambi kokuthomba. Izingane ezinokushoda kwe-GH zivame ukukhula ngaphansi kwamasentimitha amabili ngonyaka.

Ukuhlolwa kwe-GH nakho kungasiza uma kunezimpawu zokuthi umzimba wengane ukhiqiza i-GH eningi kakhulu. Isibonelo, lokhu kungenzeka ngesimo esingajwayelekile esaziwa njenge-gigantism, esibangela ukuthi amathambo amade, imisipha nezitho zomzimba zikhule ngokweqile ebuntwaneni.

Ukuhlolwa kwe-GH kubantu abadala

Imizimba yabantu abadala ithembele ku-GH ukugcina ubukhulu bemisipha namathambo, nokulawula imetabolism.

Uma wenza i-GH encane kakhulu, kungenzeka ukuthi wehlise ukuqina kwamathambo nobukhulu bemisipha. Ukuhlolwa kwegazi okujwayelekile okubizwa ngephrofayili ye-lipid kungakhombisa ushintsho emazingeni amafutha egazini lakho. Noma kunjalo, ukushoda kwe-GH akuvamile.

I-GH eyengeziwe kubantu abadala ingadala isimo esingajwayelekile esibizwa nge-acromegaly, esenza amathambo aqine. Uma ingalashwa, i-acromegaly ingadala izinkinga eziningi, kufaka phakathi ingozi enkulu yesifo samathambo nezinkinga zenhliziyo.

Ukuthatha

Amazinga e-GH aphakeme kakhulu noma aphansi kakhulu angakhombisa izimo zempilo ezinzima. Kodwa-ke, kubalulekile ukukhumbula ukuthi lezi zimo azivamile.

Udokotela wakho angalawula ukuhlolwa ukuze uhlole amazinga akho e-GH usebenzisa ukucindezelwa kwe-GH noma ukuhlolwa kokukhuthaza. Uma imiphumela yakho yokuhlolwa ikhombisa amazinga angajwayelekile we-GH, udokotela wakho kungenzeka a-oda ukuhlolwa okwengeziwe.

Uma uthola ukuthi unesimo esihlobene ne-GH, udokotela wakho uzokweluleka ngenkambo engcono yokwelashwa. I-synthetic GH ivame ukunikezwa kulabo abanamaphutha e-GH. Kokubili abadala nezingane, ukutholwa kusenesikhathi kubalulekile ukukhulisa amathuba emphumela omuhle.