Umlobi: Louise Ward
Usuku Lokudalwa: 4 Ufebhuwari 2021
Ukuvuselela Usuku: 28 Ujanuwari 2025
Anonim
Emicizumab Prophylaxis in Hemophilia A
Ividiyo: Emicizumab Prophylaxis in Hemophilia A

-Delile

Kuyini iHemlibra?

IHemlibra ngumuthi kadokotela obizwa ngegama lomkhiqizo. Kunqunyelwe ukuvimbela iziqephu zokopha noma kuzenze zingabi njalo kubantu abane-hemophilia A, noma ngabe bane-factor VIII (8) inhibitors. IHemlibra ivunyelwe ukusetshenziswa kubantu bayo yonke iminyaka.

I-Hemlibra iqukethe i-emicizumab yezidakamizwa, eyi-anti-monoclonal antibody. Lesi yisidakamizwa esenziwe ngamaseli omzimba.

IHemlibra iza njengesisombululo esinikezwa njengomjovo ngaphansi kwesikhumba sakho (ngaphansi kwesikhumba). Umhlinzeki wakho wezokunakekelwa kwempilo angakunika umjovo, noma ungazijolela ekhaya ngabantu abaneminyaka engu-7 noma ngaphezulu.

Ezifundweni zomtholampilo ezihlala izinyanga eziyisithupha noma ngaphezulu, iHemlibra inciphise inani lokuphuma kwegazi okuphelele ngo:

  • okungenani amaphesenti angama-94 kubantu abangenawo ama-factor VIII inhibitors
  • okungenani amaphesenti angama-80 kubantu abane-factor VIII inhibitors

Uhlobo olusha lomuthi

Ngaphambi kokuthi i-Food and Drug Administration (i-FDA) ivume iHemlibra, uhlobo oluyinhloko lwezokwelapha olusetshenziselwa ukwelapha i-hemophilia A lwaluyisici se-VIII.


Abantu abane-hemophilia A abanaso isici VIII, iphrotheni umzimba wakho odinga ukwakha amahlule egazi. Ukwelashwa okufakwa esikhundleni kwe-Factor VIII kufaka i-factor VIII egazini lakho. Imvamisa, into efakwa endaweni ye-factor VIII idalwa elebhu, kepha ingenziwa futhi nge-plasma yegazi enikelwe. Ukwelashwa kunikezwa njengomjovo komunye wemithambo yakho (emithanjeni).

I-Hemlibra yenziwa ngamaseli aselebhu. Esikhundleni sokufaka i-factor VIII, i-Hemlibra isebenza ngokunamathisela ezicini ezithile zokujiya (amaprotheni) egazini. Lokhu kwenza ukuthi igazi likwazi ukujiya kahle ngaphandle kwe-factor VIII, lisize ukuvikela ukopha okungalawuleki.

I-Hemlibra yisidakamizwa sokuqala esisetshenziselwa ukuvimbela ukopha kubantu abane-hemophilia A kungaba noma kunesici se-VIII inhibitor. Ama-inhibitors ama-antibodies (ama-immune system protein) ahlasela i-factor VIII futhi ayivimbele ekwakheni amahlule. Abanye abantu baba nama-inhibitors uma benikezwa i-factor VIII therapy, okwenza ukwelashwa kungasebenzi.

IHemlibra futhi iyisidakamizwa sokuqala se-hemophilia A ongasithatha njengomjovo ngaphansi kwesikhumba sakho (ngaphansi kwesikhumba). Ngaphezu kwalokho, kunamashejuli amaningi wokufaka, okufaka phakathi amasonto onke, njalo emavikini amabili, noma njalo emavikini amane. Ezinye izindlela zokwelapha i-hemophilia A zidinga ukuthi uziphuze kaningi, kusukela ngazo zonke ezinye izinsuku kuya ezikhathini eziningana ngeviki.


Ukuvunyelwa kwe-FDA

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuqala kwavuma iHemlibra ngo-2017 kubantu abane-hemophilia A ene-factor VIII inhibitors.

Ngo-2018, i-FDA yandise ukuvunyelwa kwayo ukufaka abantu abane-hemophilia A abangenayo i-factor VIII inhibitors.

I-Hemlibra ejwayelekile

IHemlibra itholakala kuphela njengomuthi wegama lomkhiqizo. Okwamanje ayitholakali ngendlela ejwayelekile.

I-Hemlibra iqukethe umuthi osebenzayo emicizumab, kwesinye isikhathi obizwa nge-emicizumab-kxwh. Ukuphela kwe- "-kxwh" kusiza ukusetha umuthi ngaphandle kwemithi efanayo engatholakala esikhathini esizayo. Le yifomethi yokuqamba ejwayelekile yama-antibody monoclonal (izidakamizwa ezenziwe ngamaseli omzimba omzimba).

Ukuphepha kwe-hemlibra

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuqoqa imibiko ngemiphumela emibi yezidakamizwa. Izisebenzi zomphakathi nezokunakekelwa kwezempilo ziletha le mibiko ku-FDA ngokusebenzisa i-MedWatch Voluntary Reporting Form nangokushayela u-800-FDA-1088 (800-322-1088). Kokubili i-FDA neGenentech, umenzi weHemlibra, baqapha ngokucophelela imibiko yezokuphepha ngeHemlibra.


Imibiko yokufa

Umenzi weHemlibra ubike ngokufa kwabantu abayi-10 emhlabeni okwenzeka ngenkathi abantu bethatha iHemlibra. Lokhu kufa kwenzeke ngemuva kokuthi i-FDA ivume umuthi. Akucaci noma lesi sidakamizwa sibangele noma yikuphi ukufa.

Umenzi weHemlibra uyaqhubeka nokuqapha imibiko yezokuphepha mayelana nalesi sidakamizwa. Uma unemibuzo yokuthi ngabe iHemlibra iphephile yini kuwe, khuluma nodokotela wakho.

Izindleko ze-Hemlibra

Njengayo yonke imithi, izindleko zeHemlibra zingahluka.

Inani langempela ozolikhokha lincike ekusetshenzisweni kwakho komshuwalense nasekhemisi oyisebenzisayo.

Usizo lwezezimali nolomshuwalense

Uma udinga ukwesekwa kwezezimali ukukhokhela iHemlibra, noma uma udinga usizo lokuqonda umshuwalense wakho, usizo luyatholakala.

UGenentech, ongumkhiqizi weHemlibra, unikela ngohlelo olubizwa nge-Access Solutions. Ukuthola eminye imininingwane nokuthola ukuthi uyakufanelekela yini ukwesekwa, shayela ku-877-233-3981 noma uvakashele iwebhusayithi yohlelo.

Isilinganiso se-Hemlibra

Isilinganiso se-Hemlibra udokotela wakho asinqumayo sizoxhomeka ezicini eziningana. Lokhu kufaka phakathi:

  • isisindo sakho
  • uhlelo lokwelashwa udokotela wakho anquma ukuthi lungcono kakhulu kuwe

Imininingwane elandelayo ichaza imithamo esetshenziswa kakhulu noma enconywayo. Kodwa-ke, qiniseka ukuthatha isilinganiso udokotela wakho akubekela sona. Udokotela wakho uzonquma isilinganiso esihle kakhulu ukuhlangabezana nezidingo zakho.

Amafomu wezidakamizwa namandla

I-Hemlibra iza ngezitsha ezinezinga elilodwa eziqukethe amandla e-dosage ahlukene:

  • 30 mg / ml
  • 60 mg / 0.4 ml
  • 105 mg / 0.7 ml
  • 150 mg / ml

Umthamo ngamunye unikezwa ngomjovo ngaphansi kwesikhumba sakho (ngaphansi kwesikhumba). Usebenzisa isitsha esisodwa ngomjovo ngamunye, bese ulahla ibhodlela kanye nanoma yiluphi uketshezi olusele esitsheni.

Isikali se-hemophilia A

IHemlibra imvamisa inikezwa kuqala ekulayisheni imithamo, elandelwa imithamo yesondlo. Ukulayisha imithamo ngokushesha kuletha umuthi emazingeni aphezulu emzimbeni wakho. Ziphakeme kakhulu kunemithamo yesondlo noma zinikezwa kaningi.

Izilinganiso zokuqala ezine zeHemlibra zilayisha amanani. Banikezwa njengo-3 mg / kg kanye ngesonto.

Umthamo ngamunye ngemuva kwalokho umthamo wokugcinwa. Udokotela wakho uzonquma isilinganiso esingcono kakhulu sokunakekelwa kwakho. Isilinganiso sakho esithile sizosuselwa kusisindo sakho. Kungenzeka:

  • 1.5 mg / kg kanye ngesonto
  • 3 mg / kg kanye njalo emavikini amabili
  • 6 mg / kg kanye njalo emavikini amane

QaphelaIkhilogremu elilodwa lesisindo somzimba lilingana no-2.2 wamakhilogremu. Isibonelo, uma unesisindo esingamakhilogremu ayi-150, umthamo wakho wokulayisha ongu-3 mg / kg uzoba ngu-204 mg weHemlibra ngesonto.

Umthamo wezingane

Imithamo yezingane isuselwa kusisindo sayo, njengemithamo yabantu abadala.

Kuthiwani uma ngiphuthelwa umthamo?

Uma uphuthelwa umthamo we-Hemlibra, wuthathe ngokushesha nje lapho ukhumbula. Bese uthatha umthamo olandelayo ngokwesheduli yakho ejwayelekile. Ungathathi imithamo emibili ngosuku olufanayo. Ukuthatha umthamo ongaphezu kowodwa ngosuku olufanayo kuzokwandisa ingozi yemiphumela emibi kakhulu.

Ngabe kuzodingeka ngisebenzise lesi sidakamizwa isikhathi eside?

I-Hemlibra ayilona ikhambi le-hemophilia, futhi idinga ukwenziwa njalo ukuze isize ukuvimbela ukopha. Ngakho-ke uma udokotela wakho ethatha isinqumo sokuthi iHemlibra iyindlela yokwelashwa ephephile nephumelelayo kuwe, kungenzeka bakunikeze yona isikhathi eside.

Alikho ikhambi le-hemophilia ngalesi sikhathi.

Imiphumela emibi ye-Hemlibra

I-Hemlibra ingadala imiphumela emibi noma emibi. Uhlu olulandelayo luqukethe eminye yemiphumela emibi engaba khona ngenkathi uthatha iHemlibra. Lolu hlu alufaki yonke imiphumela emibi engaba khona.

Ukuthola eminye imininingwane ngemiphumela engemihle ye-Hemlibra, noma amathiphu wokuthi ungabhekana kanjani nemiphumela emibi ekhathazayo, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi ejwayelekile

Imiphumela emibi ejwayelekile ye-Hemlibra ingafaka:

  • ukusabela kwesiza somjovo (ububomvu, ubuhlungu, noma isisa endaweni lapho kwafakwa khona iHemlibra)
  • ikhanda
  • ubuhlungu obuhlangene

Iningi lalemiphumela emibi ingahle ihambe ezinsukwini ezimbalwa noma emasontweni ambalwa. Uma zinzima kakhulu noma zingahambi, khuluma nodokotela wakho noma usokhemisi.

Imiphumela emibi kakhulu

Imiphumela emibi ebucayi evela eHemlibra ayijwayelekile, kepha ingenzeka.

Ukusabela okweqile

Ukungezwani komzimba akwenziwanga ezivivinyweni zokwelashwa zeHemlibra. Kodwa-ke, njengezidakamizwa eziningi, abanye abantu bangaba nokungezwani komzimba ngemuva kokuthatha iHemlibra. Izimpawu zokuphendula okuncane komzimba zingabandakanya:

  • ukuqubuka kwesikhumba
  • ukulunywa
  • ukuqhuma (ukufudumala nokubomvu esikhunjeni sakho)

Ukusabela okweqile okwedlulele akuvamile kodwa kungenzeka. Izimpawu zokuphendula okweqile kakhulu zingabandakanya:

  • i-angioedema (ukuvuvukala ngaphansi kwesikhumba sakho, imvamisa ezinkalweni zakho, izindebe, izandla, noma izinyawo)
  • ukuvuvukala kolimi lwakho, umlomo, noma umphimbo
  • inkinga yokuphefumula

Shayela udokotela wakho ngokushesha uma une-reaction engathí sina ye-hemlibra. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Amahlule egazi (uma esetshenziswa ne-PCC)

Ngesikhathi sokwelashwa ngeHemlibra, abanye abantu kwesinye isikhathi bangathola imishanguzo esiza ukuyeka ukopha, njenge-prothrombin complex concentrate (aPCC). Imiphumela emibi kakhulu ingenzeka uma uthatha le mithi ndawonye, ​​njengengozi eyengeziwe yamahlule egazi. Ubungozi bukhulu kakhulu kubantu abathatha iHemlibra ethola amayunithi angaphezu kuka-100 / kg we-aPCC ngosuku isikhathi esingaphezu kwamahora angama-24.

Izinhlobo zamahlwili egazi angenzeka uma uthatha iHemlibra ene-PCC zifaka:

  • I-thrombotic microangiopathy (amahlule egazi nokulimala emithanjeni yegazi emincane, kufaka phakathi leyo esezinso, emehlweni, ebuchosheni nakwezinye izitho). Izimpawu zingafaka:
    • isicanucanu
    • ukuhlanza
    • ukuvuvukala kwemilenze yakho nezingalo
    • ubuthakathaka
    • ukuchama kaningi kunokujwayelekile
    • ubuhlungu besisu
    • ukuhlungu obusemhlane
    • ukuphuzi kwesikhumba sakho nokumhlophe kwamehlo akho
    • ukudideka
  • Amahlule egazi kweminye imithambo yegazi, kufaka phakathi lawo asemaphashini, ekhanda, ezingalweni nasemilenzeni. Izimpawu zingafaka:
    • ikhanda
    • unenkinga yokubona
    • ekhwehlela igazi
    • ubuhlungu besifuba
    • inkinga yokuphefumula
    • ukushaya kwenhliziyo okusheshayo
    • ukuvuvukala kwemilenze yakho nezingalo
    • ubuhlungu emilenzeni nasezingalweni zakho

Uma unezimpawu ze-clot yegazi, shayela udokotela wakho ngokushesha. Shayela u-911 uma izimpawu zakho zizizwa zisongela impilo noma uma ucabanga ukuthi unezimo eziphuthumayo zezokwelapha.

Uma uba negazi ngesikhathi sokwelashwa ngeHemlibra ne-ACC, udokotela wakho kungenzeka ukuthi uyeke ukuthatha yomibili le mithi isikhashana. Udokotela wakho uzonquma ukuthi kuphephile yini ukuqala ukuthatha iHemlibra futhi.

I-Hemlibra isebenzisa

Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvumela imishanguzo kadokotela efana neHemlibra ukwelapha izimo ezithile.

I-hemlibra ye-hemophilia A

IHemlibra igunyazwe yi-FDA ukwelapha abantu bayo yonke iminyaka abane-hemophilia A. Iyamukelwa ukuthi isetshenziswe kubantu abane-inhibitors noma abangenayo i-factor VIII ukuvimbela ukopha.

I-Factor VIII (eyisishiyagalombili) yiprotheni eyenzeka ngokwemvelo egazini edlala indima ebalulekile ekwakheni amahlule egazi. Abantu abane-hemophilia A abanayo i-factor VIII, ngakho-ke igazi labo alijiyiki. Ukungakwazi ukwakha amahlule egazi kubeka abantu abane-hemophilia engcupheni yokopha okungapheli. Kwesinye isikhathi lokhu kungabulala.

Ngaphambi kokuvunywa kweHemlibra, ukwelashwa okuyinhloko kwe-hemophilia A kwakuyindlela yokwelapha efaka esikhundleni se-VIII. Le ndlela yokwelapha ithatha indawo yesici VIII esilahlekile egazini.

Kodwa abanye abantu baba nama-inhibitors uma benikezwa i-factor VIII therapy yokwelapha. Ama-inhibitors ama-antibodies (amaprotheni ama-immune system) ahlasela i-factor VIII, evimbela ukwelashwa kwe-factor VIII ekusebenzeni.

IHemlibra isebenza ngendlela ehlukile. Esikhundleni sokushintsha i-factor VIII, iHemlibra ixhumanisa amanye amaprotheni egazi ndawonye. Lokhu kwenza ukuthi igazi likwazi ukujiya kahle ngaphandle kwesici VIII. Ngenxa yokuthi ayibandakanyi ukufaka esikhundleni i-factor VIII, iHemlibra isebenza ngempumelelo noma ngabe kukhona izivimbeli egazini.

I-Hemlibra yezinye izimo

I-Hemlibra ayisetshenziselwa ukwelapha noma yiziphi ezinye izimo zokopha.

I-hemlibra ye-hemophilia B (hhayi ukusetshenziswa okufanele)

I-Hemlibra ayisetshenziswanga ukuvimbela ukuphuma kwegazi kubantu abane-hemophilia B. Lokho kungenxa yokuthi abantu abane-hemophilia B abanawo ama-clotting factor ahlukile (amaprotheni egazi) kunabantu abane-hemophilia A.

  • i-hemophilia A: ilahlekile i-clotting factor VIII (eyisishiyagalombili)
  • i-hemophilia B: ilahlekile i-clotting factor IX (ayisishiyagalolunye)

IHemlibra ayiyenzi into elahlekile ye-IX. Ngakho-ke ngeke isetshenziselwe ukuvimbela ukopha kubantu abane-hemophilia B.

IHemlibra nezingane

IHemlibra ivunyelwe yi-FDA ukuthi isetshenziswe ezinganeni zayo yonke iminyaka, ngisho nezinsana ezisanda kuzalwa. Isidakamizwa sisetshenziselwa inhloso efanayo neyabantu abadala. I-Hemlibra isiza ukuvimbela ukopha kubantu abane-hemophilia A abane-inhibitors noma ngaphandle kwe-factor VIII.

Imiyalo yokusebenzisa i-Hemlibra

Kufanele uthathe i-Hemlibra ngokwemiyalo yomhlinzeki wakho wezokunakekelwa kwempilo.

Umhlinzeki wakho wezokunakekelwa kwempilo angakunika imijovo ye-Hemlibra emtholampilo noma ehhovisi. Noma bangakufundisa ukuthi ungazifaka kanjani imijovo.

Kungasiza ukugcina uhla lwemijovo yakho. Faka imininingwane efana nale:

  • usuku lomjovo ngamunye
  • indawo yokujova
  • imininingwane ye-vial lot (ungakuthola ku-vial) *

* Ukurekhoda ulwazi lwe-vial lot kusiza abahlinzeki bezokunakekelwa kwezempilo ukulandelela ukusetshenziswa kwemithi yezinto eziphilayo, njengeHemlibra. Lolu lwazi lusizo uma kwenzeka imiphumela emibi kakhulu.

Ngezansi imininingwane yokuthi ungayifaka kanjani i-Hemlibra ngokwakho. Ukuthola imininingwane eyengeziwe, ividiyo, nezithombe ezisizayo, bheka iwebhusayithi yeHemlibra, kufaka phakathi lo mhlahlandlela wesinyathelo ngasinye.

Ukulungiselela ukujova iHemlibra

Funda lezi zinyathelo ngaphambi kokuba uzinike umjovo we-Hemlibra.

  1. Thatha isitsha (noma izitsha, kuye ngomthamo wakho) weHemlibra ngaphandle kwesiqandisi imizuzu eyi-15 ngaphambi kokuhlela ukujova. Lokhu kuvumela ukuthi imithi ifike ekamelweni lokushisa ngaphambi kokujova kwakho.
  2. Ungazami ukufudumeza isixazululo ku-microwave noma ngokusisebenzisa ngaphansi kwamanzi ashisayo. Lokhu kungenza iHemlibra iphephe kancane, futhi kungenzeka ingasebenzi futhi.
  3. Hlola i-vial ukuze uqiniseke ukuthi isisombululo sicacile kuphuzi kancane. Uma liguqubele, linemibala, noma liqukethe izinhlayiya, ungayisebenzisi. Unganyakazisi isitsha.
  4. Ngenkathi ulinde iHemlibra ukuthi ize ekamelweni lokushisa, hlanganisa izimpahla zakho. Ngaphandle kwesitsha (s) seHemlibra, uzodinga: Ukusula utshwala, ukotini gauze, ukotini amabhola, inaliti yokudlulisa, isirinji, inaliti yomjovo ngesihlangu sokuphepha, nesiqukathi sokulahla izinto esibukhali
  5. Geza izandla zakho ngensipho namanzi.
  6. Khetha indawo yakho yomjovo. Kungaba enye yalezi zingosi ezintathu: Indawo yesisu (okungenani amasentimitha ama-2 kude nenkinobho yesisu sakho), phambi kwethanga lakho, nangemuva kwengalo yakho ephezulu (uma omunye umuntu ekujova)
  7. Gwema ukujova kwizimvukuzane noma kunoma yisiphi isikhumba esibomvu, esilimele noma esinezibazi.

Ukujova iHemlibra

Landela lezi zinyathelo ukufaka i-Hemlibra.

Ilungiselela isitsha nomjovo

Ukuze ulungiselele isitsha nomjovo olungele umjovo, landela lezi zinyathelo:

  1. Susa ikepisi esitsheni bese ulilahla esitsheni sakho sokulahla izinto.
  2. Hlanza phezulu kwesitja se-vial ngokusula utshwala.
  3. Namathisela inaliti yokudlulisa (kusesembozweni sayo esivikelayo) kusipontsho. Yenza lokhu ngokucindezela nangokuhlanekezela inaliti yokudlulisa ngokwewashi ize inamathiselwe.
  4. Buyela emuva kancane ku-plunger wesirinji ukuze udonse umoya. Udokotela wakho uzokutshela inani elifanele.
  5. Bamba isirinji ngasemgqonyeni ngesandla esisodwa. Qiniseka ukuthi inaliti ikhombe phezulu.
  6. Donsa ngokucophelela ikepisi lenaliti uqonde enalithini. Ungalahli ikepisi kude. Uzodinga ukubuyisela inaliti yokudlulisa ngemuva kokuyisebenzisa. Beka ikepisi endaweni ehlanzekile, eyisicaba. Ungayibeki phansi inaliti yokudlulisa ngemuva kokuthi ingavulelwanga.

Ukugcwalisa isirinji

Nazi izinyathelo zokugcwalisa isirinji:

  1. Bamba isitsha endaweni eyisicaba. Jova inaliti yokudlulisa iqonde ngqo maphakathi nendawo yokumisa i-vial.
  2. Ukugcina inaliti esitsheni, thatha isitsha bese usiphendula sibheke phansi.
  3. Ngephuzu lenaliti ngenhla kwezinga lemithi, cindezela i-plunger ukujova umoya esikhaleni esingaphezu kwemithi. Ungafaki umoya emithini.
  4. Ukugcina umunwe wakho ku-plunger, donsela isipetu sonke phansi kuze kube yilapho ithiphu yenaliti ingaphakathi komuthi.
  5. Kancane kancane donsela phansi i-plunger ukuze ugcwalise isipontsho ngaphezu kwemali oyidingayo kumthamo wakho. (Qaphela: Uma umthamo wakho ungaphezu kwenani elisesigubhini, gcwalisa isirinji ngayo yonke imishanguzo esesigubhini. Bheka imiyalo yomkhiqizi uma udinga ukusebenzisa isitsha esingaphezu kwesisodwa ngomthamo wakho obekiwe.)
  6. Ukugcina isirinji esitsheni, hlola noma yimaphi amagwebu omoya amakhulu angakuvimbela ekuthatheni umthamo wakho obekiwe ogcwele. Uma ubona noma yikuphi, thinta ngobumnene umgqomo wesirinji ngeminwe yakho ukuze amabhamuza akhuphukele phezulu. Bese ucindezela kancane i-plunger ukuze inaliti ibe semoyeni ngaphezu kwemithi. Qhubeka ucindezela i-plunger ukuze ususe amabhamuza kusirinji.
  7. Bheka ukuthi inani lomuthi esirinji manje selingaphansi noma liyalingana nomthamo wakho onqunyiwe. Uma kunjalo, donsela i-plunger ukuze inaliti iphinde ibe semithini futhi. Bese uqhubeka udonsa i-plunger kuze kube yilapho inani elisesirinji lingaphezu komthamo wakho onqunyiwe.
  8. Phinda izinyathelo 6 no-7 ukuze uqiniseke ukuthi awekho amagwebu esirinji futhi unethamo elifanele kusirinji.
  9. Susa isipetu bese udlulisa inaliti kusuka ku-vial.

Ukulahlwa kwenaliti yokudlulisa

Uma usugcwalise isirinji, uzodinga ukumaka nokulahla inaliti yokudlulisa. Nakhu ukuthi:

  1. Bamba isirinji ngesandla esisodwa bese ulayida inaliti yokudlulisa kusikhafu sayo, osibeke endaweni eyisicaba. Ketha phezulu ukuze ikepisi lishelele phansi ukumboza inaliti.
  2. Qinisekisa ukuthi inaliti imbozwe ngesigqoko. Ngesinye isandla sakho, cindezela phansi kukhepisi ukuze usinamathisele ngokuphelele kusirinji.
  3. Susa inaliti yokudlulisa kusuka kusiponji ngokuyiphendula ngokuphikisana newashi bese udonsa ngobumnene. (Ngeke usebenzise inaliti yokudlulisa ukujova umuthi. Lokhu kungaba buhlungu futhi kungadala ukulimala kwesikhumba.)
  4. Phonsa inaliti yokudlulisa esitsheni sokulahla esibukhali.

Ukujova iHemlibra

Lapho usukulungele ukujova iHemlibra, landela lezi zinyathelo:

  1. Sula isiza sakho somjovo osikhethile ngesula sotshwala bese usivumela some okungenani imizuzwana eyi-10.
  2. Namathisela inaliti yomjovo esiringini ngokucindezela futhi usonteke ngokwewashi ize ivikeleke ngokuphelele.
  3. Donsela isihlangu sokuphepha kude nenaliti (ubheke emgqonyeni wesirinji).
  4. Susa ngokucophelela ikepisi enaliti bese uyilahla esitsheni sokulahla izinto esibukhali. Gwema ukuthinta ithiphu yenaliti, futhi ungayibeki inaliti kunoma iyiphi indawo.
  5. Ngemuva kokukhipha ikepisi, kufanele ujove i-Hemlibra ngokushesha. Hambisa i-plunger esirinji ukuhambisana nomthamo wakho onqunyiwe. Umphetho ophezulu we-plunger kufanele uhambisane nophawu lwethamo lakho elibekiwe.
  6. Namathisela isikhumba sakho endaweni yomjovo oyikhethile.
  7. Ngokushesha nangokuqinile, faka ngokugcwele inaliti nge-degree engu-45 degree noma engu-90 degree esikhunjeni esikhishwe. Ungacindezeli ku-plunger okwamanje.
  8. Lapho inaliti isifakwe ngokuphelele esikhunjeni sakho, dedela indawo encwecwe.
  9. Cindezela kancane i-plunger phansi uze ujove yonke imithi.
  10. Susa inaliti ngokuyikhipha nge-engela ofake ngalo.

Ngemuva kokujova iHemlibra

Uma usujove i-Hemlibra, landela lezi zinyathelo:

  1. Beka inaliti phansi endaweni eyisicaba.Vala inaliti ngokucindezela isihlangu sokuphepha esirinji phambili nge-engela engama-90 degree (kude nomgqomo). Lalela umsindo wokuchofoza. Lokho kukukwazisa ukuthi inaliti imbozwe ngokuphelele esivikelweni sokuphepha.
  2. Gcina inaliti esirinji. Ungayisusi. Futhi ungashintshi ikepisi lenaliti yomjovo.
  3. Phonsa isitsha, izinaliti nomjovo osetshenzisiwe esitsheni sakho sokulahla izinto.
  4. Uma ubona amaconsi egazi ambalwa endaweni yakho yokujova, cindezela ibhola likakotini noma i-gauze kuleyo ndawo. Uma ukopha kungapheli, shayela udokotela wakho.
  5. Gwema ukukhuhla indawo yokujova.

Uyithatha nini iHemlibra

Udokotela wakho uzokutshela ukuthi uthatha kangaki i-Hemlibra. Bangase bafune ukuthi uthathe i-Hemlibra kanye ngesonto, kanye njalo ngesonto, noma kanye njalo emavikini amane.

Thatha iHemlibra ngosuku olufanayo lwesonto. Isibonelo, uma uthatha iHemlibra kanye ngesonto, ungakhetha ukuyithatha njalo ngoMsombuluko.

Izikhumbuzi zemithi zingasiza ekuqinisekiseni ukuthi awuphuthelwa umthamo.

IHemlibra notshwala

Akukho ukuxhumana okwaziwayo phakathi kweHemlibra notshwala. Kodwa-ke, uma une-hemophilia A, igazi lakho alihlanganisi kahle. Ukuphuza utshwala kungavimbela negazi lakho ekwakheni amahlule ngokunciphisa inani lezinto ezijiyisayo egazini lakho. Ngenxa yalokhu, ukuphuza kakhulu utshwala ngenkathi uthatha iHemlibra kunganciphisa ukuthi iHemlibra izosebenza kanjani.

Uma uphuza utshwala, khuluma nodokotela wakho mayelana nokuthi ukuphuza ngenkathi uthatha iHemlibra kuphephile yini kuwe.

Ukusebenzisana kwe-Hemlibra

IHemlibra ingaxhumana neminye imithi eminingana. Ingasebenzisana futhi nokuhlolwa okuthile kwelebhu.

Ukuxhumana okuhlukile kungadala imiphumela ehlukile. Isibonelo, ukuxhumana okuthile kungaphazamisa ukusebenza kwesidakamizwa. Okunye ukuxhumana kukhulisa imiphumela emibi noma kuyenze ibe nzima kakhulu.

I-Hemlibra neminye imithi

Ngezansi kukhona imithi engasebenzisana neHemlibra. Lolu hlu aluqukethe yonke imishanguzo engasebenzisana neHemlibra.

Ngaphambi kokuthatha iHemlibra, khuluma nodokotela wakho kanye nosokhemisi. Batshele ngayo yonke imishanguzo oyinikezwa ngudokotela, i-counter-counter, nezinye izidakamizwa oziphuzayo. Batshele futhi nganoma yimaphi amavithamini, amakhambi, nezithako ozisebenzisayo. Ukwabelana ngalolu lwazi kungakusiza ugweme ukuhlangana okungenzeka.

Uma unemibuzo mayelana nokuhlangana kwezidakamizwa okungakuthinta, buza udokotela wakho noma usokhemisi.

I-Hemlibra kanye ne-activated prothrombin complex concentrate (aPCC)

I-activated prothrombin complex concentrate (aPCC) isidakamizwa esisiza ukumisa ukopha. Ngenkathi iHemlibra ingasetshenziswa ne-PCC, ukuthatha le mithi ndawonye kungandisa ingozi yamahlule egazi. Le ngozi inkulu kakhulu kubantu abathatha iHemlibra ethola amayunithi angaphezu kuka-100 / kg we-aPCC ngosuku isikhathi esingaphezu kwamahora angama-24.

Uma udinga i-aPCC ngenkathi uthatha iHemlibra, udokotela wakho uzokuqapha eduze ngezibonakaliso zamahlule egazi. Amanye amahlule egazi angaba bucayi, futhi kungadingeka ukuthi ufune ukwelashwa ngokushesha. (Ngeminye imininingwane, bheka isigaba se- "Hemlibra side effects" ngenhla.)

Uma uba negazi lapho uthatha le mithi ndawonye, ​​udokotela wakho uzofuna ukuthi uyeke ukuthatha iHemlibra. Bazonquma ukuthi kuphephile yini kuwe ukuqala ukuthatha umuthi futhi.

I-Hemlibra nezinye izidakamizwa ze-hemophilia A

Ukuthatha i-Hemlibra nge-hemophilia ethile Imithi ingakhuphula ubungozi bamahlule egazi. Imiyalo ethize yokusebenzisa i-Hemlibra nezinye i-hemophilia A izidakamizwa zifaka okulandelayo:

  • Yeka ukusebenzisa noma yimaphi ama-agent okudlula (ukwelashwa kwabantu abane-inhibitors) ngosuku ngaphambi kokuba uqale ukuthatha i-Hemlibra. Izibonelo zama-agent okudlula ama-anti-inhibitor coagulant complex (FEIBA) kanye ne-recaginant human coagulation Factor VIIa (NovoSeven).
  • Uma kudingeka, qhubeka nokwelashwa kwe-factor VIII kuze kube isonto elilodwa ngemuva komthamo wakho wokuqala we-Hemlibra.

Uma unemibuzo yokuthi ungazithatha kanjani ezinye izindlela zokwelapha i-hemophilia ne-Hemlibra, khuluma nodokotela wakho.

I-Hemlibra nokuhlolwa okuthile kwelebhu

IHemlibra ingaphazamisa imiphumela yezivivinyo ezithile zelebhu futhi inikeze ukufundwa okungelona iqiniso. Lezi zivivinyo zifaka phakathi ezinye ezibheka ukuthi igazi lakho lithatha isikhathi esingakanani ukuvimba. Olunye lwalezi zivivinyo ukuhlolwa kwe-thromboplastin time (aPTT) okwenziwe kwasebenza.

I-Hemlibra ingathinta imiphumela yokuhlolwa isikhathi esingangezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma udinga ukuthola izivivinyo zebhu, tshela udokotela wakho nganoma yikuphi ukwelashwa kweHemlibra yamanje noma okwedlule ukuze bakwazi uku-oda izivivinyo ezifanele.

Ezinye izindlela zokusebenzisa iHemlibra

Ezinye izindlela zokwelapha zingavimbela ukopha noma zinciphise inani lophuma kwegazi kubantu abane-hemophilia A. Ezinye zingakulungela kangcono wena kunezinye. Uma unentshisekelo yokuthola enye indlela esikhundleni seHemlibra, khuluma nodokotela wakho.

IHemlibra ihlukile ngoba:

  • isebenza ngokungafani nokwelashwa okujwayelekile (imikhiqizo ye-factor VIII engena esikhundleni)
  • isebenza kubantu abane-inhibitors ye-VIII nangaphandle kwayo
  • ukwelashwa kokuqala ongakuthatha njengomjovo ongena ngaphansi kwesikhumba (umjovo ngaphansi kwesikhumba), esikhundleni sokufakwa ngomjovo emthanjeni (umjovo emthanjeni)
  • ihlala isebenza egazini isikhathi eside, ngakho-ke ungakwazi ukuyithatha masonto onke, kanye njalo ngesonto, noma kanye ngenyanga
  • ayenziwanga nge-plasma yomuntu noma ngegazi
  • ayibangeli ukuthi i-factor VIII inhibitors ithuthuke

Ezinye izindlela zokwelapha i-hemophilia A zifaka phakathi i-anti-inhibitor coagulant complex (FEIBA), okuyi-concentrate ye-prothrombin complex concentrate (aPCC).

Izindlela zokwelapha eziningi eziguquguqukayo ze-clotting factor VIII ziyatholakala ezingasetshenziswa njalo ukusiza ukuvimbela ukuphuma kwegazi, kufaka phakathi:

  • I-Adynovate
  • Hlanganisa
  • UJivi
  • I-Kovaltry
  • Novoeight

Udokotela wakho uzokhuluma nawe ngobuhle nobubi bezindlela ezahlukahlukene zokwelashwa kwe-hemophilia A. Bazosebenzisana nawe ukuthola ukwelashwa okuhlangabezana kahle nezidingo zakho.

Isebenza kanjani iHemlibra

I-Hemophilia A yisifo esopha. Kubangelwa isici sokujiya esilahlekile esibizwa nge-factor VIII (ayisishiyagalombili). Izici zokuvala amaprotheni egazini asiza ukulawula ukopha.

Ngaphandle kwesici VIII, igazi lakho alikwazi ukwakha ihlwili lapho wopha noma ulimele. Lokhu kungaholela egazini eliyingozi, mhlawumbe elibulalayo.

I-Hemlibra i-anti-monoclonal antibody, okuyiseli lamasosha omzimba elenziwe elebhu. Idalwe kusuka kumaseli ezilwane futhi ayiqukethe i-plasma yomuntu noma igazi.

Ama-antibody, nawo avela ngokwemvelo emzimbeni, anamathisela kuma-molecule athile egazini. IHemlibra ibophezela kuma-molecule amabili: kusebenze i-clotting factor IX (ayisishiyagalolunye) kanye ne-clotting factor X (eziyishumi).

Imvamisa, i-factor VIII ixhumanisa i-factor IX ne-factor X. Kepha ku-hemophilia A, factor VIII ayikho. IHemlibra isebenza ngokudlala indima ebizodlalwa yi-factor VIII. Kuletha i-factor IX ne-factor X ndawonye ukuze bakwazi ukusiza amahlule egazi. Lokhu kusiza ukwehlisa inani lokopha okungaba khona.

I-Hemlibra isebenza kanjani kubantu abane-inhibitors?

Kwabanye abantu abane-hemophilia, amasosha abo omzimba akha amasosha omzimba (amaprotheni omzimba omzimba) ukuze afake i-VIII lapho enikezwa njengokwelashwa. La ma-antibody ahlasela isici VIII, esivimbela ukwelashwa kwe-factor VIII esikhundleni sokusebenza.

I-Hemlibra isebenza ngendlela ehlukile kunokwelashwa kwe-factor VIII. Esikhundleni sokufaka i-factor VIII, i-Hemlibra idlala indima ye-VIII eyayizodlala ngokuxhumanisa amanye amaprotheni egazi komunye nomunye. Lokhu kwenza ukuthi igazi likwazi ukujiya kahle ngaphandle kwesici VIII. Ngenxa yalokhu, iHemlibra isebenza ngempumelelo noma ngabe kukhona izivimbeli egazini.

Kuthatha isikhathi esingakanani ukusebenza?

Akwaziwa ukuthi uzoqala ngokushesha kangakanani ukubona ukuphuma kwegazi okumbalwa ngemuva kokuqala iHemlibra. Ukuhlolwa komtholampilo kukhombisile ukuthi abantu banegazi elincane kakhulu ezinyangeni eziyisithupha ngemuva kokuthatha iHemlibra. Kodwa-ke, imiphumela yecala ayibonisanga ukuthi ukwehla kwegazi kwenzeka nini okokuqala.

Lokho kusho, siyazi ukuthi ngemuva kokujova, kuthatha phakathi kosuku olulodwa noma ezimbili ukuthi igazi lakho limunce iHemlibra. Futhi amazinga angaguquguquki omuthi agcinwa egazini lakho ngemuva kwamasonto amane okuqala okuphuza.

Uma unemibuzo mayelana nokuthi kufanele ubone nini umphumela ovela eHemlibra, khuluma nodokotela wakho.

IHemlibra nokukhulelwa

Akwaziwa ukuthi iHemlibra iphephile yini ukuyithatha ngesikhathi sokukhulelwa. Akuzange kube nezifundo zabantu noma zezilwane zokuhlola ukuphepha kokusetshenziswa kweHemlibra ngesikhathi sokukhulelwa.

Uma uthatha iHemlibra futhi ucabanga ukukhulelwa, khuluma nodokotela wakho mayelana nokuthi kufanele yini uqhubeke uthatha iHemlibra.

Qiniseka ukuthi usebenzisa ukulawulwa kokubeletha ngenkathi uthatha iHemlibra uma udokotela wakho ethi akuphephile ukuthi ukhulelwe ngesikhathi sokwelashwa.

I-Hemlibra nokuncelisa

Akwaziwa noma iHemlibra idlulela ebisini lwebele lomuntu. Uma uncelisa ingane yakho ibele futhi ucabanga ukuthatha iHemlibra, khuluma nodokotela wakho ukuthi ngabe lo muthi uphephile yini enganeni yakho.

Imibuzo ejwayelekile ngeHemlibra

Nazi izimpendulo zemibuzo ebuzwa njalo ngeHemlibra.

Ngabe iHemlibra ingasetshenziswa kubantu abangenawo ama-inhibitors?

Yebo. I-Hemlibra ivunyiwe yi-FDA ukuthi isetshenziswe kubantu abane-hemophilia A abangenayo i-inhibitors (kanye nabantu abanayo). Izifundo zomtholampilo zaqhathanisa iHemlibra nokungalashwa. Babheke amaqembu amabili abantu angenawo ama-inhibitor: izingane zesilisa ezineminyaka eyi-12 nangaphezulu, nabadala besilisa. La maqembu womabili athathe umuthi okungenani amasonto angama-24 futhi abene:

  • Amaphesenti ama-95 wegazi elincane lapho uthatha i-1.5 mg / kg yeHemlibra njalo ngesonto
  • Amaphesenti angu-94 wegazi elincane lapho uthatha u-3 mg / kg weHemlibra njalo emavikini amabili

Ukusebenza kwe-Hemlibra ezifundweni kwakufana phakathi kwabantu abane-inhibitors nangaphandle kwe-inhibitors.

Ingabe i-hemlibra isetshenziselwa ukwelapha i-hemophilia B?

Cha, iHemlibra ayisetshenziselwa ukuvimbela ukopha kubantu abane-hemophilia B.

Abantu abane-hemophilia B abanawo ama-clotting factor ahlukile kunabantu abane-hemophilia A:

  • i-hemophilia A: ilahlekile i-clotting factor VIII
  • i-hemophilia B: ilahlekile i-clotting factor IX

IHemlibra yenzelwe ukusiza abantu abalahlekile i-factor VIII. Ngakho-ke, bekungeke kusebenze kubantu abalahlekile i-clotting factor IX.

Ingabe i-hemlibra yelapha i-hemophilia?

Cha. Alikho ikhambi le-hemophilia ngalesi sikhathi. I-Hemlibra isebenza ukuvikela iziqephu zokopha, kepha ayiselaphi lesi sifo.

Ingabe iHemlibra yenziwa nge-plasma yegazi?

Cha, iHemlibra ayenziwa nge-plasma yegazi. I-antibody (amaprotheni omzimba omzimba) enziwe ngamaseli aselebhu. Awekho ama-plasma womuntu noma amaseli egazi omuntu asetshenziselwa ukwenza iHemlibra.

I-Hemlibra iyahlanzwa futhi yenziwe inzalo. Futhi ayiqukethe noma yimaphi amagciwane angatheleleka kubantu.

Ngabe iHemlibra iyayandisa ingozi yokuba namahlule egazi?

IHemlibra ingakhuphula ubungozi bamahlule egazi uma ithathwa nge-activated prothrombin complex concentrate (aPCC). Lesi yisidakamizwa esisiza ukumisa ukopha ngokwandisa ukunqamuka kwegazi.

Ucwaningo lwezemitholampilo lwalubheka abantu abathathe iHemlibra belashwa nge-PCC. Abantu abathathu babene-microangiopathy ye-thrombotic (amahlule egazini emithanjeni yegazi emincane). Abantu ababili babe nemicimbi ye-thrombotic (blood clot) kweminye imithambo yegazi. Kuwo wonke lawa macala, umthamo ophelele we-PCC wawungaphezu kwamayunithi ayi-100 / kg ngosuku isikhathi esingaphezu kwamahora angama-24.

Uma udinga ukwelashwa nge-aPCC ukumisa ukuphuma kwegazi ngenkathi uthatha iHemlibra, khuluma nodokotela wakho. Ngokubambisana ningaxoxa ngobungozi bamahlule egazi.

Ngabe lesi sidakamizwa sizodala izingqinamba ngokuhlolwa kwami ​​kwelebhu njalo?

Kungenzeka. I-Hemlibra ingathinta imiphumela ekuhlolweni kwelebhu okulinganisa ukuthi amahlule wakho egazi ahamba kahle kangakanani. Olunye lwalezi zivivinyo ukuhlolwa kwe-thromboplastin time (aPTT) okwenziwe kwasebenza. I-Hemlibra ihlala emzimbeni wakho isikhathi eside, futhi ingathinta imiphumela yokuhlolwa kuze kube izinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Qiniseka ukuthi utshela udokotela wakho nganoma yimiphi imishanguzo yamanje noma eyedlule ye-Hemlibra ngaphambi kokuthatha noma yiziphi izivivinyo zebhu.

Izexwayiso ze-Hemlibra

Lesi sidakamizwa siza nesixwayiso esivela ku-Food and Drug Administration (FDA).

Isexwayiso se-FDA: i-thrombotic microangiopathy nemicimbi ye-thrombotic

Lesi sidakamizwa sinesixwayiso esibhakeleni. Lesi yisexwayiso esibi kakhulu esivela ku-FDA. Isexwayiso sebhokisi sazisa odokotela neziguli ngemiphumela yezidakamizwa engaba yingozi.

Ukuthatha i-Hemlibra nokwamukela i-prothrombin complex concentrate (aPCC) eyenzelwe ukusebenza kwegazi kungakhuphula ubungozi bamahlule amakhulu egazi. Imicimbi ye-Thrombotic (amahlule egazi) ingenzeka ezithweni ezinkulu noma ezingxenyeni zomzimba, kufaka phakathi iphaphu, ikhanda, izingalo noma imilenze. Zingahle zivele nasemithanjeni yegazi emincane ezithweni ezinjengezinso nobuchopho. Amahlule egazi angaba yingozi futhi adinga ukwelashwa ngokushesha.

Ucwaningo lwezemitholampilo lwalubheka abantu abathathe iHemlibra belashwa nge-PCC. Abantu abathathu babene-thrombotic microangiopathy (amahlule egazini emithanjeni yegazi emincane). Abantu ababili babe nemicimbi ye-thrombotic (blood clot) kweminye imithambo yegazi. Kuwo wonke lawa macala, umthamo ophelele we-PCC wawungaphezu kwamayunithi ayi-100 / kg ngosuku isikhathi esingaphezu kwamahora angama-24.

Uma uba negazi ngesikhathi sokwelashwa ngeHemlibra ne-ACC, udokotela wakho kungenzeka ukuthi uyeke ukuthatha yomibili le mithi isikhashana. Udokotela wakho uzonquma ukuthi kuphephile yini ukuqala ukuthatha iHemlibra futhi.

Qaphela: Ukuthola eminye imininingwane ngemiphumela engemihle engaba khona ye-Hemlibra, bheka isigaba esingenhla esithi “Hemlibra side effects”.

Ukudlula ngokweqile kwe-Hemlibra

Ukuthatha kakhulu iHemlibra kungakhuphula ubungozi bakho bemiphumela emibi kakhulu.

Izimpawu zokudlula ngokweqile

Izimpawu zokuthatha kakhulu iHemlibra zingafaka:

  • ikhanda
  • ubuhlungu obuhlangene

Ukuthatha iHemlibra eningi kakhulu kungakhuphula nobungozi bakho bamahlule amakhulu egazi. Kwezinye izimo, kungadingeka ukuthi ufune ukwelashwa kwamahlule egazi ngokushesha. (Ukuthola eminye imininingwane ngamachaphaza egazi, bheka isigaba se- "Hemlibra side effects" ngenhla.

Okufanele ukwenze uma kwenzeka ukweqisa ngokweqile

Uma ucabanga ukuthi uthathe kakhulu lo muthi, shayela udokotela wakho. Ungashayela futhi i-American Association of Poison Control Centers ku-800-222-1222 noma usebenzise ithuluzi labo eliku-inthanethi. Kepha uma unezimpawu ezinzima, shayela ku-911 noma uye egumbini lezimo eziphuthumayo ngokushesha.

Ukuphelelwa yisikhathi kwe-Hemlibra, ukugcina nokulahla

Uma uthola iHemlibra ekhemisi, usokhemisi uzokwengeza usuku lokuphelelwa yisikhathi kwilebula esebhodleleni. Lolu suku luvame unyaka owodwa kusukela ngosuku okwakhishwa ngalo umuthi.

Usuku lokuphelelwa isikhathi lusiza ukuqinisekisa ukusebenza komuthi ngalesi sikhathi. Isimo samanje se-Food and Drug Administration (i-FDA) ukugwema ukusebenzisa imishanguzo ephelelwe yisikhathi. Uma usebenzise umuthi ongasasetshenziswa osudlulile esikhathini sokuphela, khuluma nosokhemisi wakho. Ungahle ukwazi ukuyisebenzisa.

Isitoreji

Ukuthi umuthi uhlala ulungile isikhathi eside kangakanani kungancika ezintweni eziningi, kufaka phakathi ukuthi uwugcina kanjani futhi kuphi umuthi.

Gcina izitsha zakho zeHemlibra esiqandisini. Bafake esitsheni esivalwe ngokuqinile futhi esingamelana nokukhanya. Uma kudingeka, ungathatha izitsha ezifrijini ngaphandle kwezinsuku eziyisikhombisa. Ngemuva kwalokho kufanele uzibuyisele esiqandisini. Ungazigcini izitsha emazingeni okushisa aphezulu kuno-86 ° F (30 ° C) lapho seziphumile esiqandisini.

Ngemuva kokuvula isitsha, sisebenzise ngokushesha. Phonsa noma iyiphi ingxenye yesisombululo ongasisebenzisi.

Ukulahlwa

Uma ungasadingi ukuthatha i-Hemlibra futhi unemithi esele, kubalulekile ukuyilahla ngokuphepha. Lokhu kusiza ukuvimbela abanye, kufaka phakathi izingane nezilwane ezifuywayo, ekuthatheni lesi sidakamizwa ngengozi. Kuyasiza futhi ukugcina umuthi ungalimazi imvelo.

Ngemuva kokusebenzisa, qiniseka ukubeka izinto ezifana nezitsha, izinaliti ezinezinhlamvu zezinaliti, kanye nemijovo esitsheni sakho sokulahla.

Iwebhusayithi ye-FDA inikeza amathiphu amaningi awusizo ngokulahlwa kwemithi. Ungabuza futhi usokhemisi wakho imininingwane yokuthi ungayilahla kanjani imithi yakho.

Imininingwane yobungcweti yeHemlibra

Imininingwane elandelayo inikezwa odokotela nabanye ochwepheshe bezempilo.

Izinkomba

I-Hemlibra (emicizumab-kxwh) ivunyiwe yi-FDA ukuthi isetshenziswe njengeprhylaxis ejwayelekile yokuvimbela noma ukunciphisa imvamisa yeziqephu zokopha ezigulini zabo bonke ubudala ezine-hemophilia A (congenital factor VIII defence) enezici noma ezingenayo i-factor VIII inhibitors.

Indlela yokusebenza

I-Hemlibra iyi-bispecific (iqukethe amasayithi amabili e-antigen-binding) i-anti-monoclonal antibody ebophezela kuzo zombili i-factor IX ne-factor X. Ukubopha kuzo zombili lezi zici kubuyisela ukusebenza kwe-factor VIII okungasebenzi ngokuvala i-factor IX ne-factor X. Le ndlela yokusebenza ivumela i-coagulation cascade ukuze iqhubeke, yande ukwakheka kwamahlwili. IHemlibra ihlala isebenza lapho kukhona ama-factor VIII inhibitors.

I-Pharmacokinetics ne-metabolism

Isilinganiso sokuphila sokumunca izinsuku eziyi-1.6 kulandela ukumuncwa okungaphansi. Ukutholakala ngokuphelele kwe-bioavailability kuphakathi kwamaphesenti angama-80.4 kanye namaphesenti angama-93.1.

Kusho ukuqeda isigamu sempilo izinsuku ezingama-26.9.

Izimo

Akukho ukuphikisana nokusetshenziswa kweHemlibra.

Isitoreji

Izimbali zeHemlibra kufanele zigcinwe esiqandisini ku-36 ° F kuye ku-46 ° F (2 ° C kuye ku-8 ° C) esitsheni sokuqala, kuvikelwe ekukhanyeni. Amabhodlela akufanele aqandiswe noma anyakaziswe. Uma kudingeka, izimbiza ezingavulwa zingagcinwa ngaphandle kwesiqandisi bese zibuyiselwa esiqandisini isikhathi esingeqile ezinsukwini eziyisikhombisa emazingeni okushisa angeqi kuma-86 ° (30 ° C). Uma usususiwe ku-vial, lahla ingxenye engasetshenziswanga uma ingasetshenziswanga ngokushesha.

Ukuzikhulula: IMedical News Namuhla yenze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane iyiqiniso, iphelele futhi ihambisana nesikhathi. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nobungoti bochwepheshe bezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi. Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, izinkomba, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile awukhombisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.

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