Ngabe i-Ibuprofen ingazandisa izimpawu ze-COVID-19?

-Delile

• Kungani ibuprofen ingase ibe nzima ukutheleleka?
• Yini eyaziwayo
• Okufanele ukwenze uma unezimpawu

Ukusetshenziswa kwe-Ibuprofen nezinye izidakamizwa ezingezona ukuvuvukala (i-NSAID) ngesikhathi sokutheleleka nge-SARS-CoV-2 kuthathwa njengokuphephile, ngoba bekungenakwenzeka ukuqinisekisa ubudlelwane obuphakathi kokusetshenziswa kwalesi sidakamizwa kanye nokuba sibi kwezimpawu zokuphefumula ubhadane lwe-COVID. 19.

Ngaphezu kwalokho, isifundo esenziwa kwa-Israyeli ^[1] iziguli eziqaphile ezisebenzise ibuprofen isonto lonke ngaphambi kokutholakala kwe-COVID-19 nangesikhathi sokwelashwa kokuncipha kwezimpawu kanye neparacetamol futhi zathola ukuthi ukusetshenziswa kwe-ibuprofen akuhlobene nokwanda kwesimo sempilo yeziguli.

Ngakho-ke, abukho ubufakazi bokuthi ukusetshenziswa kwe-ibuprofen kungakhuphula ukugula nokufa kwe-COVID-19 futhi, ngakho-ke, ukusetshenziswa kwalo muthi kuboniswa ngabaphathi bezempilo, futhi kufanele kusetshenziswe ngaphansi kwesincomo sezokwelapha.

Kungani ibuprofen ingase ibe nzima ukutheleleka?

Ucwaningo olushicilelwe kumagazini Imithi Yokuphefumula yeLancet ^[2] ithi ibuprofen ingazenza zibe zimbi izimpawu kubantu abanezifo zokuphefumula ezibukhali, ngoba lo muthi uzokwazi ukwandisa ukubonakaliswa kwe-ACE, okuyi-receptor ekhona kumaseli womuntu futhi ebopha ne-coronavirus entsha. Lesi sitatimende besisuselwa ekutheni iziguli ezinesifo sikashukela kanye nomfutho wegazi ophakeme zinenani eliphakeme lama-receptors e-ACE azwakalayo, asebenzise ibuprofen namanye ama-NSAID futhi athuthukise i-COVID-19 enzima.

Olunye ucwaningo lwenziwa ngamagundane abanesifo sikashukela^[3], ikhuthaze ukusetshenziswa kwe-ibuprofen amasonto ayi-8 ngamanani aphansi kunalokho okunconyiwe, okuholele ekukhulisweni kwe-enzyme eguqula i-angiotensin 2 (ACE2) ezicutshini zenhliziyo.

Leyo enzyme, i-ACE2, ibonakala ingenye yezindawo zokungenwa kwamagciwane omndeni we-coronavirus kumaseli, futhi ngenxa yalesi sizathu, abanye ososayensi bacabanga ukuthi uma kukhona nokwanda ekuvezweni kwale enzyme kubantu, ikakhulukazi lung, kungenzeka ukuthi igciwane likwazi ukwanda ngokushesha, lidale izimpawu ezinzima kakhulu.

Yini eyaziwayo

Yize ucwaningo lukhishwe ngobudlelwano obubi phakathi kwe-ibuprofen ne-COVID-19, i-World Health Organisation kanye nezinye iziphathimandla zezempilo zikhombisile ukuthi abukho ubufakazi besayensi bokuthi ukusetshenziswa kwe-ibuprofen ngeke kuphephe, ngoba imiphumela eyethulwayo ibisuselwa ekucabangeni futhi cha izifundo zabantu empeleni zenziwe. Ngaphezu kwalokho, ezinye izifundo zikhombisile lokho ^[4]:

• Abukho ubufakazi obuqondile bokuthi ibuprofen ingaxhumana neSARS-CoV-2;
• Abukho ubufakazi bokuthi ibuprofen inesibopho sokwandisa ukubonakaliswa kwe-enzyme eguqula i-angiotensin;
• Olunye ucwaningo lwe-in vitro lukhombisile ukuthi ibuprofen "ingaphula" i-ACE receptor, yenze kube nzima ukuxhumana kweseli ulwelwesi-virus kanye nokwehlisa ubungozi begciwane elingena esitokisini ngalo mzila;
• Abukho ubufakazi bokuthi ukusetshenziswa kwe-ibuprofen kungakhulisa noma kwandise ubungozi bokutheleleka.

Kodwa-ke, kusadingeka ezinye izifundo ukuze kuqinisekiswe ukuthi abukho ubudlelwano phakathi kwe-SARS-CoV-2 nokusetshenziswa kwe-ibuprofen noma amanye ama-NSAID nokuqinisekisa ukusetshenziswa okuphephile kwale mithi.

Okufanele ukwenze uma unezimpawu

Endabeni yezimpawu ezincane ze-COVID-19, njengomkhuhlane, ukukhwehlela okunzima kanye nokuphathwa ikhanda, ngokwesibonelo, ngaphezu kokuhlukaniswa, kunconywa ukuthi uthintane nodokotela ukuze kunikezwe isiqondiso ngomuthi ozosetshenziswa ukukhulula uphawu, ukusetshenziswa kwe-paracetamol noma ibuprofen kungakhonjiswa, okufanele kusetshenziswe ngokweseluleko sezokwelapha.

Kodwa-ke, lapho izimpawu ziba nzima kakhulu, futhi kungaba nobunzima ekuphefumuleni nasezinhlungwini zesifuba, into enhle kakhulu ukuthi lowo muntu aye esibhedlela ukuze kuqinisekiswe ukutholakala kwe-COVID-19 futhi kungaqala ukwelashwa okuqondile ngenhloso yokwelashwa inhloso yokuvimbela ezinye izinkinga nokukhuthaza ikhwalithi yempilo yomuntu. Qonda ukuthi ukwelashwa kwenziwa kanjani nge-COVID-19.