Isifo sikaWaldenstrom

-Delile

• Ziyini Izimpawu Zesifo SikaWaldenstrom?
• Ziyini Izimbangela Zesifo SikaWaldenstrom?
• Sitholwa Kanjani Isifo SikaWaldenstrom?
• Siphathwa Kanjani Isifo SikaWaldenstrom?
• Ukwelashwa ngamakhemikhali
• I-Plasmapheresis
• I-Biotherapy
• Ukuhlinzwa
• Izivivinyo Zemitholampilo
• Uyini Umbono Wesikhathi Eside?

Siyini Isifo SikaWaldenstrom?

Amasosha omzimba wakho akhiqiza amaseli avikela umzimba wakho ekutheleleni. Iseli elilodwa elinjalo yi-B lymphocyte, eyaziwa nangokuthi i-B cell. Amaseli B enziwa emnkantsheni wethambo. Ziyafuduka futhi zivuthwe kuma-lymph node akho nobende. Bangaba ngamaseli e-plasma, anesibopho sokukhipha i-antibody eyaziwa ngokuthi i-immunoglobulin M, noma i-IgM. Ama-antibody asetshenziswa ngumzimba wakho ukuhlasela izifo ezihlaselayo.

Ezimweni ezingavamile, umzimba wakho ungaqala ukukhiqiza i-IgM eningi kakhulu. Uma lokhu kwenzeka, igazi lakho lizoba likhulu. Lokhu kwaziwa ngokuthi yi-hyperviscosity, futhi kwenza kube nzima ngazo zonke izitho zakho nezicubu zakho ukusebenza kahle. Lesi simo lapho umzimba wakho wenza i-IgM eningi kakhulu saziwa njengesifo sikaWaldenstrom. Ngokobuchwepheshe uhlobo lomdlavuza.

Isifo sikaWaldenstrom umdlavuza ongajwayelekile. I-American Cancer Society (ACS) ibika ukuthi kunezigameko ezingaba ngu-1 100 kuya ku-1 500 zesifo sikaWaldenstrom esitholakala unyaka nonyaka e-United States. Lesi sifo iyi-non-Hodgkin lymphoma ekhula kancane. Isifo sikaWaldenstrom saziwa nangokuthi:

• I-macroglobulinemia kaWaldenstrom
• i-lymphoplasmacytic lymphoma
• i-macroglobulinemia eyinhloko

Ziyini Izimpawu Zesifo SikaWaldenstrom?

Izimpawu zesifo sikaWaldenstrom zizohluka ngokuya ngobukhulu besimo sakho. Kwezinye izimo, abantu abanalesi simo abanazo izimpawu. Izimpawu ezivame kakhulu zalesi sifo yilezi:

• ubuthakathaka
• ukukhathala
• ukopha ezinsinini noma ekhaleni
• ukuncipha komzimba
• imihuzuko
• izilonda zesikhumba
• ukuguqulwa kwesikhumba
• izindlala ezivuvukele

Uma inani le-IgM emzimbeni wakho liphakama kakhulu, ungathola izimpawu ezingeziwe. Lezi zimpawu zivame ukwenzeka njengomphumela we-hyperviscosity futhi zifaka:

• izinguquko zombono, kufaka phakathi ukungaboni kahle nokulahleka kombono
• ikhanda
• isiyezi noma i-vertigo
• izinguquko esimweni sengqondo

Ziyini Izimbangela Zesifo SikaWaldenstrom?

Isifo sikaWaldenstrom siqala lapho umzimba wakho ukhiqiza ngokweqile ama-antibody e-IgM. Imbangela yalesi sifo ayikaziwa.

Lesi simo sivame kakhulu kubantu abanamalungu omndeni analesi sifo. Lokhu kusikisela ukuthi kungahle kube ngofuzo.

Sitholwa Kanjani Isifo SikaWaldenstrom?

Ukuthola lesi sifo, udokotela wakho uzoqala ngokwenza ukuhlolwa komzimba bese ekubuza ngomlando wakho wezempilo. Udokotela wakho angahlola ukuvuvukala ku-spleen, isibindi, noma ama-lymph node ngesikhathi sokuhlolwa.

Uma unezimpawu zesifo sikaWaldenstrom, udokotela wakho anga-oda izivivinyo ezengeziwe ukuqinisekisa ukuxilongwa kwakho. Lezi zivivinyo zingafaka:

• ukuhlolwa kwegazi ukuthola izinga lakho le-IgM nokuhlola ubukhulu begazi lakho
• i-bone marrow biopsy
• Ukuhlolwa kwe-CT kwamathambo noma izicubu ezithambile
• Ama-X-ray amathambo noma izicubu ezithambile

I-CT scan ne-X-ray yamathambo nezicubu ezithambile zisetshenziselwa ukuhlukanisa phakathi kwesifo sikaWaldenstrom nolunye uhlobo lomdlavuza olubizwa nge-multiple myeloma.

Siphathwa Kanjani Isifo SikaWaldenstrom?

Alikho ikhambi lesifo sikaWaldenstrom. Kodwa-ke, ukwelashwa kungasebenza ekulawuleni izimpawu zakho. Ukwelashwa kwesifo sikaWaldenstrom kuzoya ngobukhulu bezimpawu zakho. Uma unesifo sikaWaldenstrom ngaphandle kwezimpawu zesifo, udokotela wakho kungenzeka angancomi noma yiluphi ukwelashwa. Ungahle ungadingi ukwelashwa uze ube nezimpawu. Lokhu kungathatha iminyaka eminingana.

Uma unezimpawu zesifo, kunezindlela zokwelashwa ezahlukahlukene udokotela wakho angazincoma. Lokhu kufaka phakathi:

Ukwelashwa ngamakhemikhali

I-Chemotherapy ngumuthi ocekela phansi amaseli emzimbeni akhula ngokushesha. Ungayithola le ndlela yokwelashwa njengephilisi noma ngemithambo yegazi, okusho ngemithambo yakho. I-Chemotherapy yesifo sikaWaldenstrom yakhelwe ukuhlasela amaseli angajwayelekile akhiqiza i-IgM eyeqile.

I-Plasmapheresis

I-Plasmapheresis, noma ukushintshaniswa kwe-plasma, inqubo lapho amaprotheni amaningi ngokweqile abizwa ngokuthi ama-IgM immunoglobulins akwi-plasma asuswa egazini ngomshini, kuthi i-plasma esele ihlanganiswe ne-plasma donor bese ibuyiselwa emzimbeni.

I-Biotherapy

I-Biotherapy, noma i-biological therapy, isetshenziselwa ukukhulisa amandla omzimba wokulwa nomdlavuza. Ingasetshenziswa ngamakhemikhali.

Ukuhlinzwa

Kungenzeka ukuthi udokotela wakho angancoma ukuhlinzwa ukuze kususwe ubende. Lokhu kubizwa ngokuthi yi-splenectomy. Abantu abanale nqubo bangakwazi ukunciphisa noma ukuqeda izimpawu zabo iminyaka eminingi. Kodwa-ke, izimpawu zalesi sifo zivame ukubuyela kubantu abaye baba ne-splenectomy.

Izivivinyo Zemitholampilo

Ngemuva kokuxilongwa kwakho, kufanele futhi ubuze udokotela wakho mayelana nokuhlolwa kwemitholampilo ngemithi nezinqubo ezintsha zokwelapha isifo sikaWaldenstrom. Izilingo zomtholampilo zivame ukusetshenziselwa ukuhlola ukwelashwa okusha noma ukuphenya izindlela ezintsha zokusebenzisa izindlela zokwelapha ezikhona. INational Cancer Institute ingahle ixhase izivivinyo zokwelashwa ezingakunikeza ezinye izindlela zokwelapha ukulwa nalesi sifo.

Uyini Umbono Wesikhathi Eside?

Uma uthola ukuthi unesifo sikaWaldenstrom, umbono uzoncika ekuqhubekeni kwesifo sakho. Lesi sifo siqhubeka ngamazinga ahlukene kuye ngomuntu. Labo abanezifo ezihamba kancane banesikhathi eside sokusinda uma kuqhathaniswa nalabo abanesifo esithuthuka ngokushesha okukhulu. Ngokusho kwendatshana ku, umbono wesifo sikaWaldenstrom ungahluka. Isilinganiso sokusinda siphakathi kweminyaka emihlanu kuya kwengu-11 ngemuva kokuxilongwa.