Okudingeka Ukwazi Nge-MTHFR Gene

-Delile

• Izinhlobonhlobo zokuguquka kwe-MTHFR
• Izimpawu zokuguquka kwe-MTHFR
• Ukuhlolwa kwezinguquko ze-MTHFR
• Ukwelashwa kokukhathazeka kwezempilo okuhlobene
• Izinkinga ekukhulelweni
• Ukwengeza okungenzeka
• Ukucatshangelwa kokudla
• Ukuthatha

Sifaka imikhiqizo esicabanga ukuthi ilusizo kubafundi bethu. Uma uthenga ngezixhumanisi ezikuleli khasi, singathola ikhomishini encane. Nansi inqubo yethu.

Yini i-MTHFR?

Kungenzeka ubone isifinyezo esithi "MTHFR" sivela ezindabeni zakamuva zezempilo. Kungabonakala njengegama lesiqalekiso lapho uthi nhlá, kepha empeleni kubhekisa ekuguqulweni kwezakhi zofuzo okuvamile.

I-MTHFR imele methylenetetrahydrofolate reductase. Kuthola ukunakwa ngenxa yokuguquka kwezakhi zofuzo okungaholela emazingeni aphezulu we-homocysteine ​​egazini namazinga aphansi e-folate namanye amavithamini.

Kuke kwaba nokukhathazeka ukuthi izingqinamba ezithile zezempilo zihlotshaniswa nokuguquka kwezakhi ze-MTHFR, ngakho-ke ukuhlolwa kuye kwaba okuvame kakhulu eminyakeni edlule.

Izinhlobonhlobo zokuguquka kwe-MTHFR

Ungaba nokuguqulwa okukodwa noma okubili - noma cha - kuhlobo lwe-MTHFR. Lezi zinguquko zivame ukubizwa ngokuhlukahluka. Okuhlukile kuyingxenye ye-DNA yofuzo eyehluke kakhulu, noma iyahlukahluka, kumuntu nomuntu.

Ukuba nokuhluka okukodwa - i-heterozygous - akunamathuba amancane okuba negalelo ezindabeni zezempilo. Abanye abantu bakholelwa ukuthi ukuguquka kwezakhi ezimbili - i-homozygous - kungaholela ezinkingeni ezinkulu kakhulu. Kunezinhlobo ezimbili, noma amafomu, wezinguquko ezingenzeka kuhlobo lwe-MTHFR.

Ukuhluka okucacile yile:

• I-C677T. Cishe amaphesenti angama-30 kuye kwangama-40 wabantu baseMelika angaba nokuguquka kwezakhi zofuzo I-C677T. Abantu abangamaphesenti angama-25 abavela e-Hispanic, namaphesenti ayi-10 kuye kwayi-15 wozalo lwaseCaucasus, bane-homozygous yalokhu kwahluka.
• I-A1298C. Kunocwaningo olulinganiselwe maqondana nalokhu okuhlukile. Izifundo ezitholakalayo ngokuvamile zibhekiswe endaweni noma ngokobuhlanga. Isibonelo, ucwaningo lwango-2004 lwalugxile kubanikeli begazi abayi-120 befa lase-Ireland. Kubanikeli, i-56, noma i-46.7%, yayiyi-heterozygous yalokhu okuhlukile, kanti i-11, noma i-14.2%, yayiyi-homozygous.
• Kungenzeka futhi ukuthola kokubili ukuguqulwa kwezinguquko kwe-C677T ne-A1298C, okuyikhophi eyodwa ngayinye.

Ukuguqulwa kwezakhi zofuzo kuzuzwe njengefa, okusho ukuthi ukuzithola kubazali bakho. Ngesikhathi sokukhulelwa, uthola ikhophi elilodwa lohlobo lwe-MTHFR kumzali ngamunye. Uma bobabili benokushintshwa kwezakhi zofuzo, ubungozi bakho bokuthi kuguquke i-homozygous bukhulu kakhulu.

Izimpawu zokuguquka kwe-MTHFR

Izimpawu ziyehluka kumuntu nomuntu futhi ukusuka kokuhlukile kuye kokuhlukile. Uma wenza ukusesha kwe-inthanethi okusheshayo, cishe uzothola amawebhusayithi amaningi athi i-MTHFR ibanga ngqo izimo eziningana.

Khumbula ukuthi ucwaningo oluzungeze i-MTHFR nemiphumela yalo lusathuthuka. Ubufakazi obuxhumanisa iningi lalezi zimo zezempilo ne-MTHFR njengamanje buyashoda noma buphikisiwe.

Ngokungenzeka, ngaphandle kokuthi unezinkinga noma kwenziwe ukuhlolwa, awusoze wazi ngesimo sakho sokuguquka kwesimo se-MTHFR.

Izimo eziphakanyisiwe ukuthi zihlotshaniswe ne-MTHFR zifaka:

• izifo zenhliziyo nemithambo yegazi (ikakhulukazi amahlule egazi, isifo sohlangothi, ukuqaqanjelwa, nokuhlaselwa yinhliziyo)
• ukudana
• ukukhathazeka
• ukuphazamiseka kwengqondo okuguquguqukayo
• schizophrenia
• umdlavuza wamathumbu
• i-leukemia enamandla
• ubuhlungu obungapheli nokukhathala
• ubuhlungu bezinzwa
• migraines
• ukuphuphuma kwesisu okuvamile kwabesifazane abaneminyaka yobudala bokuzala
• ukukhulelwa okunokukhubazeka kwe-neural tube, njenge-spina bifida ne-anencephaly

Funda kabanzi mayelana nokukhulelwa okuphumelelayo nge-MTHFR.

Ingozi kungenzeka inyuke uma umuntu enezinhlobo ezimbili zezakhi zofuzo noma i-homozygous yokuguqulwa kweMTHFR.

Ukuhlolwa kwezinguquko ze-MTHFR

Izinhlangano ezahlukahlukene zezempilo - kufaka phakathi i-American College of Obstetricians and Gynecologists, College of American Pathologists, American College of Medical Genetics, kanye neAmerican Heart Association - azincomi ukuhlolwa kokuhlukahluka ngaphandle kokuthi umuntu abe namazinga aphezulu kakhulu e-homocysteine ​​noma ezinye izinkomba zezempilo.

Noma kunjalo, ungahle ube nesifiso sokuthola isimo sakho se-MTHFR. Cabanga ngokuvakashela udokotela wakho futhi nixoxe ngobuhle nobubi bokuhlolwa.

Hlala wazi ukuthi ukuhlolwa kofuzo kungenzeka kungafakwa ngumshwalense wakho. Shayela inkampani yakho yenethiwekhi uma ucabanga ukuhlolwa ukuze ubuze ngezindleko.

Amanye amakhithi wokuhlola izakhi zofuzo ekhaya anikeza nokuhlolwa kwe-MTHFR. Izibonelo zifaka:

• I-23andMe inketho ethandwayo enikezela ngozalo lofuzo kanye nemininingwane yezempilo. Futhi akubizi kakhulu ($ 200). Ukwenza lolu vivinyo, ufaka amathe kubhubhu bese uwuthumela ngeposi ebhodini. Imiphumela ithatha amasonto ayisithupha kuya kwayisishiyagalombili.
• I-My Home MTHFR ($ 150) kungenye inketho egxile ngqo ekuguqulweni kwezinguquko. Ukuhlolwa kwenziwa ngokuqoqa i-DNA ngaphakathi kwesihlathi sakho ngama-swabs. Ngemuva kokuhambisa isampuli, imiphumela ithatha isonto elilodwa noma amabili.

Ukwelashwa kokukhathazeka kwezempilo okuhlobene

Ukuba nokuhlukahluka kwe-MTHFR akusho ukuthi udinga ukwelashwa. Kungasho nje ukuthi udinga ukuthatha isengezo sikavithamini B.

Ukwelashwa kuyadingeka lapho unamazinga aphezulu kakhulu e-homocysteine, cishe ngaso sonke isikhathi ngaphezulu kwezinga elibangelwa ukuhlukahluka okuningi kwe-MTHFR. Udokotela wakho kufanele akhiphe ezinye izimbangela zokukhuphuka kwe-homocysteine, engenzeka ngokuhlukahluka kwe-MTHFR noma ngaphandle kwayo.

Ezinye izimbangela ze-homocysteine ​​ephezulu zifaka:

• i-hypothyroidism
• izimo ezinjengesifo sikashukela, i-cholesterol ephezulu, nomfutho wegazi ophezulu
• ukukhuluphala nokungasebenzi
• imithi ethile, njenge-atorvastatin, i-fenofibrate, i-methotrexate, ne-nicotinic acid

Ukusuka lapho, ukwelashwa kuzoya ngesizathu futhi akubheki iMTHFR. Okuhlukile kulapho uthola ukuthi unalezi zimo ezilandelayo ngasikhathi sinye:

• amazinga aphezulu e-homocysteine
• ukuguqulwa okuqinisekisiwe kwe-MTHFR
• ukushoda kwamavithamini ku-folate, choline, noma amavithamini B-12, B-6, noma i-riboflavin

Kulezi zimo, udokotela wakho angase asikisele ukwengezelelwa ukubhekana nokusilela kanye nemithi noma izindlela zokwelapha ukubhekana nesimo esithile sezempilo.

Abantu abanezinguquko eziguqukayo ze-MTHFR nabo bangafisa ukuthatha izinyathelo zokuvikela ukwehlisa amazinga abo e-homocysteine. Isinyathelo esisodwa sokuvimbela ukuguqula ukukhetha okuthile kwendlela yokuphila, okungasiza ngaphandle kokusebenzisa imithi. Izibonelo zifaka:

• ukuyeka ukubhema, uma ubhema
• ukuzivocavoca umzimba ngokwanele
• ukudla ukudla okunempilo, okunempilo

Izinkinga ekukhulelweni

Ukuphuphuma kwesisu okuphindaphindiwe kanye nokukhubazeka kwe-neural tube kungahle kuhlotshaniswe ne-MTHFR. IGenetic and Rare Diseases Information Center ithi ucwaningo luphakamisa ukuthi abesifazane abanezinhlobonhlobo ezimbili ze-C677T basengozini enkulu yokuba nengane ene-neural tube defect.

Ucwaningo lwango-2006 lwabheka abesifazane abanomlando wokukhulelwa yizisu okuvela njalo. Kutholakale ukuthi amaphesenti angama-59 awo abe nokuguquka kwezakhi zofuzo okunama-homozygous amaningi, kufaka phakathi i-MTHFR, ehlotshaniswa nokujiya kwegazi, kuqhathaniswa namaphesenti ayi-10 kuphela abesifazane abasesigabeni sokulawula.

Khuluma nodokotela wakho ngokuhlolwa uma ngabe kukhona kulezi zimo ezilandelayo ezisebenza kuwe:

• Uhlangabezane nezisu eziningi ezingachazeki.
• Ube nengane enenkinga ye-neural tube.
• Uyazi ukuthi unoshintsho lwe-MTHFR, futhi ukhulelwe.

Yize kunobufakazi obuncane bokukuxhasa, abanye odokotela basikisela ukuthatha imishanguzo yokuvala igazi. Ukwengeza okungeziweko kwe-folate nakho kunganconywa.

Ukwengeza okungenzeka

Ukuguqulwa kofuzo lwe-MTHFR kuvimbela indlela umzimba osebenzisa ngayo i-folic acid namanye amavithamini abalulekile we-B. Ukushintsha ukwengezwa kwalesi sakhi kungagxila ekuphikiseni imiphumela yaso.

I-folic acid empeleni inguhlobo lomuntu olwenziwe ngumuntu, isakhi esivela ngokwemvelo esitholakala ekudleni. Ukuthatha ifomu elingatholakali le-folate - i-methylated folate - kungasiza umzimba wakho ukuthi uluthole kalula.

Iningi labantu liyakhuthazwa ukuthatha i-multivitamin equkethe okungenani ama-milligram ayi-0.4 we-folic acid usuku ngalunye.

Abesifazane abakhulelwe abakhuthazwa ukuthi bashintshe amavithamini noma ukunakekelwa kokubeletha ngokuya ngesimo sabo se-MTHFR kuphela. Lokhu kusho ukuthatha umthamo ojwayelekile wama-milligrams angu-0.6 we-folic acid nsuku zonke.

Abesifazane abanomlando wokukhubazeka kwe-neural tube kufanele bakhulume nodokotela wabo ukuthola izincomo ezithile.

Amavithamini amaningi aqukethe i-methylated folate afaka:

• Thorne Basic Nutrients 2 / Usuku
• Amabhulukwe ama-Smarty Adult Aqedile
• Amavithamini kaMama Wenyoni Yokubeletha

Khuluma nodokotela wakho ngaphambi kokushintsha amavithamini nezithako. Abanye bangaphazamisa eminye imithi noma ukwelashwa okutholayo.

Udokotela wakho futhi angaphakamisa amavithamini kadokotela aqukethe i-folate ne-folic acid. Ngokuya ngomshwalense wakho, izindleko zalezi zinketho zingahluka ngokuqhathaniswa nezinhlobo ezingaphezulu kwamanani.

Ukucatshangelwa kokudla

Ukudla ukudla okune-folate kungasiza ngokwemvelo ukusekela amazinga akho ale vithamini ebalulekile. Noma kunjalo, ukwesekwa kungadingeka.

Ukukhetha okuhle kokudla kufaka:

• amaprotheni afana nobhontshisi ophekiwe, uphizi, nodali
• imifino efana nesipinashi, i-asparagus, ulethisi, ama-beet, i-broccoli, ummbila, amahlumela eBrussels, ne-bok choy
• izithelo ezifana ne-cantaloupe, i-honeydew, ubhanana, ama-raspberries, i-grapefruit, ne-strawberry
• ama-juice afana ne-orange, uphayinaphu osekheniwe, ubhamubisi, utamatisi, noma olunye ujusi wemifino
• Ibhitela lamantongomane
• imbewu ye-sunflower

Abantu abanezinguquko ze-MTHFR bangafuna ukugwema ukudla okuqukethe uhlobo lokwenziwa kwe-folate, i-folic acid - yize ubufakazi bungacaci ukuthi budingekile noma buyazuzisa.

Qiniseka ukuthi uhlola amalebula, njengoba le vithamini yengezwa ezinhlamvwini eziningi ezicebile, njenge-pasta, okusanhlamvu, izinkwa, kanye nofulawa okhiqizwa ngokuthengisa.

Funda kabanzi ngomehluko phakathi kwe-folate ne-folic acid.

Ukuthatha

Isimo sakho se-MTHFR kungenzeka noma singathinti impilo yakho. Ucwaningo oluningi luyadingeka ukuthola umthelela weqiniso, uma ukhona, ohlotshaniswa nokuhlukahluka.

Futhi, izinhlangano eziningi zezempilo ezihlonishwayo azincomi ukuhlolwa kwalolu shintsho, ikakhulukazi ngaphandle kwezinye izinkomba zezokwelapha. Khuluma nodokotela wakho ngezinzuzo nezingozi zokuhlolwa, kanye nokunye ukukhathazeka ongase ube nakho.

Qhubeka nokudla kahle, uzivocavoca umzimba, futhi usebenzise eminye imikhuba yokuphila enempilo ukusekela impilo yakho yonke.