INoradrenaline

-Delile

• Yenzelwe ini
• Isetshenziswa kanjani
• Indlela yokusebenza
• Ngubani ongafanele asebenzise
• Imiphumela emibi engaba khona

INorepinephrine, eyaziwa nangokuthi i-norepinephrine, iyisidakamizwa esisetshenziselwa ukulawula ukucindezelwa kwegazi ezindaweni ezithile ze-hypotensive futhi njengesihlanganisi ekwelapheni ukuboshwa kwenhliziyo kanye ne-hypotension ejulile.

Leli khambi litholakala njengomjovo, okufanele lisetshenziswe kuphela ngaphansi kweseluleko sezokwelapha futhi ukuphathwa kwalo kufanele kwenziwe nguchwepheshe wezempilo.

Yenzelwe ini

INorepinephrine ngumuthi okhonjiswe ukulawula ukucindezelwa kwegazi ezindaweni ezithile ezibucayi ze-hypotensive, ezimweni ezinjenge-pheochromocytomectomy, sympathectomy, polio, myocardial infarction, septicemia, transfusion blood and reaction to imithi.

Ngaphezu kwalokho, ingasetshenziswa futhi njengosizo ekwelapheni ukuboshwa kwenhliziyo kanye ne-hypotension ejulile.

Isetshenziswa kanjani

I-Norepinephrine yisidakamizwa okufanele sinikezwe kuphela uchwepheshe wezokunakekelwa kwezempilo, ngemithambo yegazi, esisombululo sokuxuba. Umthamo okufanele uphathwe kumele ubekwe ngamanye futhi unqunywe udokotela.

Indlela yokusebenza

INorepinephrine iyi-neurotransmitter enomsebenzi wokuzwana, esebenza ngokushesha, enemiphumela evelele kuma-alpha-adrenergic receptors futhi iphinyiselwe kancane kuma-beta-adrenergic receptors. Ngakho-ke, umphumela wayo obaluleke kakhulu wenzeka ekukhuliseni umfutho wegazi, okuwumphumela wemiphumela yawo evuselela i-alpha, edala i-vasoconstriction, ngokuncipha kokugeleza kwegazi ezinso, isibindi, isikhumba futhi, kaningi, imisipha yamathambo.

Ngubani ongafanele asebenzise

INoradrenaline akufanele isetshenziswe kubantu abazwela ngokweqile ezingxenyeni zefomula noma nge-mesenteric noma i-peripheral vascular thrombosis.

Ngaphezu kwalokho, akufanele inikezwe abantu abane-hypotensive ngenxa yokushoda kwevolumu yegazi, ngaphandle kwesilinganiso esiphuthumayo sokulondolozwa kwe-coronary kanye ne-cerebral arterial perfusion kuze kuphele ukwelashwa ngevolumu yegazi, ngisho nangesikhathi se-anesthesia nge-cyclopropane ne-halothane, njengoba i-ventricular tachycardia noma i-fibrillation ingenzeka.

Imiphumela emibi engaba khona

Eminye imiphumela engemihle engahle yenzeke ngemuva kokuphathwa kwe-norepinephrine ukulimala kweschemic, ukwehla kwenhliziyo, ukukhathazeka, ikhanda lesikhashana, ukuphefumula kanzima kanye necrosis endaweni yomjovo.