Ukuhlolwa kwePyruvate Kinase

-Delile

• Kungani Kuyalwa Ukuhlolwa KwePyruvate Kinase?
• Siphathwa Kanjani Isivivinyo?
• Ziyini Izingozi Zesivivinyo?
• Ukuqonda Imiphumela Yakho

Ukuhlolwa kwePyruvate Kinase

Amaseli egazi abomvu (ama-RBC) athatha umoya-mpilo emzimbeni wakho wonke. I-enzyme eyaziwa ngokuthi i-pyruvate kinase iyadingeka emzimbeni wakho ukwenza ama-RBC futhi isebenze kahle. I-pyruvate kinase testis ukuhlolwa kwegazi okusetshenziselwa ukukala amazinga we-pyruvate kinase emzimbeni wakho.

Uma une-pyruvate kinase encane kakhulu, ama-RBCs akho ehla ngokushesha kunokujwayelekile. Lokhu kunciphisa inani lama-RBC atholakalayo ukuphatha umoya-mpilo kwizitho zomzimba ezibalulekile, izicubu namaseli. Isimo esivelayo saziwa njenge-hemolytic anemia futhi singaba nemiphumela ebalulekile yezempilo.

Izimpawu ze-hemolytic anemia zifaka:

• i-jaundice (ukuphuzi kwesikhumba)
• ukukhulisa ubende (umsebenzi oyinhloko wobende ukuhlunga igazi nokubhubhisa ama-RBC amadala futhi onakalisiwe)
• i-anemia (ukushoda kwama-RBC anempilo)
• isikhumba esiphaphathekile
• ukukhathala

Udokotela wakho anganquma ukuthi unakho yini ukushoda kwe-pyruvate kinase ngokuya ngemiphumela yalokhu nokunye ukuhlolwa kokuxilongwa.

Kungani Kuyalwa Ukuhlolwa KwePyruvate Kinase?

Ukushoda kwePyruvate kinase yisifo sofuzo esinciphisa ngokweqile i-autosomal. Lokhu kusho ukuthi umzali ngamunye uphatha ufuzo olungalungile lwalesi sifo. Yize ufuzo lungakhonjiswa komunye wabazali (okusho ukuthi akukho ukuntula kwe-pyruvate kinase), isici esibi kakhulu sinethuba le-1-in-4 lokuvela kunoma yiziphi izingane abazali abanazo ndawonye.

Izingane ezizalwa ngabazali abane-gene yokushoda kwe-pyruvate kinase zizohlolelwa lesi sifo kusetshenziswa ukuhlolwa kwe-pyruvate kinase. Udokotela wakho angaphinde alayishe isivivinyo ekutholeni izimpawu zokushoda kwe-pyruvate kinase. Imininingwane eqoqwe ekuhlolweni ngokomzimba, ukuhlolwa kwe-pyruvate kinase, nokunye ukuhlolwa kwegazi kuzosiza ukuqinisekisa ukuxilongwa.

Siphathwa Kanjani Isivivinyo?

Awudingi ukwenza noma yini ethile ukuze ulungiselele ukuhlolwa kwe-pyruvate kinase. Kodwa-ke, ukuhlolwa kuvame ukuphathwa ezinganeni ezincane, ngakho-ke abazali bangafuna ukukhuluma nezingane zabo ngokuthi isivivinyo sizozizwa kanjani. Ungakhombisa ukuhlolwa kudoli ukusiza ukunciphisa ukukhathazeka kwengane yakho.

Ukuhlolwa kwe-pyruvate kinase kwenziwa egazini elithathwe ngesikhathi sokudweba okujwayelekile kwegazi. Umhlinzeki wezokunakekelwa kwempilo uzothatha isampula yegazi engalweni noma esandleni sakho esebenzisa inaliti encane noma i-blade ebizwa nge-lancet.

Igazi lizoqoqeka libe yipayipi bese liya elabhoratri liyohlaziywa. Udokotela wakho uzokwazi ukukunikeza imininingwane mayelana nemiphumela nokuthi ichaza ukuthini.

Ziyini Izingozi Zesivivinyo?

Iziguli ezenziwa ukuhlolwa kwe-pyruvate kinase zingahlangabezana nokungakhululeki ngesikhathi sokudonswa kwegazi. Kungaba nobuhlungu obuthile endaweni yomjovo kusuka kuzinti zezinaliti. Ngemuva kwalokho, iziguli zingathola ubuhlungu, ukulimala, noma ukushaywa endaweni yokujova.

Izingozi zokuhlolwa zincane. Izingozi ezingaba khona zanoma ikuphi ukudonsa igazi zifaka:

• ubunzima bokuthola isampula, okuholela kuzinti eziningi zezinaliti
• ukopha ngokweqile endaweni yenaliti
• ukuquleka ngenxa yokopha
• ukuqoqwa kwegazi ngaphansi kwesikhumba, okwaziwa njenge-hematoma
• ukuthuthukiswa kokutheleleka lapho isikhumba siphuke khona ngenaliti

Ukuqonda Imiphumela Yakho

Imiphumela yokuhlolwa kwe-pyruvate kinase izohluka ngokuya nge-laboratory ehlaziya isampula segazi. Inani elijwayelekile lokuhlolwa kwe-pyruvate kinase ngokuvamile li-179 plus noma lokususa amayunithi ayi-16 e-pyruvate kinase ngamamililitha ayi-100 ama-RBC. Amazinga aphansi we-pyruvate kinase akhombisa ubukhona bokushoda kwe-pyruvate kinase.

Alikho ikhambi lokushoda kwepyruvate kinase. Uma uthola ukuthi unalesi simo, udokotela wakho angancoma ukwelashwa okuhlukahlukene. Ezimweni eziningi, iziguli ezinokushoda kwepyruvate kinase kuzodingeka zifakwe ukumpontshelwa igazi ukuze zishintshe ama-RBC alimele. Ukumpontshelwa igazi ngumjovo wegazi ovela kumnikeli.

Uma izimpawu zesifo zinzima kakhulu, udokotela wakho angancoma i-splenectomy (ukususwa kobende). Ukususa ubende kungasiza ukunciphisa inani lama-RBC abhujiswayo. Noma ususwe ubende, izimpawu zesifo zingahlala. Izindaba ezinhle ukuthi ukwelashwa cishe kuzonciphisa izimpawu zakho futhi kuthuthukise ikhwalithi yempilo yakho.