I-R-CHOP Chemotherapy: Imiphumela emibi, Isikali, nokuningi

-Delile

• Ngabe i-R-CHOP iphatha ini?
• Ngabe i-R-CHOP isebenza kanjani?
• I-Rituximab (Rituxan)
• ICyclophosphamide (iCytoxan)
• I-Doxorubicin hydrochloride (i-Adriamycin, iRubex)
• UVincristine (Oncovin, uVincasar PFS, uVincrex)
• I-Prednisolone
• Inikezwa kanjani?
• Yimiphi imiphumela emibi engaba khona?
• Yini okufanele uyazi ngaphambi kokuba uqale ukwelashwa?
• Yini enye okudingeka uyazi?

Yini i-R-CHOP chemotherapy?

Imithi yokwelashwa ngamakhemikhali inganciphisa izicubu noma ibulale amangqamuzana omdlavuza aphambukile asele ngemuva kokuhlinzwa noma imisebe. Kuyindlela yokwelashwa okuhlelekile, okusho ukuthi inhloso yayo ukubulala amangqamuzana omdlavuza emzimbeni wakho wonke.

Yonke imithi yokwelapha ngamakhemikhali isebenza ukubulala amangqamuzana omdlavuza, kodwa ayenza ngezindlela ezahlukene. Kungakho oncologists bavame ukukhetha inhlanganisela yezidakamizwa. Basekela ukukhetha kwabo ezintweni ezifana nohlobo lomdlavuza onalo, lusabalale kangakanani, nempilo yakho iyonke.

I-R-CHOP ifaka phakathi izidakamizwa ezinhlanu zamakhemikhali:

• i-rituximab (Rituxan)
• cyclophosphamide
• i-doxorubicin hydrochloride
• i-vincristine (i-Oncovin, iVincasar PFS)
• webhilo

Ungathola i-R-CHOP noma ngaphandle kwezinye izindlela zokwelapha njengokuhlinzwa nokwelashwa ngemisebe.

Ngabe i-R-CHOP iphatha ini?

Odokotela ikakhulukazi basebenzisa i-R-CHOP ukwelapha i-non-Hodgkin lymphoma (NHL) namanye ama-lymphomas. I-Lymphoma ngumdlavuza oqala ohlelweni lwe-lymphatic.

I-R-CHOP ingaphatha nezinye izinhlobo zomdlavuza.

Ngabe i-R-CHOP isebenza kanjani?

Imithi emithathu e-R-CHOP iyi-cytotoxics enamandla, okusho ukuthi ibulala amaseli. Olunye uhlobo lwe-immunotherapy kanti olokugcina yi-steroid, ekhombisile ukuthi inemiphumela yokulwa nomdlavuza.

I-Rituximab (Rituxan)

I-Rituximab isetshenziselwa ukwelapha i-NHL. I-antibody eyodwa. Ikhomba iprotheni ebizwa nge-CD20 ebusweni bamaseli amhlophe egazi abizwa nge- “B cells. Lapho umuthi usunamathele kumaseli B, amasosha omzimba wakho ayahlasela futhi awabulale.

ICyclophosphamide (iCytoxan)

Lesi sidakamizwa singelapha izinhlobo ezahlukene zomdlavuza, kufaka phakathi i-lymphoma nomdlavuza webele nowephaphu. ICyclophosphamide ihlose i-DNA yamangqamuzana omdlavuza futhi iwakhombise ukuthi ayeke ukwehlukana.

I-Doxorubicin hydrochloride (i-Adriamycin, iRubex)

Lesi sidakamizwa iyi-anthracycline ekwazi ukwelapha izinhlobo eziningi zomdlavuza, kufaka phakathi umdlavuza webele, wamaphaphu nowe-ovari. IDoxorubicin ivimba amangqamuzana omdlavuza we-enzyme adinga ukukhula nokukhiqiza kabusha. Umbala obomvu okhanyayo uzitholele isidlaliso "usathane obomvu."

UVincristine (Oncovin, uVincasar PFS, uVincrex)

IVincristine iyi-alkaloid ekwelapha izinhlobo eziningi zomdlavuza, kufaka phakathi umdlavuza webele osezingeni eliphakeme, ama-lymphomas, ne-leukemia. Kuyaphazamisa izakhi zofuzo ukuzivimbela zingaziphindi. Lesi sidakamizwa siyi-vesicant, okusho ukuthi singalimaza izicubu nemikhumbi.

I-Prednisolone

Lesi sidakamizwa iyi-corticosteroid etholakala ngaphansi kwamagama ezinhlobonhlobo zamagama. Ngokungafani nabanye, lokhu kuyimithi yokwelapha ngomlomo. Isebenza namasosha akho omzimba ukusiza ukunciphisa:

• ukuvuvukala
• isicanucanu
• ukuhlanza
• ukusabela okweqile
• amazinga weplatelet aphansi, noma i-thrombocytopenia
• amazinga aphezulu e-calcium, noma i-hypercalcemia

Ngokubambisana, le mithi idala i-cocktail enamandla yokulwa nomdlavuza.

Inikezwa kanjani?

Ukulinganisa okujwayelekile kusekelwe ekuphakameni nasesisindo. Udokotela wakho uzobheka nanoma yiziphi ezinye izimo zempilo onazo, iminyaka yakho, nokuthi bakulindele kahle kangakanani ukuthi uyibekezelele imishanguzo lapho unquma ukushintshwa kanye nenani lemijikelezo.

Ngokuvamile abantu bathola le mithi njalo emavikini amabili kuya kwamathathu. Imvamisa, odokotela banikeza okungenani imithamo eyisithupha noma imijikelezo. Ukwelashwa kuzothatha amasonto ayi-18 noma ngaphezulu uma unemijikelezo eyengeziwe.

Ngaphambi kokwelapha ngakunye, uzodinga ukuhlolwa kwegazi ukuhlola ukubalwa kwegazi nokuthola ukuthi isibindi nezinso zakho zisebenza kahle yini ngokwanele. Uma kungenjalo, udokotela wakho angadinga ukubambezela ukwelashwa kwakho noma ukunciphisa umthamo wakho.

Ukwelashwa komuntu ngamunye kungathatha amahora ambalwa, futhi umhlinzeki wezokunakekelwa kwempilo uzokuphathisa imishanguzo ngemithambo, okusho ngomthambo osengalweni yakho. Ungayithola futhi ngechweba udokotela ohlinzayo angalifaka esifubeni sakho. Ungadinga ukuhlala esibhedlela ukuze uthole ukwelashwa kwakho, kepha abantu bangakuthola esikhungweni sokumnika abagulayo abagulayo ezimweni eziningi.

Uzohlala ubhekiwe njalo. Ngesikhathi sokwelashwa kokuqala, abahlinzeki bezokunakekelwa kwezempilo bazokuqapha ngokucophelela nganoma yiziphi izimpawu zokungazwani komzimba noma omunye umphumela osongela impilo wokwelashwa komdlavuza obizwa nge-tumor lysis syndrome.

I-Prednisolone yisidakamizwa somlomo osiphuza ekhaya izinsuku ezimbalwa ngemuva kokuthola ezinye izidakamizwa.

Yimiphi imiphumela emibi engaba khona?

Izidakamizwa ze-Chemotherapy zihlasela amangqamuzana omdlavuza. Futhi zingalimaza amaseli aphilile kule nqubo. Yingakho kunemiphumela emibi eminingi engaba khona. Akunakwenzeka ukuthi uzoba nazo zonke.

I-Chemotherapy ithinta wonke umuntu ngokuhlukile. Imiphumela emibi ingashintsha uma ukule mithi isikhathi eside, kepha imvamisa ingeyesikhashana. Ithimba lakho lezokunakekelwa kwempilo linganikeza imininingwane yokuthi ungabhekana kanjani nalo.

Imiphumela emibi kakhulu yilena:

• ukucasuka okuzungeze indawo efakwa emthanjeni noma ethekwini
• umchamo obomvu noma obomvana izinsuku ezimbalwa ngenxa ye-doxorubicin
• izinguquko zokudla
• ukushintsha kwesisindo
• ukugaya ukudla
• isicanucanu
• ukuhlanza
• ukukhathala
• ubunzima bokulala
• ukubalwa kwegazi okuphansi
• i-anemia
• ukuphuma kwamakhala emakhaleni
• ikhala eligobayo
• izinsini ezophayo
• izilonda zomlomo
• izilonda zomlomo
• ukulahleka kwezinwele
• ukulahlekelwa ukuya esikhathini, noma i-amenorrhea
• ukulahlekelwa ukuzala
• ukuqala ukuya esikhathini
• ukuzwela kwesikhumba
• izinkinga zemizwa, noma i-neuropathy

Imiphumela emibi ejwayelekile ingafaka:

• ukuqubuka kwesikhumba ngenxa yokusabela okweqile
• ukuchama okushisayo noma okubuhlungu
• izinguquko ekunambithekeni
• ushintsho kuzipho zeminwe nasezinzwaneni
• ushintsho emisipheni yenhliziyo
• isifo sohudo

Imiphumela emibi ejwayelekile ifaka phakathi izinguquko ezicutshini zamaphaphu nokuthuthukisa olunye uhlobo lomdlavuza ngokuzayo.

Yini okufanele uyazi ngaphambi kokuba uqale ukwelashwa?

Ngaphambi kokuqala i-chemotherapy, uzohlangana ne-oncologist yakho. Lesi yisikhathi sokubuza imibuzo mayelana nokuthi yini ongayilindela ngesikhathi nangemuva kokwelashwa. Landela lezi zeluleko:

• Tshela udokotela wakho uma uthatha amaphilisi okulawula ukubeletha, eminye imithi, noma izithako zokudla. Eminye yale mikhiqizo, ngisho naleyo engaphezulu kwekhawunta, ingadala ukuxhumana okulimazayo.
• Uma njengamanje uncelisa, kufanele uyeke ngoba le mithi ingadlula ebisini lwakho lwebele iye enganeni yakho.
• Tshela udokotela wakho uma ucabanga ukuthi kungenzeka ukhulelwe. Le mithi ingalimaza ingane yakho futhi ibangele ukukhubazeka kokuzalwa.
• Izidakamizwa ze-Chemotherapy zingathinta ukuzala kwakho futhi zivuse ukuya esikhathini kokuqala. Uma uhlela umndeni, khuluma nodokotela wakho ngezinketho zokuhlela umndeni futhi mhlawumbe uhlangane nongoti wokuzala uma kunesidingo ngaphambi kokwelapha kwakho kokuqala.
• Izidakamizwa ze-Chemotherapy zithinta amasosha akho omzimba. Ungatholi noma yimiphi imigomo ngesikhathi se-chemotherapy, bese ubuza udokotela wakho ukuthi kuzokuphepha nini ukwenza njalo.
• Imiphumela emibi evela ekhemotherapy kufanele ilindelwe, kepha ingalawuleka ngemithi, amakhambi asekhaya, kanye nezindlela zokwelapha ezihambisanayo. Unganqikazi ukukhuluma nodokotela wakho ngemiphumela emibi ekhathazayo.

Yini enye okudingeka uyazi?

Njengoba amasonto edlula, uzojwayela uhlelo lokwelashwa, kodwa imiphumela emibi ingaqhubeka. Ungahle ukhathale. Kungumqondo omuhle ukuthi omunye umuntu akuqhubele uye lapho ubuya khona ngamakhemikhali futhi akusekele ngezinye izindlela ngesikhathi sokwelashwa.

Lezi zeluleko zingakusiza ukuthi wenze ukwelashwa ngamakhemikhali ngokunethezeka futhi kungakhathazi kakhulu:

• Gqoka izingubo ezikahle uphathe ijezi noma ingubo. Abanye abantu baze beze nomcamelo noma iziliphu abazithandayo.
• Letha okokufunda noma imidlalo ukudlulisa isikhathi.
• Uma ukhathele, vumela ukuthi ulale ngesikhathi sokulashwa.
• Tshela umhlengikazi noma udokotela wakho uma unezimpawu ezingavamile.

Ngaphandle kwamakhemikhali, kubalulekile futhi ukwenza okulandelayo:

• Qhubeka nokudla ukudla okunomsoco, noma ngabe awunaso isifiso sokudla.
• Phuza uketshezi oluningi futhi uhlale unamanzi.
• Thola ukuphumula okuningi.
• Bamba iqhaza emsebenzini omnene womzimba noma nini lapho ungakhona.
• Finyelela usizo ngemisebenzi nangeminye imisebenzi.
• Gwema ukuba phakathi kwabantu abanezifo ezithathelwanayo ngoba amasosha akho omzimba azoba ntekenteke.
• Hlala uzibandakanya nomndeni wakho nabangane bakho, kepha zinike isikhathi sakho lapho udinga ukwenza njalo.