I-Rituxan ye-MS

-Delile

• Mayelana nokusetshenziswa kwezidakamizwa ezingekho kwelebula
• Ingabe i-Rituxan iphephile futhi iyasebenza ekwelapheni i-MS?
• Ingabe kuyasebenza?
• Kuphephile?
• Uyini umehluko phakathi kweRituxan ne-Ocrevus?
• Ukuthatha

Ukubuka konke

I-Rituxan (igama elijwayelekile elithi rituximab) umuthi kadokotela ohlose iphrotheni ebizwa nge-CD20 kumaseli omzimba B amaseli. Kuvunyelwe yi-U.S. Food and Drug Administration (FDA) ukwelapha izifo ezifana ne-Non-Hodgkin's lymphoma ne-rheumatoid arthritis (RA).

Odokotela kwesinye isikhathi banikeza i-Rituxan yokwelapha i-multiple sclerosis (MS), yize i-FDA ingazange iyivume yalokhu kusetshenziswa. Lokhu kubhekiswa njengokusebenzisa izidakamizwa “okungekho kwelebula”.

Mayelana nokusetshenziswa kwezidakamizwa ezingekho kwelebula

Ukusetshenziswa kwezidakamizwa ezingekho kwelebula kusho ukuthi umuthi ovunyelwe yi-FDA ngenhloso eyodwa usetshenziselwa injongo eyehlukile engavunyelwe.

Kodwa-ke, udokotela usengasisebenzisa lesi sidakamizwa ngaleyo njongo. Lokhu kungenxa yokuthi i-FDA ilawula ukuhlolwa nokuvunywa kwezidakamizwa, kodwa hhayi ukuthi odokotela bazisebenzisa kanjani izidakamizwa ukwelapha iziguli zabo. Ngakho-ke udokotela wakho angakunika umuthi kodwa bacabanga ukuthi ungcono kakhulu ukunakekelwa kwakho. Funda kabanzi ngokusetshenziswa kwezidakamizwa ezingekho kwelebula.

Uma udokotela wakho ekunika umuthi ozowusebenzisa ngaphandle kwelebula, kufanele uzizwe ukhululekile ukubuza noma yimiphi imibuzo ongaba nayo. Unelungelo lokubandakanyeka kunoma yiziphi izinqumo mayelana nokunakekelwa kwakho.

Izibonelo zemibuzo ongayibuza zifaka:

• Kungani unikeze ukusetshenziswa okungekho kwelebula kwalesi sidakamizwa?
• Ngabe ikhona eminye imishanguzo evunyelwe engenza into efanayo?
• Ngabe umshuwalense wami wezempilo uzokwemboza lokhu kusetshenziswa kwezidakamizwa ezingekho kwelebula?
• Uyazi ukuthi yimiphi imiphumela emibi engingaba nayo kulo muthi?

Ingabe i-Rituxan iphephile futhi iyasebenza ekwelapheni i-MS?

Akukho ukuvumelana mayelana nokuthi i-Rituxan iphephe futhi isebenza kahle kangakanani ekwelapheni i-MS, kepha ucwaningo lukhombisa ukuthi ikhombisa isithembiso.

Ingabe kuyasebenza?

Yize bekungekho izifundo ezanele zokuqhathanisa ukusebenza kwangempela komhlaba ukwahlulela ngokuphelele i-Rituxan njengokwelashwa okuphumelelayo kwe-MS, izimpawu ezinhle zisikisela ukuthi kungenzeka kube njalo.

Ucwaningo lwe-Swedish MS registry luqhathanisa i-Rituxan nezindlela zendabuko zokuqala zokuguqula ukwelashwa ezinjenge

• I-Tecfidera (dimethyl fumarate)
• I-Gilenya (fingolimod)
• I-Tysabri (natalizumab)

Ngokuya kokuyekiswa kwezidakamizwa nokusebenza komtholampilo ekubuyiseleni emuva-ekunciphiseni i-multiple sclerosis (RRMS), iRituxan yayingeyona kuphela inketho ehamba phambili yokwelashwa kokuqala, kepha futhi ikhombise nemiphumela emihle kakhulu.

Kuphephile?

I-Rituxan isebenza njenge-ejenti ediliza i-B. Ngokusho, ukuncipha kwesikhathi eside kwamaseli e-peripheral B ngeRituxan kubonakala kuphephile, kepha kudingeka ukutadisha okwengeziwe.

Imiphumela emibi yeRituxan ingafaka:

• ukumnika ukusabela okufana nokuqubuka, ukulunywa nokuvuvukala
• izinkinga zenhliziyo njengokushaya kwenhliziyo okungajwayelekile
• Izinkinga zezinso
• izinsini ezophayo
• ubuhlungu besisu
• imfiva
• Ukugodola
• izifo
• Ubuhlungu bomzimba
• isicanucanu
• ukuqubuka
• ukukhathala
• amaseli egazi amhlophe aphansi
• inkathazo yokulala
• ulimi oluvuvukele

Amaphrofayli okuphepha ezinye izindlela zokwelapha ezinjengeGilenya neTysabri kubantu abane-MS anemibhalo ebanzi kuneRituxan.

Uyini umehluko phakathi kweRituxan ne-Ocrevus?

I-Ocrevus (ocrelizumab) umuthi ovunyelwe yi-FDA osetshenziselwa ukwelashwa kwe-RRMS kanye ne-primary progressive multiple sclerosis (PPMS).

Abanye abantu bakholelwa ukuthi i-Ocrevus inguhlobo olwenziwe kabusha iRituxan. Bobabili basebenza ngokukhomba amaseli we-B anama-molecule e-CD20 ebusweni bawo.

UGenentech - umqambi wazo zombili lezi zidakamizwa - uthi kunokwehluka kwamangqamuzana nokuthi umuthi ngamunye uhlangana namasosha omzimba ngokuhlukile.

Umehluko omkhulu ukuthi izinhlelo eziningi zomshuwalense wezempilo zimboza i-Ocrevus yokwelashwa kwe-MS kuneRituxan.

Ukuthatha

Uma wena - noma umuntu osondelene nawe - une-MS futhi unomuzwa wokuthi i-Rituxan ingaba yindlela yokwelashwa ehlukile, xoxa ngale ndlela nodokotela wakho. Udokotela wakho anganikeza ukuqonda ngezindlela ezahlukahlukene zokwelashwa nokuthi zizosisebenzela kanjani isimo sakho esithile.