Ukuthatha i-Biologics kanye Nokuphinda Ulawule I-Psoriatic Arthritis Yakho

-Delile

• Yini i-biologics?
• Izinhlobo ze-biologics
• Abatacept
• I-Adalimumab
• Isiqinisekiso se-pegol
• Etanercept
• IGolimumab
• I-Infliximab
• Ustekinumab
• Izindlela zokwelapha ezihlanganayo
• Imiphumela emibi nezixwayiso
• I-Biologics iyingxenye yohlelo lokuphathwa kwe-PsA

Ukubuka konke

I-Psoriatic arthritis (i-PsA) iyisifo esingelapheki, futhi kudingeka ukwelashwa okuqhubekayo ukuvimbela ukulimala okuhlala njalo kwamalunga. Ukwelashwa okulungile futhi kunganciphisa inani lama-arthritis flare-ups.

I-Biologics wuhlobo olulodwa nje lwemithi esetshenziselwa ukwelapha i-PsA. Lokhu kusebenza ngokucindezela amasosha akho omzimba ngakho-ke iyeka ukuhlasela amalunga enempilo futhi idale ubuhlungu nomonakalo.

Yini i-biologics?

I-biologics yizinhlayiyana zezidakamizwa zokuguqula izifo (i-DMARD). Ama-DMARD amisa amasosha akho omzimba ekubangeleni ukuvuvukala kwe-PsA nezinye izimo ezizimele.

Ukunciphisa ukuvuvukala kunemiphumela emibili emikhulu:

• Kungaba nobuhlungu obuncane ngoba ukuvuvukala ezindaweni ezihlangene kuyimbangela yokuhlangana.
• Ukulimala kungancishiswa.

I-Biologics isebenza ngokuvimba amaprotheni omzimba okhiqiza ukuvuvukala. Ngokungafani namanye ama-DMARD, i-biologics ilawulwa ukumnika noma ukujova kuphela.

I-Biologics inqunyelwe njengokwelashwa komugqa wokuqala kubantu abane-PsA esebenzayo. Uma i-biologic yokuqala oyizamayo ingazinciphisi izimpawu zakho, udokotela wakho angakushintshela kumuthi ohlukile kuleli klasi.

Izinhlobo ze-biologics

Izinhlobo ezine ze-biologics zisetshenziselwa ukwelapha i-PsA:

• isimila necrosis factor-alpha (TNF-alpha) inhibitors: adalimumab (Humira), certolizumab pegol (Cimzia), etanercept (Enbrel), golimumab (Simponi Aria), infliximab (Remicade)
• i-interleukin 12/23 (IL-12/23) inhibitors: ustekinumab (Stelara)
• i-interleukin 17 (IL-17 inhibitors): ixekizumab (Taltz), secukinumab (Cosentyx)
• T cell inhibitors: abatacept (i-Orencia)

Le mithi ivimba amaprotheni athile abonisa ukuthi amasosha akho omzimba ahlasela amaseli anempilo, noma akhomba amaseli omzimba abandakanyeka empendulweni yokuvuvukala. Umgomo we-subtype ngayinye ye-biologic ukuvimbela inqubo yokuvuvukala ukuqala.

Ama-biologics amaningana ayatholakala. Okulandelayo kunqunyelwe kakhulu i-PsA.

Abatacept

I-Abatacept (i-Orencia) iyi-T cell inhibitor. Amaseli we-T amangqamuzana amhlophe egazi. Babamba iqhaza ekuphenduleni komzimba, nasekubangeleni ukuvuvukala. I-Orencia ihlose ama-T cell ukwehlisa ukuvuvukala.

I-Orencia ibuye ilaphe isifo samathambo (RA) kanye ne-juvenile idiopathic arthritis (JIA). Kutholakala njengokumnika ngomthambo, noma njengomjovo ozinikeza wona.

I-Adalimumab

I-Adalimumab (Humira) isebenza ngokuvimba i-TNF-alpha, iphrotheni ekhuthaza ukuvuvukala. Abantu abane-PsA bakhiqiza i-TNF-alpha eningi kakhulu esikhunjeni nasemalungeni abo.

I-Humira ngumuthi ojojoweyo. Futhi kunqunyelwe isifo sikaCrohn nezinye izinhlobo zesifo samathambo.

Isiqinisekiso se-pegol

I-Certolizumab pegol (Cimzia) ingenye yezidakamizwa ze-TNF-alpha. Yenzelwe ukuphatha izinhlobo ezinolaka ze-PsA, kanye nesifo sikaCrohn, RA, ne-ankylosing spondylitis (AS).

I-Cimzia inikezwa njenge-self-injection.

Etanercept

I-Etanercept (Enbrel) nayo iyisidakamizwa se-TNF-alpha. Iphakathi kwemithi endala evunyelwe ukwelashwa kwe-PsA, futhi isetshenziselwa ukwelapha ezinye izinhlobo zesifo samathambo.

I-Enbrel izijovele ngokwakho izikhathi ezimbili noma ezimbili ngeviki.

IGolimumab

IGolimumab (iSimponi) isidakamizwa se-TNF-alpha esenzelwe ukwelapha iPSA esebenzayo. Futhi kunqunyelwe i-RA elinganiselayo kuya kwelinzima, i-ulcerative colitis (UC) esezingeni eliphakathi nendawo, kanye ne-AS esebenzayo.

Uthatha uSimponi kanye ngenyanga ngokuzijova ngokwakho.

I-Infliximab

I-Infliximab (Remicade) inguqulo yokumnika yomuthi we-TNF-alpha. Uthola ukumnika ehhovisi likadokotela kathathu phakathi namasonto ayisithupha. Ngemuva kokwelashwa kokuqala, ama-infusions anikezwa njalo ezinyangeni ezimbili.

I-Remicade ibuye iphathe isifo sikaCrohn, UC, ne-AS. Odokotela bangayinikeza i-RA, kanye ne-methotrexate.

Ixekizumab

Ixekizumab (Taltz) iyi-IL-17 inhibitor. Ivimbela i-IL-17, ebandakanyeka ekuphenduleni komzimba.

Uthola iTaltz njengochungechunge lwemijovo ngaphansi kwesikhumba njalo emavikini amabili, bese njalo njalo emavikini amane.

I-Secukinumab

ISecukinumab (Cosentyx) ingenye ye-IL-17 inhibitor. Kuvunyelwe ukwelashwa kwe-psoriasis ne-PsA, kanye ne-AS.

Uyithatha njengesibhamu ngaphansi kwesikhumba sakho.

Ustekinumab

I-Ustekinumab (Stelara) iyi-IL-12/23 inhibitor. Ivimba amaprotheni IL-12 ne-IL-23, abangela ukuvuvukala ku-PsA. I-Stelara ivunyelwe ukwelapha i-PsA esebenzayo, i-plaque psoriasis, kanye nesifo sikaCrohn's.

UStenara uza njengomjovo. Ngemuva komjovo wokuqala, uphinde uphathwe ngemuva kwamasonto amane, bese uphinda unikezwa kanye njalo emavikini ayi-12.

Izindlela zokwelapha ezihlanganayo

Ukuze uthole i-PsA emaphakathi neqinile, i-biologics ibalulekile ekuphatheni izimpawu zesikhashana nezesikhathi eside kanye nezinkinga. Kodwa-ke, udokotela wakho futhi angancoma ezinye izindlela zokwelashwa.

Udokotela wakho angakunikeza izidakamizwa ezingezona ukuvuvukala (ama-NSAID) ezinhlungu ezihlangene. Lokhu kunciphisa nokuvuvukala. Izinhlobo ze-Over-the-counter (OTC), ezinjenge-ibuprofen (Advil), zitholakala kabanzi, kanye namafomula kadokotela namandla.

Njengoba ukusetshenziswa kwesikhathi eside kungandisa ingozi yokuphuma kwesisu, izinkinga zenhliziyo, nokushaya uhlangothi, ama-NSAID kufanele asetshenziswe kancane futhi ngomthamo ophansi kakhulu ongakhona.

Ukube ubune-psoriasis ngaphambi kwe-PsA, lapho-ke futhi ungadinga izindlela zokwelapha ukusiza ukunciphisa ukuqubuka kwesikhumba nezinkinga zezipikili. Izinketho zokwelashwa ezingaba khona zifaka phakathi i-corticosteroids, ukwelashwa okulula, namafutha okugcoba.

Imiphumela emibi nezixwayiso

Imiphumela emibi kakhulu ye-biologics ukusabela kwesikhumba (njengokubomvu nokuqubuka) endaweni yomjovo. Ngoba i-biologics ilawula amasosha akho omzimba, ungahle ube sengcupheni yokuthola izifo.

Imiphumela emibi ejwayelekile, kepha emibi, ifaka:

• i-psoriasis eya iba yimbi
• ukutheleleka okuphezulu kokuphefumula
• isifo sofuba
• Izimpawu ezifana ne-lupus (ezifana nobuhlungu bemisipha namalunga, umkhuhlane nokulahleka kwezinwele)

Khuluma ne-rheumatologist yakho ngale miphumela emibi engaba khona, futhi ubheke isimo sakho ngokucophelela. Shayela ngokushesha uma usola ukuthi unokusabela okungafanele emithini yakho.

Futhi, abesifazane abakhulelwe noma abahlela ukukhulelwa kufanele basebenzise i-biologics ngokunakekela.

Yize imiphumela enganeni ekhulayo ingaqondakali kahle, kukhona amathuba okuba nezinkinga ngokukhulelwa. Ngokuya ngobukhulu be-PsA, abanye odokotela batusa ukumisa ukwelashwa ngesikhathi sokukhulelwa.

I-Biologics iyingxenye yohlelo lokuphathwa kwe-PsA

Ama-biologics aletha ithemba kwabaningi nge-PsA. Akusizi nje kuphela ukuthi i-biologics isiza ukuphatha izimpawu ze-PsA, iphinde inciphise isimo esonakalisayo sokuvuvukala okuyisisekelo.

Noma kunjalo, kubalulekile ukukhumbula ukuthi i-biologics iyingxenye eyodwa yohlelo lwakho lokuphatha lwe-PsA lwesikhathi eside. Khuluma nodokotela wakho mayelana nezinguquko zendlela yokuphila neminye imithi engasiza.