Thalidomide

-Delile

• Intengo
• Izinkomba
• Isetshenziswa kanjani
• Okuqhamuka uma udla imishanguzo
• Izimo

I-Thalidomide ngumuthi osetshenziselwa ukwelapha uchoko okuyisifo esidalwa yigciwane elithinta isikhumba nezinzwa, esidala ukuzwa, ubuthakathaka bemisipha nokukhubazeka. Ngaphezu kwalokho, kunconywa nasezigulini ezine-HIV kanye ne-lupus.

Lo muthi wokusetshenziswa ngomlomo, njengamaphilisi, ungasetshenziswa kuphela ekunconyweni ngudokotela futhi uphikiswe ngokuphelele ekukhulelweni futhi uvinjelwe kwabesifazane abaneminyaka yobudala bokuzala, phakathi kokuya esikhathini nokuya esikhathini, njengoba kuholela ekulimaleni kwengane, njengokungabikho kwezindebe, izingalo nemilenze, inani elandayo leminwe, i-hydrocephalus noma ukungasebenzi kahle kwenhliziyo, amathumbu nezinso, isibonelo. Ngalesi sizathu, esimweni sokusebenzisa lo muthi ukukhombisa ukwelashwa, kufanele kusayinwe isikhathi sokuzibophezela.

Intengo

Lo muthi uvinjelwe ukusetshenziswa esibhedlela kuphela futhi unikezwa mahhala nguhulumeni ngakho-ke awuthengiswa ezikhemisi.

Izinkomba

Ukusetshenziswa kwe-Thalidomide kukhonjisiwe ekwelashweni:

• Uchoko, okuwuhlobo lokuphendula kochoko uhlobo II noma uhlobo lwe-erythema nodosum;
• Ingculaza, ngoba yehlisa umkhuhlane, ukungezwani komzimba nobuthakathaka bemisipha:
• ILupus, isifo se-graft-versus-host, ngoba ukuvuvukala kuyancipha.

Ukuqala kwesenzo somuthi kungahluka phakathi kwezinsuku ezimbili kuya ezinyangeni ezi-3, kuya ngesizathu sokwelashwa futhi kungasetshenziswa kuphela ngabesifazane abangekho eminyakeni yobudala bokuzala nasezinganeni ezingaphezu kweminyaka eyi-12.

Isetshenziswa kanjani

Ukusetshenziswa kwalo muthi kumathebulethi kungaqalwa ngokuncoma kukadokotela nangemva kokulandela umthetho olandelwayo othile wokusetshenziswa kwalo muthi odinga ukuthi isiguli sisayine ifomu lokuvuma. Ngokuvamile, udokotela uncoma ukuthi:

• Ukwelashwa kokuphendula kochoko uhlobo lwefindo noma uhlobo II phakathi kuka-100 kuya ku-300 mg, kanye ngosuku, ngesikhathi sokulala noma okungenani, ihora eli-1 ngemuva kwesidlo sakusihlwa;
• Ukwelashwa kwe-ei-ritema ye-nodular ye-lepromatous, qala kuze kufike ku-400 mg ngosuku, bese wehlisa imithamo amasonto ama-2, uze ufinyelele kumthamo wesondlo, ophakathi kuka-50 no-100 mg ngosuku.
• Isifo esilimazayo, ehambisana ne-HIV: 100 kuya ku-200 mg kanye ngosuku ngesikhathi sokulala noma ihora eli-1 ngemuva kokudla kokugcina.

Ngesikhathi sokwelashwa umuntu akufanele abe nokuxhumana okusondelene futhi uma kwenzeka, izindlela ezimbili zokuvimbela inzalo kufanele zisetshenziswe ngasikhathi sinye, njengephilisi lokuvimbela inzalo, elinokujova noma elifakelwe nekhondomu noma idiyaphragm. Ngaphezu kwalokho, kubalulekile ukuqala ukuvimbela ukukhulelwa cishe inyanga engu-1 ngaphambi kokuqala ukwelashwa kanye namanye amasonto ama-4 ngemuva kokumiswa.

Endabeni yamadoda enza ucansi nabesifazane abaseminyakeni yobudala bokuzala, kufanele basebenzise amakhondomu kunoma yiluphi uhlobo lokuxhumana okusondelene.

Okuqhamuka uma udla imishanguzo

Imiphumela emibi kakhulu yokusebenzisa lo muthi uma isetshenziswa ngowesifazane okhulelwe, okuholela ekuphambekeni kwengane. Ngaphezu kwalokho, kungaholela ekushoshozelweni, ebuhlungu ezandleni, ezinyaweni nasekukhathazekeni komzimba.

Ukungabekezelelani emathunjini, ukozela, isiyezi, i-anemia, i-leukopenia, i-leukemia, i-purpura, i-arthritis, ubuhlungu beqolo, umfutho wegazi ophansi, i-vein thrombosis ejulile, i-angina, isifo senhliziyo, ukukhathazeka, uvalo, i-sinusitis, ukukhwehlela, ubuhlungu besisu, uhudo noma ijele nakho zenzeka. isisu, i-conjunctivitis, isikhumba esomile.

Izimo

Ukusetshenziswa kwalo muthi kuphikiswa ngokuphelele ekukhulelweni ngoba kubangela ukukhubazeka enganeni, njengokungabikho kwemilenze, izingalo, izindebe noma izindlebe, ngaphezu kokungasebenzi kahle kwenhliziyo, izinso, amathumbu nesibeletho, ngokwesibonelo.

Ngaphezu kwalokho, izingane ezingama-40% ziyafa ngemuva nje kokuzalwa futhi ziphikiswa nangesikhathi sokuncelisa, ngoba umphumela wazo awaziwa. Futhi ayinakusetshenziswa uma kwenzeka ukungezwani komzimba neThalidomide noma enye yezingxenye zayo.