I-calcium pyrophosphate arthritis

I-calcium pyrophosphate dihydrate (CPPD) isifo samathambo yisifo esihlangene esingadala ukuhlaselwa yi-arthritis. Njenge-gout, amakristalu akha amajoyinti. Kepha kulesi sifo samathambo, amakristalu awakhiwa nge-uric acid.

Ukufakwa kwe-calcium pyrophosphate dihydrate (CPPD) kubangela lolu hlobo lwe-arthritis. Ukwakhiwa kwaleli khemikhali kwakha amakristalu kuqwanga lwamalunga. Lokhu kuholela ekuhlaselweni kokuvuvukala okuhlangene nobuhlungu emadolweni, ezihlakaleni, emaqakaleni, emahlombe nakwamanye amalunga. Ngokuphikisana ne-gout, ukuhlangana kwe-metatarsal-phalangeal kozwane olukhulu akuthinteki.

Phakathi kwabantu abadala asebekhulile, i-CPPD iyimbangela ejwayelekile yesifo samathambo esingazelelwe (esibucayi) kwilunga elilodwa. Ukuhlaselwa kubangelwa:

• Ukulimala ejoyintini
• Umjovo we-Hyaluronate ejoyinini
• Ukugula kwezokwelapha

Isifo samathambo se-CPPD sithinta kakhulu asebekhulile ngoba ukonakala kwamalunga kanye ne-osteoarthritis kuyanda ngokukhula. Ukulimala ngokuhlanganyela okunjalo kwandisa ukuthambekela kokufakwa kwe-CPPD. Kodwa-ke, i-CPPD arthritis kwesinye isikhathi ingathinta abantu abasha abanezimo ezinjenge:

• I-Hemochromatosis
• Isifo seParathyroid
• Ukwehluleka kwezinso okuxhomeke ku-Dialysis

Ezimweni eziningi, isifo samathambo se-CPPD asibangeli zimpawu. Esikhundleni salokho, ama-x-ray amajoyinti athintekile afana namadolo akhombisa ukufakwa kwesici se-calcium.

Abanye abantu abanezimali ezingapheli ze-CPPD emajoyintini amakhulu bangaba nalezi zimpawu ezilandelayo:

• Ubuhlungu
• Ukuvuvukala
• Imfudumalo
• Ububomvu

Ukuhlaselwa kobuhlungu obuhlangene kungahlala izinyanga. Kungase kungabikho zimpawu phakathi kokuhlaselwa.

Kwabanye abantu isifo samathambo i-CPPD sidala umonakalo omkhulu ejoyinini.

I-CPPD arthritis nayo ingenzeka emgogodleni, kokubili okuphansi nangaphezulu. Ukucindezela emithanjeni yomgogodla kungadala ubuhlungu ezandleni noma emilenzeni.

Ngoba izimpawu ziyafana, i-CPPD arthritis ingadideka ne:

• I-Gouty arthritis (sifo)
• I-osteoarthritis
• Isifo samathambo

Izimo eziningi ze-arthritic zibonisa izimpawu ezifanayo. Ukuhlola ngokucophelela uketshezi oluhlangene lwamakristalu kungasiza udokotela ukuthola isimo.

Ungase uvivinywe okulandelayo:

• Ukuhlolwa okuhlangene koketshezi ukuthola amangqamuzana amhlophe egazi namakhemikhali e-calcium pyrophosphate
• Ama-x-ray ahlangene wokubheka ukulimala okuhlangene kanye nokufakwa kwe-calcium ezindaweni ezihlangene
• Okunye ukuhlolwa kwe-imaging ngokuhlanganyela njenge-CT scan, i-MRI noma i-ultrasound, uma kudingeka
• Ukuhlolwa kwegazi ukuhlola izimo ezixhunyaniswe ne-calcium pyrophosphate arthritis

Ukwelashwa kungabandakanya ukususa uketshezi ukunciphisa ingcindezi ejoyintini. Kufakwa inaliti emalungeni bese kufuthwa uketshezi. Ezinye izindlela zokwelashwa ezivamile yilezi:

• Imijovo ye-steroid: ukwelapha amalunga avuvukele kakhulu
• Ama-Oral steroids: ukwelapha amalunga amaningi avuvukile
• Imithi eqeda ukuvuvukala (ama-NSAID): ukunciphisa izinhlungu
• IColchicine: ukwelapha ukuhlaselwa yisifo samathambo se-CPPD
• Kwi-arthritis engapheli ye-CPPD kumajoyinti amaningi i-methotrexate noma i-hydroxychloroquine ingasiza

Iningi labantu lenza kahle ngokwelashwa ukunciphisa izinhlungu ezihlangene ezihlangene. Umuthi ofana ne-colchicine ungasiza ukuvimbela ukuhlaselwa okuphindayo. Akukho muthi wokususa amakristalu we-CPPD.

Ukulimala okungapheli okuhlangene kungenzeka ngaphandle kokwelashwa.

Shayela umhlinzeki wakho wezokunakekelwa kwezempilo uma uhlaselwa ukuvuvukala okuhlangene nobuhlungu obuhlangene.

Ayikho indlela eyaziwayo yokuvimbela lesi sifo. Kodwa-ke, ukwelapha ezinye izinkinga ezingadala isifo samathambo se-CPPD kungenza isimo sibe nzima kakhulu.

Ukuvakashelwa okuqhubekayo njalo kungasiza ekuvimbeleni ukulimala unomphela kwamajoyinti athintekile.

Isifo sokubekwa se-calcium pyrophosphate dihydrate; Isifo se-CPPD; I-Acute / chronic CPPD arthritis; I-Pseudogout; I-Pyrophosphate arthropathy; I-Chondrocalcinosis

• Ukuvuvukala okuhlangene kwehlombe
• I-osteoarthritis
• Ukwakheka kokuhlanganiswa

Andrés M, Sivera F, Pascual E. Therapy for CPPD: izinketho nobufakazi. ICurr Rheumatol Rep. 2018; 20 (6): 31. I-PMID: 29675606 pubmed.ncbi.nlm.nih.gov/29675606/.

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I-Terkeltaub R. Isifo se-calcium esine-calcium: i-calcium pyrophosphate dihydrate ne-calcium phosphate eyisisekelo. Ku: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, abahleli. Incwadi kaKelley noFirestein yeRheumatology. Umhlaka 10. IPhiladelphia, PA: Elsevier; 2017: isahluko 96.