Ukuntuleka kwe-Factor XII (Hageman factor)

Ukushoda kwe-Factor XII yisifo esizuzwe njengefa esithinta iprotheni (factor XII) ebandakanyeka ekunqandeni igazi.

Lapho wopha, uchungechunge lwezinto ezenzekayo emzimbeni olusiza ukwakheka kwamahlule egazi. Le nqubo ibizwa ngokuthi yi-coagulation cascade. Kubandakanya amaprotheni akhethekile abizwa ngokuthi yi-coagulation noma ama-clotting factor. Ungaba nethuba eliphakeme lokopha ngokweqile uma eyodwa noma eziningi zalezi zinto zilahlekile noma zingasebenzi ngendlela efanele.

I-Factor XII ingesinye sezici ezinjalo. Ukuntuleka kwalesi sici akubangeli ukuthi wophe ngokweqile. Kepha, igazi lithatha isikhathi eside kunokujwayelekile ukumbozwa kushubhu lokuhlola.

Ukushoda kwe-Factor XII kuyisifo esingajwayelekile esizuzwe njengefa.

Ngokuvamile azikho izimpawu.

Ukushoda kwe-Factor XII kuvame ukutholakala lapho kwenziwa ukuvala ukuvivinya ukuhlolwa okujwayelekile.

Ukuhlolwa kungafaka:

• Isilinganiso se-Factor XII ukukala umsebenzi we-factor XII
• Isikhathi esinqunyelwe se-thromboplastin (PTT) sokubheka ukuthi kuthatha isikhathi esingakanani ukuthi igazi livale
• Ukuxuba ukutadisha, ukuhlolwa okukhethekile kwe-PTT ukuqinisekisa ukuntuleka kwe-factor XII

Ukwelashwa ngokuvamile akudingeki.

Lezi zinsizakusebenza zinganikeza imininingwane eminingi ngokushoda kwe-factor XII:

• I-National Hemophilia Foundation - www.hemophilia.org/Bleeding-Disorders/Izinhlobo- ze-Bleeding-Disorders/Other-Factor-Deficiencies/Factor-XII
• Inhlangano Kazwelonke Yezinkinga Ezingajwayelekile - rarediseases.org/rare-diseases/factor-xii-deficiency
• Isikhungo Sokwaziswa se-NIH Genetic and Rare Diseases - rarediseases.info.nih.gov/diseases/6558/factor-xii-deficiency

Umphumela kulindeleke ukuthi ube muhle ngaphandle kokwelashwa.

Ngokuvamile azikho izinkinga.

Umhlinzeki wezokunakekelwa kwempilo uvame ukuthola lesi simo lapho eqhuba ezinye izivivinyo zelebhu.

Lesi yisifo esizuzwe njengefa. Ayikho indlela eyaziwayo yokuyivimba.

Ukushoda kwe-F12; Ukushoda kwesici seHageman; Isici se-Hageman; Ukushoda kwe-HAF

• Amahlule egazi

UGailani D, Wheeler AP, Neff AT. Ukukhubazeka okujwayelekile kwe-coagulation factor. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ama-eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 137.

IHholo JE. I-hemostasis negazi coagulation. Ku: IHholo JE, kuhleliwe. Incwadi kaGuyton neHholo yePhysical Physiology. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2016: isahluko 37.

I-Ragni MV. Ukuphazamiseka kokopha: ukuswela kwe-coagulation factor. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 174.