I-Polyarteritis nodosa

I-Polyarteritis nodosa yisifo esibi somthambo wegazi. Imithambo emincane naphakathi nendawo iyavuvukala futhi ilimale.

Imithambo yegazi yimithambo yegazi ethwala igazi elicebile oksijini kuzitho kanye nezicubu. Imbangela ye-polyarteritis nodosa ayaziwa. Isimo senzeka lapho amaseli athile omzimba ehlasela imithambo ethintekile. Izicubu ezondliwa yimithambo ethintekile azitholi umoya-mpilo nokondleka ezikudingayo. Ukulimala kwenzeka ngenxa yalokho.

Abantu abadala abaningi kunezingane bathola lesi sifo.

Abantu abane-hepatitis B esebenzayo noma i-hepatitis C bangaba nalesi sifo.

Izimpawu zidalwa ukulimala kwezitho ezithintekile. Isikhathi esiningi kuthinteka isikhumba, amalunga, imisipha, umgudu wamathumbu, inhliziyo, izinso, nohlelo lwezinzwa.

Izimpawu zifaka:

• Ubuhlungu besisu
• Ukwehla kwesifiso sokudla
• Ukukhathala
• Imfiva
• Izinhlungu ezihlangene
• Ubuhlungu bemisipha
• Ukwehla kwesisindo ngokungenhloso
• Ubuthakathaka

Uma kuthinteka izinzwa, ungaba ndikindiki, ubuhlungu, ukushiswa, nobuthakathaka. Ukulimala kwesistimu yezinzwa kungadala ukushaywa unhlangothi noma ukuquleka.

Azikho izivivinyo zelebhu ezithile ezitholakalayo zokuxilonga i-polyarteritis nodosa. Kunezinkinga eziningi ezinezici ezifana ne-polyarthritis nodosa. Lokhu kwaziwa ngokuthi "ukulingisa."

Uzoba nokuhlolwa okuphelele ngokomzimba.

Ukuhlolwa kwelebhu okungasiza ekwenzeni ukuxilongwa nokulawula ukulingiswa kufaka phakathi:

• Qedela ukubalwa kwegazi (i-CBC) ngokuhlukahluka, i-creatinine, ukuhlolwa kwe-hepatitis B no-C, kanye nokuhlolwa komchamo
• Izinga le-sedimentation ye-Erythrocyte (ESR) noma i-C-reactive protein (CRP)
• I-Serum protein electrophoresis, ama-cryoglobulins
• Amazinga wokugcwalisa weSerum
• I-Arteriogram
• I-biopsy yezicubu
• Okunye ukuhlolwa kwegazi kuzokwenziwa ukukhipha imibandela efanayo, efana ne-systemic lupus erythematosus (ANA) noma i-granulomatosis ene-polyangiitis (ANCA)
• Ukuhlolela i-HIV
• Ama-Cryoglobulins
• Ama-anti-phospholipid antibodies
• Amasiko egazi

Ukwelashwa kufaka imithi yokwenqabela ukuvuvukala namasosha omzimba. Lokhu kungafaka i-steroids, njenge-prednisone. Imithi efanayo, efana ne-azathioprine, methotrexate noma i-mycophenolate evumela ukunciphisa umthamo we-steroids nayo isetshenziswa njalo. Cyclophosphamide isetshenziswa ezimweni ezinzima.

Nge-polyarteritis nodosa ehlobene ne-hepatitis, ukwelashwa kungafaka i-plasmapheresis nemithi elwa namagciwane.

Ukwelashwa kwamanje nge-steroids nezinye izidakamizwa ezicindezela amasosha omzimba (njenge-azathioprine noma i-cyclophosphamide) kungathuthukisa izimpawu nethuba lokusinda isikhathi eside.

Izinkinga ezimbi kakhulu zivame ukubandakanya izinso kanye nomgudu wamathumbu.

Ngaphandle kokwelashwa, umbono ubi.

Izinkinga zingafaka:

• Isifo senhliziyo
• I-necrosis yamathumbu nokugcotshwa
• Ukuhluleka kwezinso
• Unhlangothi

Shayela umhlinzeki wakho wezokunakekelwa kwezempilo uma uba nezimpawu zalesi sifo. Ukuxilongwa nokwelashwa kusenesikhathi kungathuthukisa ithuba lomphumela omuhle.

Akukho ukuvimbela okwaziwayo. Kodwa-ke, ukwelashwa kusenesikhathi kungavimbela ukulimala nezimpawu ezithile.

I-Periarteritis nodosa; I-PAN; I-vasculitis ehlelekile ye-necrotizing

• I-Microscopic polyarteritis 2
• Uhlelo lokujikeleza kwegazi

Luqmani R, Awisat A. Polyarteritis nodosa kanye nokuphazamiseka okuhlobene. Ku: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, abahleli. Incwadi kaFirestein & Kelley yeRheumatology. Umhla ka-11. IPhiladelphia, PA: Elsevier; 2021: isahluko 95.

UPuéchal X, uPagnoux C, uBaron G, et al. Ukungeza i-azathioprine ku-remission-induction glucocorticoids ye-eosinophilic granulomatosis ne-polyangiitis (i-Churg-Strauss), i-microscopic polyangiitis, noma i-polyarteritis nodosa ngaphandle kwezici ezimbi zokubikezela: isilingo esingahleliwe, esilawulwayo. I-Arthritis Rheumatol. 2017; 69 (11): 2175-2186. PMID: 28678392 www.pubmed.ncbi.nlm.nih.gov/28678392/.

I-Shanmugam VK. I-Vasculitis namanye ama-arteriopathies angavamile. Ku: Sidawy AN, Perler BA, ama-eds. Rutherford’s Vascular Surgery and Endovascular Therapy. Umhlaka 9. IPhiladelphia, PA: Elsevier; 2019: isahluko 137.

Itshe uJH. Ama-vasculitides ahlelekile. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 254.