Ukushoda okukhethiwe kwe-IgA

Ukushoda okukhethiwe kwe-IgA yisifo esivame kakhulu sokushoda komzimba. Abantu abanalesi sifo banezinga eliphansi noma elingekho leprotheyini yegazi ebizwa nge-immunoglobulin A.

Ukushoda kwe-IgA kuvame ukuzuzwa njengefa, okusho ukuthi kudluliselwa emindenini. Kodwa-ke, kukhona namacala okushoda okubangelwa izidakamizwa i-IgA.

Kungahle kutholwe njengefa njengokuziphatha okuphezulu kwe-autosomal noma kwe-autosomal. Ngokuvamile kutholakala kubantu abavela eYurophu. Akuvamile kakhulu kubantu bezinye izinhlanga.

Abantu abaningi abanenkinga ye-IgA ekhethiwe abanazimpawu.

Uma umuntu enezimpawu, zingafaka iziqephu ezivamile ze:

• I-bronchitis (ukutheleleka komoya)
• Uhudo olungamahlalakhona
• I-Conjunctivitis (ukutheleleka kweso)
• Ukuvuvukala kwamathumbu, kufaka phakathi i-ulcerative colitis, isifo se-Crohn, kanye nokugula okufana ne-sprue
• Ukutheleleka komlomo
• I-Otitis media (ukutheleleka kwendlebe okuphakathi)
• I-pneumonia (ukutheleleka kwamaphaphu)
• Sinusitis (isifo sesono)
• Ukutheleleka kwesikhumba
• Izifo ezingenhla zokuphefumula

Ezinye izimpawu zifaka:

• I-Bronchiectasis (isifo lapho amasaka amancane omoya emaphashini elimala futhi akhuliswa)
• Isifuba somoya ngaphandle kwesizathu esaziwayo

Kungaba nomlando womndeni wokushoda kwe-IgA. Ukuhlolwa okungenziwa kufaka phakathi:

• Izilinganiso ze-IgG subclass
• Ama-immunoglobulin amaningi
• I-serum immunoelectrophoresis

Akukho ukwelashwa okuqondile okutholakalayo. Abanye abantu bakhula kancane kancane amazinga ajwayelekile e-IgA ngaphandle kokwelashwa.

Ukwelashwa kubandakanya ukuthatha izinyathelo zokwehlisa inani nokuqina kwezifo. Imithi elwa namagciwane ivame ukudingeka ukwelapha ukutheleleka ngamagciwane.

Ama-immunoglobulin anikezwa ngomthambo noma ngomjovo ukukhulisa amasosha omzimba.

Ukwelashwa kwezifo okuzenzakalelayo kuncike enkingeni ethile.

Qaphela: Abantu abanenkinga ephelele ye-IgA bangakha ama-anti-IgA antibodies uma benikezwa imikhiqizo yegazi nama-immunoglobulin. Lokhu kungaholela ekungezeleleni komzimba noma ekusongeleni i-anaphylactic shock. Kodwa-ke, banganikezwa ngokuphepha ama-immunoglobulin we-IgA.

Ukushoda kwe-IgA okukhethiwe akulimazi kangako kunezinye izifo eziningi zokuqina komzimba.

Abanye abantu abanenkinga ye-IgA bazolulama bebodwa futhi bakhiqize i-IgA ngobuningi obukhulu esikhathini esiyiminyaka.

Ukuphazamiseka kokuzimela komzimba okufana nesifo samathambo, i-systemic lupus erythematosus, ne-celiac sprue kungaqala.

Abantu abanenkinga ye-IgA bangakha amasosha omzimba ku-IgA. Ngenxa yalokho, bangaba nokusabela okunzima, ngisho nokusongela ukuphila ekumpontshelweni igazi nemikhiqizo yegazi.

Uma unokuntuleka kwe-IgA, qiniseka ukuthi ukusho kumhlinzeki wakho wezokunakekelwa kwezempilo uma i-immunoglobulin noma okunye ukumpontshelwa kwengxenye yegazi kuphakanyiswa njengokwelashwa kwanoma isiphi isimo.

Ukwelulekwa ngofuzo kungaba lusizo kulabo abazoba ngabazali abanomlando womndeni wokuntuleka kwe-IgA okukhethiwe.

Ukushoda kwe-IgA; I-Immunodepress - Ukushoda kwe-IgA; Ukucindezelwa kwe-Immunosuppressed - IgA; I-Hypogammaglobulinemia - Ukushoda kwe-IgA; Ukushoda kwe-Agammaglobulinemia - IgA

• Amasosha omzimba

ICunningham-Rundles C. Izifo eziyinhloko zokuzivikela emzimbeni. Ku: IGoldman L, iSchafer AI, ama-eds. Imithi yeGoldman-Cecil. Umhla ka-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 236.

USullivan KE, uBuckley RH. Ukukhubazeka okuyisisekelo kokukhiqizwa kwama-antibody. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Incwadi kaNelson Yezingane. Umhlaka 21. IPhiladelphia, PA: Elsevier; 2020: isahluko 150.