Isilinganiso se-Factor VIII

Isilingo se-factor VIII ukuhlolwa kwegazi ukukala umsebenzi we-factor VIII. Lokhu kungenye yamaprotheni asiza ihlule legazi.

Kudingeka isampula yegazi.

Akukho ukulungiselela okukhethekile okudingekayo.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulinyazeka okuncane. Lokhu maduzane kuyaphela.

Lokhu kuhlola kusetshenziselwa ukuthola imbangela yokopha kakhulu (kwehle ukunqamuka kwegazi). Noma, kungahle ku-odelwe uma ilungu lomndeni laziwa ukuthi line-hemophilia A. Ukuhlolwa kungenziwa futhi ukubona ukuthi isebenza kanjani kahle i-hemophilia A.

Inani elijwayelekile lingu-50% kuya ku-200% wokulawulwa kwelabhorethri noma inani lesethenjwa.

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma angahlola amasampula ahlukile. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Ukwehla komsebenzi we-factor VIII kungenzeka ngenxa ye:

• I-Hemophilia A (ukuphazamiseka kokopha okubangelwa ukuntuleka kwegazi lokuvala igazi i-VIII)
• Ukuphazamiseka lapho amaprotheni alawula ukujiya kwegazi eba ngaphezu kokusebenza okusatshalalisiwe kwe-intravascular coagulation (DIC)
• Ubukhona be-Factor VIII inhibitor (antibody)
• Isifo seVon Willebrand (olunye uhlobo lwesifo sokopha)

Umsebenzi owandisiwe kungenzeka ngenxa ye-:

• Ukuguga
• Isifo sikashukela
• Isifo sesibindi
• Ukuvuvukala
• Ukukhulelwa
• Ukukhuluphala ngokweqile

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo iyehluka ngobukhulu ukusuka komunye umuntu iye komunye, futhi kusukela kolunye uhlangothi lomzimba kuye kolunye. Ukuthola isampula yegazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Lokhu kuhlolwa kuvame ukwenziwa kubantu abanezinkinga zokopha. Ingozi yokopha kakhulu inkulu kancane kubantu abanezinkinga zokopha kunabanye.

I-antigen yePlasma factor VIII; Isici se-antihemophilia; AHF

UCarcao M, Moorehead P, uLillicrap D.Hemophilia A noB B. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, eds. I-Hematology: Izimiso Eziyisisekelo Nokuzijwayeza. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2018: isahluko 135.

IChernecky CC, iBerger BJ. I-Factor VIII (i-antihemophilia factor, AHF) - igazi. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 504-505.

UNapolitano M, uSchmaier AH, uKessler CM. I-Coagulation kanye ne-fibrinolysis. Ku: McPherson RA, Pincus MR, abahleli. UHenry’s Clinical Diagnosis and Management by Laboratory Methods. Umhla ka-23. ISt Louis, MO: Elsevier; 2017: isahluko 39.