Ukuhlolwa kokukhuthaza kwe-ACTH

Ukuhlolwa kokukhuthaza kwe-ACTH kukala ukuthi izindlala ze-adrenal ziphendula kahle kanjani kwi-adrenocorticotropic hormone (ACTH). I-ACTH yihomoni ekhiqizwa endlaleni ye-pituitary evuselela izindlala ze-adrenal ukukhipha i-hormone ebizwa nge-cortisol.

Ukuhlolwa kwenziwa ngale ndlela elandelayo:

• Kudonswa igazi lakho.
• Ube usuthola isibhamu (umjovo) we-ACTH, imvamisa ungena emisipheni ehlombe lakho. I-ACTH ingaba ifomu elenziwe ngabantu (lokwenziwa).
• Ngemuva kwemizuzu engama-30 noma imizuzu engama-60, noma yomibili, kuya ngokuthi uthola i-ACTH engakanani, igazi lakho liyadonswa futhi.
• Ilebhu ihlola izinga le-cortisol kuwo wonke amasampula egazi.

Ungase futhi ube nokunye ukuhlolwa kwegazi, kufaka phakathi i-ACTH, njengengxenye yokuhlolwa kwegazi kokuqala. Kanye nokuhlolwa kwegazi, ungahle ube nokuhlolwa komchamo we-cortisol noma umchamo wokuhlola i-17-ketosteroids, okubandakanya ukuqoqa umchamo esikhathini esingamahora angama-24.

Ungadinga ukukhawulela imisebenzi futhi udle ukudla okuphezulu kuma-carbohydrate amahora ayi-12 kuya kwangu-24 ngaphambi kokuhlolwa. Ungacelwa ukuthi uzile ukudla amahora angu-6 ngaphambi kokuhlolwa. Kwesinye isikhathi, akukho ukulungiselela okukhethekile okudingekayo. Ungacelwa ukuthi uyeke ukuthatha imithi okwesikhashana, njenge-hydrocortisone, engaphazamisa ukuhlolwa kwegazi kwe-cortisol.

Lapho inaliti ifakwa ukudonsa igazi, abanye abantu bezwa ubuhlungu obulinganiselayo. Abanye bazizwa beshaywa noma betinyelwa kuphela. Ngemuva kwalokho, kungahle kube nokushaywa okuthile noma ukulinyazeka okuncane. Lokhu maduzane kuyaphela.

Ukujova ehlombe kungadala ubuhlungu obulinganiselayo noma ukuhlabana.

Abanye abantu bazizwa behlazekile, benovalo, noma behlanjululwa ngemuva komjovo we-ACTH.

Lokhu kuhlolwa kungasiza ekunqumeni ukuthi ngabe izindlala zakho ze-adrenal ne-pituitary zivamile yini. Kuvame ukusetshenziswa kakhulu lapho umhlinzeki wakho wezokunakekelwa kwempilo ecabanga ukuthi unenkinga ye-adrenal gland, enjengesifo i-Addison noma ukungakwazi ukusebenza kwamathambo. Iphinde isetshenziselwe ukubona ukuthi ngabe izindlala zakho ze-pituitary ne-adrenal seziluleme ekusetshenzisweni isikhathi eside kwemithi ye-glucocorticoid, njenge-prednisone.

Ukwanda kwe-cortisol ngemuva kokuvuselelwa yi-ACTH kulindeleke. Izinga leCortisol ngemuva kokuvuselelwa kwe-ACTH kufanele libe ngaphezulu kwe-18 kuye ku-20 mcg / dL noma i-497 iye ku-552 nmol / L, kuya ngomthamo we-ACTH osetshenzisiwe.

Ububanzi bamanani ajwayelekile bungahluka kancane phakathi kwamalabhorethri ahlukene. Amanye amalebhu asebenzisa izilinganiso ezahlukahlukene noma angahlola izinhlobo ezihlukile. Khuluma nomhlinzeki wakho mayelana nencazelo yemiphumela yakho ethile yokuhlolwa.

Lokhu kuhlolwa kuyasiza ekutholeni ukuthi ngabe unayo:

• Inkinga enkulu ye-adrenal (isimo esisongela impilo esenzeka lapho ingekho i-cortisol eyanele)
• Isifo i-Addison (izindlala ze-adrenal azikhiqizi i-cortisol eyanele)
• I-Hypopituitarism (i-pituitary gland ayikhiqizi ama-hormone anele njenge-ACTH)

Kunengozi encane ethintekayo ekuthatheni igazi lakho. Imithambo nemithambo iyehluka ngobukhulu ukusuka komunye umuntu iye komunye, futhi kusukela kolunye uhlangothi lomzimba kuye kolunye. Ukuthatha igazi kwabanye abantu kungaba nzima kakhulu ukwedlula kwabanye.

Ezinye izingozi ezihambisana nokudonswa igazi zincane, kepha zingafaka:

• Ukopha ngokweqile
• Ukuquleka noma uzizwe unekhanda elincane
• Ukubhoboza okuningi ukuthola imithambo
• I-hematoma (ukuqoqwa kwegazi ngaphansi kwesikhumba)
• Ukutheleleka (ingozi encane noma kunini lapho isikhumba siphukile)

Ukuvivinywa kokugcinwa kwe-adrenal; Ukuhlolwa kokukhuthaza kweCosyntropin; Ukuhlolwa kokukhuthaza i-Cortrosyn; Ukuhlolwa kokukhuthaza kweSinacthen; Ukuhlolwa kokukhuthaza kweTetracosactide

UBarthel A, uWillenberg HS, uGruber M, uBornstein SR. Ukungasebenzi kahle kwe-adrenal. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, abahleli. I-Endocrinology: Eyabantu Abadala Neyengane. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 102.

IChernecky CC, iBerger BJ. Ukuhlolwa kokukhuthaza kwe-ACTH - ukuxilonga. Ku: IChernecky CC, iBerger BJ, ama-eds. Ukuhlolwa Kwelabhoratri Nezinqubo Zokuxilonga. Umhlaka 6. ISt Louis, MO: Elsevier Saunders; 2013: 98.

UStewart PM, iNewell-Price JDC. I-adrenal cortex. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, abahleli. Incwadi kaWilliams ye-Endocrinology. Umhlaka 13. IPhiladelphia, PA: Elsevier; 2016: isahluko 15.