USirolimus

-Delile

• Ukuze usebenzise amabhodlela esixazululo, landela lezi zinyathelo:
• Ngaphambi kokuthatha i-sirolimus,
• I-Sirolimus ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo noma leyo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha:

I-Sirolimus ingandisa ingozi yokuthi uzoba nokutheleleka noma umdlavuza, ikakhulukazi i-lymphoma (umdlavuza wengxenye yamasosha omzimba) noma umdlavuza wesikhumba. Ukuze wehlise amathuba okuba nomdlavuza wesikhumba, hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikhumba selanga ngesikhathi sokwelashwa kwakho. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: umkhuhlane, umphimbo obuhlungu, amakhaza, ukuchama kaningi noma okubuhlungu, noma ezinye izimpawu zokutheleleka; izilonda ezintsha noma izinguquko esikhunjeni; ukujuluka ebusuku; izindlala ezivuvukile entanyeni, emakhwapheni, noma emgodini; ukuncipha kwesisindo okungaqondakali; ukuphefumula kanzima; ubuhlungu besifuba; ubuthakathaka noma ukukhathala okungapheli; noma ubuhlungu, ukuvuvukala, noma ukugcwala esiswini.

I-Sirolimus ingadala imiphumela emibi kakhulu noma ukufa ezigulini ezibe nokufakelwa kwesibindi noma amaphaphu. Lo muthi akufanele unikezwe ukuvimbela ukwenqatshwa kokufakelwa kwesibindi noma amaphaphu.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-sirolimus.

Khuluma nodokotela wakho ngezingozi zokuthatha i-sirolimus.

I-Sirolimus isetshenziswa ngokuhlangana neminye imithi ukuvimbela ukwenqatshwa kokufakelwa kwezinso. USirolimus usesigabeni semithi ebizwa ngama-immunosuppressants. Isebenza ngokucindezela amasosha omzimba.

I-Sirolimus iza njengethebhulethi kanye nesisombululo (uketshezi) ukuthatha ngomlomo. Imvamisa kuthathwa kanye ngosuku, kungaba njalo ngokudla noma njalo ngaphandle kokudla. Ukukusiza ukuthi ukhumbule ukuthatha i-sirolimus, yithathe ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-sirolimus njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Gwinya wonke amaphilisi; ungawahlukanisi, ungawahlafune noma uwagxoze.

Udokotela wakho mhlawumbe uzolungisa umthamo wakho we-sirolimus ngesikhathi sokwelashwa kwakho, imvamisa hhayi ngaphezu kwesisodwa ezinsukwini eziyisikhombisa kuya kweziyishumi nane.

Qhubeka uthathe i-sirolimus noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-sirolimus ngaphandle kokukhuluma nodokotela wakho.

Isixazululo seSirolimus singahlakulela umusi lapho siqandisiwe. Uma lokhu kwenzeka, vumela ibhodlela lime ekamelweni lokushisa bese ulinyakazisa ngobumnene kuze kuphele umusi. Ukuhaza akusho ukuthi umuthi wonakele noma awuphephile ukuwusebenzisa.

Ukuze usebenzise amabhodlela esixazululo, landela lezi zinyathelo:

1. Vula ibhodlela lesisombululo. Ekusebenziseni kokuqala, faka ishubhu lepulasitiki ngesivalo siqinise ebhodleleni lize libe phezulu nangaphezulu kwebhodlela. Ungasusi ebhodleleni uma usufakiwe.
2. Ekusetshenzisweni ngakunye, faka ngokuqinile elinye lamasirinji we-amber, i-plunger ifakwe ngaphakathi, ekuvulekeni kwephubhu lepulasitiki.
3. Dweba inani lesixazululo udokotela wakho asinike lona ngokukhipha ngobunono iphenyi yesipontsho kuze kube yilapho umugqa omnyama weplunger ulinophawu olufanele kusirinji. Gcina ibhodlela limile. Uma amagwebu akha ku-syringe, thululela isirinji ebhodleleni bese uphinda lesi sinyathelo.
4. Thela isirinji engilazini noma enkomishini epulasitiki equkethe okungenani ama-ounces amabili (amamililitha angama-60 [1/4 inkomishi]) yamanzi noma ijusi lewolintshi. Ungasebenzisi ijusi le-apula, ijusi lamagilebhisi, noma olunye uketshezi. Govuza ngamandla umzuzu owodwa uphuze ngokushesha.
5. Gcwalisa inkomishi okungenani ngama-ounces amane (120 milliliters [1/2 inkomishi]) yamanzi noma ijusi lewolintshi. Govuza ngamandla bese uphuza isisombululo sokugeza.
6. Lahla umjovo osetshenzisiwe.

Uma udinga ukuphatha isirinji egcwele kuwe, qhafaza ikepisi embobeni bese ufaka isipetu esikhwameni sokuphatha. Sebenzisa umuthi esirinji ngaphakathi kwamahora angama-24.

I-Sirolimus nayo isetshenziswa kwesinye isikhathi ukwelapha i-psoriasis. Khuluma nodokotela wakho mayelana nezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-sirolimus,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-sirolimus, noma imuphi omunye umuthi, noma iziphi izithako kumaphilisi we-sirolimus noma isixazululo. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, kanye nezithako zokudla okunomsoco okwenzayo. Qinisekisa ukusho noma yikuphi kokulandelayo: ama-antibiotic e-aminoglycoside afana ne-amikacin, i-gentamicin, i-kanamycin, i-neomycin (i-Neo-Fradin, i-Neo-Rx), i-streptomycin, ne-tobramycin (i-Tobi); i-amphotericin B (i-Abelcet, i-AmBisome, i-Amphocin, i-Fungizone); i-angiotensin-converting enzyme (ACE) inhibitors efana ne-benazepril (Lotensin), i-captopril (i-Capoten), i-enalapril (i-Vasotec), i-fosinopril (i-Monopril), i-lisinopril (i-Prinivil, i-Zestril), i-moexipril (i-Univasc), i-perindopril) ), i-ramipril (i-Altace), ne-trandolapril (i-Mavik); ama-antifungals afana ne-clotrimazole (Lotrimin), i-fluconazole (i-Diflucan), i-itraconazole (i-Sporanox), i-ketoconazole (i-Nizoral), ne-voriconazole (i-Vfend); i-bromocriptine (i-Cycloset, i-Parlodel); i-cimetidine (Tagamet); i-cisapride (Propulsid) (ayitholakali e-U.S.); i-clarithromycin (i-Biaxin); i-danazol (iDanocrine); i-diltiazem (iCardizem, iDilacor, iTiazac); i-erythromycin (E.E.S., E-Mycin, Erythrocin); I-HIV protease inhibitors efana ne-indinavir (Crixivan) ne-ritonavir (Norvir, eKaletra); imithi ethile ye-cholesterol; imishanguzo yokuquleka efana ne-carbamazepine (Tegretol), phenobarbital (Luminal), ne-phenytoin (Dilantin); i-metoclopramide (Reglan); i-nicardipine (Cardene); i-rifabutin (i-Mycobutin); i-rifampin (i-Rifadin, i-Rimactane); i-rifapentine (Priftin); i-telithromycin (Ketek); i-troleandomycin (TAO) (ayitholakali e-U.S.); kanye ne-verapamil (Calan, Covera, Isoptin, Verelan). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• uma uthatha i-cyclosporine (Neoral) i-gelatin capsules noma isisombululo, thatha amahora amane ngaphambi kwe-sirolimus.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• Tshela udokotela wakho uma ngabe uke waba ne-cholesterol ephezulu noma i-triglycerides noma isifo sesibindi.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Kufanele usebenzise indlela ephumelelayo yokulawula ukubeletha ngaphambi kokuqala ukuthatha i-sirolimus, ngenkathi uthatha i-sirolimus, kanye namasonto ayi-12 ngemuva kokumisa i-sirolimus. Uma ukhulelwa ngenkathi uthatha i-sirolimus, shayela udokotela wakho.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-sirolimus.
• ungenayo imigomo ngaphandle kokukhuluma nodokotela wakho.

Gwema ukuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Sirolimus ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ubuhlungu besisu
• ikhanda
• ukuqunjelwa
• isifo sohudo
• isicanucanu
• ubuhlungu obuhlangene

Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo noma leyo ebhalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha:

• ukopha okungajwayelekile noma ukulinyazwa
• ukukhwehlela
• isikhumba esivuvukile, esibomvu, esiqhekekile
• isifuba
• ukuqubuka
• ukulunywa
• ukuphefumula kanzima noma ukugwinya
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka

I-Sirolimus ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina amaphilisi ekamelweni lokushisa kude nokukhanya, ukushisa okweqile, nomswakama (hhayi endlini yangasese). Gcina imithi ewuketshezi esiqandisini, kude nokukhanya, ivalwe ngokuqinile, bese ulahla noma imuphi umuthi ongasetshenziswanga inyanga eyodwa ngemuva kokuvulwa kwebhodlela. Ungafrizi. Uma kudingeka, ungagcina amabhodlela kuze kube yizinsuku eziyi-15 ekamelweni lokushisa.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Rapamune^®

• I-Rapamycin