I-Peginterferon Alfa-2b (i-PEG-Intron)

-Delile

• Ukuze usebenzise ipeni lomjovo we-peginterferon alfa-2b, landela lezi zinyathelo:
• Ukuze usebenzise i-peginterferon alfa-2b ku-vial, landela lezi zinyathelo:
• Ngaphambi kokuthatha i-peginterferon alfa-2b,
• I-Peginterferon alfa-2b ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo, noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha:

I-Peginterferon alfa-2b ingadala noma ibhebhethekise lezi zimo ezilandelayo ezingaba zimbi noma ezingadala ukufa: izifo; ukugula ngengqondo kubandakanya ukucindezeleka, izinkinga zemizwa nezokuziphatha, noma imicabango yokuzilimaza noma ukuzibulala noma ukubulala abanye; ukuqala ukusebenzisa izidakamizwa zasemgwaqweni futhi uma ubuzisebenzisa phambilini; ukuphazamiseka kweschemic (izimo lapho kutholakala khona igazi elincane endaweni yomzimba) njenge-angina (ubuhlungu besifuba), isifo senhliziyo, noma i-colitis (ukuvuvukala kwamathumbu); nokuphazamiseka kokuzilimaza komzimba (izimo lapho amasosha omzimba ahlasela khona ingxenye eyodwa noma ezingaphezulu zomzimba) ezingathinta igazi, amalunga, izinso, isibindi, amaphaphu, imisipha, isikhumba noma indlala yegilo. Tshela udokotela wakho uma unesifo; noma uma uke waba nesifo sokuzivikela komzimba; i-atherosclerosis (ukuncipha kwemithambo yegazi emafutheni anamafutha); umdlavuza; ubuhlungu besifuba; isifo sofuba; isifo sikashukela; isifo senhliziyo; umfutho wegazi ophakeme; i-cholesterol ephezulu; I-HIV (i-human immunodeficiency virus) noma i-AIDS (i-immunodeficiency syndrome); ukushaya kwenhliziyo okungajwayelekile; ukugula kwengqondo kubandakanya ukucindezeleka, ukukhathazeka, noma ukucabanga noma ukuzama ukuzibulala; isifo sesibindi ngaphandle kwesifo sokusha kwesibindi kohlobo C; noma inhliziyo, izinso, amaphaphu noma isifo segilo. Phinda utshele udokotela wakho uma uphuza noma wake waphuza utshwala obuningi, noma uma usebenzisa noma usebenzise izidakamizwa zasemgwaqweni noma usebenzise ngokweqile imithi kadokotela. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: uhudo olunegazi noma ukunyakaza kwamathumbu; ubuhlungu besisu, ubumnene noma ukuvuvukala; ubuhlungu besifuba; ukushaya kwenhliziyo okungajwayelekile; ushintsho esimweni sakho sengqondo noma ekuziphatheni kwakho; ukucindezeleka; ukucasuka; ukukhathazeka; imicabango yokuzibulala noma yokuzilimaza; ukubona izinto ezingekho (ukubona izinto noma ukuzwa amazwi angekho); imizwa evuthayo noma ejabule ngokungavamile; ukulahlekelwa ukuxhumana neqiniso; isimilo esinolaka; ukuphefumula kanzima; umkhuhlane, ukubanda, ukukhwehlela, umphimbo obuhlungu, noma ezinye izimpawu zokutheleleka; ukopha okungavamile noma ukulimaza; umchamo onombala omnyama; ukunyakaza okukhanyayo okukhanyayo; ukukhathala ngokweqile; ukuphuzi kwesikhumba noma kwamehlo; ubuhlungu obukhulu bemisipha noma obuhlangene; noma ukwanda kwesifo somzimba.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-peginterferon alfa-2b.

Udokotela wakho kanye nosokhemisi bazokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-peginterferon alfa-2b futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa i-peginterferon alfa-2b.

Sebenzisa nge-ribavirin (Copegus, Rebetol):

Ungathatha i-peginterferon alpha-2b ngomunye umuthi obizwa nge-ribavirin (Copegus, Rebetol). I-Ribavirin ingasiza i-peginterferon alpha-2b isebenze kangcono ukwelapha isimo sakho, kepha futhi ingadala nemiphumela emibi kakhulu. Ingxenye esele yalesi sigaba iveza ubungozi bokuthatha i-ribavirin. Uma uthatha i-ribavirin, kufanele ufunde lolu lwazi ngokucophelela. Udokotela wakho kanye nosokhemisi bazokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-ribavirin futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

I-Ribavirin ingadala i-anemia (isimo lapho kuncipha khona inani lamaseli abomvu egazi). Tshela udokotela wakho uma uke wahlaselwa yinhliziyo futhi uma uke waba nengcindezi ephezulu yegazi, izinkinga zokuphefumula, noma isiphi isimo esithinta igazi lakho njenge-sickle cell anemia (isimo esizuzwe njengefa lapho amangqamuzana abomvu egazi abunjwe ngokungajwayelekile futhi ayikwazi ukuletha i-oxygen kuzo zonke izingxenye zomzimba) noma i-thalassemia (i-anemia yaseMedithera; isimo lapho amangqamuzana egazi abomvu engenayo into eyanele edingekayo ukuthwala i-oxygen), noma isifo senhliziyo. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: ukukhathala ngokweqile, isikhumba esiphaphathekile, ikhanda elibuhlungu, isiyezi, ukudideka, ukushaya kwenhliziyo okusheshayo, ubuthakathaka, ukuphefumula okuncane, noma ubuhlungu besifuba.

Ezigulini zesifazane ezithatha i-ribavirin:

Ungathathi i-ribavirin uma ukhulelwe noma uhlela ukukhulelwa. Akufanele uqale ukuthatha i-ribavirin kuze kube ukuhlolwa kokukhulelwa kubonise ukuthi awukhulelwe. Kufanele usebenzise izindlela ezimbili zokulawula ukubeletha futhi uhlolwe ukukhulelwa njalo ngenyanga ngenkathi welashwa nangezinyanga eziyisithupha ngemuva kwalokho. Shayela udokotela wakho ngokushesha uma ukhulelwa ngalesi sikhathi. I-Ribavirin ingadala ingozi noma ibulale umbungu.

Ezigulini zesilisa ezithatha i-ribavirin:

Ungathathi i-ribavirin uma umlingani wakho ekhulelwe noma ehlela ukukhulelwa. Uma unomlingani ongakhulelwa, akufanele uqale ukuthatha i-ribavirin kuze kube ukuhlolwa kokukhulelwa kukhombisa ukuthi akakhulelwe. Kufanele usebenzise izindlela ezimbili zokulawula ukubeletha, kufaka phakathi ikhondomu ene-spermicide ngesikhathi sokwelashwa kwakho nezinyanga eziyisithupha ngemuva kwalokho. Umlingani wakho kumele ahlolelwe ukukhulelwa njalo ngenyanga ngalesi sikhathi. Shayela udokotela wakho ngokushesha uma umlingani wakho ekhulelwa. I-Ribavirin ingadala ingozi noma ibulale umbungu.

I-Peginterferon alfa-2b isetshenziswa yodwa noma ihlanganiswe ne-ribavirin (umuthi) ukwelapha ukutheleleka okungapheli (kwesikhathi eside) kwesifo sokusha kwesibindi kohlobo C (ukuvuvukala kwesibindi okubangelwa igciwane) kubantu abakhombisa izimpawu zokulimala kwesibindi nabangakaze welashwa nge-interferon alpha (umuthi ofana ne-peginterferon alfa-2b) esikhathini esedlule. I-Peginterferon alfa-2b isekilasini lemithi ebizwa ngama-interferon. I-Peginterferon alpha-2b iyinhlanganisela ye-interferon ne-polyethylene glycol, esiza i-interferon ukuthi ihlale isebenza emzimbeni wakho isikhathi eside. I-Peginterferon alpha-2b isebenza ngokwehlisa inani le-virus ye-hepatitis C (HCV) emzimbeni. I-Peginterferon alfa-2b ingahle ingelaphe i-hepatitis C noma ikuvikele ekutholeni izinkinga ze-hepatitis C ezifana ne-cirrhosis (scarring) yesibindi, ukwehluleka kwesibindi, noma umdlavuza wesibindi. I-Peginterferon alfa-2b kungenzeka ingavimbi ukusakazeka kwesifo sokusha kwesibindi kohlobo C kwabanye abantu.

I-Peginterferon alfa-2b iza njenge-powder esitsheni nasesipeni esisodwa somjovo womthamo wokuxuba noketshezi nokujova ngomgogodla (kusendlalelo esinamafutha ngaphansi kwesikhumba). Kuvamise ukujova kanye ngesonto ngosuku olufanayo lwesonto, ngasikhathi sosuku noma ngasikhathi sinye. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa i-peginterferon alfa-2b njengoba nje kuqondisiwe. Ungawusebenzisi kakhulu lo muthi noma uwusebenzise kaningi noma isikhathi eside kunokuyalelwa ngudokotela wakho.

I-Peginterferon alfa-2b ilawula i-hepatitis C kepha kungenzeka ingayelaphi. Qhubeka nokusebenzisa i-peginterferon alfa-2b noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa i-peginterferon alfa-2b ngaphandle kokukhuluma nodokotela wakho.

Sebenzisa kuphela uhlobo nohlobo lwe-interferon olunqunywe udokotela wakho. Ungasebenzisi olunye uhlobo lwe-interferon noma ushintshe phakathi kwe-peginterferon alfa-2b ezitsheni nasezibayeni zomjovo ngaphandle kokukhuluma nodokotela wakho. Uma ushintshela kuhlobo oluhlukile noma uhlobo lwe-interferon, umthamo wakho ungadinga ukuguqulwa.

Ungazijova i-peginterferon alfa-2b ngokwakho noma umngane noma isihlobo sikunikeze imijovo. Ngaphambi kokusebenzisa i-peginterferon alfa-2b okokuqala ngqa, funda imiyalo ebhaliwe eza nayo. Buza udokotela wakho noma usokhemisi ukuthi akubonise noma umuntu ozobe ejova umuthi ukuthi ungawujova kanjani. Uma omunye umuntu ezokujova ngemithi, qiniseka ukuthi uyazi ukuthi angazigwema kanjani izinti zezinaliti ngengozi ukuvimbela ukusabalala kwe-HCV.

Ungajova i-peginterferon alfa-2b noma yikuphi engxenyeni engaphandle yezingalo zakho ezingaphezulu, amathanga akho, noma isisu sakho ngaphandle kwenkaba yakho (inkinobho yesisu) kanye nesinqe. Musa ukujova esiswini sakho uma uzacile kakhulu. Sebenzisa indawo ehlukile ngomjovo ngamunye. Ungafaki i-peginterferon alfa-2b endaweni lapho isikhumba sibuhlungu khona, sibomvu, silimele, sinezibazi, sicasulwa, noma sithelelekile; inezimpawu zokulula noma izigaxa; noma engavamile nganoma iyiphi indlela.

Ungalokothi usebenzise noma wabelane ngamasirinji, izinaliti, izibaya zomjovo, noma izitsha zemithi. Lahla izinaliti, imijovo nezibaya zomjovo esitsheni esingamelana nokubhoboza. Khuluma nodokotela wakho noma usokhemisi mayelana nokuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Ukuze usebenzise ipeni lomjovo we-peginterferon alfa-2b, landela lezi zinyathelo:

1. Thatha ibhokisi eliqukethe ipeni lomjovo esiqandisini unikeze isikhathi sokuthi lifinyelele izinga lokushisa ekamelweni. Bheka usuku lokuphelelwa yisikhathi oluprintwe kwikhadibhodi, futhi ungalisebenzisi ibhokisi uma usuku lokuphelelwa yisikhathi seludlulile. Qiniseka ukuthi ibhokisi linezinto ezilandelayo: ipeni lomjovo, inaliti elahlwayo, neziphuzo zotshwala. Ungase futhi udinge ibhandeshi lokunamathisela kanye nocezu lukayesu oyinyumba ongakusebenzisa ngemuva komjovo wakho.
2. Bheka efasiteleni lepeni lomjovo bese uqinisekisa ukuthi ikamelo lokugcina igobolondo liqukethe ithebhulethi emhlophe qwa emhlophe ephelele noma eyizingcezu, noma impuphu.
3. Geza izandla zakho kahle ngensipho namanzi, hlambulula bese womisa ithawula. Kubalulekile ukugcina indawo osebenzela kuyo, izandla zakho, nendawo okujova kuyo kuhlanzekile ukuvikela ukutheleleka.
4. Bamba ipeni lomjovo liqonde (inkinobho yomthamo ibheke phansi). Ungasebenzisa phansi kwekhathoni njengetreyi yokulinganisa ukubamba ipeni endaweni yalo. Cindezela ndawonye uhhafu wesibaya ngokuqinile uze uzwe ukuchofoza.
5. Linda imizuzwana eminingana ukuze impuphu incibilike ngokuphelele.
6. Ngobumnene vula ipeni lomjovo ubheke phansi kabili ukuxuba ikhambi. Unganyakazisi ipeni lomjovo.
7. Phendulela ipeni lomjovo ohlangothini lwesokudla phezulu bese ubheka ngefasitela ukubona ukuthi isixazululo esixubekile sichithwe ngokuphelele. Uma kusekhona igwebu, linda lize lizinze. Kujwayelekile ukubona amabhamuza amancane eduze kwaphezulu kwesixazululo. Uma ikhambi lingacaci noma uma ubona izinhlayiya, ungalisebenzisi, bese ufonela udokotela noma usokhemisi wakho.
8. Faka ipeni lomjovo kuthileyi lomthamo, nenkinobho yokufaka ngezansi. Sula isembozo senjoloba sepeni lomjovo ngephedi yotshwala.
9. Susa ithebhu lephepha lokuvikela enalithini yomjovo. Gcina ipeni lomjovo liqonde threyi lomthamo bese ucindezela ngobumnene inaliti yomjovo ngqo epeni lomjovo. Sula inaliti ngokuphepha endaweni. Ungabona okunye uketshezi kuphuma ngaphansi kwekepisi imizuzwana embalwa. Linda kuze kume lokhu ngaphambi kokuya esinyathelweni esilandelayo.
10. Susa ipeni lomjovo kuthileyi wethamo. Bamba ipeni ngokuqinile bese ukhipha inkinobho yokufaka emzimbeni lapho izohamba khona, uze ubone amabhande amnyama (imigqa) engezansi kwenkinobho yokulinganisa. Qaphela ukuthi ungacindezeli inkinobho yokufaka ngaphakathi uze ulungele ukujova umuthi.
11. Guqula inkinobho yokufaka kuze kube yilapho inombolo efana nedosi yakho enqunyiwe ihlanganiswe nethebhu yokulinganisa. Uma ungaqiniseki ukuthi iyiphi inombolo efana nomthamo wakho, yima, bese ushayela udokotela noma usokhemisi ngaphambi kokujova noma imuphi umuthi.
12. Khetha indawo yakho yomjovo bese uhlanza isikhumba endaweni ngephedi yotshwala. Lindela indawo ezokoma.
13. Susa ikepisi elingaphandle enalithini yenaliti yomjovo. Kungaba noketshezi oluzungeze ikepisi lenaliti yangaphakathi. Lokhu kujwayelekile. Lapho isikhumba endaweni yomjovo sesomile, khipha ikepisi lenaliti yangaphakathi. Qaphela ukuthi ungathinti inaliti nganoma yini.
14. Bamba ipeni lomjovo ngeminwe yakho ezungezwe umgqomo womzimba wepeni nesithupha sakho kunkinobho yokulinganisa.
15. Ngesinye isandla sakho, nciphisa isikhumba endaweni oyihlanzele umjovo. Faka inaliti esikhunjeni esicwilisiwe engxenyeni yama-degree angama-45 kuya kwangu-90.
16. Jova umuthi ngokucindezela inkinobho yokulinganisa phansi kancane nangokuqinile uze ungakwazi ukuyiqhubekisela phambili. Gcina isithupha sakho sicindezelwe phansi kunkinobho yokulinganisa ukuze uthole eminye imizuzwana emi-5 ukuze uqiniseke ukuthi uthola umthamo ophelele.
17. Donsela inaliti yepeni lomjovo esikhunjeni sakho nge-engeli efanayo oyifaka esikhunjeni sakho.
18. Cindezela ngobumnene indawo yomjovo ngebhandishi elincane noma nge-gauze oyinyumba uma kunesidingo imizuzwana embalwa, kodwa ungawubhucabhubi noma uwuhlikihle indawo okujova kuyo.
19. Uma kukhona ukopha, vala indawo yomjovo ngebhandeshi lokunamathela.
20. Lahla ipeni lomjovo inaliti isanamathele esitsheni esingabhobozi. Ungayiphindi inaliti.
21. Ngemuva kwamahora amabili ujove, hlola indawo yomjovo ukuthi ibomvu, ukuvuvukala, noma isisa. Uma unokuthinta kwesikhumba futhi kungacaci ezinsukwini ezimbalwa noma kubi kakhulu, shayela udokotela wakho noma unesi.

Ukuze usebenzise i-peginterferon alfa-2b ku-vial, landela lezi zinyathelo:

1. Geza izandla zakho kahle ngensipho namanzi, hlambulula, bese womisa ithawula.
2. Bheka usuku lokuphelelwa yisikhathi oluprintwe kwikhadibhodi le-peginterferon alfa-2b futhi ungalisebenzisi ibhokisi uma usuku lokuphelelwa yisikhathi seludlulile. Khipha izimpahla ezilandelayo ebhokisini ulibeke endaweni yokusebenza ehlanzekile: isitsha se-peginterferon alfa-2b, isitsha samanzi oyinyumba somjovo (i-diluent), imijovo emibili enezinaliti ezixhunywe, namaphakethe otshwala.
3. Susa isisongeli sokuzivikela kwesinye sezirinji.
4. Khipha amakepisi wokuzivikela eziqongweni zesitsha se-peginterferon alfa-2b kanye ne-vial diluent. Hlanza izitobha zenjoloba eziqongweni zazo zombili izitsha ngephedi yotshwala.
5. Susa ikepisi lenaliti evikelayo bese ugcwalisa isirinji ngomoya ngokudonsela i-plunger emuva kumaki we-0.7 mL emgqonyeni.
6. Bamba isitsha samanzi oyinyumba siqonde ngaphandle kokuthinta phezulu okuhlanziwe ngezandla zakho.
7. Faka inaliti yesirinji ngesitobha senjoloba bese ucindezela phansi ku-plunger ukujova umoya ovela esirinji ungene esitsheni.
8. Guqula i-vial ubheke phansi nesirinji isanamathiselwe, futhi uqiniseke ukuthi ichopho lenaliti lisoketshezi. Donsela phansi u-0.7 mL wamanzi oyinyumba ngokudonsa isipontsho ubuyele ngqo kumaki we-0.7 mL.
9. Susa inaliti esitsheni esincibilikayo ngokuyidonsa iqonde phezulu esitobhini senjoloba. Ungathinti inaliti nganoma yini.
10. Faka inaliti ngesitobha senjoloba sesivalo se-peginterferon alfa-2b, bese ubeka ithiphu yenaliti odongeni lwengilazi lwe-vial.
11. Faka kancane u-0.7 ml wamanzi oyinyumba ukuze yehle ngengilazi ngaphakathi kwesivalo. Musa ukukhomba ukusakazwa kwamanzi oyinyumba empuphu emhlophe ezansi kwesitsha.
12. Susa inaliti esitsheni ngokudonsa isirinji uqonde ngqo esitobhini senjoloba. Bamba umkhono wezokuphepha uwuqinise bese uwudonsela phezu kwenaliti uze uzwe ukuchofoza futhi umugqa oluhlaza okuso mkhono umboza umugqa obomvu enalithini. Chitha isirinji esitsheni esiveza ukubhoboza.
13. Gwema ngobumnene i-vial ngokunyakaza okuyindilinga kuze kube yilapho i-powder ichithwa ngokuphelele. Uma isixazululo sibanda, gingqa isitsha ngobumnene ezandleni zakho ukusifudumeza.
14. Uma amabhamuza omoya akhe, linda kuze kufike lapho isixazululo sesilungile futhi onke amagwebu enyukele phezulu kwesixazululo futhi anyamalala ngaphambi kokuya esinyathelweni esilandelayo.
15. Bheka ngokucophelela uketshezi olusebhodleleni. Musa ukujova uketshezi ngaphandle kokuthi kucace, kungenambala, futhi akuqukethe izinhlayiya.
16. Hlanza isivalo senjoloba esitsheni se-peginterferon alfa-2b futhi ngenye iphedi yotshwala.
17. Susa okufakwayo okuvikelayo kusirinji yesibili. Susa ikepisi evikelayo enalithini yesipontsho.
18. Gcwalisa isirinji ngomoya ngokudonsela i-plunger kumaki we-mL ofana nomthamo wakho onqunyiwe. Uma ungaqiniseki ukuthi imuphi umjovo wesirinji ofana nomthamo wakho, yima bese ushayela udokotela noma usokhemisi ngaphambi kokujova umuthi.
19. Bamba umfuma we-peginterferon alfa-2b ume ngaphandle kokuthinta phezulu kwesihlanza esihlanzekile ngezandla zakho.
20. Faka inaliti yesirinji esitsheni sesisombululo se-peginterferon alfa-2b, bese ucindezela phansi ku-plunger ukujova umoya ku-vial.
21. Bamba isitsha nomjovo bese ujikisa kancane i-vial ubheke phansi nenaliti isengaphakathi kwesivalo. Gcina ithiphu yenaliti kusixazululo.
22. Kancane kancane donsela i-plunger yesirinji emuva kumaki ofanele ukukhipha inani le-peginterferon alfa-2b elinqunywe udokotela wakho.
23. Donsela isirinji ngqo ngaphandle kwesitsha. Ungathinti inaliti nganoma yini.
24. Bheka amagwebu omoya kusirinji. Uma ubona noma yimaphi amagwebu, bamba isirinji ngenaliti ekhombe phezulu bese uthinta ngobumnene isirinji kuze kuphume amagwebu. Ngemuva kwalokho, cindezela ngokucophelela isipuni se-syringe kancane kancane kuze kuphele amabhamu, ngaphandle kokucindezela noma yisiphi isixazululo ngaphandle kwesirinji.
25. Khetha indawo yokujova bese uhlanza isikhumba endaweni ngephedi yotshwala. Lindela indawo ezokoma.
26. Susa ikepisi lokuzivikela enalithini. Qiniseka ukuthi umkhono wokuphepha wesirinji ucindezelwe ngokuqinile emgqeni wesirinji ukuze inaliti ivezwe ngokuphelele.
27. Gcoba isikhumba esivulekile esingu-2-intshi (5-centimeter) sesikhumba esivulekile endaweni yomjovo. Ngesinye isandla sakho, thatha isipontsho usibambe njengepensela ngephuzu (wotho) wenaliti ubheke phezulu. Phusha inaliti cishe u-1/4 intshi (amasentimitha angu-0.6) esikhunjeni esicwilisiwe nge-engela engu-45- kuya ku-90-degree, usebenzisa i-quick, efana ne-dart.
28. Vumela isikhumba esincinyiwe sikhululeke bese usebenzisa leso sandla ukusiza ukubamba umgqomo wesirinji.
29. Donsa i-plunger yesirinji emuva kancane. Uma igazi lingena esirinji, inaliti ingene emthanjeni wegazi. Musa ukujova. Khipha inaliti nge-engeli elifanayo oyifaka esikhunjeni, bese ulahla isipontsho esitsheni esingavimba ukubhoboza. Phinda lezi zinyathelo ezingenhla ukulungisa umthamo omusha usebenzisa isipontsho esisha nesitsha esisha. Uma kungekho gazi elingena esirinji, jovela umuthi ngokucindezela ngobumnene iplunger ize iye phansi emgqonyeni wesirinji.
30. Bamba iphedi yotshwala eduze kwenaliti bese udonsa inaliti iqonde ngqo esikhunjeni. Cindezela iphedi yotshwala ngaphezulu kwesiza somjovo imizuzwana embalwa. Ungahlikihli noma uhlikihle isiza somjovo. Uma kunopha, lumboze ngebhandishi.
31. Mboza isirinji ngomkhono wokuphepha ngendlela efanayo naleyo owimboze ngayo isirinji yokuqala. (Bheka Isinyathelo 12 ngenhla.) Lahla isirinji nenaliti esitsheni esingavimba ukubhoboza.
32. Ngemuva kwamahora amabili ujove, hlola indawo yomjovo ukuthi ibomvu, ukuvuvukala, noma isisa. Uma unokuthinta kwesikhumba futhi kungacaci ezinsukwini ezimbalwa noma kubi kakhulu, shayela udokotela wakho noma unesi.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-peginterferon alfa-2b,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-peginterferon alfa-2b, amanye ama-alpha interferon, noma imiphi eminye imithi, noma i-polyethylene glycol (i-PEG). Buza udokotela wakho ukuthi awunasiqiniseko sokuthi umuthi owugulisayo yi-alpha interferon.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO kanye ne-methadone (iDolophine, iMethadose). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• Tshela udokotela wakho noma usokhemisi uma ngabe uke wafakelwa isitho somzimba (ukuhlinzekwa ukufaka ingxenye yomzimba) noma uma uke waba nanoma yimiphi imibandela eshiwo esigabeni ESIBALULEKILE SEXWAYISO noma okunye kwalokhu okulandelayo: izinkinga zokulala, noma izinkinga ngamehlo akho noma amanyikwe.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. I-Peginterferon alfa-2b ingalimaza umbungu noma ikwenze ukuthi uphuphume (ulahlekelwe yingane yakho). Khuluma nodokotela wakho ngokusebenzisa isilawuli sokubeletha ngenkathi uthatha lo muthi. Akufanele uncelise ibele ngenkathi uthatha lo muthi.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthatha i-peginterferon alfa-2b.
• kufanele wazi ukuthi i-peginterferon alfa-2b ingakwenza ukozele, ube nesiyezi, noma udideke. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• kufanele wazi ukuthi ungahlangabezana nezimpawu ezinjengomkhuhlane, umkhuhlane, izinhlungu zemisipha, nobuhlungu obuhlangene ngesikhathi sokwelashwa kwakho nge-peginterferon alfa-2b. Uma lezi zimpawu ziyakhathaza, buza udokotela wakho ukuthi kufanele yini uthathe izinhlungu zokuthenga nokunciphisa imfiva ngaphambi kokujova umthamo ngamunye we-peginterferon alfa-2b. Ungahle ufune ukujova i-peginterferon alfa-2b ngesikhathi sokulala ukuze ukwazi ukulala ngezimpawu.
• hlela ukuphumula ngokwanele nokuvivinya umzimba okuvamile ngesikhathi sokwelashwa kwakho. Khuluma nodokotela wakho ngezindlela eziphephile zokuzivocavoca ngesikhathi sokwelashwa kwakho.

Phuza okungenani izingilazi ezi-10 ezigcwele zamanzi noma amajusi acwebile ngaphandle kwe-caffeine noma utshwala nsuku zonke ngenkathi welashwa nge-peginterferon alfa-2b. Qaphela ikakhulukazi ukuphuza uketshezi olwanele emasontweni okuqala okwelashwa kwakho.

Qiniseka ukuthi udla kahle ngesikhathi sokwelashwa kwakho. Uma uphethwe yisisu noma ungenaso isifiso sokudla, yidla ukudla okulula okulula noma ukudla okuncane okuncane usuku lonke.

Uma ukhumbula umthamo ongabanjwanga kungakadluli usuku ngemuva kokuhlelelwa ukuwujova, jovela umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Bese ujove umthamo wakho olandelayo ngosuku lwakho oluhleliwe njalo ngesonto elilandelayo. Uma ungakhumbuli umthamo ongabanjwanga kuze kudlule izinsuku ezimbalwa, hlola udokotela wakho ngalokho okufanele ukwenze. Ungawuphindi kabili umthamo olandelayo noma uthathe umthamo ongaphezu kowodwa ngesonto ngaphandle kokukhuluma nodokotela wakho.

I-Peginterferon alfa-2b ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ukulimaza, ubuhlungu, ububomvu, ukuvuvukala, ukulunywa, noma ukucasuka endaweni lapho ujove khona i-peginterferon alfa-2b
• isicanucanu
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• shintsha ngendlela izinto ezinambitha ngayo
• isifo sohudo
• ukuqunjelwa
• isilungulela
• ukuncipha komzimba
• ikhanda
• isiyezi
• ukudideka
• ukulahleka kwezinwele noma ukuncipha
• ukulunywa
• ubunzima bokugxila
• ukuzwa kubanda noma kushisa ngaso sonke isikhathi
• izinguquko esikhunjeni sakho
• umlomo owomile
• ukujuluka
• ukuqhuma
• ikhala eligijimayo
• ubunzima bokulala noma ukulala

Eminye imiphumela emibi ingaba mibi. Lezi zimpawu ezilandelayo azivamile, kepha uma uhlangabezana nenye yazo, noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha:

• ukuqubuka
• isifuba
• ubunzima bokugwinya
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, amehlo, izandla, izinyawo, amaqakala noma imilenze engezansi
• ukushaqeka
• ukushaya kwenhliziyo okusheshayo
• isikhumba esiphaphathekile
• ubuhlungu beqolo

I-Peginterferon alfa-2b ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina izibaya zomjovo we-peginterferon alfa-2b esiqandisini, futhi ungazivezi ekushiseni. Gcina izitsha ze-peginterferon alfa-2b powder ekamelweni lokushisa futhi kude nokushisa okwedlulele nomswakama (hhayi endlini yangasese) Kungcono ukujova isisombululo se-peginterferon alfa-2b ezitsheni noma ezibayeni zomjovo ngemuva kokuxubana. Uma kunesidingo, izimbiza noma izibaya zomjovo eziqukethe isisombululo se-peginterferon alfa-2b esilungisiwe zingagcinwa esiqandisini amahora angafika kwangu-24. Ungafaki i-peginterferon alfa-2b.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Uma isisulu singawile, shayela udokotela okuyalele lo muthi. Udokotela angafuna ukuhlola isisulu eduze kakhudlwana futhi enze izivivinyo zaselebhu.

Ungavumeli noma ngubani omunye umuntu ukuthi asebenzise umuthi wakho noma enye yezimpahla zakho zomjovo. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

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