Isihloko se-Estradiol

-Delile

• Ukuze usebenzise ijeli le-estradiol, landela lezi zinyathelo:
• Ukuze usebenzise i-estradiol emulsion, landela lezi zinyathelo:
• Ngaphambi kokusebenzisa i-estradiol yama-topical,
• I-estradiol yesihloko ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

I-Estradiol yandisa ubungozi bokuthi uzoba nomdlavuza we-endometrium (umdlavuza wolwelwesi lwesibeletho [isibeletho]). Uma usebenzisa i-estradiol isikhathi eside, iba nkulu ingozi yokuba nomdlavuza we-endometrium. Uma ungazange ube ne-hysterectomy (ukuhlinzwa ukukhipha isibeletho), kufanele unikezwe omunye umuthi obizwa nge-progestin ongawuthatha nge-topical estradiol. Lokhu kunganciphisa ingozi yokuba nomdlavuza we-endometrium kepha kungakhuphula ubungozi bokuthola ezinye izinkinga zempilo, kufaka phakathi umdlavuza webele. Ngaphambi kokuba uqale ukusebenzisa i-estradiol ye-topical, tshela udokotela wakho uma ngabe unomdlavuza noma uke waba nomdlavuza futhi uma wopha ngokweqile noma ngokungajwayelekile esithweni sangasese sowesifazane. Shayela udokotela wakho ngokushesha uma unegazi elingajwayelekile noma elingajwayelekile ngesikhathi sowelashwa nge-topical estradiol. Udokotela wakho uzokubuka eduze ukuze akusize uqinisekise ukuthi awunawo umdlavuza we-endometrium ngesikhathi noma ngemuva kokwelapha kwakho.

Ocwaningweni olukhulu, abesifazane abathathe ama-estrogens (iqembu lemithi efaka i-estradiol) ngomlomo nama-progestin babesengozini enkulu yokuhlaselwa yisifo senhliziyo, imivimbo, amahlule egazini emaphashini noma emilenzeni, umdlavuza webele, kanye nokuwohloka komqondo (ukulahlekelwa yikhono cabanga, funda, futhi uqonde). Abesifazane abasebenzisa i-topical estradiol bodwa noma ngama-progestin bangaba nengozi enkulu yokuthuthukisa lezi zimo. Tshela udokotela wakho uma ubhema noma ubhema ugwayi, uma uke wahlaselwa yinhliziyo noma wahlaselwa isifo sohlangothi ngonyaka odlule futhi uma wena noma omunye emndenini wakho uke waba namahlule egazini noma umdlavuza webele. Phinda utshele udokotela wakho uma uke waba nomfutho wegazi ophakeme noma waba nomfutho ophakeme wegazi, amazinga aphezulu egazi e-cholesterol noma amafutha, isifo sikashukela, isifo senhliziyo, i-lupus (isimo lapho umzimba uhlasela izicubu zawo ezidala ukulimala nokuvuvukala), izigaxa zamabele, noma i-mammogram engajwayelekile (i-x-ray yebele esetshenziselwa ukuthola umdlavuza webele).

Lezi zimpawu ezilandelayo zingaba yizimpawu zezimo ezibucayi zezempilo ezibalwe ngenhla.Shayela udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo ngenkathi usebenzisa i-estradiol ye-topical: ikhanda elibuhlungu, elibuhlungu; ukuhlanza okungazelelwe, okunzima; izinkinga zokukhuluma; isiyezi noma ukuquleka; ukulahleka okungazelelwe okuphelele noma okuncane kombono, ukubona kabili; ubuthakathaka noma ukuba ndikindiki kwengalo noma komlenze; ukuchoboza ubuhlungu besifuba noma isisindo sesifuba; ukukhwehlela igazi; ukuphefumula ngokuzumayo; izigaxa zamabele noma ezinye izinguquko zamabele; khulula izingono; ubunzima bokucabanga kahle, ukukhumbula, noma ukufunda izinto ezintsha; noma ubuhlungu, ubumnene, noma ubomvu emlenzeni owodwa.

Ungathatha izinyathelo zokwehlisa ubungozi bokuthi uzoba nenkinga enkulu yezempilo ngenkathi usebenzisa i-estradiol yama-topical. Ungasebenzisi i-topical estradiol wedwa noma ne-progestin ukuvikela isifo senhliziyo, isifo senhliziyo, noma imivimbo. Sebenzisa umthamo ophansi kakhulu we-estradiol yama-topical elawula izimpawu zakho futhi usebenzise kuphela i-estradiol yama-topical uma kudingeka. Khuluma nodokotela wakho njalo ezinyangeni ezi-3-6 ukunquma ukuthi kufanele usebenzise umthamo ophansi we-topical estradiol noma kufanele uyeke ukusebenzisa umuthi.

Kufanele uhlole amabele akho njalo ngenyanga futhi une-mammogram kanye nokuhlolwa kwebele okwenziwa ngudokotela minyaka yonke ukusiza ukuthola umdlavuza webele ngokushesha ngangokunokwenzeka. Udokotela wakho uzokutshela ukuthi ungawahlola kanjani kahle amabele akho nokuthi ngabe kufanele ube nalezi zivivinyo kaningi ngaphezu kwesisodwa ngonyaka ngenxa yomlando wakho wezempilo noma womndeni.

Tshela udokotela wakho uma uhlinzwa noma uzobe usembhedeni. Udokotela wakho angakutshela ukuthi uyeke ukusebenzisa i-topical estradiol amasonto ama-4-6 ngaphambi kokuhlinzwa noma indawo yokulala ukunciphisa ingozi yokuthi uzoba namahlule egazi.

Khuluma nodokotela wakho njalo mayelana nezingozi nezinzuzo zokusebenzisa i-estradiol yama-topical.

I-Estradiol topical gel kanye ne-emulsion (ingxube yohlobo lwe-lotion) isetshenziselwa ukwelapha nokuvimbela ukushisa okushisayo (ukushisa okushisayo; imizwa enamandla yokushisa nokujuluka) kwabesifazane ababhekene nokunqamuka kokuya esikhathini (ushintsho lwempilo, ukuphela kwezikhathi zokuya esikhathini njalo ngenyanga). I-gel yama-topical ye-Estradiol nayo isetshenziselwa ukwelapha ukoma kwesitho sangasese sowesifazane, ukulunywa nokushisa kwabesifazane ababhekene nokunqamuka kokuya esikhathini. Kodwa-ke, abesifazane abanezimpawu ezihluphayo kuphela ukushisa kwesitho sangasese sowesifazane, ukulunywa, nokoma bangazuza kakhulu emithini esetshenziswe phezulu esithweni sangasese. I-Estradiol isekilasini lemithi ebizwa ngama-estrogen hormone. Isebenza ngokufaka esikhundleni se-estrogen evame ukukhiqizwa ngumzimba.

I-toprostol estradiol iza njengejeli, isifutho, kanye ne-emulsion yokufaka esikhunjeni. Ngokuvamile kufakwa kanye ngosuku. I-Estradiol emulsion kufanele isetshenziswe ekuseni. Ijeli le-Estradiol lingasetshenziswa noma ngasiphi isikhathi sosuku, kepha kufanele lisetshenziswe ngasikhathi sosuku zonke izinsuku. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa i-estradiol yama-topical njengoba iqondisiwe. Ungayisebenzisi ngaphezulu noma ngaphansi kwayo noma uyisebenzise kaningi kunokuyalelwa ngudokotela wakho.

Uma usebenzisa ijeli le-estradiol, kufanele ulisebenzise ungqimba oluncane engalweni eyodwa, ukusuka esihlakaleni kuye ehlombe. Uma usebenzisa i-estradiol emulsion, kufanele uyisebenzise kuwo womabili amathanga namathole (imilenze engezansi). Ungafaki i-estradiol gel noma i-emulsion emabeleni akho. Qiniseka ukuthi isikhumba lapho uzofaka khona i-topical estradiol sihlanzekile futhi somile ngokuphelele, futhi asibomvu, asicasukile, noma asiphukile.

Uma ugeza noma ugeza noma usebenzisa i-sauna, sebenzisa i-topical estradiol ngemuva kokuqeda ukugeza, ukushawa noma ukusebenzisa i-sauna futhi usomise isikhumba sakho ngokuphelele. Uma uhlela ukubhukuda, vumela isikhathi esiningi ngangokunokwenzeka phakathi kokufaka ijeli ye-estradiol nokubhukuda. Ungasebenzisi i-sunscreen kungekudala ngaphambi kwalokho, ngasikhathi sinye, noma ngemuva nje kokufaka i-estradiol yama-topical.

Ijeli le-Estradiol lingasha. Uma ufaka i-estradiol gel, ungabhemi noma usondele emlilweni noma uvule ilangabi kuze kube yilapho ijeli yoma.

Qaphela ukuthi ungatholi ijeli ye-estradiol emehlweni akho. Uma uthola ijeli le-estradiol emehlweni akho, geza ngamanzi amaningi afudumele khona manjalo. Shayela udokotela uma amehlo akho ecasuka.

Kufanele usebenzise ijeli ye-estradiol ngokwakho. Ungavumeli noma ngubani omunye ahlikihle ijeli esikhunjeni sakho.

Ukuze usebenzise ijeli le-estradiol, landela lezi zinyathelo:

1. Ngaphambi kokusebenzisa umthamo wakho wokuqala we-gel ye-estradiol, susa ikhava enkulu yepompo bese ucindezela ngokugcwele iphampu kabili. Geza ijeli eliphuma phansi kusinki noma ulilahle ngokuphepha ukuze lingafinyeleleki ezinganeni nasezifuyweni. Lokhu kubamba ipompo ukuze ikhiphe inani elifanayo lemithi njalo lapho icindezelwa. Ungasiphindi lesi sinyathelo ngemuva kokuqala kokusebenzisa ipompo.
2. Bamba ipompo ngesandla esisodwa bese ufaka inkomishi yesinye isandla sakho ngezansi kombhobho wepompo. Cindezela ipompo ngokuqinile nangokuphelele ukukhipha umthamo owodwa wejel entendeni yesandla sakho.
3. Sebenzisa isandla sakho ukusabalalisa ijeli ngokuncanyana ngangokunokwenzeka kuyo yonke ingalo yakho. Zama ukumboza ingaphakathi nengaphandle lengalo yakho kusukela esihlakaleni kuye ehlombe ngejeli.
4. Ungayihlikihli noma uyihlikihle ijeli esikhunjeni sakho. Linda imizuzu engu-5 ukuvumela isikhumba some ngaphambi kokumboza ingalo yakho ngezingubo.
5. Mboza iphampu ngamakepisi amancane namakhulu okuvikela.
6. Geza izandla zakho ngensipho namanzi.

Ukuze usebenzise i-estradiol emulsion, landela lezi zinyathelo:

1. Thola izikhwama ezimbili ze-estradiol emulsion bese uhlala endaweni enethezekile.
2. Vula isikhwama esisodwa se-estradiol emulsion ngokusika noma ukudabula amanothi eduze kwaphezulu kwesikhwama.
3. Beka isikhwama esicaba ngaphezulu kwethanga lakho lesobunxele bese ukuphela okuvulekile kubheke edolweni lakho.
4. Bamba isiphetho esivaliwe sesikhwama ngesandla esisodwa bese usebenzisa umunwe wangaphambili wesinye isandla ukusunduza wonke ama-emulsion asesikhwameni ethangeni lakho.
5. Sebenzisa isandla esisodwa noma sobabili ukugcoba i-emulsion kulo lonke ithanga lakho nethole imizuzu emithathu uze ungene ngokuphelele.
6. Hlikihla noma iyiphi i-emulsion esele ezandleni zakho ezinqeni.
7. Phinda izinyathelo 1-6 usebenzisa isikhwama esisha se-estradiol emulsion kanye nethanga lakho langakwesokudla ukuze ufake okuqukethwe kwesikhwama sesibili ethangeni lakho langakwesokudla nethole.
8. Linda kuze kube yilapho isikhumba lapho ufake khona i-estradiol emulsion sesomile ngokuphelele bese usimboza ngezingubo.
9. Geza izandla zakho ngensipho namanzi.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokusebenzisa i-estradiol yama-topical,

• Tshela udokotela kanye nosokhemisi wakho uma une-aleji ku-estradiol gel noma i-emulsion, noma imiphi eminye imikhiqizo ye-estrogen, noma imiphi eminye imithi, noma iziphi izithako ze-gel ye-estradiol noma i-emulsion. Buza usokhemisi wakho ukuthola uhlu lwezithako ze-gel ye-estradiol noma i-emulsion noma uma ungenaso isiqiniseko sokuthi umuthi owugulayo une-estrogen.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela nemishanguzo ongayinikiwe, amavithamini, nezithako zokudla okunomsoco, okwenzayo noma ohlela ukukuthatha. Qiniseka ukuthi usho noma yikuphi kokulandelayo: ama-antifungal anjenge-itraconazole (Sporanox) ne-ketoconazole (Nizoral); carbamazepine (Carbatrol, Epitol, Tegretol); i-clarithromycin (i-Biaxin); i-erythromycin (E.E.S, i-Erythrocin); i-lovastatin (Altocor, Mevacor); imithi yesifo se-thyroid; i-phenobarbital; i-rifampin (iRifadin, iRimactane, eRifamate); kanye ne-ritonavir (iNorvir, eKaletra), Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.
• tshela udokotela wakho uma uke waba nesifo somoya noma wake waba naso? ukuquleka; ikhanda le-migraine; i-endometriosis (isimo lapho uhlobo lwethishu eligudla isibeletho [isibeletho] lukhula kwezinye izindawo zomzimba); i-uterine fibroids (ukukhula esibelethweni okungewona umdlavuza); ukuphuzi kwesikhumba noma kwamehlo, ikakhulukazi ngesikhathi sokukhulelwa noma ngenkathi usebenzisa umkhiqizo we-estrogen; amazinga aphezulu kakhulu noma aphansi kakhulu e-calcium egazini lakho; i-porphyria (isimo lapho izinto ezingajwayelekile zakha khona egazini futhi zidale izinkinga ngesikhumba noma ngohlelo lwezinzwa) noma i-gallbladder, igilo, isibindi, amanyikwe, noma isifo sezinso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Uma ukhulelwa ngenkathi usebenzisa i-estradiol yama-topical, shayela udokotela wakho.
• hlela ukugwema ukuvezwa yilanga ngokungadingekile noma isikhathi eside futhi ugqoke izingubo zokuzivikela, izibuko zelanga, nesikhumba selanga. Khumbula ukuvumela isikhathi esithile phakathi kokusebenzisa i-estradiol yama-topical nokufaka i-sunscreen. Ijeli le-Estradiol lingenza isikhumba sakho sizwele ekukhanyeni kwelanga.
• kufanele wazi ukuthi i-estradiol yama-topical ingalimaza abanye abantu abathinta umuthi osesikhunjeni sakho noma esitsheni. Kuyingozi kakhulu kwabesilisa nasezinganeni. Ungavumeli omunye umuntu ukuthi akuthinte isikhumba lapho ufake khona i-estradiol ye-topical ihora elilodwa ngemuva kokufaka umuthi. Uma othile ethinta i-estradiol yama-topical, lowo muntu kufanele ageze isikhumba sakhe ngensipho namanzi ngokushesha okukhulu.

Khuluma nodokotela wakho mayelana nokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthatha lo muthi.

Uma ukhohlwa ukusebenzisa umthamo we-gel ye-estradiol kodwa ukhumbule ngaphezu kwamahora ayi-12 ngaphambi kokuthi uhlelelwe ukusebenzisa umthamo wakho olandelayo, sebenzisa umthamo ongabanjwanga khona manjalo. Uma ukhumbula ngaphansi kwamahora angu-12 ngaphambi kokuthi uhlelelwe ukusebenzisa umthamo wakho olandelayo, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile ngosuku olulandelayo. Ungafaki i-gel eyengeziwe ukwenzela umthamo ophuthelwe.

Uma ukhohlwa ukufaka i-estradiol emulsion ekuseni, yisebenzise ngokushesha lapho ukhumbula. Ungafaki i-emulsion eyengeziwe ukwenzela umthamo ophuthelwe futhi ungasebenzisi i-estradiol emulsion ngaphezu kwesisodwa usuku ngalunye.

I-estradiol yesihloko ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ikhanda
• ubuhlungu besifuba noma isisa
• isicanucanu
• isifo sohudo
• ukuqunjelwa
• igesi
• isilungulela
• ukuzuza kwesisindo noma ukwehla
• ukuguquka kwemizwelo
• ukudana
• uvalo
• ubuthongo
• ubunzima bokulala noma ukulala
• izinguquko ezifisweni zocansi
• ukuhlungu obusemhlane
• ikhala eligijimayo
• ukukhwehlela
• izimpawu ezinjengomkhuhlane
• ukulahleka kwezinwele
• ukukhula kwezinwele okungafuneki
• mnyama kwesikhumba ebusweni
• ubunzima bokugqoka amalensi wokuxhumana
• ukucasuka noma ukubomvu kwesikhumba lapho usebenzise khona i-estradiol yama-topical
• ukuvuvukala, ukubomvu, ukushisa, ukucasula, noma ukulunywa kwesitho sangasese sowesifazane
• ukukhishwa kwesitho sangasese sowesifazane

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• Amehlo aqhamukayo
• ukuphuzi kwesikhumba noma kwamehlo
• ukulunywa
• ukulahlekelwa isifiso sokudla
• imfiva
• ubuhlungu obuhlangene
• isisu sesisu, ubuhlungu, noma ukuvuvukala
• ukunyakaza okunzima ukulawula
• isifuba
• ukuqubuka noma amabhamuza esikhunjeni
• ukuvuvukala, kwamehlo, kobuso, izindebe, ulimi, umphimbo, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ukushaqeka
• isifuba
• ukuphefumula kanzima noma ukugwinya

I-toprostol estradiol ingakhuphula ingozi yokuba nomdlavuza wama-ovari kanye nesifo se-gallbladder esingadinga ukwelashwa ngokuhlinzwa. Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi.

I-estradiol yesihloko ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Ungafrizi i-estradiol yama-topical. Gcina ijeli ye-estradiol kude nelangabi elivulekile. Lahla ipompo yakho ye-estradiol gel ngemuva kokusebenzisa imithamo engama-64 noma ngabe ayinalutho ngokuphelele.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• isicanucanu
• ukuhlanza
• ukopha esithweni sangasese

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho angalawula izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho ku-estradiol yama-topical.

Ngaphambi kokwenza noma yiluphi uvivinyo lwelabhoratri, tshela udokotela wakho kanye nabasebenzi belebhuthi ukuthi usebenzisa i-estradiol eyisihloko.

Ungavumeli omunye umuntu asebenzise imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UDivigel^®
• U-Elestrin^®
• I-Estrasorb^®
• I-EstroGel^®
• I-Evamist^®

• Ukwelashwa Kwe-Estrogen Replacement
• ERT