Ukujova kwe-Irinotecan

-Delile

• Ngaphambi kokuthola i-irinotecan,
• I-Irinotecan ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:
• Izimpawu zokudlula ngokweqile zingafaka:

Umjovo we-Irinotecan kufanele unikezwe ngaphansi kokuqondisa kukadokotela onolwazi lokunikeza imishanguzo yamakhemikhali yomdlavuza.

Ungathola lezi zimpawu ezilandelayo ngenkathi uthola umthamo we-irinotecan noma kuze kube amahora angama-24 ngemuva kwalokho: ikhala eligobayo, amathe akhuphukile, abafundi abanciphayo (imibuthano emnyama phakathi kwamehlo), amehlo anamanzi, ukujuluka, ukugeleza, uhudo ( kwesinye isikhathi kubizwa ngokuthi 'yisifo sohudo sakuqala'), kanye neziqubu zesisu. Tshela udokotela wakho uma uhlangabezana nalezi zimpawu. Udokotela wakho angakunika imithi yokuvikela noma yokwelapha lezi zimpawu.

Ungase futhi ube nohudo olunzima (kwesinye isikhathi olubizwa ngokuthi '' uhudo sekwedlule isikhathi '') ngaphezu kwamahora angama-24 ngemuva kokuthola i-irinotecan. Lolu hlobo lohudo lungasongela impilo ngoba lungahlala isikhathi eside futhi luholele ekuphelelweni amanzi emzimbeni, ekuthelelekeni, ekuhlulekeni kwezinso, nakwezinye izinkinga. Tshela udokotela wakho uma uke waba nokuvinjelwa kwamathumbu noma ukuvimbela emathunjini akho. Tshela udokotela kanye nosokhemisi wakho uma usebenzisa noma iyiphi yale mithi elandelayo: eminye imithi yokwelapha ngamakhemikhali yomdlavuza; isisu (‘amaphilisi amanzi’); noma ama-laxatives afana ne-bisacodyl (Dulcolax) noma i-senna (e-Correctol, Ex-Lax, Peri-Colace, Senokot).

Ngaphambi kokuba uqale ukwelashwa kwakho nge-irinotecan, khuluma nodokotela wakho ukuthi yini okufanele uyenze uma unesihudo sekwephuzile. Udokotela wakho mhlawumbe uzokutshela ukuthi ugcine i-loperamide (Imodium AD) ukuze ukwazi ukuqala ukuyithatha ngokushesha uma uba nesifo sohudo sekwephuzile. Udokotela wakho mhlawumbe uzokutshela ukuthi uthathe i-loperamide ngezikhathi ezithile phakathi nosuku nobusuku. Qiniseka ukuthi ulandela izinkomba zikadokotela wakho ngokuthatha i-loperamide; lokhu kuzohluka kunezikhombisi-ndlela eziphrintwe kwilebula lephakeji le-loperamide. Udokotela wakho uzokutshela nokuthi yikuphi ukudla okufanele ukudle nokuthi yikuphi ukudla okufanele ukukugweme ukulawula isifo sohudo ngesikhathi welashwa. Phuza uketshezi oluningi bese ulandela lokhu kudla ngokucophelela.

Shayela udokotela wakho ngokushesha lapho uqala ukukhishwa yisisu ngesikhathi sokwelashwa kwakho. Phinda ushayele udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: umkhuhlane (izinga lokushisa liphakeme kuno-100.4 ° F); ukuqhaqhazela okubandayo; indle emnyama noma enegazi; uhudo olungapheli phakathi kwamahora angama-24; ikhanda elikhanyayo, isiyezi, noma ukuquleka; noma isicanucanu esinzima nokuhlanza okukuyekisa ukuphuza noma yini. Udokotela wakho uzokubuka ngokucophelela futhi angakuphatha ngamanzi noma ngama-antibiotic uma kudingeka.

I-Irinotecan ingadala ukwehla kwenani lamaseli egazi enziwe ngomnkantsha wakho. Tshela udokotela wakho uma uke waba nesifo segazi noma seGilbert's syndrome (wehlise ikhono lokwephula i-bilirubin, into yemvelo emzimbeni) futhi uma uphathwa ngemisebe esiswini sakho noma okhalweni (indawo ephakathi kwamathambo enqulu ) noma uma uke waphathwa ngalolu hlobo lwemisebe. Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: imfiva, ukubanda, ukukhwehlela, noma ezinye izimpawu zokutheleleka; ukuphelelwa umoya; ukushaya kwenhliziyo okusheshayo; ikhanda; isiyezi; isikhumba esiphaphathekile; ukudideka; ukukhathala ngokweqile, noma ukopha okungavamile noma ukulimaza.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ukuze ahlole impendulo yomzimba wakho ku-irinotecan.

Khuluma nodokotela wakho ngezingozi zokusebenzisa i-irinotecan.

I-Irinotecan isetshenziswa yodwa noma ihlanganiswe neminye imithi yokwelapha umdlavuza wekoloni noma we-rectal (umdlavuza oqala emathunjini amakhulu). I-Irinotecan isekilasini lemithi elwa namagciwane ebizwa nge-topoisomerase I inhibitors. Isebenza ngokumisa ukukhula kwamangqamuzana omdlavuza.

I-Irinotecan iza njengoketshezi okufanele inikezwe ngaphezu kwemizuzu engama-90 ngemithambo (emthanjeni) ngudokotela noma umhlengikazi. Imvamisa ayinikezwa kaningi ngaphezu kwesisodwa ngesonto, ngokwesheduli eshintsha isonto elilodwa noma ngaphezulu lapho uthola i-irinotecan ngesonto elilodwa noma ngaphezulu lapho ungawutholi umuthi. Udokotela wakho uzokhetha uhlelo oluzokusebenzela kangcono kakhulu.

Udokotela wakho angadinga ukubambezela ukwelashwa kwakho futhi alungise umthamo wakho uma uhlangabezana nemiphumela ethile emibi. Qiniseka ukuthi utshela udokotela wakho ukuthi uzizwa kanjani ngenkathi welashwa nge-irinotecan.

Udokotela wakho angakunika imithi yokuvikela isicanucanu, ukuhlanza ngaphambi kokuthola umthamo ngamunye we-irinotecan. Udokotela wakho futhi angakunikeza eminye imithi ukuvimbela noma ukwelapha eminye imiphumela emibi.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

I-Irinotecan kwesinye isikhathi iyasetshenziswa kanye neminye imithi yokwelapha umdlavuza omncane wamaphaphu weseli. Khuluma nodokotela wakho ngezingozi zokusebenzisa lo muthi ngesimo sakho.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola i-irinotecan,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-irinotecan, sorbitol, noma eminye imithi.
• tshela udokotela wakho uma uthatha i-ketoconazole (Nizoral). Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-ketoconazole isonto elilodwa ngaphambi kokuba uqale ukwelashwa kwakho nge-irinotecan noma ngesikhathi sokwelashwa kwakho.
• utshele udokotela wakho uma uthatha i-wort yaseSt. Akufanele uthathe i-wort yaseSt. John amasonto ama-2 ngaphambi kokuba uqale ukwelashwa kwakho nge-irinotecan noma ngesikhathi sokwelashwa kwakho.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo kanye nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: atazanavir (Reyataz); gemfibrozil (Lopid); imishanguzo yokuquleka efana ne-carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital (Luminal), phenytoin (Dilantin, Phenytek); i-rifabutin (i-Mycobutin); kanye ne-rifampin (iRifadin, iRimactane, eRifamate neRifater). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• utshele udokotela wakho uma uke waba nesifo sikashukela noma wake waba naso; ukungabekezelelani kwe-fructose (ukungakwazi ukugaya ushukela wemvelo otholakala esithelweni); noma isifo sesibindi, samaphaphu noma sezinso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uhlele ukuba nobaba wengane. Wena noma umlingani wakho akufanele ukhulelwe ngenkathi uthola i-irinotecan. Uzodinga ukuthi ube nokuhlolwa kokukhulelwa okungekuhle ngaphambi kokuthi uqale ukuthola le mithi. Uma ungowesifazane, sebenzisa ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga eziyisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise izilawuli zokubeletha ezisebenzayo (amakhondomu) ngesikhathi sokwelashwa kwakho nezinyanga ezi-3 ngemuva komthamo wakho wokugcina. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthola i-irinotecan, shayela udokotela wakho. I-Irinotecan ingalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Akufanele uncelise ibele ngenkathi uthola umjovo we-irinotecan, nezinsuku eziyi-7 ngemuva komthamo wakho wokugcina.
• kufanele wazi ukuthi lo muthi unganciphisa ukuzala kwabesilisa nabesifazane. Khuluma nodokotela wakho ngezingozi zokuthola umjovo we-irinotecan.
• uma uhlinzwa, kufaka phakathi ukuhlinzwa kwamazinyo, tshela udokotela noma udokotela wamazinyo ukuthi uthola i-irinotecan.
• kufanele wazi ukuthi i-irinotecan ingakwenza ube nesiyezi noma uthinte umbono wakho, ikakhulukazi phakathi namahora angama-24 okuqala ngemuva kokuthola umthamo. Ungashayeli imoto noma usebenzise imishini uze wazi ukuthi lo muthi ukuthinta kanjani.
• khuluma nodokotela wakho ngaphambi kokuba uthole noma yimiphi imigomo ngenkathi welashwa nge-irinotecan.

Udokotela wakho uzokutshela ngokudla okukhethekile okufanele ukulandele ukusiza ukulawula isifo sohudo ngenkathi welashwa. Landela le miyalo ngokucophelela.

Khuluma nodokotela wakho ngokudla isithelo samagilebhisi nokuphuza ijusi lamagilebhisi ngenkathi uthola lo muthi.

I-Irinotecan ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• ukuhlanza
• ukuqunjelwa
• ukuvuvukala nezilonda emlonyeni
• isilungulela
• ukulahlekelwa isifiso sokudla
• ukuncipha komzimba
• ukulahleka kwezinwele
• ubuthakathaka
• ubuthongo
• ubuhlungu, ikakhulukazi ubuhlungu emuva

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SESEXWAYISO, shayela udokotela wakho ngokushesha:

• ubuhlungu besifuba
• ukuphuzi kwesikhumba noma kwamehlo
• isisu esivuvukile
• ukukhuluphala okungalindelekile noma okungavamile
• ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuqubuka
• isifuba
• ukulunywa
• ukuphefumula kanzima noma ukugwinya

Abanye abantu abathola i-irinotecan baba namahlwili egazi emilenzeni, emaphashini, ebuchosheni noma ezinhliziyweni. Akukho lwazi olwanele ukusho ukuthi i-irinotecan ibangele amahlule egazi. Khuluma nodokotela wakho ngezingozi zokuthola i-irinotecan.

I-Irinotecan ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthola lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka:

• umphimbo obuhlungu, umkhuhlane, amakhaza, ukukhwehlela nezinye izimpawu zokutheleleka
• isifo sohudo esibi

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• ICamptosar^®

• I-CPT-11