Inaliti ye-Sipuleucel-T

-Delile

• Ngaphambi kokuthola umjovo we-sipuleucel-T,
• Umjovo weSipuleucel-T ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

Umjovo weSipuleucel-T usetshenziselwa ukwelapha izinhlobo ezithile zomdlavuza we-Prostate advanced. Umjovo weSipuleucel-T usekilasini lemithi ebizwa nge-autologous cellular immunotherapy, uhlobo lomuthi olungiselelwe kusetshenziswa amaseli avela egazini lesiguli uqobo. Isebenza ngokubangela amasosha omzimba omzimba (iqembu lamaseli, izicubu, nezitho ezivikela umzimba ekuhlaselweni amagciwane, amagciwane, amangqamuzana omdlavuza, nezinye izinto ezibangela izifo) ukulwa namaseli omdlavuza.

Umjovo weSipuleucel-T uza njengokumiswa (uketshezi) okuzofakwa cishe imizuzu engama-60 emthanjeni ngudokotela noma umhlengikazi osehhovisi likadokotela noma esikhungweni sokumnika. Imvamisa inikezwa kanye njalo emavikini ama-2 isiyonke semithamo emithathu.

Cishe ezinsukwini ezi-3 ngaphambi kokunikezwa umthamo ngamunye womjovo we-sipuleucel-T, kuzothathwa isampula lamangqamuzana akho amhlophe egazi esikhungweni sokuqoqa amaseli kusetshenziswa inqubo ebizwa ngeleukapheresis (inqubo esusa amangqamuzana amhlophe egazi emzimbeni). Le nqubo izothatha cishe amahora amathathu kuya kwayi-4. Isampula izothunyelwa kumenzi futhi ihlanganiswe neprotheyini ukulungiselela umthamo womjovo we-sipuleucel-T. Ngoba lo muthi wenziwe ngamaseli akho, uzonikezwa wena kuphela.

Khuluma nodokotela wakho mayelana nokuthi ungayilungiselela kanjani i-leukapheresis nokuthi yini ongayilindela ngesikhathi nangemva kwenqubo. Udokotela wakho uzokutshela ukuthi yini okufanele uyidle futhi uyiphuze nokuthi yini okufanele uyigweme ngaphambi kwenqubo. Ungahle ube nemiphumela engemihle, enjengesiyezi, ukukhathala, ukuncinza eminweni noma emlonyeni, ukuzwa ukubanda, ukuquleka, kanye nesicanucanu ngesikhathi senqubo. Ungazizwa ukhathele ngemuva kwenqubo, ngakho-ke ungafuna ukuhlela umuntu ozokushayela ekhaya.

Umjovo we-Sipuleucel-T kufanele unikezwe zingakapheli izinsuku ezi-3 kusukela ngesikhathi salungiswa. Kubalulekile ukufika ngesikhathi futhi ungaphuthelwa noma yimaphi ama-aphoyintimenti ahleliwe okuqoqwa kwamaseli noma ukuthola umthamo ngamunye wokwelashwa.

Umjovo we-Sipuleucel-T ungadala ukusabela okweqile kokugula ngesikhathi sokumnika futhi cishe imizuzu engama-30 ngemuva kwalokho. Udokotela noma umhlengikazi uzokuqapha ngalesi sikhathi ukuze aqiniseke ukuthi awunampendulo ebucayi emithini. Uzonikezwa eminye imithi imizuzu engama-30 ngaphambi kokufakwa kwakho ukuvimbela ukusabela kumjovo we-sipuleucel-T. Tshela udokotela noma unesi wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: isicanucanu, ukuhlanza, ukugodola, umkhuhlane, ukukhathala ngokweqile, isiyezi, ukuphefumula kanzima, ukushaya kwenhliziyo okusheshayo noma okungajwayelekile, noma ubuhlungu besifuba.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthola umjovo we-sipuleucel-T,

• Tshela udokotela wakho kanye nosokhemisi uma ungenwe igciwane lesilonda se-sipuleucel-T, noma imuphi omunye umuthi, noma iziphi izithako zomjovo we-sipuleucel-T. Buza usokhemisi noma udokotela wakho noma hlola imininingwane yesiguli somkhiqizi ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi usho noma yikuphi okulandelayo: eminye imithi ethinta amasosha omzimba njenge-azathioprine (Imuran); i-cyclosporine (iNeoral, iSandimmune); imithi yomdlavuza; i-methotrexate (i-Rheumatrex); i-steroids yomlomo efana ne-dexamethasone (i-Decadron, i-Dexone), i-methylprednisolone (i-Medrol), i-prednisolone, ne-prednisone (i-Deltasone); i-sirolimus (i-Rapamune); futhi tacrolimus (Prograf).
• Tshela udokotela wakho uma uke waba nesifo sohlangothi noma senhliziyo noma samaphaphu.
• kufanele wazi ukuthi i-sipuleucel-T isetshenziselwa amadoda kuphela.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Uma uphuthelwa isikhathi sokuqoqa amaseli akho, kufanele ushayele udokotela wakho kanye nendawo yokuqoqa khona manjalo. Uma uphuthelwa isikhathi sokuthola umjovo we-sipuleucel-T, kufanele ushayele udokotela wakho khona manjalo. Ungadinga ukuphinda inqubo yokuqoqa amaseli akho uma umthamo olungiselelwe womjovo we-sipuleucel-T uzophelelwa yisikhathi ngaphambi kokuthi unikezwe wona.

Umjovo weSipuleucel-T ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isicanucanu
• Ukugodola
• ukukhathala noma ubuthakathaka
• ikhanda
• ubuhlungu emuva noma ngokuhlanganyela
• ubuhlungu bemisipha noma ukuqina
• ukuzamazama okungalawuleki kwengxenye yomzimba
• ukujuluka

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha:

• ububomvu noma ukuvuvukala eduze kwendawo esikhunjeni lapho uthole khona ukumnika kwakho noma lapho kwaqoqwa khona amaseli
• umkhuhlane ngaphezu kuka-100.4 ° F (38 ° C)
• inkulumo ehamba kancane noma enzima
• isiyezi noma ukuquleka okungazelelwe
• ubuthakathaka noma ukuba ndikindiki kwengalo noma komlenze
• ubunzima bokugwinya
• igazi emchameni

Umjovo weSipuleucel-T ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngesikhathi sokwelashwa kwakho ngalo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina konke ukubonana nodokotela wakho, isikhungo sokuqoqwa kwamaseli, kanye nelabhorethri. Udokotela wakho anga-oda izivivinyo ezithile zelebhu ukuze ahlole impendulo yomzimba wakho kumjovo we-sipuleucel-T.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• Ukuziphindiselela^®