Umlobi: Clyde Lopez
Usuku Lokudalwa: 22 Ujulayi 2021
Ukuvuselela Usuku: 11 Udisemba 2024
Anonim
Kathryn Davis, MD, MSTR: Off-Label Clobazam Use in Refractory Epilepsy
Ividiyo: Kathryn Davis, MD, MSTR: Off-Label Clobazam Use in Refractory Epilepsy

-Delile

I-Clobazam ingakhuphula ubungozi bezinkinga zokuphefumula ezinkulu noma ezisongela ukuphila, ukuthambisa, noma ikhoma uma zisetshenziswa kanye nemithi ethile. Tshela udokotela wakho uma uthatha noma uhlela ukuthatha: ama-anti-depressants; imithi yokukhathazeka, ukugula kwengqondo, nokuhlaselwa; isidambisi; amaphilisi okulala; ama-opioid afana ne-codeine, i-fentanyl (i-Duragesic, i-Subsys), i-morphine (i-Astramorph, i-Kadian), noma i-oxycodone (ePercocet, eRoxicet, amanye); noma izinto zokunciphisa umzimba. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho futhi uzokuqapha ngokucophelela. Uma uthatha i-clobazam nganoma iyiphi yale mithi futhi uba nezimpawu ezilandelayo, shayela udokotela wakho ngokushesha noma ufune usizo oluphuthumayo lwezokwelapha ngokushesha: isiyezi esingavamile, ikhanda elikhanyayo, ukulala ngokweqile, ukuphefumula okunenkinga noma okunzima, noma ukungaphenduli. Qiniseka ukuthi umnakekeli wakho noma amalungu omndeni wakho ayazi ukuthi yiziphi izimpawu ezingabucayi ukuze bakwazi ukubiza udokotela noma ukunakekelwa kwezimo eziphuthumayo uma ungakwazi ukufuna ukwelashwa uwedwa.


I-Clobazam ingaba umkhuba wokwakha. Ungathathi umthamo omkhulu, thatha kaningi, noma isikhathi eside kunalokho okutshelwa ngudokotela wakho. Tshela udokotela wakho uma uke waphuza utshwala obuningi, uma usebenzisa noma usebenzise izidakamizwa zasemgwaqweni, noma usebenzise ngokweqile imithi kadokotela. Ungaphuzi utshwala noma usebenzise izidakamizwa zasemgwaqeni ngenkathi welashwa. Ukuphuza utshwala noma ukusebenzisa izidakamizwa zasemgwaqeni ngenkathi welashwa nge-clobazam nakho kwandisa ingozi yokuthi uzohlangabezana nale miphumela emibi, esongela impilo. Phinda utshele udokotela wakho uma uke waba nokudangala noma uke waba nokugula okuthile kwengqondo.

I-Clobazam ingadala ukuthembela emzimbeni (isimo lapho kuvela khona izimpawu ezingemnandi zomzimba uma umuthi umiswa ngokungazelelwe noma uthathwe ngemithamo emincane), ikakhulukazi uma uwuthatha izinsuku ezimbalwa uye emavikini ambalwa. Ungayeki ukuthatha le mithi noma uthathe amanani amancane ngaphandle kokukhuluma nodokotela wakho. Ukumisa i-clobazam ngokuzumayo kungasenza sibe sibi kakhulu isimo sakho futhi kubangele nezimpawu zokuhoxa ezingahlala amasonto ambalwa ziye ezinyangeni ezingaphezu kwezingu-12. Udokotela wakho mhlawumbe uzokwehlisa umthamo wakho we-clobazam kancane kancane. Shayela udokotela wakho noma uthole ukwelashwa okuphuthumayo uma uhlangabezana nalezi zimpawu ezilandelayo: ukunyakaza okungavamile; kukhala ezindlebeni zakho; ukukhathazeka; izinkinga zememori; ubunzima bokugxila; izinkinga zokulala; ukuquleka; ukuqhaqhazela; ukudikiza kwemisipha; izinguquko empilweni yengqondo; ukucindezeleka; ukuvutha noma ukubhoboza umuzwa ezandleni, ezingalweni, emilenzeni noma ezinyaweni; ukubona noma ukuzwa izinto abanye abangaziboni noma abazizwayo; imicabango yokuzilimaza noma ukuzibulala wena noma abanye; ukukhathazeka ngokweqile; noma ukulahlekelwa ukuxhumana neqiniso.


I-Clobazam isetshenziswa neminye imishanguzo yokulawula ukubanjwa kwabantu abadala nezingane ezineminyaka engu-2 nangaphezulu abane-Lennox-Gastaut syndrome (isifo esidala ukuquleka futhi esivame ukudala ukubambezeleka kwentuthuko). I-Clobazam isekilasini lemithi ebizwa nge-benzodiazepines. Isebenza ngokunciphisa umsebenzi kagesi ongajwayelekile ebuchosheni.

I-Clobazam iza njengethebhulethi kanye nokumiswa (uketshezi) ukuthatha ngomlomo, futhi njengefilimu ukufaka olimini. Imvamisa iphuzwa kanye noma kabili ngosuku, noma ngaphandle kokudla. Thatha i-clobazam ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi.

Uma ungeke ukwazi ukuwagwinya wonke amaphilisi, ungawahlephula phakathi ku-mark mark noma uwagxoze uwahlanganise nenani elincane le-appleauce.

Uketshezi luza i-adaptha kanye nemijovo emibili yokulinganisa ngomlomo. Sebenzisa kuphela imijovo emibili yomthamo womlomo ukukala umthamo wakho bese ugcine umjovo wesibili. Uma umjovo wokuqala womlomo ulimele noma ulahlekile, umjovo wesibili ohlinzekiwe ungasetshenziswa ukubuyisela.


Ukuthatha uketshezi, landela lezi zinyathelo:

  1. Ngaphambi kokusetshenziswa kokuqala, vula ibhodlela bese ufaka ngokuqinile i-adaptha entanyeni yebhodlela kuze kube yilapho i-adaptha ephezulu ilingana naphezulu. Ungasusi i-adaptha phakathi nesikhathi usebenzisa le bhodlela.
  2. Nyakazisa uketshezi kahle ngaphambi kokusebenzisa ngakunye ukuxuba umuthi ngokulinganayo.
  3. Ukukala umthamo wakho, cindezela i-plunger yesipontsho kuze kufike phansi bese ufaka isirinji ku-adaptha yebhodlela eliqondile. Bese uphendukisa ibhodlela ubheke phansi bese udonsela i-plunger kancane kancane kuze kube yilapho indandatho emnyama ihambisana nomthamo obekiwe.
  4. Susa isirinji kusuka ku-adaptha yamabhodlela bese ucwilisa kancane uketshezi kusuka kusirinji uye ekhoneni lomlomo wakho.
  5. Beka ikepisi lamabhodlela phezu kwe-adaptha njalo emva kokusetshenziswa ngakunye.
  6. Geza isirinji yomlomo njalo emva kokuyisebenzisa. Ukugeza isirinji, susa iplanja ngokuphelele, ugeze umphongolo kanye nensipho ngamanzi, ugeze, bese uvumela ukuthi wome. Ungazifaki izingxenye zesiponji ku-Umshini wokuwasha izitsha.

Ukuthatha ifilimu, landela lezi zinyathelo:

  1. Vula isikhwama se-foil bese ususa ifilimu. Qiniseka ukuthi izandla zakho zomile futhi zihlanzekile.
  2. Beka ifilimu ngaphezulu kolimi lwakho.
  3. Vala umlomo wakho bese ugwinya amathe akho ngokujwayelekile. Musa ukuhlafuna, ukukhafula, noma ukukhuluma ngenkathi ifilimu incibilika. Ungathathi neziphuzo.
  4. Geza izandla zakho.

Uma udokotela wakho ekutshele ukuthi uthathe ifilimu engaphezu kweyodwa ngomthamo ngamunye, linda kuze kufike ifilimu yokuqala ngaphambi kokuba uqede ifilimu yesibili.

Udokotela wakho mhlawumbe uzokuqala ngomthamo ophansi we-clobazam futhi akhuphule kancane umthamo wakho, hhayi ngaphezu kwesisodwa njalo ngesonto.

Abanye abantu bangaphendula ngokuhlukile ku-clobazam ngokuya ngofuzo lwabo noma ukwakheka kofuzo. Udokotela wakho angalawula ukuhlolwa kwegazi ukusiza ukuthola umthamo we-clobazam okungcono kakhulu kuwe.

IClobazam ingasiza ukulawula isimo sakho kepha ngeke iselaphe. Qhubeka uthathe i-clobazam noma ngabe uzizwa uphilile. Ungayeki ukuthatha i-clobazam ngaphandle kokukhuluma nodokotela wakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa nge-clobazam futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-clobazam,

  • Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-clobazam, noma imiphi eminye imithi, noma iziphi izithako ezibhebheni ze-clobazam, ukumiswa, noma ifilimu. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
  • Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi eminye imishanguzo kadokotela neyokungabhalisi, amavithamini, izithasiselo zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO nanoma yikuphi okulandelayo: ama-antihistamine; i-dextromethorphan (iDelsym, eNuedexta, eRobitussin DM); i-fluconazole (iDiflucan); i-fluvoxamine (i-Luvox); i-omeprazole (Prilosec, eZegerid); noma i-ticlopidine. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imishanguzo eminingi ingaxhumana ne-clobazam, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imishanguzo oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
  • utshele udokotela wakho uma uke wacabanga noma wazilimaza noma uzibulale, noma uhlela noma uzama ukwenza kanjalo noma amaphaphu, izinso, noma isifo sesibindi.
  • utshele udokotela wakho uma ukhulelwe noma uhlela ukukhulelwa. Uma uthatha i-clobazam njalo ezinyangeni ezimbalwa ezedlule zokukhulelwa kwakho, ingane yakho ingathola izimpawu zokuhoxa ngemuva kokuzalwa. Tshela udokotela wengane yakho ngokushesha uma ingane yakho ihlangabezana nalezi zimpawu ezilandelayo: ukucasuka, ukukhathazeka ngokweqile, ukulala okungavamile, ukukhala okuphezulu, ukuzamazama okungalawuleki kwengxenye yomzimba, ukuhlanza, noma isifo sohudo. Uma ukhulelwa ngenkathi uthatha i-clobazam, shayela udokotela wakho.
  • uma usebenzisa izinto zokuvimbela inzalo zehomoni (amaphilisi okulawula ukubeletha, amabala, izindandatho, okufakelwa, imijovo, noma amadivayisi we-intrauterine), kufanele wazi ukuthi lolu hlobo lokulawulwa kokuzalwa kungenzeka lungasebenzi kahle uma lusetshenziswa ne-clobazam. Izindlela zokuvimbela inzalo zeHormonal akufanele zisetshenziswe njengendlela yakho kuphela yokulawula ukuzalwa ngenkathi uthatha i-clobazam kanye nezinsuku ezingama-28 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezingezona ezesibeletho ezizokusebenzela.
  • tshela udokotela wakho uma uncelisa. Uma uncelisa ngenkathi uthatha i-clobazam, tshela udokotela wakho uma ingane yakho ingondli kahle noma izele ngokweqile.
  • khuluma nodokotela wakho ngezingozi nezinzuzo zokuthatha lo muthi uma uneminyaka engama-65 noma ngaphezulu. Abantu abadala asebekhulile kufanele bathole imithamo ephansi ye-clobazam ngoba imithamo ephezulu ingahle ingasebenzi kangcono futhi ingadala imiphumela emibi kakhulu.
  • kufanele wazi ukuthi i-clobazam ingakwenza ukozele futhi ithinte ukucabanga kwakho, ikhono lokwenza izinqumo nokuxhumana. Ungashayeli imoto, sebenzisa imishini, noma wenze ezinye izinto eziyingozi uze wazi ukuthi lo muthi ukuthinta kanjani.
  • kufanele wazi ukuthi impilo yakho yengqondo ingashintsha ngezindlela ezingalindelekile futhi ungazibulala (ucabanga ngokuzilimaza noma ukuzibulala noma ukuhlela noma ukuzama ukwenza kanjalo) ngenkathi uthatha i-clobazam. Inani elincane labantu abadala nezingane ezineminyaka engu-5 nangaphezulu (cishe umuntu oyedwa kwabangu-500) abathathe ama-anticonvulsants, njenge-clobazam, ukwelapha izimo ezahlukahlukene phakathi kwezifundo zokwelashwa baba ukuzibulala ngesikhathi belashwa. Abanye balaba bantu bahlakulela imicabango yokuzibulala nokuziphatha kungakapheli isonto elilodwa beqale ukuthatha umuthi. Wena nodokotela wakho nizonquma ukuthi izingozi zokuthatha umuthi we-anticonvulsant zinkulu yini kunezingozi zokungawuthathi umuthi. Wena, umndeni wakho, noma umnakekeli wakho kufanele ushayele udokotela wakho ngokushesha uma uhlangabezana nalezi zimpawu ezilandelayo: ukwethuka; ukuphazamiseka noma ukungahlaliseki; ukucasuka okusha noma okuya kuba kubi, ukukhathazeka, noma ukucindezeleka; ukwenza izinkanuko eziyingozi; ubunzima bokulala noma ukulala; ulaka, intukuthelo, noma ukuziphatha okunodlame; i-mania (i-frenzied, imood ejabule ngokungavamile); ukucabanga ngokuzilimaza noma ukuzibulala, noma ukuhlela noma ukuzama ukwenza kanjalo; noma olunye uguquko olungajwayelekile ekuziphatheni noma emoyeni. Qiniseka ukuthi umndeni wakho noma umnakekeli wakho uyazi ukuthi yiziphi izimpawu ezingaba zimbi kakhulu ukuze bakwazi ukubiza udokotela uma ungakwazi ukuzifunela ukwelashwa wedwa.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Thatha umthamo ongabanjwanga ngokushesha nje lapho uwukhumbula. Kodwa-ke, uma sekuyisikhathi somthamo olandelayo, weqa umthamo ongabanjwanga bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ungathathi umthamo ophindwe kabili ukwenza okulahlekile.

I-Clobazam ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

  • ukukhathala
  • izinkinga ngokuxhumanisa
  • kunzima ukukhuluma noma ukugwinya
  • ukumunca amathe
  • shintsha ekudleni
  • ukuhlanza
  • ukuqunjelwa
  • ukukhwehlela
  • ubuhlungu obuhlangene

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu noma lezo ezisohlwini lweZINYATHELO EZIKHETHEKILE noma IZEXWAYISO EZIBALULEKILE, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

  • ukuchama okunzima, okubuhlungu, noma okuvamile
  • ukukhwehlela, ukuphefumula kanzima, umkhuhlane
  • izilonda emlonyeni wakho, ukuqubuka, isifuba, isikhumba esihlabayo noma esikhanyayo
  • imfiva

I-Clobazam ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Musa ukuvula isikhwama se-foil sefilimu kuze kube ngaphambi kokuthi ulungele ukuyisebenzisa. Gcina i-clobazam endaweni ephephile ukuze kungabikho omunye umuntu ongayithatha ngengozi noma ngenhloso. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese). Gcina ukumiswa kwe-clobazam (uketshezi) endaweni emile. Ungasebenzisi noma yiluphi uketshezi olusele ngaphezu kwezinsuku ezingama-90 ngemuva kokuqala ukuvula ibhodlela.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Izimpawu zokudlula ngokweqile zingafaka okulandelayo:

  • ukozela
  • ukudideka
  • ukungabi namandla
  • izinkinga ngokuxhumanisa
  • ukuphefumula kancane, okungajulile
  • ukuncipha kwesifiso sokuphefumula
  • ukuquleka
  • ukungaboni kahle

Gcina wonke ama-aphoyintimenti nodokotela wakho.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. I-Clobazam yinto elawulwayo. Okubhalwe phansi kungagcwaliswa izikhathi ezimbalwa kuphela; buza usokhemisi wakho uma unemibuzo.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

  • Onfi®
  • Sympazan®
Kugcine ukubuyekezwa - 05/15/2021

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