Mipomersen Injection

-Delile

• Ngaphambi kokujova umjovo wemipomersen,
• Umjovo weMipomersen ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

Umjovo weMipomersen ungadala ukulimala kwesibindi. Tshela udokotela wakho uma uphuza noma wake waphuza utshwala obuningi nokuthi unesifo sesibindi noma uke waba naso, kufaka phakathi ukulimala kwesibindi okwenzeka ngenkathi uthatha omunye umuthi. Udokotela wakho mhlawumbe uzokutshela ukuthi ungasebenzisi umjovo wemipomersen uma unesifo sesibindi. Tshela udokotela wakho kanye nosokhemisi uma uhlala uphuza i-acetaminophen (iTylenol, kweminye imithi yezinhlungu) futhi uma uthatha i-amiodarone (Cordarone, Pacerone); eminye imithi ye-cholesterol ephezulu; i-methotrexate (i-Rheumatrex, i-Trexall); i-tamoxifen (i-Soltamox); noma i-tetracycline antibiotic efana ne-doxycycline (Doryx, Vibra-Tabs, Vibramycin), minocycline (Dynacin, Minocin), ne-tetracycline (Sumycin). Uma uhlangabezana nalezi zimpawu ezilandelayo, shayela udokotela wakho ngokushesha: isicanucanu, ukuhlanza, ukungathandi ukudla, ubuhlungu besisu, ukukhathala ngokweqile, ukuphuzi kwesikhumba noma kwamehlo, umchamo omnyama, noma ukulunywa.

Ukuphuza utshwala kwandisa ubungozi bokuthi uzodala ukulimala kwesibindi ngesikhathi sokwelashwa kwakho ngomjovo wemipomersen. Ungaphuzi isiphuzo esidakayo esingaphezu kwesisodwa ngosuku ngenkathi usebenzisa lo muthi.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile ngaphambi nangesikhathi sokwelashwa kwakho ukuze ahlole impendulo yomzimba wakho kumjovo we-mipomersen.

Ngenxa yobungozi bokulimala kwesibindi, sekuhlelwe uhlelo lokuqapha iziguli ezisebenzisa umjovo wemipomersen. Udokotela wakho uzodinga ukuqedela ukuqeqeshwa nokubhalisa ngohlelo ngaphambi kokuyalela lo muthi. Uzokwazi ukuthola imithi yakho kuphela ekhemisi eliqinisekisiwe ukukhipha umjovo wemipomersen. Buza udokotela wakho ukuthola eminye imininingwane yokuthi ungayithola kanjani imithi yakho.

Udokotela wakho noma usokhemisi uzokunikeza ishidi lemininingwane yesiguli lomkhiqizi (Umhlahlandlela Wezokwelapha) lapho uqala ukwelashwa ngomjovo we-mipomersen futhi isikhathi ngasinye lapho ugcwalisa umuthi wakho. Funda imininingwane ngokucophelela bese ubuza udokotela noma usokhemisi wakho uma unemibuzo. Ungavakashela futhi iwebhusayithi ye-Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) noma iwebhusayithi yomkhiqizi ukuthola i-Medication Guide.

Khuluma nodokotela wakho ngezingozi zokusebenzisa umjovo wemipomersen.

Umjovo weMipomersen usetshenziselwa ukwehlisa amazinga e-cholesterol nezinye izinto ezinamafutha egazini kubantu abane-homozygous family hypercholesterolemia (HoFH; isimo esingajwayelekile esizuzwe njengefa esidala amazinga aphezulu kakhulu we-cholesterol egazini, okwandisa ubungozi besifo senhliziyo). Abanye abantu abane-HoFH bangalashwa nge-LDL apheresis (inqubo esusa i-LDL egazini), kepha umjovo wemipomersen akufanele usetshenziswe kanye nalokhu kwelashwa. Umjovo weMipomersen akufanele usetshenziselwe ukwehlisa amazinga e-cholesterol kubantu abangenayo i-HoFH. Umjovo weMipomersen usesigabeni semithi ebizwa nge-antisense oligonucleotide (ASO) inhibitors. Isebenza ngokuvimbela izinto ezithile ezinamafutha ekubeni zakhiwe emzimbeni.

Umjovo weMipomersen uza njengesisombululo sokujova ngaphansi kwesikhumba. Kuvame ukujova kanye ngesonto. Jova umjovo we-mipomersen ngosuku olufanayo lweviki nangesikhathi esifanayo sosuku ngaso sonke isikhathi lapho uwujova. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Sebenzisa umjovo wemipomersen njengoba uqondisiwe. Ungayifaki ngaphezulu noma ngaphansi kwayo noma uyijoje kaningi kunokuyalelwa ngudokotela wakho.

Umjovo weMipomersen ungasiza ukulawula i-cholesterol yakho kepha ngeke uselaphe isimo sakho. Kungathatha izinyanga eziyisithupha noma ngaphezulu ukuthi izinga lakho le-cholesterol lehle kakhulu. Qhubeka nokusebenzisa umjovo we-mipomersen noma ngabe uzizwa uphilile. Ungayeki ukusebenzisa umjovo we-mipomersen ngaphandle kokukhuluma nodokotela wakho.

Ungazijova ngokwakho i-mipomersen noma ube nomngane noma isihlobo esikujolela umuthi. Udokotela wakho uzokukhombisa wena noma umuntu ozobe ejova umuthi ukuthi umjovo kanjani. Wena kanye nomuntu ozojova umuthi kufanele ufunde imiyalelo yomkhiqizi yokusetshenziswa eza nomuthi. Buza udokotela wakho uma unemibuzo noma ungaqondi ukuthi ungayijova kanjani imipomersen.

Umjovo weMipomersen ufika ngamasirinji agcwaliswe ngaphambili nasezimbizeni. Uma usebenzisa izigaxa zomjovo we-mipomersen, udokotela wakho uzokutshela ukuthi hlobo luni lomjovo okufanele ulusebenzise nokuthi ungawudonsela kanjani umuthi esirinji. Ungahlanganisi noma imuphi omunye umuthi esirinji nomjovo we-mipomersen.

Thatha umjovo we-mipomersen esiqandisini okungenani imizuzu engama-30 ngaphambi kokuhlela ukujova ukuvumela umuthi ukuthi ufike ekamelweni lokushisa. Gcina isirinji emaphaketheni ayo ukuze uyivikele ekukhanyeni ngalesi sikhathi. Ungazami ukufudumeza isirinji ngokufudumeza nganoma iyiphi indlela.

Njalo bheka umjovo we-mipomersen ngaphambi kokuwujova. Qiniseka ukuthi ukufakwa kuvaliwe, akulimaleki futhi kufakwa ilebula ngegama elifanele lomuthi kanye nosuku lokuphelelwa yisikhathi olungadlulanga. Bheka ukuthi isixazululo esiku-vial noma isirinji sicacile futhi singenambala noma siphuzi kancane. Ungasebenzisi i-vial noma isirinji uma ilimele, iphelelwe yisikhathi, ibala, noma inamafu noma uma iqukethe izinhlayiya.

Ungajova i-mipomersen noma yikuphi engxenyeni engaphandle yezingalo zakho ezingaphezulu, amathanga akho, noma isisu sakho, ngaphandle kwenkaba yakho (inkinobho yesisu) nendawo engama-intshi amabili kuyo. Khetha indawo ehlukile njalo lapho ufaka umuthi. Ungafaki esikhunjeni esibomvu, esivuvukile, esinegciwane, esinamabala, esinamathambo, esishiswe yilanga noma esithintwa ukuqubuka noma isifo sesikhumba esifana ne-psoriasis.

Isirinji noma igabha eligcwaliswe kuqala liqukethe kuphela umjovo owanele we-mipomersen ngomthamo owodwa. Ungazami ukusebenzisa izigaxa noma imijovo kaningi. Lahla imijovo esetshenzisiwe esitsheni esingamelana nokubhoboza. Buza udokotela wakho noma usokhemisi ukuthi ungasilahla kanjani isitsha esingamelana nokubhoboza.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokujova umjovo wemipomersen,

• Tshela udokotela kanye nosokhemisi wakho uma unegciwane ku-mipomersen, noma imuphi omunye umuthi, noma esinye isithako somjovo we-mipomersen. Buza usokhemisi wakho noma uhlole Umhlahlandlela Wezokwelapha ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela neyokungabhalisi, amavithamini, izithako zokudla okunempilo, nemikhiqizo yamakhambi oyithathayo noma ohlela ukuyithatha. Qiniseka ukuthi uyayisho imithi efakwe kuhlu esigabeni ESIBALULEKILE SESEXWAYISO. Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi.
• ungafaki noma imiphi eminye imishanguzo ngasikhathi sinye ojova ngayo imipomersen. Buza udokotela wakho noma usokhemisi ukuthi uyojova nini imithi yakho.
• Tshela udokotela wakho uma uke waba nesifo sezinso noma wake waba naso.
• tshela udokotela wakho uma ukhulelwe, hlela ukukhulelwa, noma uncelisa. Kufanele usebenzise ukulawulwa kokubeletha ukuvimbela ukukhulelwa ngesikhathi sokwelashwa kwakho. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma ukhulelwa ngesikhathi sokwelashwa kwakho, yeka ukusebenzisa umjovo we-mipomersen bese ushayela udokotela wakho ngokushesha.

Yidla ukudla okunamafutha aphansi, okunamafutha amancane. Qiniseka ukuthi ulandela zonke izincomo zokuzivocavoca nezokudla ezenziwa ngudokotela wakho noma udokotela odlayo. Ungavakashela futhi iwebhusayithi yeNational Cholesterol Education Program (NCEP) ku-http: //www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf ukuthola eminye imininingwane ephathelene nokudla.

Uma ukhumbula okungenani izinsuku ezintathu ngaphambi komthamo wakho olandelayo ohleliwe, thatha umthamo ongabanjwanga ngokushesha. Kodwa-ke, uma ukhumbula ngaphansi kwezinsuku ezintathu ngaphambi komthamo wakho olandelayo ohleliwe, weqa umthamo ongabanjwanga bese uqhubeka nesimiso sakho sokulinganisa okujwayelekile. Musa ukujova umthamo ophindwe kabili ukwenzela okulahlekile.

Umjovo weMipomersen ungadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• ububomvu, ubuhlungu, isisa, ukuvuvukala, ukushintsha kombala, ukulunywa, noma ukulinyazwa kwesikhumba lapho wajova khona imipomersen
• izimpawu ezinjengomkhuhlane, imfiva, ukugodola, ubuhlungu bemisipha, ubuhlungu bamalunga, ubuthakathaka nokukhathala okungenzeka kwenzeke ezinsukwini ezimbili zokuqala ngemuva kokujova imipomersen
• ikhanda
• ubunzima bokulala noma ukulala
• ubuhlungu ezandleni noma emilenzeni

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu noma lezo ezibalwe esigabeni ESIBALULEKILE SEXWAYISO, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ubuhlungu besifuba
• ukushaya kwenhliziyo
• ukuvuvukala kwezingalo, izandla, izinyawo, amaqakala, noma imilenze engezansi
• ukuqubuka
• isifuba
• ukuvuvukala kobuso, umphimbo, ulimi, izindebe, noma amehlo
• ukushaqeka
• ubunzima bokugwinya noma ukuphefumula

Umjovo weMipomersen ungadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi usebenzisa lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Yigcine esiqandisini futhi uyivikele ekukhanyeni. Uma singenaso isiqandisi, ungabeka umuthi ekamelweni lokushisa kuze kube yizinsuku eziyi-14.

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Ungavumeli omunye umuntu ukuthi athathe imithi yakho. Buza usokhemisi wakho noma imiphi imibuzo onayo mayelana nokugcwalisa umuthi wakho.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• I-Kynamro^®