Uzipho lukaDeveli: Izinzuzo, Imiphumela emibi kanye Nesilinganiso

-Delile

• Uyini uzipho lukaDeveli?
• Kwangathi Kunganciphisa Ukuvuvukala
• Kwangathi Kungathuthukiswa I-Osteoarthritis
• Kwangathi Kunganciphisa Izimpawu Ze-Gout
• Kwangathi Kungadambisa Ubuhlungu Basemuva
• Kwangathi Kungakhuthaza Ukwehlisa Isisindo
• Imiphumela emibi nokusebenzisana
• Izilinganiso ezinconyiwe
• Okusemqoka

Uzipho lukaDeveli, olwaziwa ngokwesayensi njenge I-Harpagophytum procumbens, isitshalo esidabuka eNingizimu Afrika. Inesibongo segama layo elithusayo ezithelweni zayo, ezithwala ukuqagela okuncane okufana ne-hook.

Ngokwesiko, izimpande zalesi sitshalo zisetshenziselwe ukwelapha izifo ezahlukahlukene, ezinjengomkhuhlane, ubuhlungu, isifo samathambo nokugaya ukudla (1).

Lo mbhalo ubuyekeza izinzuzo ezingaba khona ngozipho lukaDeveli.

Uyini uzipho lukaDeveli?

Uzipho lukaDeveli luyisitshalo esiqhakazayo somndeni wesesame. Impande yayo ipakisha izinhlanganisela zezitshalo eziningana ezisebenzayo futhi isetshenziswa njengesengezo semithi.

Ikakhulu, uzipho lukaDeveli luqukethe ama-iridoid glycosides, isigaba samakhemikhali akhombise imiphumela elwa nokuvuvukala ().

Ezinye kodwa hhayi zonke izifundo ziphakamisa ukuthi i-iridoid glycosides nayo ingaba nemiphumela yokulwa ne-antioxidant. Lokhu kusho ukuthi isitshalo singaba namandla okugwema imiphumela elimaza amaseli yama-molecule angazinzile abizwa ngama-radicals amahhala (3,,).

Ngalezi zizathu, izengezo zikadeveli zenzipho ziye zafundwa njengekhambi elingaba khona lezimo ezihlobene nokuvuvukala, njenge-arthritis ne-gout. Ngaphezu kwalokho, kuphakanyisiwe ukunciphisa izinhlungu futhi kungaxhasa ukwehla kwesisindo.

Ungathola izengezo zikadeveli zenzipho ngesimo sezinto ezixutshiwe kanye namaphilisi, noma umhlabathi ube yimpuphu ecolekileyo. Iphinde isetshenziswe njengesithako kuma-herbal teas ahlukahlukene.

Uzipho lukaDeveli luyisengezo semithi esetshenziswa ngokuyinhloko njengenye indlela yokwelapha i-arthritis nobuhlungu. Iza ngezindlela eziningi, kufaka phakathi ukukhishwa okugxile, ama-capsule, izimpushana kanye netiye yamakhambi.

Kwangathi Kunganciphisa Ukuvuvukala

Ukuvuvukala kuyimpendulo yemvelo yomzimba wakho ekulimaleni nasekutheleleni. Uma usika umunwe wakho, shaya idolo lakho noma wehle nomkhuhlane, umzimba wakho uphendula ngokwenza amasosha akho omzimba asebenze ().

Ngenkathi okunye ukuvuvukala kudingekile ukuvikela umzimba wakho ekulimaleni, ukuvuvukala okungapheli kungalimaza impilo. Eqinisweni, ucwaningo oluqhubekayo luxhumanise ukuvuvukala okungapheli nesifo senhliziyo, isifo sikashukela nokuphazamiseka kobuchopho (,,).

Vele, kukhona nezimo ezibonakala ngqo ngokuvuvukala, njengezifo zamathumbu ezivuthayo (IBD), i-arthritis ne-gout (, 11,).

Uzipho lukaDeveli luphakanyisiwe njengekhambi elingaba khona lezimo zokuvuvukala ngoba liqukethe izinhlanganisela zezitshalo ezibizwa nge-iridoid glycosides, ikakhulukazi i-harpagoside. Ku-tube-test kanye nasezifundweni zezilwane, i-harpagoside inqande izimpendulo zokuvuvukala ().

Isibonelo, ucwaningo kumagundane lubonise ukuthi i-harpagoside icindezele kakhulu isenzo sama-cytokines, angama-molecule emzimbeni wakho aziwa ukukhuthaza ukuvuvukala ().

Yize uzipho lukaDeveli lungafundwanga kakhulu kubantu, ubufakazi bokuqala buveza ukuthi kungaba yindlela ehlukile yokwelapha yezimo zokuvuvukala.

Uzipho lukaDeveli luqukethe izinhlanganisela zezitshalo ezibizwa nge-iridoid glycosides, ezikhonjisiwe ukucindezela ukuvuvukala ezifundweni ze-test-tube kanye nasezifundweni zezilwane.

Kwangathi Kungathuthukiswa I-Osteoarthritis

I-Osteoarthritis yindlela ejwayelekile kakhulu ye-arthritis, ethinta abantu abadala abangaphezu kwezigidi ezingama-30 e-US ().

Kwenzeka lapho isembozo sokuzivikela emaphethelweni amathambo akho ahlangene - okuthiwa uqwanga - siphela. Lokhu kudala ukuthi amathambo ahlangane ndawonye, ​​kuholele ukuvuvukala, ukuqina nobuhlungu (16).

Izifundo ezisezingeni eliphakeme ziyadingeka, kepha ucwaningo lwamanje lukhombisa ukuthi uzipho lukaDeveli lungasebenza ekunciphiseni ubuhlungu obuhambisana ne-osteoarthritis.

Isibonelo, isifundo esisodwa somtholampilo esihilela abantu abangu-122 abane-osteoarthritis yamadolo nesinqe siphakamise ukuthi u-2,610 mg wensipho kaDeveli nsuku zonke angasebenza ekunciphiseni ubuhlungu be-osteoarthritis njenge-diacerein, umuthi ovame ukusetshenziswa ukwelapha lesi simo ().

Ngokufanayo, isifundo sezinyanga ezi-2 kubantu abangama-42 abane-osteoarthritis engapheli sathola ukuthi ukwengeza nsuku zonke ngozipho lukaDeveli kuhlangene ne-turmeric ne-bromelain, okucatshangwa ukuthi kunemiphumela yokulwa nokuvuvukala futhi, kwehlise ubuhlungu nge-average engu-46% ().

Ucwaningo luphakamisa ukuthi uzipho lukadeveli lungasiza ekunciphiseni ubuhlungu obuhlangene obuhambisana ne-osteoarthritis futhi lungasebenza njenge-diacerein yokuqeda izinhlungu.

Kwangathi Kunganciphisa Izimpawu Ze-Gout

I-Gout ingenye indlela ejwayelekile ye-arthritis, ebonakala ngokuvuvukala okubuhlungu nokubomvu emalungeni, imvamisa ezinzwaneni, emaqakaleni nasemadolweni ().

Kubangelwa ukwakheka kwe-uric acid egazini, okwakhiwa lapho ama-purines - amakhemikhali atholakala ekudleni okuthile - ehla ().

Imithi, efana nezidakamizwa ezingezona ukuvuvukala (ama-NSAID), zivame ukusetshenziselwa ukunciphisa ubuhlungu nokuvuvukala okubangelwa yi-gout.

Ngenxa yemiphumela yayo yokulwa nokuvuvukala kanye namandla okunciphisa izinhlungu, uzipho lukaDeveli luye lwaphakanyiswa njengenye indlela yokwelapha kulabo abane-gout (20).

Futhi, abanye abacwaningi basikisela ukuthi ingehlisa i-uric acid, yize ubufakazi besayensi bunqunyelwe. Kokunye ukuhlola, ukulinganiswa okuphezulu kukazipho kasathane kunciphise amazinga e-uric acid kumagundane (21, 22).

Yize i-test-tube nocwaningo lwezilwane lukhombisa ukuthi uzipho lukaDeveli lunganciphisa ukuvuvukala, izifundo zokwelashwa ukusekela ukusetshenziswa kwalo kwe-gout ngokukhethekile azitholakali.

Ngokuya ngocwaningo olulinganiselwe, kuye kwaphakanyiswa uzipho lukaDeveli ukunciphisa izimpawu ze-gout ngenxa yemiphumela yokulwa nokuvuvukala namandla okunciphisa amazinga e-uric acid.

Kwangathi Kungadambisa Ubuhlungu Basemuva

Ubuhlungu obuphansi emuva buwumthwalo kwabaningi. Eqinisweni, kulinganiselwa ukuthi i-80% yabantu abadala iyakuthola kwesinye isikhathi noma kwesinye (23).

Kanye nemiphumela yokulwa nokuvuvukala, uzipho lukaDeveli lukhombisa okungaba khona njengokudambisa izinhlungu, ikakhulukazi ezinhlungwini ezisezingeni eliphansi. Abaphenyi bathi lokhu kubangelwa i-harpagoside, isakhi esisebenzayo sezitshalo ku-devil's claw.

Kokunye ukuhlola, ukukhishwa kwe-harpagoside kubonakale kusebenza ngendlela efanayo njengesidakamizwa esingaqedi ukuvuvukala (i-NSAID) esibizwa nge-Vioxx. Ngemuva kwamasonto e-6, izinhlungu ezisezingeni eliphansi zababambiqhaza zehliswe ngama-23% aphakathi ne-harpagoside ne-26% nge-NSAID ().

Futhi, izifundo ezimbili zomtholampilo zathola ukuthi ama-50-100 amagremu we-harpagoside ngosuku ayephumelela kakhulu ekunciphiseni ubuhlungu obuphansi emuva uma kuqhathaniswa nolunye ukwelashwa, kepha kudingeka izifundo eziningi ukuqinisekisa le miphumela (,).

Uzipho lukaDeveli lukhombisa okungaba khona njengokudambisa izinhlungu, ikakhulukazi ezinhlungwini ezisezingeni eliphansi. Abaphenyi bathi lokhu kubangelwa isakhi sezitshalo ku-devil's claw okuthiwa i-harpagoside. Kodwa-ke, kudingeka olunye ucwaningo ukuqinisekisa le miphumela.

Kwangathi Kungakhuthaza Ukwehlisa Isisindo

Ngaphandle kokwehlisa ubuhlungu nokuvuvukala, uzipho lukaDeveli lunganciphisa isifiso sokudla ngokusebenzisana ne-hormone yendlala ghrelin ().

IGhrelin ifihliwe isisu sakho. Omunye wemisebenzi yawo eyinhloko ukukhombisa ubuchopho bakho ukuthi yisikhathi sokudla ngokwandisa isifiso sokudla ().

Ocwaningweni olwenziwe kumagundane, izilwane ezithola impuphu kadeveli yempuphu edle ukudla okuncane kakhulu emahoreni amane alandelayo kunalezo eziphathwe nge-placebo ().

Yize le miphumela ithakazelisa, le miphumela yokunciphisa inkanuko ayikakafundwa ebantwini. Ngakho-ke, ubufakazi obuningi bokusekela ukusebenzisa uzipho lukaDeveli lokwehlisa isisindo abutholakali ngalesi sikhathi.

Uzipho lukaDeveli lungacindezela isenzo se-ghrelin, i-hormone emzimbeni wakho ekhulisa isifiso sokudla futhi ekhombise ubuchopho bakho ukuthi sekuyisikhathi sokudla. Kodwa-ke, ucwaningo olwenziwe ngabantu ngalesi sihloko alutholakali.

Imiphumela emibi nokusebenzisana

Uzipho lukaDeveli lubonakala luphephile lapho luthathwa ngemithamo efinyelela ku-2,610 mg nsuku zonke, yize imiphumela yesikhathi eside ingakaze iphenywe (29).

Imiphumela emibi ebikiwe imnene, okuvame kakhulu ukuhanjiswa yisisu. Imiphumela emibi kakhulu ifaka ukungezwani komzimba, ikhanda nokukhwehlela ().

Kodwa-ke, ezinye izimo zingakubeka engcupheni enkulu yokuphendula okubi kakhulu (31):

• Ukuphazamiseka kwenhliziyo: Ucwaningo lukhombisile ukuthi uzipho lukadeveli lungathinta ukushaya kwenhliziyo, ukushaya kwenhliziyo nomfutho wegazi.
• Isifo sikashukela: Uzipho lukaDeveli lunganciphisa amazinga kashukela egazini futhi luqinise imiphumela yemithi yesifo sikashukela.
• Amatshe amatshe amatshe amatshe amatshe amatshe amatshe: Ukusetshenziswa kokhokho kukadeveli kungakhuphula ukwakheka kwenyongo futhi kwenze izinkinga zibe zimbi kakhulu kulabo abanezinyongo.
• Izilonda zesisu: Ukukhiqizwa kwe-asidi esiswini kungakhuphuka ngokusetshenziswa kozipho lukaDeveli, okungakhulisa izilonda zep peptic.

Imithi ejwayelekile nayo ingaxhumana kabi nozipho lukaDeveli, kufaka phakathi imishanguzo kadokotela engeyona yokuvuvukala (ama-NSAID), izinciphisi zegazi nezinciphisi ze-asidi esiswini (31)

• Ama-NSAID: Uzipho lukaDeveli lunganciphisa ukumuncwa kwamaNSAID adumile, njengeMotrin, iCelebrex, iFeldene neVoltaren.
• Abanciphisa igazi: Uzipho lukaDeveli lungathuthukisa imiphumela yeCoumadin (eyaziwa nangokuthi i-warfarin), engaholela ekwandeni kokopha nokulimala.
• Isinciphisi se-asidi esiswini: Uzipho lukaDeveli lunganciphisa imiphumela yezinciphisi ze-asidi esiswini, njengePepcid, Prilosec nePrevacid.

Lolu akulona uhlu olubandakanya konke ukuhlangana kwemithi. Ukuze ube ohlangothini oluphephile, hlala uxoxa ngokusebenzisa kwakho izithasiselo nodokotela wakho.

Kubantu abaningi, ubungozi bemiphumela emibi kukadeveli uzipho buphansi. Kodwa-ke, kungahle kungafaneleki kubantu abanezimo ezithile zezempilo nalabo abathatha imithi ethile.

Izilinganiso ezinconyiwe

Uzipho lukaDeveli lungatholakala njenge-extract egxiliwe, i-capsule, ithebhulethi noma i-powder. Iphinde isetshenziswe njengesithako kuma-herbal teas.

Lapho ukhetha isengezo, funa ukugxila kwe-harpagoside, isakhi esisebenzayo kuzipho lukadeveli.

Imithamo ka-600-2,610 mg we-devil's claw nsuku zonke isetshenzisiwe kwizifundo ze-osteoarthritis nobuhlungu beqolo. Ngokuya ngokuhlushwa kokukhishwa, lokhu kuvamise ukulingana no-50-100 mg we-harpagoside ngosuku (,,,).

Ngaphezu kwalokho, isithasiselo esibizwa nge-AINAT sisetshenzisiwe njengekhambi le-osteoporosis. I-AINAT iqukethe u-300 mg wezinzipho zikadeveli, kanye no-200 mg we-turmeric no-150 mg we-bromelain - ezinye izitshalo ezimbili zezitshalo okukholakala ukuthi zinemiphumela yokulwa nokuvuvukala ().

Kwezinye izimo, izifundo ezanele zokuthola imithamo esebenzayo azitholakali. Ngaphezu kwalokho, uzipho lukaSathane lusetshenziselwe kuze kube unyaka owodwa ezifundweni. Kodwa-ke, uzipho lukaDeveli lubonakala luphephile kubantu abaningi ngemithamo efinyelela ku-2,610 mg ngosuku (29).

Khumbula ukuthi izimo ezithile, njengesifo senhliziyo, isifo sikashukela, amatshe ezinso nezilonda zesisu, zingakhuphula ubungozi bakho bemiphumela emibi lapho uthatha uzipho lukaSathane.

Futhi, noma imuphi umthamo wensipho kaDeveli ungaphazamisa imithi okungenzeka uyayiphuza. Lokhu kufaka phakathi izidakamizwa ezingezona ukuvuvukala (ama-NSAID), izinciphisi zegazi nezinciphisi ze-asidi esiswini.

Uzipho lukaDeveli lubonakala lunenzuzo ngemithamo ka-600-2610 mg ngosuku. Kudingeka izifundo eziningi ukuthola ukuthi ngabe le mishamo iyasebenza yini futhi iphephile isikhathi eside.

Okusemqoka

Uzipho lukaDeveli lungadambisa izinhlungu ezidalwa yizimo zokuvuvukala njengesifo samathambo futhi lungacindezela ama-hormone endlala.

Imithamo yansuku zonke ka-600-2,610 mg ibonakala iphephile, kepha asikho isincomo esisemthethweni esikhona.

Imiphumela emibi ngokuvamile imnene, kodwa uzipho lukaDeveli lungase ludale izinkinga ezithile zezempilo futhi luxhumane nemithi ethile.

Njengazo zonke izithasiselo, uzipho lukaDeveli kufanele lusetshenziswe ngokuqapha. Qiniseka ukuthi ukhuluma nodokotela wakho ngaphambi kokukuthatha.