IHemoglobin Electrophoresis

-Delile

• Kuyini i-hemoglobin electrophoresis?
• Kusetshenziselwa ini?
• Kungani ngidinga i-hemoglobin electrophoresis?
• Kwenzekani ngesikhathi se-hemoglobin electrophoresis?
• Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?
• Ingabe zikhona izingozi ku-hemoglobin electrophoresis?
• Isho ukuthini imiphumela?
• Ngabe kukhona okunye engidinga ukukwazi nge-hemoglobin electrophoresis?
• Izinkomba

Kuyini i-hemoglobin electrophoresis?

IHemoglobin yiprotheni kumaseli akho abomvu egazi athwala umoya-mpilo osuka emaphashini wakho uye kuwo wonke umzimba wakho. Kunezinhlobo ezahlukahlukene ze-hemoglobin. I-Hemoglobin electrophoresis isivivinyo esilinganisa izinhlobo ezahlukene ze-hemoglobin egazini. Iphinde ibheke izinhlobo ezingajwayelekile ze-hemoglobin.

Izinhlobo ezijwayelekile ze-hemoglobin zifaka:

• IHemoglobin (Hgb) A, uhlobo oluvame kakhulu lwe-hemoglobin kubantu abadala abaphilile
• IHemoglobin (Hgb) F, i-hemoglobin yesibungu. Lolu hlobo lwe-hemoglobin lutholakala ezinganeni ezingakazalwa nezisanda kuzalwa. I-HgbF ishintshwa yi-HgbA ngemuva nje kokuzalwa.

Uma amazinga we-HgbA noma i-HgbF ephezulu kakhulu noma ephansi kakhulu, angakhombisa izinhlobo ezithile ze-anemia.

Izinhlobo ezingavamile ze-hemoglobin zifaka:

• IHemoglobin (Hgb) S. Lolu hlobo lwe-hemoglobin lutholakala ku-sickle cell disease. Isifo se-Sickle cell yisifo esizuzwe ngofuzo esidala ukuthi umzimba wenze amaseli abomvu aqinile, amile okwegazi. Amaseli egazi abomvu anempilo ayashintsha ukuze akwazi ukuhamba kalula ngemithambo yegazi. Amaseli agulayo angabambeka emithanjeni yegazi, abangele ubuhlungu obukhulu futhi obungapheli, ukutheleleka, nezinye izinkinga.
• IHemoglobin (Hgb) C. Lolu hlobo lwe-hemoglobin aluthwali kahle umoya-mpilo. Kungadala uhlobo oluncane lwe-anemia.
• IHemoglobin (Hgb) E. Lolu hlobo lwe-hemoglobin lutholakala kakhulu kubantu bohlanga oluseningizimu-mpumalanga ye-Asia. Abantu abane-HgbE ngokuvamile abanazo izimpawu noma izimpawu ezincane ze-anemia.

Isivivinyo se-hemoglobin electrophoresis sisebenzisa amandla kagesi kusampula yegazi. Lokhu kwehlukanisa izinhlobo ezejwayelekile nezingavamile ze-hemoglobin. Uhlobo ngalunye lwe-hemoglobin lungabe selulinganiswa ngalunye.

Amanye amagama: Hb electrophoresis, ukuhlolwa kwe-hemoglobin, ukuhlolwa kwe-hemoglobinopathy, i-hemoglobin fractionation, i-Hb ELP, isikrini sesikela

Kusetshenziselwa ini?

I-Hemoglobin electrophoresis ilinganisa amazinga e-hemoglobin futhi ibheke izinhlobo ezingavamile ze-hemoglobin. Isetshenziswa kaningi ukusiza ukuxilonga i-anemia, isifo se-sickle cell, nezinye izifo ze-hemoglobin.

Kungani ngidinga i-hemoglobin electrophoresis?

Ungadinga ukuhlolwa uma unezimpawu zesifo se-hemoglobin. Lokhu kufaka phakathi:

• Ukukhathala
• Isikhumba esiphaphathekile
• I-jaundice, isimo esidala ukuthi isikhumba namehlo akho abe phuzi
• Ubuhlungu obukhulu (isifo se-sickle cell)
• Izinkinga zokukhula (ezinganeni)

Uma usanda kuba nengane, ingane yakho esanda kuzalwa izohlolwa njengengxenye yokuhlolwa kwezingane ezisanda kuzalwa. Ukuhlolwa okusanda kuzalwa kuyiqembu lezivivinyo ezinikezwa izingane eziningi zaseMelika ngemuva nje kokuzalwa. Ukuhlolwa kuhlola izimo ezahlukahlukene. Eziningi zalezi zimo zingelashwa uma zitholakale kusenesikhathi.

Ungase futhi ufune ukuhlolwa uma usengozini yokuba nengane enesifo se-sickle cell noma enye i-hemoglobin disorder. Izici zobungozi zifaka:

• Umlando womndeni
• Isizinda sobuhlanga
  • E-United States, iningi labantu abanezifo ze-sickle cell bangabakhokho base-Afrika.
  • I-Thalassemia, esinye isifo se-hemoglobin esizuzwe njengefa, sivame kakhulu kubantu base-Italiya, eGreek, eMpumalanga Ephakathi, e-Southern Asia nase-Afrika.

Kwenzekani ngesikhathi se-hemoglobin electrophoresis?

Uchwepheshe wezempilo uzothatha isampula yegazi emthanjeni osengalweni yakho, esebenzisa inaliti encane. Ngemuva kokuthi kufakwe inaliti, kuzoqoqwa inani elincane legazi kufakwe ithubhu yokuhlola noma isitsha. Ungase uzizwe uluma kancane lapho inaliti ingena noma iphuma. Lokhu ngokuvamile kuthatha imizuzu engaphansi kwemihlanu.

Ukuhlola usana olusanda kuzalwa, umhlinzeki wezokunakekelwa kwempilo uzohlanza isithende sengane yakho ngotshwala bese ephoqa isithende ngenaliti encane. Umhlinzeki uzoqoqa amaconsi ambalwa egazi bese efaka ibhandishi kusayithi.

Ngabe kukhona engizodinga ukukwenza ukulungiselela isivivinyo?

Awudingi noma yimaphi amalungiselelo akhethekile wokuhlolwa kwe-hemoglobin electrophoresis.

Ingabe zikhona izingozi ku-hemoglobin electrophoresis?

Kunengozi encane kakhulu yokuhlolwa kwegazi. Ungaba nobuhlungu obuncane noma ukulimaza lapho kufakwe khona inaliti, kepha izimpawu eziningi ziyaphela ngokushesha.

Ingane yakho ingazizwa incanyana lapho isithende sibhakwa, futhi umhuzuko omncane ungakheka esizeni. Lokhu kufanele kudlule ngokushesha.

Isho ukuthini imiphumela?

Imiphumela yakho izokhombisa izinhlobo ze-hemoglobin etholakele namazinga ngakunye.

Amazinga e-hemoglobin aphakeme kakhulu noma aphansi kakhulu angasho ukuthi:

• I-Thalassemia, isimo esithinta ukukhiqizwa kwe-hemoglobin. Izimpawu zisukela kokumnene kuya kokubi.
• Imfanelo yeseli eligulayo. Kulesi simo, unofuzo olulodwa lwe-sickle cell nohlobo olulodwa olujwayelekile. Iningi labantu abanesici se-sickle cell abanazo izinkinga zempilo.
• Isifo se-Sickle cell
• Isifo se-Hemoglobin C, isimo esidala uhlobo oluncane lwe-anemia futhi kwesinye isikhathi ubende obukhulisiwe nobuhlungu obuhlangene
• Isifo se-Hemoglobin SC, isimo esidala uhlobo olumaphakathi noma olulinganiselayo lwesifo se-sickle cell

Imiphumela yakho ingakhombisa nokuthi ngabe inkinga ethile imnene, imaphakathi, noma inzima.

Imiphumela yokuhlolwa kwe-hemoglobin electrophoresis ivame ukuqhathaniswa nezinye izivivinyo, kufaka phakathi ukubalwa kwegazi okuphelele kanye ne-blood smear. Uma unemibuzo ngemiphumela yakho, khuluma nomhlinzeki wakho wezokunakekelwa kwempilo.

Funda kabanzi mayelana nokuhlolwa kwelabhorethri, ububanzi bezinkomba, nemiphumela yokuqonda.

Ngabe kukhona okunye engidinga ukukwazi nge-hemoglobin electrophoresis?

Uma usengozini yokuba nengane ene-hemoglobin disorder oyizuze njengefa, ungahle uthande ukukhuluma nomeluleki wezofuzo. Umeluleki wezofuzo uchwepheshe oqeqeshwe ngokukhethekile kwezofuzo nasekuhloleni izakhi zofuzo. Angakusiza uqonde ukuphazamiseka nobungozi bakho bokukudlulisela enganeni yakho.

Izinkomba

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Imininingwane ekulesi siza akufanele isetshenziswe esikhundleni sezokunakekelwa kwezokwelapha noma iseluleko. Xhumana nomhlinzeki wezempilo uma unemibuzo ngempilo yakho.