Ingabe i-Psoriasis yisifo Esizenzakalelayo?

-Delile

• Ukubuka konke
• Ukuqonda izifo ezizimele
• Izimo ezivamile zokuzivikela komzimba
• I-Psoriasis njengesifo esizimele
• Ukwelashwa okuqonde amasosha omzimba
• Izidakamizwa ezindala
• I-Biologics
• Abamelene ne-TNF
• I-biologics entsha
• I-Psoriasis nobungozi bezinye izimo ezizimele
• Umbono

Ukubuka konke

I-Psoriasis yisifo sesikhumba esivuthayo esibonakala ngamachashazi abomvu esikhumba esikhumba embozwe ngezikali ezimhlophe zesiliva. Kuyisimo esingalapheki. Izimpawu zingafika zidlule, futhi zingahluka ngokuqina.

I-Psoriasis yisimo esivamile, esithinta cishe amaphesenti amathathu wabantu emhlabeni. Cishe abantu abayizigidi ezingama-7.4 e-United States bane-psoriasis.

Imbangela ngqo ye-psoriasis ayiqinisekile. Kucatshangwa ukuthi kuyinhlanganisela yofuzo, izici zemvelo, kanye namasosha akho omzimba.

Ngokuya ngentuthuko yocwaningo eminyakeni embalwa edlule, i-psoriasis ngokuvamile ibekwe njengesifo esizimele. Lokhu kusho ukuthi amaseli omzimba wakho, abizwa ngama-T cell, ahlasela ngephutha amaseli akho esikhumba njengabahlaseli bakwamanye amazwe. Lokhu kubangela ukuthi amangqamuzana akho esikhumba akhule ngokushesha, okuholele kwizilonda zesikhumba se-psoriasis.

Akubona bonke abacwaningi abacabanga ukuthi i-psoriasis yisifo sokuzimela komzimba. Abanye bayavuma ukuthi i-psoriasis yisimo esilawulwa amasosha omzimba. Kepha umbono wabo uthi i-psoriasis ibangelwa ukusabela okungajwayelekile okuhlobene nezakhi zofuzo kubhaktheriya besikhumba.

Ukuqonda izifo ezizimele

Imvamisa amasosha akho omzimba ayawabona amaseli akho futhi awahlaseli. Izifo zokuzivikela ngokuzenzakalela lapho amasosha akho omzimba ehlasela ngephutha amaseli angathi angaphandle kwabahlaseli abahlasela umzimba wakho.

Kunezifo ezingaphezu kuka-100 ezizimele. Ezinye izifo ezizimele komzimba zibandakanya ingxenye eyodwa kuphela yomzimba wakho - njengesikhumba sakho ku-psoriasis. Okunye kuhlelekile, okubandakanya umzimba wakho wonke.

Okuhlangene ngokufana konke ukuphazamiseka kokuzimela komzimba ukuthi kubangelwa inhlanganisela yezakhi zofuzo nezici zemvelo.

Impela ukuthi izakhi zofuzo nezimo zemvelo zihlangana kanjani ukudala izifo eziningi ezahlukahlukene yisihloko socwaningo oluqhubekayo.

Kuze kube manje, okwaziwayo ukuthi abantu abanokuthambekela kofuzo kokuzivikela komzimba bangase babe namathuba ama-2 kuye kwayi-5 amathuba okuba nesifo sokuzivikela komzimba njengabantu abangenaso isakhi sofuzo.

Iqembu lezakhi zofuzo elibandakanyekayo libizwa ngokuthi yi-histocompatibility complex, eyaziwa nge-HLA. I-HLA yehlukile kuwo wonke umuntu.

Ukuthambekela kofuzo kokuzimela komzimba kungahle kusebenze emindenini, kepha amalungu omndeni angakhula ngezifo ezahlukahlukene ezizimele. Futhi, uma unesifo esisodwa se-autoimmune, unengozi enkulu yokuthola esinye.

Kuncane okwaziwayo mayelana nezici ezithile zemvelo ezibangela isifo se-autoimmune kumuntu onesifo sofuzo sokuzimela.

Izimo ezivamile zokuzivikela komzimba

Nazi ezinye zezifo ezivame kakhulu ezenzakalelayo:

• isifo se-celiac (ukusabela ku-gluten)
• thayipha isifo sikashukela esingu-1
• izifo ezivuthayo zamathumbu, kufaka phakathi iCrohn's
• i-lupus (systemic lupus erythematosus, ethinta isikhumba, izinso, amalunga, ubuchopho nezinye izitho)
• isifo samathambo (ukuvuvukala kwamalunga)
• I-Sjögren's syndrome (ukoma emlonyeni wakho, amehlo, nakwezinye izindawo)
• i-vitiligo (ukulahleka kwesikhumba sombala, esidala amabala amhlophe)

I-Psoriasis njengesifo esizimele

Iningi lososayensi namuhla likholelwa ukuthi i-psoriasis yisifo esizimele. Kudala kwaziwa ukuthi amasosha omzimba abandakanyeka ku-psoriasis. Kodwa indlela eqondile ayiqinisekile.

Eminyakeni engamashumi amabili edlule, ucwaningo selusungule ukuthi izakhi zofuzo kanye namaqembu ezakhi zofuzo ahlotshaniswa ne-psoriasis abelwana ngezifo ezaziwayo zokuzivikela komzimba. Ucwaningo luphinde lwathola ukuthi imishanguzo yokuvikela imishanguzo iyindlela entsha yokwelapha i-psoriasis. Le mithi isebenza ngokucindezela amasosha omzimba ahlasela izicubu ezinempilo.

Ucwaningo luyaqhubeka endimeni yamaseli omzimba ama-T e-psoriasis. Amaseli e-T "amasosha" amasosha omzimba avame ukulwa nezifo. Lapho ama-T cell ehlasela kabi futhi esikhundleni salokho ehlasela isikhumba esinempilo, akhipha amaprotheni akhethekile abizwa ngokuthi ama-cytokines. Lokhu kubangela ukuthi amangqamuzana esikhumba ande futhi akhe phezu kwesikhumba sakho, okuholela ekutheni kube nezilonda ze-psoriatic.

I-athikili ka-2017 ibike ngocwaningo olusha olukhombe ukusebenzisana kwamaseli athile we-T kanye nama-interleukin asevele aziwa ukuthi ayabandakanyeka ekwakhiweni kwe-psoriasis. Njengoba imininingwane eminingi yaziwa, kungenzeka ukuthi kutholakale izindlela zokwelashwa ezihlosiwe ezintsha.

Ukwelashwa okuqonde amasosha omzimba

Ukwelashwa kwe-psoriasis kuya ngohlobo nobukhulu besimo, impilo yakho ejwayelekile, nezinye izinto.

Nazi izindlela zokwelapha ezahlukahlukene eziqondise ezicini ezithile kumasosha omzimba abangela ukuvuvukala. Lezi zivame ukusetshenziselwa lapho izimpawu zakho ze-psoriasis ziphakathi kokuqina. Qaphela ukuthi imishanguzo emisha ibiza kakhulu.

Izidakamizwa ezindala

Izidakamizwa ezimbili ezindala ezisetshenziselwa ukucindezela amasosha omzimba kanye nezimpawu ezicacile ze-psoriasis yi-methotrexate ne-cyclosporine. Lezi zombili ziyasebenza, kepha zinemiphumela emibi enobuthi lapho zisetshenziswa isikhathi eside.

I-Biologics

Abamelene ne-TNF

Isidakamizwa sakamuva sihlose into ebangela ukuvuvukala okubizwa nge-tumor necrosis factor (TNF). I-TNF iyi-cytokine eyenziwe izingxenye zomzimba wokuzivikela ezifana nama-T cell. Le mithi emisha ibizwa ngama-antagonists e-TNF.

Imithi elwa ne-TNF iyasebenza, kepha incane kune-biologics entsha. Izidakamizwa eziphikisayo ze-TNF zifaka:

• i-adalimumab (Humira)
• i-etanercept (Enbrel)
• infliximab (i-Remicade)
• isitifiketi se-certolizumab (Cimzia)

I-biologics entsha

Okusanda kwenziwa kwe-biologics kuhlose futhi kuvimbe izindlela ezithile ze-T kanye ne-interleukin ezibandakanyeka ku-psoriasis. Ama-biologics amathathu ahlose i-IL-17 avunyelwe kusukela ngo-2015:

• secukinumab (Cosentyx)
• ixekizumab (Taltz)
• brodalumab (Siliq)

Ezinye izidakamizwa zihlose ukuvimba enye indlela ye-interleukin (I-23 ne-IL-12):

• ustekinuman (Stelara) (IL-23 no-IL-12)
• i-guselkumab (Tremfya) (IL-23)
• I-tildrakizumab-asmn (Ilumya) (IL-23)
• i-risankizumab-rzaa (i-Skyrizi) (IL-23)

Lezi biologics zikhombisile ukuthi ziphephile futhi ziyasebenza.

I-Psoriasis nobungozi bezinye izimo ezizimele

Ukuba nesifo esisodwa sokuzivikela komzimba njenge-psoriasis kukubeka ekuthuthukiseni esinye isifo sokuzilimaza. Ingozi iyanda uma i-psoriasis yakho inzima.

Amaqembu ezakhi zofuzo abeka phambili ekuthuthukiseni i-autoimmune disorder ayafana ezinhlotsheni ezahlukahlukene zezifo ezizimele. Ezinye zezinqubo zokuvuvukala nezici zemvelo nazo ziyafana.

Izinkinga ezinkulu ezizimele ezihambisana ne-psoriasis yilezi:

• i-psoriatic arthritis, ethinta amaphesenti angama-30 kuya kwangu-33 abantu abane-arthritis
• isifo samathambo
• isifo se-celiac
• Isifo sikaCrohn nezinye izifo zamathumbu
• i-multiple sclerosis
• lupus (systemic lupus erythematosus noma i-SLE)
• izifo ze-thyroid
• Isifo seSjögren
• ukulahleka kwezinwele okuzenzakalelayo (i-alopecia areata)
• pemphigoid oyinkunzi

I-psoriasis inesifo samathambo.

Ubudlelwano be-psoriasis nezinye izifo ezizimele yisihloko sesifundo esiqhubekayo. Okunye okufundwayo yinhlangano ye-psoriasis namazinga aphezulu okufa aqhamuka kulezo zifo.

Umbono

Umbono wabantu abane-psoriasis muhle kakhulu. Isimo asikwazi ukwelashwa, kepha ukwelashwa kwamanje kungagcina izimpawu zilawulwa.

Ucwaningo lwezokwelapha luyaqhubeka nokuthola imininingwane eminingi mayelana nezimbangela ze-psoriasis nokunye ukuphazamiseka komzimba. Lokhu kutholwa okusha kusiza ekwakhiweni kwemithi emisha ekhomba ngqo futhi ivimbe izindlela zezifo.

Isibonelo, ezinye izidakamizwa eziningana ezibhekiswe ku-interleukin-23 manje sezisezivivinyweni zokwelashwa. Ezinye izindlela ezintsha kungenzeka ziphume ocwaningweni oluqhubekayo ngezifo ezizimele ngokujwayelekile.

Khuluma nodokotela wakho ngokubamba iqhaza ezivivinyweni eziqhubekayo zomtholampilo nangentuthuko entsha. Ungase futhi ufune ukujoyina iqembu le-inthanethi le-psoriasis / PsA.