Iyini iMethotrexate?

-Delile

• Yenzelwe ini
• Isetshenziswa kanjani
• 1. Isifo samathambo
• 2. I-Psoriasis
• 3. Umdlavuza
• Imiphumela emibi engaba khona
• Ngubani ongafanele asebenzise

Ithebhulethi yeMethotrexate iyikhambi eliboniswe ekwelapheni i-rheumatoid arthritis ne-psoriasis enamandla engaphenduli kwezinye izindlela zokwelapha. Ngaphezu kwalokho, i-methotrexate iyatholakala njengesijovo, esetshenziswa ekhemotherapy yokwelapha umdlavuza.

Leli khambi litholakala ngesimo sephilisi noma umjovo futhi lingatholakala emakhemisi ngaphansi kwegama leTecnomet, Enbrel ne-Endofolin, isibonelo.

Yenzelwe ini

I-Methotrexate kumathebulethi ikhonjisiwe ekwelapheni isifo samathambo, ngoba inemiphumela emasosheni omzimba, anciphisa ukuvuvukala, isenzo sayo siqashelwa kusukela ngeviki lesithathu lokwelashwa.Ekwelapheni i-psoriasis, i-methotrexate inciphisa ukwanda nokuvuvukala kwamaseli esikhumba kanye nemiphumela yayo kubonwa emavikini ayi-1 kuye kwayi-4 ngemuva kokuqala kokwelashwa.

I-methotrexate ejojowe ikhonjiswa ukwelapha i-psoriasis enamandla kanye nezinhlobo zomdlavuza ezilandelayo:

• Ama-neoplasms we-Gestational trophoblastic;
• Ama-leukemias acute lymphocytic;
• Umdlavuza omncane wamaphaphu wamangqamuzana;
• Umdlavuza wekhanda nentamo;
• Umdlavuza webele;
• I-Osteosarcoma;
• Ukwelashwa kanye ne-prophylaxis ye-lymphoma noma i-leukemia ye-meningeal;
• Ukwelashwa kwe-Palliative kwezicubu eziqinile ezingasebenzi;
• I-non-Hodgkin's lymphomas kanye neBurkitt's lymphoma.

Isetshenziswa kanjani

1. Isifo samathambo

Umthamo womlomo onconyiwe ungaba ngu-7.5 mg, kanye ngesonto noma u-2.5 mg, njalo emahoreni ayi-12, ngemithamo emithathu, elawulwa njengomjikelezo, kanye ngesonto.

Imithamo yohlobo ngalunye kufanele ilungiswe kancane kancane ukufeza impendulo enhle, kepha akufanele yeqe umthamo ophelele weviki ongu-20 mg.

2. I-Psoriasis

Umthamo womlomo onconywayo ngu-10 - 25 mg ngesonto, kuze kube kutholakala impendulo eyanele noma, kungenjalo, ngu-2.5 mg, njalo ngamahora ayi-12, ngemithamo emithathu.

Imithamo yomuthi ngamunye ingalungiswa kancane kancane ukufeza impendulo efanele yomtholampilo, igweme ukweqa umthamo we-30 mg ngeviki.

Ezimweni ze-psoriasis eqinile, lapho kusetshenziswa i-methotrexate ejojowe khona, kufanele kunikezwe isilinganiso esisodwa se-10 kuye ku-25 mg ngesonto kuze kube kutholakala impendulo eyanele. Funda ukukhomba izimpawu ze-psoriasis nokuthi yikuphi ukunakekelwa okubalulekile okufanele ukwenze.

3. Umdlavuza

Ububanzi bomthamo wokwelashwa we-methotrexate yezinkomba ze-oncological ubanzi kakhulu, kuya ngohlobo lomdlavuza, isisindo somzimba nezimo zesiguli.

Imiphumela emibi engaba khona

Imiphumela emibi kakhulu engahle yenzeke ngesikhathi sokwelashwa ngamaphilisi e-methotrexate yikhanda elibuhlungu, ukuqina kwentamo, ukuhlanza, umkhuhlane, ukubomvu kwesikhumba, i-uric acid eyengeziwe nokuncipha kwenani lesidoda, ukuvela kwezilonda zomlomo, ukuvuvukala kolimi kanye izinsini, isifo sohudo, kunciphise amaseli amhlophe egazi nokubala kweplatelet, ukwehluleka kwezinso ne-pharyngitis.

Ngubani ongafanele asebenzise

Ithebhulethi yeMethotrexate iyaphikiswa kwiziguli ezinokungezwani komzimba ne-methotrexate noma enye into yokwakheka, abesifazane abakhulelwe, abesifazane abancelisayo, abantu abanamasosha omzimba abuthaka, isibindi esibi noma ukungasebenzi kahle kwezinso nezinguquko kumaseli egazi njengokuncipha kwamaseli egazi amaseli amhlophe egazi, okubomvu amangqamuzana egazi namaplatelets.