Izizathu Ezi-6 Zokuzama I-Biologics Yesifo Sakho SikaCrohn

-Delile

• 1. Awuphenduli ekwelashweni kwendabuko kwezifo zikaCrohn
• 2. Uthola ukuxilongwa okusha
• 3. Uhlangabezana nenkinga eyaziwa ngokuthi ama-fistula
• 4. Ufuna ukugcina ukuxolelwa
• 5. Umthamo ungaba kanye ngenyanga
• 6. I-Biologics ingaba nemiphumela emibi embalwa kune-steroids
• Ukunqoba ukungabaza kwakho
• Ukukhetha i-biologic

Njengomuntu ophila nesifo sikaCrohn, kungenzeka ukuthi uke wezwa nge-biologics futhi kungenzeka ukuthi uke wacabanga nokuzisebenzisa ngokwakho. Uma kukhona okubambe emuva, ufike endaweni efanele.

Nazi izizathu eziyisithupha ongafuna ukubuyekeza ngazo lolu hlobo lokwelashwa oluthuthukile, namathiphu wokuthi ungakwenza kanjani lokhu.

1. Awuphenduli ekwelashweni kwendabuko kwezifo zikaCrohn

Mhlawumbe ubuthatha imishanguzo ehlukene yezifo zikaCrohn, njenge-steroids kanye nama-immunomodulators, isikhashana manje. Kodwa-ke, useneziqubu kaningana ngonyaka.

Imikhombandlela ye-American College of Gastroenterology (ACG) incoma ngokuqinile ukuthatha umenzeli we-biologic uma unesifo sikaCrohn esisesimweni esiphakathi nesinamandla esiphikisana nama-steroids noma ama-immunomodulators. Udokotela wakho futhi angacabanga ngokuhlanganisa i-biologic ne-immunomodulator, noma ngabe awukazami lezo zidakamizwa ngokwehlukana okwamanje.

2. Uthola ukuxilongwa okusha

Ngokwesiko, izinhlelo zokwelashwa kwesifo sikaCrohn zazihilela indlela yokukhuphuka. Izidakamizwa ezingabizi kakhulu, njenge-steroids, zazanywa kuqala, kuyilapho ama-biologics abiza kakhulu azanywa okokugcina.

Muva nje, imihlahlandlela igqugquzela indlela ephezulu yokwelashwa, njengoba ubufakazi buveze imiphumela ephumelelayo yokwelashwa kwe-biologic ezigulini ezisanda kutholakala.

Isibonelo, isifundo esisodwa esikhulu sedatha yezimangalo zokwelashwa ithole ukuthi ukuqala i-biologics ekuqaleni kwenkambo yokwelashwa kwesifo sikaCrohn kuthuthukisa ukusabela emithini.

Iqembu lokutadisha eliqale ukulwa ne-TNF biologics kusenesikhathi lalinamazinga aphansi kakhulu ama-steroid adinga ukwelashwa kwama-flare-ups kunamanye amaqembu okufunda. Baphinde bahlinza okumbalwa ngenxa yesifo sikaCrohn.

3. Uhlangabezana nenkinga eyaziwa ngokuthi ama-fistula

AmaFistula ukuxhumana okungavamile phakathi kwezitho zomzimba. Esikhathini sesifo sikaCrohn, i-fistula ingenzeka lapho isilonda sidlulela odongeni lwakho lwamathumbu, oluxhuma amathumbu akho nesikhumba, noma amathumbu akho nesinye isitho.

Uma i-fistula itheleleka, ingasongela impilo. I-Biologics eyaziwa ngokuthi i-TNF inhibitors ingahle inqunywe udokotela wakho uma une-fistula ngoba iyasebenza kakhulu.

I-FDA igunyaze i-biologics ngokukhethekile ukwelapha isifo sikaCrohn esibhakabhakeni nokugcina ukuvalwa kwe-fistula.

4. Ufuna ukugcina ukuxolelwa

AmaCorticosteroids aziwa ngokuletha ukuxolelwa kodwa awakwazi ukugcina lokho kuxolelwa. Uma ngabe uthathe i-steroids izinyanga ezintathu noma ngaphezulu, udokotela wakho angakuqala ku-biologic esikhundleni salokho. Ucwaningo lomtholampilo lubonisa ukuthi i-anti-TNF biologics iyakwazi ukugcina ukuxolelwa ezigulini ezinesifo sikaCrohn esibi kakhulu.

I-ACG inqume ukuthi izinzuzo zale mithi yokugcina ukuxolelwa zidlula ukulimala kweziguli eziningi.

5. Umthamo ungaba kanye ngenyanga

Umcabango womjovo ungasabisa, kepha ngemuva kokutholwa okumbalwa kokuqala, iningi le-biologics liphathwa kanye ngenyanga. Ngaphezu kwalokhu, inaliti incane kakhulu, kanti umuthi ujovwa ngaphansi kwesikhumba sakho.

Iningi le-biologics nalo linikezwa ngendlela ye-auto-injector - lokhu kusho ukuthi ungathola imijovo ngaphandle kokubona inaliti. Ungazinikeza ngisho ne-biologics ethile ekhaya ngemuva kokuthi uqeqeshwe kahle ukuthi ungakwenza kanjani lokho.

6. I-Biologics ingaba nemiphumela emibi embalwa kune-steroids

ICorticosteroids esetshenziselwa ukwelapha isifo sikaCrohn, njenge-prednisone noma i-budesonide, isebenza ngokucindezela wonke amasosha omzimba.

Ngakolunye uhlangothi, i-Biologics, isebenza ngendlela ekhethiwe ngokukhomba amaprotheni athile kumasosha akho omzimba asevele efakazelwe ukuthi ahlobene nokuvuvukala kukaCrohn. Ngalesi sizathu, banemiphumela emibi embalwa kune-corticosteroids.

Cishe yonke imithi inobungozi bemiphumela emibi. Ku-biologics, imiphumela emibi kakhulu ehlobene nokuthi iphathwa kanjani. Ungahle uthole ukuthukuthela okuncane, ukuba bomvu, ubuhlungu, noma ukusabela endaweni yomjovo.

Kukhona nobungozi obuphakeme kancane bokutheleleka, kepha ubungozi abuphakeme njengezinye izidakamizwa, njenge-corticosteroids.

Ukunqoba ukungabaza kwakho

I-biologic yokuqala yesifo sikaCrohn yavunywa ngo-1998, ngakho-ke i-biologics inokuhlangenwe nakho okuncane nokuhlolwa kokuphepha ukuze bazibonise. Ungahle ube manqikanqika ukuzama ukwelashwa kwe-biologic ngoba uzwile ukuthi yizidakamizwa "ezinamandla" noma wesaba izindleko eziphezulu.

Yize kuyiqiniso ukuthi i-biologics ibhekwa njengenketho yokwelashwa enolaka kakhulu, i-biologics nayo iyizidakamizwa ezibhekiswe kakhulu, futhi zisebenza kahle kakhulu.

Ngokungafani nezinye izindlela zokwelapha ezindala zesifo sikaCrohn esenza buthakathaka amasosha omzimba, izidakamizwa ze-biologic zikhomba amaprotheni athile okuvuvukala aziwa ngokubandakanyeka kwisifo sikaCrohn. Ngokuphambene nalokho, izidakamizwa ze-corticosteroid zicindezela wonke amasosha omzimba wakho.

Ukukhetha i-biologic

Ngaphambi kwe-biologics, zazimbalwa izindlela zokwelashwa ngaphandle kokuhlinzwa kwabantu abanesifo esibi sikaCrohn. Manje kunezinketho eziningi:

• i-adalimumab (Humira, Exemptia)
• isitifiketi se-certolizumab (Cimzia)
• infliximab (Remicade, Remsima, Inflectra)
• i-natalizumab (Tysabri)
• ustekinumab (Stelara)
• i-vedolizumab (Entyvio)

Kuzofanele usebenze nenkampani yakho yomshuwalense ukuthola ukuthi ngabe i-biologic ethile imbozwe ngaphansi kohlelo lwakho.

Kusobala ukuthi imishanguzo ye-biologic ithuthukise ukwakheka kwamathuba okwelapha isifo sikaCrohn nezinye izinkinga ezizimele. Ucwaningo luyaqhubeka nokukhula kwi-biologics, okwenza kube lula ukuthi ezinye izindlela zokwelashwa zingatholakala esikhathini esizayo.

Ekugcineni, uhlelo lwakho lokwelashwa yisinqumo esenziwe kahle nodokotela wakho.