Osimertinib

-Delile

• Ngaphambi kokuthatha i-osimertinib,
• I-Osimertinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:
• Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

I-Osimertinib isetshenziselwa ukusiza ukuvimbela uhlobo oluthile lomdlavuza wamaphaphu ongelona amaseli amancane (i-NSCLC) ukuthi ungabuyi ngemuva kokuba isimila sesisusiwe ngokuhlinzwa kubantu abadala. Iphinde isetshenziswe njengokwelashwa kokuqala kohlobo oluthile lwe-NSCLC olusabalale lwaya kwezinye izingxenye zomzimba kubantu abadala. I-Osimertinib ibuye isetshenziselwe ukwelapha izinhlobo ezithile ze-NSCLC ezisabalalele kwezinye izingxenye zomzimba kubantu abadala abebengelashwa ngempumelelo ngeminye imithi yokwelashwa ngamakhemikhali efanayo. U-Osimertinib usesigabeni semithi ebizwa nge-kinase inhibitors. Isebenza ngokuvimba ukusebenza kweprotheni engavamile ekhombisa ukuthi amangqamuzana omdlavuza ayanda. Lokhu kusiza ukumisa noma ukubambezela ukusabalala kwamangqamuzana omdlavuza futhi kungasiza ekunciphiseni izicubu.

U-Osimertinib uza njengethebhulethi azoyithatha ngomlomo. Imvamisa kuthathwa nokudla noma ngaphandle kokudla kanye ngosuku. Ubude bokwelashwa kwakho buncike ekutheni lo muthi usebenza kanjani kuwe, kanye nemiphumela emibi oyitholayo. Thatha i-osimertinib ngasikhathi sinye nsuku zonke. Landela izinkomba ezikulebuli kadokotela wakho ngokucophelela, bese ubuza udokotela noma usokhemisi wakho ukuthi akuchaze nganoma iyiphi ingxenye ongayiqondi. Thatha i-osimertinib njengoba nje kuqondisiwe. Ungayithathi kancane noma uyithathe kaningi kunokuyalelwa ngudokotela wakho.

Uma ungakwazi ukugwinya amaphilisi, beka ithebhulethi ngezipuni ezine (2 oz (60 ml) wamanzi) bese unyakazisa kuze kube yilapho ithebhulethi iba yizicucu ezincane. Phuza ingxube ngokushesha. Thela enye ingxenye yenkomishi (4 oz [120 mL]) enkomishini yamanzi (8 oz [240 mL]) esitsheni osisebenzisile, ugeze, uphuze ukuqinisekisa ukuthi uthola umthamo ophelele we-osimertinib. Ungasebenzisi amanzi anekhabhoni noma olunye uketshezi ukuncibilikisa ithebhulethi ye-osimertinib. Ungayichobozi ithebhulethi noma ushise ingxube. Uma uneshubhu le-nasogastric (NG), udokotela wakho noma usokhemisi uzokuchaza ukuthi ungayinikeza kanjani le ngxube ngepayipi le-NG.

Udokotela wakho angamisa ukwelashwa kwakho okwesikhashana noma unomphela noma anciphise umthamo wakho we-osimertinib ngokuya ngemiphumela oyitholayo. Qiniseka ukuthi ukhuluma nodokotela wakho mayelana nokuthi uzizwa kanjani ngesikhathi sokwelashwa kwakho. Ungayeki ukuthatha i-osimertinib ngaphandle kokukhuluma nodokotela wakho.

Buza usokhemisi noma udokotela wakho ikhophi lemininingwane yomkhiqizi yesiguli.

Lo muthi ungabekelwa okunye ukusetshenziswa; buza udokotela wakho noma usokhemisi ukuthola eminye imininingwane.

Ngaphambi kokuthatha i-osimertinib,

• Tshela udokotela wakho kanye nosokhemisi uma unegciwane ku-osimertinib, noma imiphi eminye imithi, noma yiziphi izithako kuthebhulethi ye-osimertinib. Buza usokhemisi wakho ukuthola uhlu lwezithako.
• Tshela udokotela wakho kanye nosokhemisi ukuthi imiphi imishanguzo kadokotela noma ongayinikiwe, amavithamini, izithako zokudla okunomsoco ozithathayo noma ohlela ukuzithatha. Qiniseka ukuthi usho noma ikuphi kokulandelayo: anagrelide (Agrylin); i-arsenic trioxide (iTrisenox); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-chloroquine (Aralen); i-chlorpromazine; i-cilostazol (i-Pletal); i-citalopram (Celexa); i-donepezil (i-Aricept); i-escitalopram (iLexapro); i-haloperidol (iHaldol); imithi yenhliziyo noma yegazi; i-methadone (i-Dolophine, i-Methadose); i-oxaliplatin (i-Eloxatin); i-phenytoin (iDilantin, Phenytek); ipimozide (i-Orap); i-quinidine (ku-Nuedexta); i-rifampin (i-Rifadin, i-Rimactane, e-Rifamate, i-Rifater); i-rosuvastatin (iCrestor); i-sulfasalazine (i-Azulfidine); thioridazine; i-topotecan (iHycamtin); kanye ne-vandetanib (Caprelsa). Udokotela wakho angadinga ukushintsha imithamo yemithi yakho noma akuqaphele ngokucophelela ngemiphumela emibi. Eminye imithi eminingi ingase futhi ihlanganyele ne-osimertinib, ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyiphuzayo, ngisho nalawo angaveli kulolu hlu.
• utshele udokotela wakho ukuthi uthatha miphi imikhiqizo yamakhambi, ikakhulukazi iSt John's wort.Udokotela wakho mhlawumbe uzokutshela ukuthi ungathathi i-wort yaseSt.John ngenkathi uthatha i-osimertinib.
• utshele udokotela wakho uma ngabe uke waba ne-QT syndrome ende noma (wake waba nesimo esandisa ingozi yokuhlaselwa ukushaya kwenhliziyo okungajwayelekile okungadala ukuquleka noma ukufa ngokuzuma); ukushaya kwenhliziyo okungajwayelekile; ukwehluleka kwenhliziyo (isimo lapho inhliziyo ingakwazi ukupompa igazi elanele kwezinye izingxenye zomzimba); ephakeme noma engaphansi kwamazinga ajwayelekile we-sodium, potassium, calcium, noma i-magnesium egazini lakho; izinkinga zamehlo; noma ezinye izimo zamaphaphu.
• kufanele wazi ukuthi i-osimertinib inganciphisa ukuzala kwabesilisa nabesifazane. Kodwa-ke, akufanele ucabange ukuthi wena noma umlingani wakho anikwazi ukukhulelwa. Tshela udokotela wakho uma ukhulelwe, noma uhlele ukukhulelwa. Uzodinga ukuthatha ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi akufanele ukhulelwe ngenkathi uthatha i-osimertinib. Sebenzisa ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho ne-osimertinib, kanye namasonto ayisithupha ngemuva komthamo wakho wokugcina. Uma ungowesilisa futhi umlingani wakho angakhulelwa, kufanele usebenzise ukulawulwa kokubeletha okusebenzayo ngesikhathi sokwelashwa kwakho nezinyanga ezi-4 ngemuva komthamo wakho wokugcina. Khuluma nodokotela wakho ngezindlela zokulawula ukubeletha ezizokusebenzela. Uma wena noma umlingani wakho ukhulelwa ngenkathi uthatha i-osimertinib, shayela udokotela wakho ngokushesha. U-Osimertinib angalimaza umbungu.
• tshela udokotela wakho uma uncelisa. Udokotela wakho angakutshela ukuthi ungancelisi ngesikhathi sokwelashwa kwakho kanye namaviki amabili ngemuva komthamo wakho wokugcina.

Ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, qhubeka nokudla okuvamile.

Yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho sokulinganisa esivamile. Ungathathi umthamo sekwephuzile noma uthathe umthamo ophindwe kabili ukwenzela okulahlekile.

I-Osimertinib ingadala imiphumela emibi. Tshela udokotela wakho uma kukhona kulezi zimpawu ezinzima noma ezingapheli:

• isifo sohudo
• ukuqunjelwa
• ukuqubuka
• ukulunywa
• isikhumba esomile noma esiqhekezayo
• eczema
• isicanucanu
• ukuhlanza
• ukulahlekelwa isifiso sokudla
• ukuvuvukala noma izilonda emlonyeni
• ukuhlungu obusemhlane
• izinguquko zezipikili ezibandakanya ukuvuvukala, ububomvu, ubuhlungu, ukuhlukana, ukwephuka, nokwehlukana noma ukulahlekelwa kusuka ku-nailbed

Eminye imiphumela emibi ingaba mibi. Uma uhlangabezana nenye yalezi zimpawu, shayela udokotela wakho ngokushesha noma uthole ukwelashwa okuphuthumayo:

• ukushesha, noma ukushaya kwenhliziyo; ukuphelelwa umoya; ukuvuvukala kwamaqakala noma izinyawo, noma ukuzizwa unekhanda elincane
• imfiva; ukuphefumula okusha noma okuya kuba kubi; ukuphefumula kanzima, noma ukukhwehlela
• ukuqhuma kwesikhumba noma ukuxebuka
• amabala ansomi, ububomvu, noma isifuba ezingalweni, emilenzeni ephansi, noma ezinqeni
• ubuhlungu besifuba
• ukukhathala ngokweqile
• amehlo avuvukile, abomvu, acwebe noma abuhlungu; ukuzwela ekukhanyeni; noma izinguquko zombono

I-Osimertinib ingadala eminye imiphumela emibi. Shayela udokotela wakho uma unezinkinga ezingavamile ngenkathi uthatha lo muthi.

Uma uthola imiphumela emibi kakhulu, wena noma udokotela wakho ungathumela umbiko kuhlelo lwe-Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting online (http://www.fda.gov/Safety/MedWatch) noma ngocingo ( 1-800-332-1088).

Gcina le mithi esitsheni efike ngayo, ivalwe ngokuqinile, futhi lapho izingane zingafinyeleleki khona. Gcina ekamelweni lokushisa futhi kude nokushisa okweqile nomswakama (hhayi endlini yangasese).

Kubalulekile ukugcina yonke imishanguzo ingabonakali futhi ifinyeleleke ezinganeni njengoba iziqukathi eziningi (njengezingqondo zamaphilisi zamasonto onke kanye nalawo amaconsi wamehlo, okhilimu, amabala, kanye nama-inhalers) azimeleki ezinganeni futhi izingane ezincane zingazivula kalula. Ukuvikela izingane ezisencane ekufakeni ubuthi, hlala uvala amakepisi okuphepha bese ubeka umuthi endaweni ephephile - eyodwa ephezulu futhi engekho futhi engabonakali kubo futhi efinyelela kuyo. http://www.upandaway.org

Imithi engadingeki kufanele ilahlwe ngezindlela ezikhethekile zokuqinisekisa ukuthi izilwane ezifuywayo, izingane nabanye abantu abakwazi ukuzidla. Kodwa-ke, akufanele ukhiphe le mithi ethoyilethi. Esikhundleni salokho, indlela engcono kakhulu yokulahla imithi yakho ngohlelo lokubuyisa umuthi. Khuluma nosokhemisi wakho noma uthinte umnyango wangakini wokulahla udoti / wokusebenzisa kabusha ukuze ufunde ngezinhlelo zokubuyisa emphakathini wakho. Bheka iwebhusayithi yakwa-FDA's Safe Disposal of Medicines (http://goo.gl/c4Rm4p) ukuthola eminye imininingwane uma ungakwazi ukufinyelela kuhlelo lokubuyisa.

Uma kwenzeka ukweqisa ngokweqile, shayela ucingo losizo lokulawula ubuthi ku-1-800-222-1222. Imininingwane iyatholakala online ku-https: //www.poisonhelp.org/help. Uma isisulu siwile, saba nokuquleka, sinenkinga yokuphefumula, noma singakwazi ukuvuswa, shayela ngokushesha abezimo eziphuthumayo ku-911.

Gcina wonke ama-aphoyintimenti nodokotela wakho kanye nelabhorethri. Udokotela wakho uzo-oda izivivinyo ezithile zomsebenzi wenhliziyo ngaphambi nangesikhathi sokwelashwa kwakho ukuze aqiniseke ukuthi kuphephile kuwe ukuthatha i-osimertinib, nokuhlola ukuphendula komzimba wakho emithini. Udokotela wakho angaphinde ahlele ukuhlolwa kwelebhu ngaphambi kokuba uqale ukwelashwa kwakho ukuthola ukuthi umdlavuza wakho ungelashwa nge-osimertinib.

Kubalulekile ukuthi ugcine uhlu olubhaliwe lwayo yonke imishanguzo oyisebenzisayo kadokotela kanye nokungabhaliswanga (ngaphezulu kokuthenga), kanye nanoma yimiphi imikhiqizo efana namavithamini, amaminerali, noma ezinye izithako zokudla. Kufanele uze nalolu hlu njalo uma uvakashela udokotela noma uma ungeniswa esibhedlela. Kubaluleke kakhulu futhi nemininingwane ebalulekile ukuthi uphathe uma kwenzeka kunezimo eziphuthumayo.

• UTagrisso^®