Ungaluqonda kanjani ukuhlolwa kwe-TGO-AST: I-Aspartate Aminotransferase

-Delile

• Kusho ukuthini i-AST ephezulu
• Isizathu se-Ritis
• Lapho kuhlolwa ukuhlolwa

Ukuhlolwa kwe-aspartate aminotransferase noma i-oxalacetic transaminase (AST noma i-TGO), ukuhlolwa kwegazi kucelwa ukuphenya izilonda ezibeka engozini ukusebenza okujwayelekile kwesibindi, njenge-hepatitis noma i-cirrhosis, ngokwesibonelo.

I-oxalacetic transaminase noma i-aspartate aminotransferase iyi-enzyme ekhona esibindi futhi ijwayele ukuphakama lapho ukulimala kwesibindi kungapheli, ngoba kutholakala ngaphakathi ngaphakathi esitokisini sesibindi. Kodwa-ke, le enzyme ingaba khona nasenhliziyweni, futhi ingasetshenziswa njenge-marker yenhliziyo, engakhombisa ukuthi i-infarction noma i-ischemia.

Njengophawu lwesibindi, i-AST ivame ukulinganiswa kanye ne-ALT, njengoba ingaphakanyiswa kwezinye izimo, ingacacisi kahle ngale njongo. O inani lesethenjwa le-enzyme liphakathi kuka-5 no-40 U / L wegazi, ongahluka ngokwe-laboratory.

Kusho ukuthini i-AST ephezulu

Yize ukuhlolwa kwe-AST / TGO kungacacisiwe, udokotela anga-oda lokhu kuhlolwa kanye nokunye okukhombisa impilo yesibindi, njengokulinganisa kwe-gamma-glutamyltransferase (GGT), i-alkaline phosphatase (ALK) futhi, ikakhulukazi i-ALT / TGP. Funda kabanzi mayelana nokuhlolwa kwe-ALT.

I-AST eyandisiwe, noma i-TGO ephezulu, ingakhombisa:

• I-pancreatitis enamandla;
• Isifo sokusha kwesibindi kohlobo;
• I-hepatitis enotshwala;
• Isifo sokuqina kwesibindi;
• Ithumba esibindini;
• Umdlavuza wesibindi oyinhloko;
• Ukuhlukumezeka okukhulu;
• Ukusetshenziswa kwemithi edala ukulimala kwesibindi;
• Ukungakwazi ukusebenza kwenhliziyo;
• Ischemia;
• Isifinyezo;
• Ukushisa;
• I-Hypoxia;
• Ukuvinjelwa kwamapayipi e-bile, njenge-cholangitis, i-choledocholithiasis;
• Ukulimala kwemisipha kanye ne-hypothyroidism;
• Ukusetshenziswa kwamakhambi afana ne-heparin therapy, salicylates, opiates, tetracycline, thoracic noma isoniazid

Amanani angaphezu kuka-150 U / L ngokuvamile akhombisa ukulimala kwesibindi nangaphezulu kuka-1000 U / L angakhombisa isifo sokusha kwesibindi esidalwa ukusetshenziswa kwemithi, njenge-paracetamol, noma i-ischemic hepatitis, ngokwesibonelo. Ngakolunye uhlangothi, ukwehla kwamanani we-AST kungakhombisa ukusweleka kukavithamini B6 endabeni yabantu abadinga i-dialysis.

[ukuhlolwa-ukubuyekeza-tgo-tgp]

Isizathu se-Ritis

Isizathu se-Ritis sisetshenziselwa ukwelashwa ukuhlola ubukhulu bokulimala kwesibindi futhi ngaleyo ndlela kutholakale ukwelashwa okungcono kakhulu kwalesi simo. Lesi silinganiso sibheka amanani we-AST ne-ALT futhi uma ephakeme kuno-1 kukhombisa ukulimala okubi kakhulu, njenge-cirrhosis noma umdlavuza wesibindi, isibonelo. Lapho ingaphansi kuka-1 kungakhombisa isigaba esibucayi se-hepatitis yegciwane, ngokwesibonelo.

Lapho kuhlolwa ukuhlolwa

Ukuhlolwa kwegazi kwe-TGO / AST kungalawulwa ngudokotela lapho kudingeka ukuhlola impilo yesibindi, ngemuva kokubona ukuthi umuntu ukhuluphele ngokweqile, unamafutha esibindi noma ukhombisa izimpawu noma izimpawu ezifana nombala wesikhumba ophuzi, izinhlungu isisu sohlangothi lwangakwesokudla noma uma kwenzeka kunezitulo ezikhanyayo nomchamo omnyama.

Ezinye izimo lapho kungasiza futhi ukuhlola le enzyme ngemuva kokusebenzisa imishanguzo engalimaza isibindi nokuhlola isibindi sabantu abaphuza iziphuzo eziningi zotshwala.