I-Primary-Progressive vs. MS Ebuyisela kabusha

-Delile

• Yini i-MS eyinhloko eqhubekayo?
• Yiziphi izimpawu ezijwayelekile ze-PPMS?
• Ngubani othola i-PPMS?
• Yini ebangela i-PPMS?
• Uyini umbono we-PPMS?
• Yikuphi ukwelashwa okutholakalayo kwe-PPMS?
• Kuyini ukubuyisela kabusha i-MS?
• Yiziphi izimpawu ezivamile ze-RRMS?
• Ngubani othola i-RRMS?
• Yini ebangela i-RRMS?
• Uyini umbono weRRMS?
• Yikuphi ukwelashwa kweRRMS?
• Uyini umehluko phakathi kwe-PPMS ne-RRMS?
• Iminyaka yokuqala
• Izimbangela
• Umbono
• Izinketho zokwelashwa

Ukubuka konke

I-Multiple sclerosis (MS) yisifo esingelapheki esidala ukulimala kwemizwa. Izinhlobo ezine eziyinhloko ze-MS yilezi:

• isifo esihlukaniswe ngokwasemtholampilo (i-CIS)
• i-MS ebuyisa kabusha (RRMS)
• i-MS-progressive MS (PPMS)
• i-MS eqhubekayo yesibili (SPMS)

Uhlobo ngalunye lwe-MS luholela ekubikezelweni okuhlukile, amazinga obukhali, nezindlela zokwelashwa. Qhubeka ufunde ukuze uthole ukuthi i-PPMS ihluke kanjani kwi-RRMS.

Yini i-MS eyinhloko eqhubekayo?

I-PPMS ingenye yezinhlobo ezingavamile ze-MS, ezithinta cishe amaphesenti angu-15 abo bonke abatholakala benesimo. Ngenkathi ezinye izinhlobo ze-MS zibonakaliswa ukuhlaselwa okunamandla, okubizwa ngokuthi ukubuyela emuva, kulandelwe izikhathi zokungasebenzi, okubizwa ngokuthi ukuxolelwa, i-PPMS ibangela izimpawu eziya ngokuya ziba zimbi.

I-PPMS ingashintsha ngokuhamba kwesikhathi. Isikhathi sokuphila nalesi simo singahlukaniswa njenge:

• isebenza ngokuqhubeka uma kunezimpawu eziya ziba zimbi noma umsebenzi omusha we-MRI noma ubuyela emuva
• isebenza ngaphandle kokuqhubeka uma izimpawu noma umsebenzi we-MRI ukhona, kepha izimpawu azikabi nzima kakhulu
• ayisebenzi ngaphandle kokuqhubekela phambili uma kungekho zimpawu noma umsebenzi we-MRI futhi akukho kukhubazeka okwandayo
• ayisebenzi ngokuqhubekela phambili uma kukhona ukubuyela emuva noma umsebenzi we-MRI, futhi izimpawu ziba nzima kakhulu

Yiziphi izimpawu ezijwayelekile ze-PPMS?

Izimpawu ze-PPMS zingahluka, kepha izimpawu ezijwayelekile zifaka:

• izinkinga zokubona
• kunzima ukukhuluma
• izinkinga zokuhamba
• inkathazo ngokulinganisela
• ubuhlungu obujwayelekile
• imilenze eqinile futhi ebuthakathaka
• inkathazo ngememori
• ukukhathala
• Inkinga ngesinye namathumbu
• ukudana

Ngubani othola i-PPMS?

Abantu bavame ukutholakala bene-PPMS eminyakeni engama-40 nengama-50, kuyilapho labo abatholakala bene-RRMS beba seminyakeni yama-20 nengama-30. Abesilisa nabesifazane batholakala ukuthi bane-PPMS ngamazinga afanayo, ngokungafani ne-RRMS, ethinta kakhulu abesifazane.

Yini ebangela i-PPMS?

Izimbangela ze-MS azaziwa. Umbono ovame kakhulu uphakamisa ukuthi i-MS iqala njengenqubo yokuvuvukala yohlelo lokuzivikela komzimba oludala ukulimala emgodleni we-myelin. Lesi yisembozo esivikelayo esizungeze izinzwa zesistimu yezinzwa emaphakathi.

Enye inkolelo ukuthi kuyimpendulo yomzimba womzimba ebangelwa ukutheleleka ngegciwane. Kamuva, ukwehla kwemizwa noma ukulimala kwenzeka.

Obunye ubufakazi busikisela ukuthi i-MS eyisiqalo eqhubekayo iyingxenye yomtholampilo we-MS futhi ayihlukile ekubuyiseleni emuva i-MS.

Uyini umbono we-PPMS?

I-PPMS ithinta wonke umuntu ngokuhlukile. Ngenxa yokuthi i-PPMS iqhubeka, izimpawu zivame ukuba zimbi kakhulu kunokuba ngcono. Iningi labantu linenkinga yokuhamba. Abanye abantu futhi banezinkinga zokuthuthumela nezinkinga zokubona.

Yikuphi ukwelashwa okutholakalayo kwe-PPMS?

Ukwelashwa kwe-PPMS kunzima kakhulu kune-RRMS. Kubandakanya ukusebenzisa izindlela zokwelapha zokuzivikela ezifweni. Banganikela ngosizo lwesikhashana kepha bangasetshenziswa kuphela ngokuphepha izinyanga ezimbalwa kuya onyakeni ngesikhathi.

I-Ocrelizumab (Ocevus) ukuphela kwemithi evunyelwe yi-FDA yokwelapha i-PPMS.

Alikho ikhambi le-PPMS, kepha ungaphatha isimo.

Izidakamizwa ezithile zokuguqula izifo (ama-DMD) kanye ne-steroids zingasiza ukuphatha izimpawu. Ukugcina indlela yokuphila enempilo ehlanganisa ukudla ukudla okunomsoco nokuzivocavoca umzimba kungasiza. Ukuvuselelwa ngokusebenzisa ukwelashwa ngokomzimba nangokomsebenzi nakho kungasiza.

Kuyini ukubuyisela kabusha i-MS?

I-RRMS uhlobo oluvame kakhulu lwe-MS. Ithinta cishe amaphesenti angama-85 abo bonke abantu abatholakala ukuthi bane-MS. Iningi labantu liqala ukutholakala line-RRMS. Lokho kuxilongwa kuvamise ukushintsha ngemuva kwamashumi eminyaka ambalwa kuya enkambweni eqhubeka ngokwengeziwe.

Igama lokuphindisela kabusha i-MS lichaza inkambo yalesi simo. Imvamisa ihilela izikhathi zokuphindaphindeka okunamandla nezikhathi zokuxolelwa.

Ngesikhathi sokubuyela emuva, izimpawu ezintsha zingabonisa, noma izimpawu ezifanayo zingavuka futhi zibe nzima kakhulu. Ngesikhathi sokuxolelwa, abantu bangaba nezimpawu ezimbalwa, noma izimpawu zingabi nzima kangako amasonto, izinyanga, noma iminyaka.

Ezinye izimpawu ze-RRMS zingaba unomphela. Lezi zibizwa ngokuthi izimpawu eziyinsalela.

I-RRMS ihlukaniswa njenge:

• iyasebenza uma kukhona ukubuyela emuva noma izilonda ezitholakala kwi-MRI
• ayisebenzi uma kungekho ukubuyela emuva noma umsebenzi we-MRI
• ukuwohloka lapho izimpawu ziba nzima ngokwedlulele ngemuva kokubuyela emuva
• kungabi kubi kakhulu lapho izimpawu zingakhuli ngokuya ziba zimbi ngokwengeziwe ngemuva kokubuyela emuva

Yiziphi izimpawu ezivamile ze-RRMS?

Izimpawu ziyahluka kumuntu ngamunye, kepha izimpawu ezijwayelekile ze-RRMS zifaka:

• izinkinga ngokuxhumanisa nokulinganisela
• ukuba ndikindiki
• ukukhathala
• ukungakwazi ukucabanga kahle
• izinkinga ngombono
• ukudana
• izinkinga zokuchama
• Inkinga yokubekezelela ukushisa
• ubuthakathaka bemisipha
• ukuhamba kanzima

Ngubani othola i-RRMS?

Iningi labantu litholwa ukuthi line-RRMS eminyakeni engama-20 nengama-30, okuncane kunokuthola ukuxilongwa okujwayelekile kwezinye izinhlobo ze-MS, njenge-PPMS. Abesifazane basengozini ephindwe kabili yokutholakala kunabesilisa.

Yini ebangela i-RRMS?

Umbono owodwa ojwayelekile ngukuthi i-RRMS yisimo esingalapheki sokuzivikela komzimba esenzeka lapho umzimba uqala ukuzihlasela. Amasosha omzimba ahlasela imicu yezinzwa yomgogodla wezinzwa kanye nezendlalelo ezivimbayo, ezibizwa nge-myelin, ezivikela imicu yezinzwa.

Lokhu kuhlaselwa kubangela ukuvuvukala futhi kudale izindawo ezincane zomonakalo. Lo monakalo wenza kube nzima ngezinzwa ukuhambisa imininingwane emzimbeni. Izimpawu ze-RRMS ziyahlukahluka kuye ngendawo yomonakalo.

Isizathu se-MS asaziwa, kepha kungenzeka ukuthi kukhona okubangela izakhi zofuzo nezemvelo ze-MS. Omunye umbono uphakamisa ukuthi igciwane, elinjengo-Epstein-Barr, lingahle libangele i-MS.

Uyini umbono weRRMS?

Lesi simo sithinta umuntu ngamunye ngokuhlukile. Abanye abantu bangaphila impilo enempilo ngokubuyela emuva okungajwayelekile okungabangeli izinkinga ezinkulu. Abanye bangaba nokuhlaselwa okuvamile ngezimpawu eziqhubekayo ezigcina ziholele ezinkingeni ezinzima.

Yikuphi ukwelashwa kweRRMS?

Kunemithi eminingi evunyelwe yi-FDA yokwelapha i-RRMS. Le mithi ijwayele ukunciphisa ukwenzeka kokuphindelela nokuthuthuka kwezilonda ezintsha. Zibuye zinciphise ukuqhubeka kweRRMS.

Uyini umehluko phakathi kwe-PPMS ne-RRMS?

Yize i-PPMS ne-RRMS zombili izinhlobo ze-MS, kukhona umehluko ocacile phakathi kwazo, njenge:

Iminyaka yokuqala

Ukuxilongwa kwe-PPMS kuvame ukwenzeka kubantu abaneminyaka engama-40 nengama-50, kuyilapho i-RRMS ithinta labo abaneminyaka engama-20 nengama-30.

Izimbangela

Kokubili i-PPMS ne-RRMS kubangelwa ukuvuvukala nokuhlaselwa kwamasosha omzimba ku-myelin kanye nemicu yezinzwa. I-RRMS ivame ukuba nokuvuvukala okuningi kune-PPMS.

Labo abane-PPMS banezibazi eziningi namabala, noma izilonda, ezintanjeni zabo zomgogodla, kuyilapho labo abane-RRMS benezilonda eziningi ebuchosheni.

Umbono

I-PPMS iyaqhubeka nezimpawu ziya ngokuya ziba zimbi ngokuhamba kwesikhathi, kuyilapho i-RRMS ingaletha njengokuhlaselwa okunamandla ngesikhathi eside sokungasebenzi. I-RRMS ingahle ikhule ibe uhlobo oluqhubekayo lwe-MS, olubizwa nge-MS progressive MS, noma i-SPMS, ngemuva kwesikhathi esithile.

Izinketho zokwelashwa

Ngenkathi i-Ocrelizumab kungukuphela kwemithi evunyelwe yi-FDA yokwelapha i-PPMS, kunezinto eziningi ezingasiza. Kukhona neminye imishanguzo ecwaningwayo. I-RRMS inezokwelapha ezingaphezu kweshumi ezivunyelwe.

Iziguli ezine-PPMS ne-RRMS zingazuza ekuvuseleleni ngokwelashwa ngokomzimba nangokomsebenzi. Kunemithi eminingi odokotela abangayisebenzisa ukusiza abantu abane-MS ukuphatha izimpawu zabo.